Aging Cell

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The overexpression of major antioxidant enzymes does not extend the lifespan of mice
Aging Cell - Tập 8 Số 1 - Trang 73-75 - 2009
Viviana Pérez, Holly Van Remmen, Alex Bokov, Charles J. Epstein, Jan Vijg, Arlan Richardson
SummaryWe evaluated the effect of overexpressing antioxidant enzymes on the lifespans of transgenic mice that overexpress copper zinc superoxide dismutase (CuZnSOD), catalase, or combinations of either CuZnSOD and catalase or CuZnSOD and manganese superoxide dismutase (MnSOD). Our results show that the overexpression of these major antioxidant enzymes, which are kn...... hiện toàn bộ
Chelation of hippocampal zinc enhances long‐term potentiation and synaptic tagging/capture in CA1 pyramidal neurons of aged rats: implications to aging and memory
Aging Cell - Tập 16 Số 1 - Trang 136-148 - 2017
Mahesh Shivarama Shetty, Mahima Sharma, Sreedharan Sajikumar
SummaryAging is associated with decline in cognitive functions, prominently in the memory consolidation and association capabilities. Hippocampus plays a crucial role in the formation and maintenance of long‐term associative memories, and a significant body of evidence shows that impairments in hippocampal function correlate with aging‐related memory loss. A number...... hiện toàn bộ
Defective recruitment of motor proteins to autophagic compartments contributes to autophagic failure in aging
Aging Cell - Tập 17 Số 4 - 2018
Eloy Bejarano, John W. Murray, Xintao Wang, Olatz Pampliega, David Yin, Bindi Patel, Andrea Yuste, Allan W. Wolkoff, Ana María Cuervo
SummaryInability to preserve proteostasis with age contributes to the gradual loss of function that characterizes old organisms. Defective autophagy, a component of the proteostasis network for delivery and degradation of intracellular materials in lysosomes, has been described in multiple old organisms, while a robust autophagy response has been linked to longevit...... hiện toàn bộ
Blueberry polyphenols increase lifespan and thermotolerance in Caenorhabditis elegans
Aging Cell - Tập 5 Số 1 - Trang 59-68 - 2006
Mark A. Wilson, Barbara Shukitt‐Hale, Wilhelmina Kalt, Donald K. Ingram, James A. Joseph, Catherine A. Wolkow
SummaryThe beneficial effects of polyphenol compounds in fruits and vegetables are mainly extrapolated from in vitro studies or short‐term dietary supplementation studies. Due to cost and duration, relatively little is known about whether dietary polyphenols are beneficial in whole animals, particularly with respect to aging. To address t...... hiện toàn bộ
Alterations in intrinsic neuronal excitability during normal aging
Aging Cell - Tập 6 Số 3 - Trang 327-336 - 2007
John F. Disterhoft, M. Matthew Oh
SummaryNormal aging subjects, including humans, have difficulty learning hippocampus‐dependent tasks. For example, at least 50% of normal aging rabbits and rats fail to meet a learning criterion in trace eyeblink conditioning. Many factors may contribute to this age‐related learning impairment. An important cause is the reduced intrinsic excitability observed in hi...... hiện toàn bộ
RNA‐seq of the aging brain in the short‐lived fish N. furzeri – conserved pathways and novel genes associated with neurogenesis
Aging Cell - Tập 13 Số 6 - Trang 965-974 - 2014
Mario Baumgart, Marco Groth, Stefan Priebe, Aurora Savino, Giovanna Testa, Andreas Dix, Roberto Ripa, Francesco Spallotta, Carlo Gaetano, Michela Ori, Eva Terzibasi Tozzini, Reinhard Guthke, Matthias Platzer, Alessandro Cellerino
SummaryThe brains of teleost fish show extensive adult neurogenesis and neuronal regeneration. The patterns of gene regulation during fish brain aging are unknown. The short‐lived teleost fish Nothobranchius furzeri shows markers of brain aging including reduced learning performances, gliosis, and reduced adult neurogenesis. We used ... hiện toàn bộ
Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice
Aging Cell - Tập 15 Số 5 - Trang 973-977 - 2016
Carolyn M Roos, Bin Zhang, Allyson K. Palmer, Mikołaj Ogrodnik, Tamar Pirtskhalava, Nassir M Thalji, Michael A Hagler, Diana Jurk, Leslie Smith, Grace Casaclang‐Verzosa, Yi Zhun Zhu, Marissa J. Schafer, Tamar Tchkonia, James L. Kirkland, Jordan D. Miller
Fibroblasts from long‐lived Snell dwarf mice are resistant to oxygen‐induced in vitro growth arrest
Aging Cell - Tập 5 Số 1 - Trang 89-96 - 2006
Scott Maynard, Richard A. Miller
SummarySnell dwarf mice live longer than controls, and show lower age‐adjusted rates of lethal neoplastic diseases. Fibroblast cells from adult dwarf mice are resistant to the lethal effects of oxidative and nonoxidative stresses, including the carcinogen methyl methanesulfonate. We now report that dwarf‐derived fibroblasts are slow to enter the stage of growth arr...... hiện toàn bộ
Gene expression profile of long‐lived Ames dwarf mice and Little mice
Aging Cell - Tập 3 Số 6 - Trang 423-441 - 2004
Daniel Amador‐Noguez, Kazuo Yagi, Susan Venable, Gretchen J. Darlington
SummaryAmes dwarf mice (Prop1df/df) and Little mice (Ghrhrlit/lit) are used as models of delayed aging and show significant increases in lifespan (50% and 25%, respectively) when compared wi...... hiện toàn bộ
β‐galactosidase liên quan đến lão hóa là β‐galactosidase lysosome Dịch bởi AI
Aging Cell - Tập 5 Số 2 - Trang 187-195 - 2006
Bo Yun Lee, Jung A Han, Jun Sub Im, Amelia Morrone, Kimberly L. Johung, Edward C. Goodwin, Wim J. Kleijer, Daniel DiMaio, Eun Seong Hwang
Tóm tắtLão hóa tái sinh hạn chế sự sinh sản của các tế bào soma được nuôi cấy và có thể phản ánh sự lão hóa tế bào in vivo. Chỉ số sinh học được sử dụng phổ biến nhất để xác định tế bào lão hóa và lão hóa là β‐galactosidase liên quan đến lão hóa (SA‐β‐gal), được định nghĩa là hoạt động β‐galactosidase có thể phát hiện được ở pH 6.0 trong ...... hiện toàn bộ
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