Fibroblastic response to treatment with different preparations rich in growth factors Tập 42 Số 2 - Trang 162-170 - 2009
Eduardo Anitua, Mikel Sánchez, Mar Zalduendo, María de la Fuente, Roberto Prado, Gorka Orive, Isabel Andı́a
AbstractObjectives: Preparations rich in growth factors (PRGF) release them plus bioactive proteins at localized sites, with the aim of triggering healing and regenerative processes. The prevailing paradigm suggests that their influence on proliferation, angiogenesis and the extracellular matrix synthesis is minimal. However, variations in t...... hiện toàn bộ
Stem cells and neurological diseases Tập 41 Số s1 - Trang 94-114 - 2008
David C. Hess, Cesar V. Borlongan
Abstract. Cells of the central nervous system were once thought to be incapable of regeneration. This dogma has been challenged in the last decade with studies showing new, migrating stem cells in the brain in many rodent injury models and findings of new neurones in the human hippocampus in adults. Moreover, there are reports of bone marrow‐derived cells developing...... hiện toàn bộ
Hepatic stem cells: from inside and outside the liver? Tập 37 Số 1 - Trang 1-21 - 2004
Malcolm Alison, Pamela Vig, Francesco Paolo Russo, Brian Bigger, Eunice Amofah, Michael Themis, Stuart J. Forbes
Abstract. The liver is normally proliferatively quiescent, but hepatocyte loss through partial hepatectomy, uncomplicated by virus infection or inflammation, invokes a rapid regenerative response from all cell types in the liver to perfectly restore liver mass. Moreover, hepatocyte transplants in animals have shown that a certain proportion of hepatocytes in foetal...... hiện toàn bộ
MicroRNA‐494 suppresses cell proliferation and induces senescence in A549 lung cancer cells Tập 45 Số 1 - Trang 32-38 - 2012
Hiroaki Ohdaira, Masaki Sekiguchi, Kenichi Miyata, Kenichi Yoshida
AbstractObjectives: MicroRNAs (miRNAs) are small functional RNAs that regulate mRNAs for degradation or translational suppression. In the present study, we aimed to reveal functional importance of miRNA‐494 (miR‐494) in A549 human lung cancer cells.Materials and methods: We established A549 cells that...... hiện toàn bộ
Cell kinetic status of haematopoietic stem cells Tập 34 Số 2 - Trang 71-83 - 2001
Michael C. Mackey
Abstract.The haematopoietic stem cell (HSC) population supports a tremendous cellular production over the course of an animal’s lifetime, e.g. adult humans produce their body weight in red cells, white cells and platelets every 7 years, while the mouse produces about 60% of its body weight in the course of a 2 year lifespan. Understanding how the HSC population car...... hiện toàn bộ
Impact of oxygen environment on mesenchymal stem cell expansion and chondrogenic differentiation Tập 42 Số 4 - Trang 471-484 - 2009
Axel Krinner, Matthias Zscharnack, Augustinus Bader, Dirk Drasdo, Joerg Galle
AbstractIntroduction: In vitro expansion and differentiation of mesenchymal stem cells (MSC) rely on specific environmental conditions, and investigations have demonstrated that one crucial factor is oxygen environment.Objectives: In order to understand the impact of oxygen...... hiện toàn bộ
Diffusion‐limited binding explains binary dose response for local arterial and tumour drug delivery Tập 42 Số 3 - Trang 348-363 - 2009
Abraham R. Tzafriri, A. Levin, Elazer R. Edelman
AbstractBackground: Local drug delivery has transformed medicine, yet it remains unclear how drug efficacy depends on physicochemical properties and delivery kinetics. Most therapies seek to prolong release, yet recent studies demonstrate sustained clinical benefit following local bolus endovascular delivery.Objec...... hiện toàn bộ