Aging Cell

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β‐galactosidase liên quan đến lão hóa là β‐galactosidase lysosome Dịch bởi AI
Aging Cell - Tập 5 Số 2 - Trang 187-195 - 2006
Bo Yun Lee, Jung A Han, Jun Sub Im, Amelia Morrone, Kimberly L. Johung, Edward C. Goodwin, Wim J. Kleijer, Daniel DiMaio, Eun Seong Hwang
Tóm tắtLão hóa tái sinh hạn chế sự sinh sản của các tế bào soma được nuôi cấy và có thể phản ánh sự lão hóa tế bào in vivo. Chỉ số sinh học được sử dụng phổ biến nhất để xác định tế bào lão hóa và lão hóa là β‐galactosidase liên quan đến lão hóa (SA‐β‐gal), được định nghĩa là hoạt động β‐galactosidase có thể phát hiện được ở pH 6.0 trong ...... hiện toàn bộ
Sustained high levels of neuregulin‐1 in the longest‐lived rodents; a key determinant of rodent longevity
Aging Cell - Tập 11 Số 2 - Trang 213-222 - 2012
Yael H. Edrey, Diana Casper, Dorothée Huchon, James Mele, Jonathan Gelfond, Deborah M. Kristan, Eviatar Nevo, Rochelle Buffenstein
SummaryNaked mole‐rats (Heterocephalus glaber), the longest‐lived rodents, live 7–10 times longer than similarly sized mice and exhibit normal activities for approximately 75% of their lives. Little is known about the mechanisms that allow them to delay the aging process and live so long. Neuregulin‐1 (NRG‐1) signaling is critical for nor...... hiện toàn bộ
The angiotensin‐(1‐7)/Mas receptor axis protects from endothelial cell senescence via klotho and Nrf2 activation
Aging Cell - Tập 18 Số 3 - 2019
Alejandra Romero, Álvaro San Hipólito‐Luengo, Laura A. Villalobos, Susana Vallejo, Inés Valencia, Patrycja Michalska, Natalia Pajuelo‐Lozano, Isabel Sánchez‐Pérez, Rafael León, José Luis Bartha, María‐Jesús Sanz, Jorge D. Erusalimsky, Carlos F. Sánchez‐Ferrer, Tania Romacho, Concepción Peiró
AbstractEndothelial cell senescence is a hallmark of vascular aging that predisposes to vascular disease. We aimed to explore the capacity of the renin–angiotensin system (RAS) heptapeptide angiotensin (Ang)‐(1‐7) to counteract human endothelial cell senescence and to identify intracellular pathways mediating its potential protective action. In human umbilical vein...... hiện toàn bộ
Reduction in glutamate uptake is associated with extrasynaptic NMDA and metabotropic glutamate receptor activation at the hippocampal CA1 synapse of aged rats
Aging Cell - Tập 9 Số 5 - Trang 722-735 - 2010
Brigitte Potier, Jean‐Marie Billard, Sylvain Rivière, Pierre‐Marie Sinet, Isabelle Denis, Gaëlle Champeil‐Potokar, Barbara Grintal, Anne Jouvenceau, Mélanie Kollen, P. Dutar
SummaryThis study aims to determine whether the regulation of extracellular glutamate is altered during aging and its possible consequences on synaptic transmission and plasticity. A decrease in the expression of the glial glutamate transporters GLAST and GLT‐1 and reduced glutamate uptake occur in the aged (24–27 months) Sprague–Dawley rat hippocampus. Glutamaterg...... hiện toàn bộ
Meta‐analysis on blood transcriptomic studies identifies consistently coexpressed protein–protein interaction modules as robust markers of human aging
Aging Cell - Tập 13 Số 2 - Trang 216-225 - 2014
Erik B. van den Akker, Willemijn M. Passtoors, Rick Jansen, Erik W. van Zwet, Jelle J. Goeman, Marc Hulsman, Valur Emilsson, Markus Perola, Gonneke Willemsen, Brenda W.J.H. Penninx, Bas Heijmans, Andrea B. Maier, Dorret I. Boomsma, Joost N. Kok, P. Eline Slagboom, Marcel J. T. Reinders, Marian Beekman
SummaryThe bodily decline that occurs with advancing age strongly impacts on the prospects for future health and life expectancy. Despite the profound role of age in disease etiology, knowledge about the molecular mechanisms driving the process of aging in humans is limited. Here, we used an integrative network‐based approach for combining multiple large‐scale expr...... hiện toàn bộ
Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans
Aging Cell - Tập 6 Số 1 - Trang 95-110 - 2007
Malene Hansen, Stefan Taubert, Douglas K. Crawford, Nataliya Libina, Seung‐Jae Lee, Cynthia Kenyon
SummaryMany conditions that shift cells from states of nutrient utilization and growth to states of cell maintenance extend lifespan. We have carried out a systematic lifespan analysis of conditions that inhibit protein synthesis. We find that reducing the levels of ribosomal proteins, ribosomal‐protein S6 kinase or translation‐initiation factors increases the life...... hiện toàn bộ
Towards a gene expression biomarker set for human biological age
Aging Cell - Tập 12 Số 2 - Trang 324-326 - 2013
Alice C. Holly, David Melzer, Luke C. Pilling, William Henley, Dena Hernandez, Andrew Singleton, Stefania Bandinelli, Jack M. Guralnik, Luigi Ferrucci, Lorna W. Harries
SummaryWe have previously described a statistical model capable of distinguishing young (age <65 years) from old (age ≥75 years) individuals. Here we studied the performance of a modified model in three populations and determined whether individuals predicted to be biologically younger than their chronological age had biochemical and functional measures consiste...... hiện toàn bộ
Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements
Aging Cell - Tập 12 Số 2 - Trang 247-256 - 2013
Marco De Cecco, Steven W. Criscione, Edward Peckham, Sara Hillenmeyer, Eliza A. Hamm, Jayameenakshi Manivannan, Adam Peterson, Jill A. Kreiling, Nicola Neretti, John M. Sedivy
SummaryReplicative cellular senescence is an important tumor suppression mechanism and also contributes to aging. Progression of both cancer and aging include significant epigenetic components, but the chromatin changes that take place during cellular senescence are not known. We used formaldehyde assisted isolation of regulatory elements (... hiện toàn bộ
Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans
Aging Cell - Tập 15 Số 5 - Trang 903-913 - 2016
Benjamin P. Lee, Luke C. Pilling, Florence Emond, Kevin Flurkey, David Harrison, Rong Yuan, Luanne L. Peters, George A. Kuchel, Luigi Ferrucci, David Melzer, Lorna W. Harries
Analysis of individual cells identifies cell‐to‐cell variability following induction of cellular senescence
Aging Cell - Tập 16 Số 5 - Trang 1043-1050 - 2017
Christopher D. Wiley, James M. Flynn, Christapher S. Morrissey, Ronald Lebofsky, Joe Shuga, Xiao Dong, Marc Unger, Jan Vijg, Simon Melov, Judith Campisi
SummarySenescent cells play important roles in both physiological and pathological processes, including cancer and aging. In all cases, however, senescent cells comprise only a small fraction of tissues. Senescent phenotypes have been studied largely in relatively homogeneous populations of cultured cells. In vivo, senescent cells are gen...... hiện toàn bộ
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