Aging Cell
SCOPUS (2002-2025)SCIE-ISI
1474-9726
1474-9718
Anh Quốc
Cơ quản chủ quản: WILEY , Wiley-Blackwell Publishing Ltd
Lĩnh vực:
AgingCell Biology
Phân tích ảnh hưởng
Các bài báo tiêu biểu
The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
Tập 14 Số 4 - Trang 644-658 - 2015
β‐galactosidase liên quan đến lão hóa là β‐galactosidase lysosome Dịch bởi AI
Tập 5 Số 2 - Trang 187-195 - 2006
Tóm tắtLão hóa tái sinh hạn chế sự sinh sản của các tế bào soma được nuôi cấy và
có thể phản ánh sự lão hóa tế bào in vivo. Chỉ số sinh học được sử dụng phổ biến
nhất để xác định tế bào lão hóa và lão hóa là β‐galactosidase liên quan đến lão
hóa (SA‐β‐gal), được định nghĩa là hoạt động β‐galactosidase có thể phát hiện
được ở pH 6.0 trong các tế bào lão hóa, nhưng nguồn gốc của SA‐β‐gal và vai trò
...
Fat tissue, aging, and cellular senescence
Tập 9 Số 5 - Trang 667-684 - 2010
SummaryFat tissue, frequently the largest organ in humans, is at the nexus of
mechanisms involved in longevity and age‐related metabolic dysfunction. Fat
distribution and function change dramatically throughout life. Obesity is
associated with accelerated onset of diseases common in old age, while fat
ablation and certain mutations affecting fat increase life span. Fat cells turn
over throughout t...
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
Tập 6 Số 1 - Trang 95-110 - 2007
SummaryMany conditions that shift cells from states of nutrient utilization and
growth to states of cell maintenance extend lifespan. We have carried out a
systematic lifespan analysis of conditions that inhibit protein synthesis. We
find that reducing the levels of ribosomal proteins, ribosomal‐protein S6 kinase
or translation‐initiation factors increases the lifespan of Caenorhabditis
elegans. T...
SIRT1 transgenic mice show phenotypes resembling calorie restriction
Tập 6 Số 6 - Trang 759-767 - 2007
SummaryWe generated mice that overexpress the sirtuin, SIRT1. Transgenic mice
have been generated by knocking in SIRT1 cDNA into the β‐actin locus. Mice that
are hemizygous for this transgene express normal levels of β‐actin and higher
levels of SIRT1 protein in several tissues. Transgenic mice display some
phenotypes similar to mice on a calorie‐restricted diet: they are leaner than
littermate co...
DNA damage response and cellular senescence in tissues of aging mice
Tập 8 Số 3 - Trang 311-323 - 2009
SummaryThe impact of cellular senescence onto aging of organisms is not fully
clear, not at least because of the scarcity of reliable data on the mere
frequency of senescent cells in aging tissues. Activation of a DNA damage
response including formation of DNA damage foci containing activated H2A.X
(γ‐H2A.X) at either uncapped telomeres or persistent DNA strand breaks is the
major trigger of cell ...
A senescent cell bystander effect: senescence‐induced senescence
Tập 11 Số 2 - Trang 345-349 - 2012
SummarySenescent cells produce and secrete various bioactive molecules including
interleukins, growth factors, matrix‐degrading enzymes and reactive oxygen
species (ROS). Thus, it has been proposed that senescent cells can damage their
local environment, and a stimulatory effect on tumour cell growth and
invasiveness has been documented. However, it was unknown what effect, if any,
senescent cells...
Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice
Tập 15 Số 5 - Trang 973-977 - 2016
Reduced oxygen tension attenuates differentiation capacity of human mesenchymal stem cells and prolongs their lifespan
Tập 6 Số 6 - Trang 745-757 - 2007
SummaryMesenchymal stem cells (MSC) are capable of differentiating into bone,
fat, cartilage, tendon and other organ progenitor cells. Despite the abundance
of MSC within the organism, little is known about their in vivo properties or
about their corresponding in vivo niches. We therefore isolated MSC from spongy
(cancellous) bone biopsies of healthy adults. When compared with the surrounding
marr...
Measuring biological aging in humans: A quest
Tập 19 Số 2 - 2020
AbstractThe global population of individuals over the age of 65 is growing at an
unprecedented rate and is expected to reach 1.6 billion by 2050. Most older
individuals are affected by multiple chronic diseases, leading to complex drug
treatments and increased risk of physical and cognitive disability. Improving or
preserving the health and quality of life of these individuals is challenging
due t...