Aging Cell

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The overexpression of major antioxidant enzymes does not extend the lifespan of mice
Aging Cell - Tập 8 Số 1 - Trang 73-75 - 2009
Viviana Pérez, Holly Van Remmen, Alex Bokov, Charles J. Epstein, Jan Vijg, Arlan Richardson
SummaryWe evaluated the effect of overexpressing antioxidant enzymes on the lifespans of transgenic mice that overexpress copper zinc superoxide dismutase (CuZnSOD), catalase, or combinations of either CuZnSOD and catalase or CuZnSOD and manganese superoxide dismutase (MnSOD). Our results show that the overexpression of these major antioxidant enzymes, which are kn...... hiện toàn bộ
NK and NKT cell functions in immunosenescence
Aging Cell - Tập 3 Số 4 - Trang 177-184 - 2004
Eugenio Mocchegiani, Marco Malavolta
SummaryImmunosenescence is defined as the state of dysregulated immune function that contributes to the increased susceptibility to infection, cancer and autoimmune diseases observed in old organisms, including humans. However, dysregulations in the immune functions are normally counterbalanced by continuous adaptation of the body to the deteriorations that occur o...... hiện toàn bộ
Age‐associated loss of Sirt1‐mediated enhancement of glucose‐stimulated insulin secretion in beta cell‐specific Sirt1‐overexpressing (BESTO) mice
Aging Cell - Tập 7 Số 1 - Trang 78-88 - 2008
Kathryn Moynihan Ramsey, Kathryn F. Mills, Akiko Satoh, Shin‐ichiro Imai
SummaryThe Sir2 (silent information regulator 2) family of NAD‐dependent deacetylases regulates aging and longevity across a wide variety of organisms, including yeast, worms, and flies. In mammals, the Sir2 ortholog Sirt1 promotes fat mobilization, fatty acid oxidation, glucose production, and insulin secretion...... hiện toàn bộ
Measuring biological aging in humans: A quest
Aging Cell - Tập 19 Số 2 - 2020
Luigi Ferrucci, Marta González‐Freire, Elisa Fabbri, Eleanor M. Simonsick, Toshiko Tanaka, Zenobia Moore, Shabnam Salimi, Felipe Sierra, Rafael de Cabo
AbstractThe global population of individuals over the age of 65 is growing at an unprecedented rate and is expected to reach 1.6 billion by 2050. Most older individuals are affected by multiple chronic diseases, leading to complex drug treatments and increased risk of physical and cognitive disability. Improving or preserving the health and quality of life of these...... hiện toàn bộ
MicroRNA‐134‐5p inhibition rescues long‐term plasticity and synaptic tagging/capture in an Aβ(1–42)‐induced model of Alzheimer’s disease
Aging Cell - Tập 19 Số 1 - 2020
Nimmi Baby, Nithyakalyani Alagappan, S. Thameem Dheen, Sreedharan Sajikumar
AbstractProgressive memory loss is one of the most common characteristics of Alzheimer's disease (AD), which has been shown to be caused by several factors including accumulation of amyloid β peptide (Aβ) plaques and neurofibrillary tangles. Synaptic plasticity and associative plasticity, the cellular basis of memory, are impaired in AD. Recent studies suggest a fu...... hiện toàn bộ
Sirtuins at the crossroads of stemness, aging, and cancer
Aging Cell - Tập 16 Số 6 - Trang 1208-1218 - 2017
C. O'Callaghan, Athanassios Vassilopoulos
SummarySirtuins are stress‐responsive proteins that direct various post‐translational modifications (PTMs) and as a result, are considered to be master regulators of several cellular processes. They are known to both extend lifespan and regulate spontaneous tumor development. As both aging and cancer are...... hiện toàn bộ
Chelation of hippocampal zinc enhances long‐term potentiation and synaptic tagging/capture in CA1 pyramidal neurons of aged rats: implications to aging and memory
Aging Cell - Tập 16 Số 1 - Trang 136-148 - 2017
Mahesh Shivarama Shetty, Mahima Sharma, Sreedharan Sajikumar
SummaryAging is associated with decline in cognitive functions, prominently in the memory consolidation and association capabilities. Hippocampus plays a crucial role in the formation and maintenance of long‐term associative memories, and a significant body of evidence shows that impairments in hippocampal function correlate with aging‐related memory loss. A number...... hiện toàn bộ
Defective recruitment of motor proteins to autophagic compartments contributes to autophagic failure in aging
Aging Cell - Tập 17 Số 4 - 2018
Eloy Bejarano, John W. Murray, Xintao Wang, Olatz Pampliega, David Yin, Bindi Patel, Andrea Yuste, Allan W. Wolkoff, Ana María Cuervo
SummaryInability to preserve proteostasis with age contributes to the gradual loss of function that characterizes old organisms. Defective autophagy, a component of the proteostasis network for delivery and degradation of intracellular materials in lysosomes, has been described in multiple old organisms, while a robust autophagy response has been linked to longevit...... hiện toàn bộ
Oxidative stress and mitochondrial impairment can be separated from lipofuscin accumulation in aged human skeletal muscle
Aging Cell - Tập 6 Số 2 - Trang 245-256 - 2007
Eveline Hütter, Mette Skovbro, Barbara Lener, Clara Prats, Rasmus Rabøl, Flemming Dela, Pidder Jansen‐Dürr
SummaryAccording to the free radical theory of aging, reactive oxygen species (ROS) act as a driving force of the aging process, and it is generally believed that mitochondrial dysfunction is a major source of increased oxidative stress in tissues with high content of mitochondria, such as muscle or brain. However, recent experiments in mouse models of premature ag...... hiện toàn bộ
Cardiolipin remodeling by ALCAT1 links mitochondrial dysfunction to Parkinson’s diseases
Aging Cell - Tập 18 Số 3 - 2019
Chengjie Song, Jun Zhang, Shasha Qi, Zhen Liu, Xiaoyang Zhang, Yue Zheng, John‐Paul Andersen, Weiping Zhang, Randy Strong, Paul Anthony Martinez, Nicolas Musi, Jia Nie, Yuguang Shi
AbstractCardiolipin (CL) is a mitochondrial signature phospholipid that is required for membrane structure, respiration, dynamics, and mitophagy. Oxidative damage of CL by reactive oxygen species is implicated in the pathogenesis of Parkinson's disease (PD), but the underlying cause remains elusive. This work investigated the role of ALCAT1, an acyltransferase that...... hiện toàn bộ
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