Aging Cell
SCOPUS (2002-2023)SCIE-ISI
1474-9726
1474-9718
Anh Quốc
Cơ quản chủ quản: WILEY , Wiley-Blackwell Publishing Ltd
Lĩnh vực:
AgingCell Biology
Các bài báo tiêu biểu
The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs
Tập 14 Số 4 - Trang 644-658 - 2015
β‐galactosidase liên quan đến lão hóa là β‐galactosidase lysosome Dịch bởi AI Tóm tắt Lão hóa tái sinh hạn chế sự sinh sản của các tế bào soma được nuôi cấy và có thể phản ánh sự lão hóa tế bào in vivo . Chỉ số sinh học được sử dụng phổ biến nhất để xác định tế bào lão hóa và lão hóa là β‐galactosidase liên quan đến lão hóa (SA‐β‐gal), được định nghĩa là hoạt động β‐galactosidase có thể phát hiện được ở pH 6.0 trong ... ... hiện toàn bộ
Tập 5 Số 2 - Trang 187-195 - 2006
Fat tissue, aging, and cellular senescenceSummary Fat tissue, frequently the largest organ in humans, is at the nexus of mechanisms involved in longevity and age‐related metabolic dysfunction. Fat distribution and function change dramatically throughout life. Obesity is associated with accelerated onset of diseases common in old age, while fat ablation and certain mutations affecting fat increase life span.... ... hiện toàn bộ
Tập 9 Số 5 - Trang 667-684 - 2010
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegansSummary Many conditions that shift cells from states of nutrient utilization and growth to states of cell maintenance extend lifespan. We have carried out a systematic lifespan analysis of conditions that inhibit protein synthesis. We find that reducing the levels of ribosomal proteins, ribosomal‐protein S6 kinase or translation‐initiation factors increases the life... ... hiện toàn bộ
Tập 6 Số 1 - Trang 95-110 - 2007
SIRT1 transgenic mice show phenotypes resembling calorie restrictionSummary We generated mice that overexpress the sirtuin, SIRT1. Transgenic mice have been generated by knocking in SIRT1 cDNA into the β‐actin locus. Mice that are hemizygous for this transgene express normal levels of β‐actin and higher levels of SIRT1 protein in several tissues. Transgenic mice display some phenotypes similar to mice on a calorie‐restricted diet: t... ... hiện toàn bộ
Tập 6 Số 6 - Trang 759-767 - 2007
DNA damage response and cellular senescence in tissues of aging miceSummary The impact of cellular senescence onto aging of organisms is not fully clear, not at least because of the scarcity of reliable data on the mere frequency of senescent cells in aging tissues. Activation of a DNA damage response including formation of DNA damage foci containing activated H2A.X (γ‐H2A.X) at either uncapped telomeres or persistent DNA strand bre... ... hiện toàn bộ
Tập 8 Số 3 - Trang 311-323 - 2009
A senescent cell bystander effect: senescence‐induced senescenceSummary Senescent cells produce and secrete various bioactive molecules including interleukins, growth factors, matrix‐degrading enzymes and reactive oxygen species (ROS). Thus, it has been proposed that senescent cells can damage their local environment, and a stimulatory effect on tumour cell growth and invasiveness has been documented. However, it was unknown wha... ... hiện toàn bộ
Tập 11 Số 2 - Trang 345-349 - 2012
Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice
Tập 15 Số 5 - Trang 973-977 - 2016
Reduced oxygen tension attenuates differentiation capacity of human mesenchymal stem cells and prolongs their lifespanSummary Mesenchymal stem cells (MSC) are capable of differentiating into bone, fat, cartilage, tendon and other organ progenitor cells. Despite the abundance of MSC within the organism, little is known about their in vivo properties or about their corresponding in vivo niches. We therefore isolated MSC from spong... ... hiện toàn bộ
Tập 6 Số 6 - Trang 745-757 - 2007
Measuring biological aging in humans: A questAbstract The global population of individuals over the age of 65 is growing at an unprecedented rate and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple chronic diseases, leading to complex drug treatments and increased risk of physical and cognitive disability. Improving or preserving the health and quality of life of these... ... hiện toàn bộ
Tập 19 Số 2 - 2020