The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

Aging Cell - Tập 14 Số 4 - Trang 644-658 - 2015
Yi Zhun Zhu1, Tamar Tchkonia1, Tamar Pirtskhalava1, Adam C. Gower2, Husheng Ding1, Nino Giorgadze1, Allyson K. Palmer1, Yuji Ikeno3,4, Gene B. Hubbard3,4, Marc E. Lenburg2, Steven P. O’Hara1, Nicholas F. LaRusso1, Jordan D. Miller1, Carolyn M Roos1, Grace Verzosa1, Nathan K. LeBrasseur1, Jonathan D. Wren5, Joshua N. Farr1, Sundeep Khosla1, Michael B. Stout1, Sara J. McGowan6, Heike Fuhrmann‐Stroissnigg6, Aditi U. Gurkar6, Jing Zhao6, Debora Colangelo6, Akaitz Dorronsoro6, Yuan Ling6, Amira S. Barghouthy6, Diana C. Navarro6, Tokio Sano6, Paul D. Robbins6, Laura J. Niedernhofer6, James L. Kirkland1
1Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA
2Section of Computational Biomedicine, Boston University School of Medicine, Boston, MA, USA
3Departments of Pathology Barshop Institute for Longevity and Aging Studies The University of Texas Health Science Center San Antonio TX USA
4Research Service, Geriatric Research and Education Clinical Center, Audie L. Murphy VA Hospital South Texas Veterans Health Care System, San Antonio, TX, USA.
5Department of Biochemistry and Molecular Biology, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
6Department of Metabolism and Aging, The Scripps Research Institute, Jupiter, FL, USA

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Tài liệu tham khảo

10.1128/MCB.00293-08

10.1111/j.1440-1681.2006.04373.x

10.1038/nature10600

10.1038/nrd4175

10.1016/j.leukres.2014.09.016

10.2174/18715206113139990114

10.1093/gerona/glp213

10.1158/2159-8290.CD-12-0018

10.1038/sj.bjc.6604676

10.1016/0306-3623(95)02001-2

10.1371/journal.pbio.0060301

10.1159/000343320

10.1161/CIRCULATIONAHA.108.822403

10.1101/gad.13.22.2905

10.1073/pnas.1119296109

10.1093/jnci/djn491

10.1016/j.devcel.2014.11.012

10.3402/pba.v1i0.7219

10.1038/nature12437

10.1152/ajpheart.00292.2006

10.1038/sj.onc.1207116

10.1016/j.bbamcr.2008.09.009

10.1158/0008-5472.CAN-04-3995

Ghosal G, 2013, DNA damage tolerance: a double‐edged sword guarding the genome, Transl. Cancer Res., 2, 107

10.1113/jphysiol.2013.268680

10.1377/hlthaff.2013.0052

10.1038/onc.2010.13

10.1158/1535-7163.MCT-13-0500

10.1016/j.dnarep.2011.04.026

10.3748/wjg.v11.i29.4511

10.1126/science.1122446

10.1093/ppar/23.4.12

10.1016/j.exger.2012.11.014

Kirkland JL, 2014, Clinical strategies and animal models for developing senolytic agents, Exp. Gerontol.

10.1038/ncb1448

10.1016/j.cell.2008.06.049

10.1016/j.cell.2008.03.039

10.1111/j.1474-9726.2010.00567.x

10.1093/gerona/glp068

10.1002/ddr.21235.

10.1002/(SICI)1097-0215(20000515)86:4<570::AID-IJC20>3.0.CO;2-T

10.1158/1078-0432.CCR-06-1112

10.1093/emboj/18.3.632

10.1158/1078-0432.CCR-10-2616

10.1002/jcb.22760

10.1023/B:APPT.0000045801.15585.dd

10.1002/jcp.20510

10.1152/ajpheart.00735.2012

Schneider DJ, 2008, The effect of plasminogen activator inhibitor type 1 on apoptosis, Thromb. Haemost., 100, 1037, 10.1160/TH08-04-0234

10.1038/cddis.2012.188

10.1073/pnas.0506580102

10.1093/bioinformatics/btm369

10.1002/hep.26993

10.1152/ajpendo.00202.2006

10.1111/j.1474-9726.2010.00608.x

10.1172/JCI64098

10.1172/JCI45785

10.1158/0008-5472.CAN-07-5850

Truffaux N, 2014, Preclinical evaluation of dasatinib alone and in combination with cabozantinib for the treatment of diffuse intrinsic pontine glioma, Neuro Oncol.

10.1016/j.cell.2009.04.037

Wang E, 1995, Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved, Cancer Res., 55, 2284

10.1007/s10549-011-1902-7

10.1111/j.1582-4934.2012.01612.x

10.1016/j.leukres.2013.03.003

10.1038/nature05529

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Aging Cell

Tập 14 Số 4

644-658

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