The overexpression of major antioxidant enzymes does not extend the lifespan of mice

Aging Cell - Tập 8 Số 1 - Trang 73-75 - 2009
Viviana Pérez1,2, Holly Van Remmen1,2,3,4, Alex Bokov1,3, Charles J. Epstein5,6, Jan Vijg7, Arlan Richardson1,2,4
1Barshop Institute for Longevity and Aging Studies,
2Department of Cellular and Structural Biology
3Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
4Geriatric Research Education and Clinical Center, South Texas Veterans Health Care System, San Antonio, TX 78229, USA
5Department of Pediatrics, School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
6Institute of Human Genetics and
7Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA

Tóm tắt

SummaryWe evaluated the effect of overexpressing antioxidant enzymes on the lifespans of transgenic mice that overexpress copper zinc superoxide dismutase (CuZnSOD), catalase, or combinations of either CuZnSOD and catalase or CuZnSOD and manganese superoxide dismutase (MnSOD). Our results show that the overexpression of these major antioxidant enzymes, which are known to scavenge superoxide and hydrogen peroxide in the cytosolic and mitochondrial compartments, is insufficient to extend lifespan in mice.

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Aging Cell

Tập 8 Số 1

73-75

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