Immortalized Human Brain Endothelial Cell Line HCMEC/D3 as a Model of the Blood-Brain Barrier Facilitates In Vitro Studies of Central Nervous System Infection by Cryptococcus neoformans

American Society for Microbiology - Tập 8 Số 11 - Trang 1803-1807 - 2009
Kiem Vu1, Babette B. Weksler2, Ignacio A. Romero3, Angie Gelli1
1Department of Pharmacology, School of Medicine, University of California, Genome and Biomedical Sciences Facility, Davis, California
2Division of Hematology-Medical Oncology, Weill Medical College of Cornell University, New York, New York
3Department of Biological Sciences , The Open University , Walton Hall, Milton Keynes, United Kingdom

Tóm tắt

ABSTRACT Cryptococcus neoformans cells must cross the blood-brain barrier prior to invading the central nervous system. Here we demonstrate that the immortalized human brain endothelial cell line HCMEC/D3 is a useful alternative to primary brain endothelial cells as a model of the blood-brain barrier for studies of central nervous system infection.

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