Aging Cell
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The overexpression of major antioxidant enzymes does not extend the lifespan of mice
Aging Cell - Tập 8 Số 1 - Trang 73-75 - 2009
SummaryWe evaluated the effect of overexpressing antioxidant enzymes on the
lifespans of transgenic mice that overexpress copper zinc superoxide dismutase
(CuZnSOD), catalase, or combinations of either CuZnSOD and catalase or CuZnSOD
and manganese superoxide dismutase (MnSOD). Our results show that the
overexpression of these major antioxidant enzymes, which are known to scavenge
superoxide and hy...
NK and NKT cell functions in immunosenescence
Aging Cell - Tập 3 Số 4 - Trang 177-184 - 2004
SummaryImmunosenescence is defined as the state of dysregulated immune function
that contributes to the increased susceptibility to infection, cancer and
autoimmune diseases observed in old organisms, including humans. However,
dysregulations in the immune functions are normally counterbalanced by
continuous adaptation of the body to the deteriorations that occur over time.
These adaptive changes ...
Age‐associated loss of Sirt1‐mediated enhancement of glucose‐stimulated insulin secretion in beta cell‐specific Sirt1‐overexpressing (BESTO) mice
Aging Cell - Tập 7 Số 1 - Trang 78-88 - 2008
SummaryThe Sir2 (silent information regulator 2) family of NAD‐dependent
deacetylases regulates aging and longevity across a wide variety of organisms,
including yeast, worms, and flies. In mammals, the Sir2 ortholog Sirt1 promotes
fat mobilization, fatty acid oxidation, glucose production, and insulin
secretion in response to nutrient availability. We previously reported that an
increased dosage ...
Measuring biological aging in humans: A quest
Aging Cell - Tập 19 Số 2 - 2020
AbstractThe global population of individuals over the age of 65 is growing at an
unprecedented rate and is expected to reach 1.6 billion by 2050. Most older
individuals are affected by multiple chronic diseases, leading to complex drug
treatments and increased risk of physical and cognitive disability. Improving or
preserving the health and quality of life of these individuals is challenging
due t...
MicroRNA‐134‐5p inhibition rescues long‐term plasticity and synaptic tagging/capture in an Aβ(1–42)‐induced model of Alzheimer’s disease
Aging Cell - Tập 19 Số 1 - 2020
AbstractProgressive memory loss is one of the most common characteristics of
Alzheimer's disease (AD), which has been shown to be caused by several factors
including accumulation of amyloid β peptide (Aβ) plaques and neurofibrillary
tangles. Synaptic plasticity and associative plasticity, the cellular basis of
memory, are impaired in AD. Recent studies suggest a functional relevance of
microRNAs (...
Sirtuins at the crossroads of stemness, aging, and cancer
Aging Cell - Tập 16 Số 6 - Trang 1208-1218 - 2017
SummarySirtuins are stress‐responsive proteins that direct various
post‐translational modifications (PTMs) and as a result, are considered to be
master regulators of several cellular processes. They are known to both extend
lifespan and regulate spontaneous tumor development. As both aging and cancer
are associated with altered stem cell function, the possibility that the
involvement of sirtuins i...
Chelation of hippocampal zinc enhances long‐term potentiation and synaptic tagging/capture in CA 1 pyramidal neurons of aged rats: implications to aging and memory
Aging Cell - Tập 16 Số 1 - Trang 136-148 - 2017
SummaryAging is associated with decline in cognitive functions, prominently in
the memory consolidation and association capabilities. Hippocampus plays a
crucial role in the formation and maintenance of long‐term associative memories,
and a significant body of evidence shows that impairments in hippocampal
function correlate with aging‐related memory loss. A number of studies have
implicated alter...
Defective recruitment of motor proteins to autophagic compartments contributes to autophagic failure in aging
Aging Cell - Tập 17 Số 4 - 2018
SummaryInability to preserve proteostasis with age contributes to the gradual
loss of function that characterizes old organisms. Defective autophagy, a
component of the proteostasis network for delivery and degradation of
intracellular materials in lysosomes, has been described in multiple old
organisms, while a robust autophagy response has been linked to longevity. The
molecular mechanisms respo...
Oxidative stress and mitochondrial impairment can be separated from lipofuscin accumulation in aged human skeletal muscle
Aging Cell - Tập 6 Số 2 - Trang 245-256 - 2007
SummaryAccording to the free radical theory of aging, reactive oxygen species
(ROS) act as a driving force of the aging process, and it is generally believed
that mitochondrial dysfunction is a major source of increased oxidative stress
in tissues with high content of mitochondria, such as muscle or brain. However,
recent experiments in mouse models of premature aging have questioned the role
of m...
Cardiolipin remodeling by ALCAT1 links mitochondrial dysfunction to Parkinson’s diseases
Aging Cell - Tập 18 Số 3 - 2019
AbstractCardiolipin (CL) is a mitochondrial signature phospholipid that is
required for membrane structure, respiration, dynamics, and mitophagy. Oxidative
damage of CL by reactive oxygen species is implicated in the pathogenesis of
Parkinson's disease (PD), but the underlying cause remains elusive. This work
investigated the role of ALCAT1, an acyltransferase that catalyzes pathological
remodelin...
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