American Society for Microbiology
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Heterogeneity in Mitochondrial Morphology and Membrane Potential Is Independent of the Nuclear Division Cycle in Multinucleate Fungal Cells
American Society for Microbiology - Tập 11 Số 3 - Trang 353-367 - 2012
ABSTRACT In the multinucleate filamentous fungus Ashbya gossypii , nuclei divide
asynchronously in a common cytoplasm. We hypothesize that the division cycle
machinery has a limited zone of influence in the cytoplasm to promote nuclear
autonomy. Mitochondria in cultured mammalian cells undergo cell cycle-specific
changes in morphology and membrane potential and therefore can serve as a
reporter of...
Sterol Regulatory Element Binding Proteins in Fungi: Hypoxic Transcription Factors Linked to Pathogenesis
American Society for Microbiology - Tập 9 Số 3 - Trang 352-359 - 2010
ABSTRACT Sterol regulatory element binding proteins (SREBPs) are membrane-bound
transcription factors whose proteolytic activation is controlled by the cellular
sterol concentration. Mammalian SREBPs are activated in cholesterol-depleted
cells and serve to regulate cellular lipid homeostasis. Recent work demonstrates
that SREBP is functionally conserved in fungi. While the ability to respond to
st...
Independent Metalloregulation of Ace1 and Mac1 in Saccharomyces cerevisiae
American Society for Microbiology - Tập 4 Số 11 - Trang 1863-1871 - 2005
ABSTRACT Ace1 and Mac1 undergo reciprocal copper metalloregulation in yeast
cells. Mac1 is functional as a transcriptional activator in copper-deficient
cells, whereas Ace1 is a transcriptional activator in copper-replete cells.
Cells undergoing a transition from copper-deficient to copper-sufficient
conditions through a switch in the growth medium show a rapid inactivation of
Mac1 and a correspon...
Saccharomyces cerevisiae Heat Shock Transcription Factor Regulates Cell Wall Remodeling in Response to Heat Shock
American Society for Microbiology - Tập 4 Số 6 - Trang 1050-1056 - 2005
ABSTRACT The heat shock transcription factor Hsf1 of the yeast Saccharomyces
cerevisiae regulates expression of genes encoding heat shock proteins and a
variety of other proteins as well. To better understand the cellular roles of
Hsf1, we screened multicopy suppressor genes of a temperature-sensitive hsf1
mutation. The RIM15 gene, encoding a protein kinase that is negatively regulated
by the cycl...
Role of Heat Shock Transcription Factor in Saccharomyces cerevisiae Oxidative Stress Response
American Society for Microbiology - Tập 6 Số 8 - Trang 1373-1379 - 2007
ABSTRACT The heat shock transcription factor Hsf1 of the yeast Saccharomyces
cerevisiae regulates the transcription of a set of genes that contain heat shock
elements (HSEs) in their promoters and function in diverse cellular processes,
including protein folding. Here, we show that Hsf1 activates the transcription
of various target genes when cells are treated with oxidizing reagents,
including th...
Regulation of Thermotolerance by Stress-Induced Transcription Factors in Saccharomyces cerevisiae
American Society for Microbiology - Tập 7 Số 5 - Trang 783-790 - 2008
ABSTRACT The heat shock transcription factor Hsf1 and the general stress
transcription factors Msn2 and Msn4 (Msn2/4) are major regulators of the heat
shock response in Saccharomyces cerevisiae . Here, we show that transcriptional
activation of their target genes, including HSP104 , an antistress chaperone
gene, is obligatory for thermotolerance. Although Hsf1 activity might be
necessary before th...
Immortalized Human Brain Endothelial Cell Line HCMEC/D3 as a Model of the Blood-Brain Barrier Facilitates In Vitro Studies of Central Nervous System Infection by Cryptococcus neoformans
American Society for Microbiology - Tập 8 Số 11 - Trang 1803-1807 - 2009
ABSTRACT Cryptococcus neoformans cells must cross the blood-brain barrier prior
to invading the central nervous system. Here we demonstrate that the
immortalized human brain endothelial cell line HCMEC/D3 is a useful alternative
to primary brain endothelial cells as a model of the blood-brain barrier for
studies of central nervous system infection.
ATP Synthase Is Responsible for Maintaining Mitochondrial Membrane Potential in Bloodstream Form Trypanosoma brucei
American Society for Microbiology - Tập 5 Số 1 - Trang 45-53 - 2006
ABSTRACT The mitochondrion of Trypanosoma brucei bloodstream form maintains a
membrane potential, although it lacks cytochromes and several Krebs cycle
enzymes. At this stage, the ATP synthase is present at reduced, although
significant, levels. To test whether the ATP synthase at this stage is important
for maintaining the mitochondrial membrane potential, we used RNA interference
(RNAi) to knock...
Copper-Dependent Iron Assimilation Pathway in the Model Photosynthetic EukaryoteChlamydomonas reinhardtii
American Society for Microbiology - Tập 1 Số 5 - Trang 736-757 - 2002
ABSTRACTThe unicellular green algaChlamydomonas reinhardtiiis a valuable model
for studying metal metabolism in a photosynthetic background. A search of
theChlamydomonasexpressed sequence tag database led to the identification of
several components that form a copper-dependent iron assimilation pathway
related to the high-affinity iron uptake pathway defined originally
forSaccharomyces cerevisiae....
The Pre-mRNA Splicing Machinery of Trypanosomes: Complex or Simplified?
American Society for Microbiology - Tập 9 Số 8 - Trang 1159-1170 - 2010
ABSTRACT Trypanosomatids are early-diverged, protistan parasites of which
Trypanosoma brucei , Trypanosoma cruzi , and several species of Leishmania cause
severe, often lethal diseases in humans. To better combat these parasites, their
molecular biology has been a research focus for more than 3 decades, and the
discovery of spliced leader (SL) trans splicing in T. brucei established a key
differen...
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