Use of RNAi screens to uncover resistance mechanisms in cancer cells and identify synthetic lethal interactions

Drug Discovery Today: Technologies - Tập 11 - Trang 11-18 - 2014
Paul Diehl1, Donato Tedesco1, Alex Chenchik1
1Cellecta, Inc., 320 Logue Ave, Mountain View, CA 94043, United States

Tài liệu tham khảo

Golub, 1999, Molecular classification of cancer: class discovery and class prediction by gene expression monitoring, Science, 238, 531, 10.1126/science.286.5439.531

Chin, 2006, Genomic and transcriptional abberrations linked to breast cancer pathophysiologies, Cancer Cell, 10, 529, 10.1016/j.ccr.2006.10.009

Barrentina, 2012, The Cancer Cell Line Encyclopedia enables predictive modeling of anticancer drug sensitivity, Nature, 483, 603, 10.1038/nature11003

Ciriello, 2013, Emerging landscape of oncogenic signature across human cancers, Nat Genet, 45, 11271133, 10.1038/ng.2762

Costanzo, 2010, The genetic landscape of a cell, Science, 327, 425, 10.1126/science.1180823

Zuk, 2012, The mystery of missing heritability: genetic interactions create phantom heritability, Proc Natl Acad Sci USA, 109, 1193, 10.1073/pnas.1119675109

Weinstein, 2000, Disorders in cell cicuitry during multistage carcinogenesis: the role of homeostasis, Carcinogenesis, 21, 857, 10.1093/carcin/21.5.857

Varmus, 2006, The new era of cancer research, Science, 312, 1162, 10.1126/science.1126758

Canaani, 2009, Minireview: methodological approaches in application of synthetic lethality screening towards anticancer therapy, Br J Cancer, 100, 1213, 10.1038/sj.bjc.6605000

Kaelin, 2009, Synthetic lethality: a framework for the development of wise cancer therapeutics, Genome Med, 1, 99, 10.1186/gm99

Ashworth, 2008, A synthetic lethal therapeutic approach: poly(ADP) ribose polymerase inhibits for the treatment of cancers deficient in DNA double-strand repair, J Clin Oncol, 26, 3785, 10.1200/JCO.2008.16.0812

Michiue, 2009, Induction of in vivo synthetic lethal RNAi responses to treat glioblastoma, Cancer Biol Ther, 8, 2304, 10.4161/cbt.8.23.10271

Nijman, 2011, Synthetic lethality: general principles, utility and detection using genetic screens in human cells, FEBS Lett, 585, 1, 10.1016/j.febslet.2010.11.024

Sanda, 2013, TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemia, Cancer Discov, 3, 564, 10.1158/2159-8290.CD-12-0504

Sims, 2011, interference screening using pooled shRNA libraries and next generation sequencing, Genome Biol, 12, p. R104, 10.1186/gb-2011-12-10-r104

Marcotte, 2012, Essential gene profiles in breast, pancreatic, and ovarian cancer cells, Cancer Discov, 2, 172, 10.1158/2159-8290.CD-11-0224

Laufer, 2013, Mapping genetic interactions in human cancer cells with RNAi and multiparametic phenotyping, Nat Methods, 10, 427, 10.1038/nmeth.2436

Silva, 2008, Profiling essential genes in human mammary cells by multiplex RNAi screening, Science, 319, 617, 10.1126/science.1149185

Luo, 2008, Highly parallel identification of essential genes in cancer cells, Proc Natl Acad Sci USA, 105, 20380, 10.1073/pnas.0810485105

Scholl, 2009, Synthetic lethal interaction between oncogenic KRAS dependency and STK33 suppression in human cancer cells, Cell, 137, 821, 10.1016/j.cell.2009.03.017

Babij, 2011, STK33 kinase activity is nonessential in KRAS-dependant cancer cells, Cancer Res, 71, 5818, 10.1158/0008-5472.CAN-11-0778

Dussault, 2011, STK33 kinase is not essential in KRAS-dependent cells-response, Cancer Res, 71, p. 7717, 10.1158/0008-5472.CAN-11-3068

Prahallad, 2012, Unresponsiveness of colon cancer to BRAF(V600e) inhibition thorough feedback activation of EGFR, Nature, 483, 100, 10.1038/nature10868

Fredebohm, 2013, Depletion of RAD17 sensitizes pancreatic cancer cells to gemcitabine, J Cell Sci, 126, 3380, 10.1242/jcs.124768

Qin, 2012, Identification of unique sensitizing targets for anti-inflammatory CDDO-Me in metastatic melanoma by a large-scale synthetic lethal RNAi screening, Pigment Cell Melanoma Res, 26, 97, 10.1111/pcmr.12031

Mills, 2013, RNAi screening uncovers Dhx9 as a modifier of ABT-737 resistance in an Eu-myc/Bcl-2 mouse model, Blood, 121, 3402, 10.1182/blood-2012-06-434365

Liu, 2009, A genome-wide synthetic dosage lethality screen reveals multiple pathways that require the function of ubiquitin-binding proteins Rad23 and Dsk2, BMC Biol, 7, 75, 10.1186/1741-7007-7-75

Dompe, 2011, A whole-genome RNAi screen identifies an 8q22 gene cluster that inhibits death receptor-mediated apoptosis, Proc Natl Acad Sci USA, 108, E943, 10.1073/pnas.1100132108

Schlabach, 2008, Cancer proliferation gene discovery through functional genomics, Science, 319, 620, 10.1126/science.1149200

Bommi-Reddy, 2008, Kinase requirements in human cells: Ill. Altered kinase requirements in VHL–/– cancer cells detected in a pilot synthetic lethal screen, Proc Natl Acad Sci USA, 105, 16484, 10.1073/pnas.0806574105

Cheung, 2011, Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer, Proc Natl Acad Sci USA, 108, 12372, 10.1073/pnas.1109363108

Brough, 2011, Functional viability profiles of breast cancer, Cancer Discov, 1, 260, 10.1158/2159-8290.CD-11-0107

Tedesco, 2012, Identification of genes specific for viability of prostate cancer cells using a pooled lentiviral shRNA expression library, Biotechniques, 52, 198, 10.2144/000113830

Vicent, 2010, Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models, J Clin Invest, 120, 3940, 10.1172/JCI44165

Lamy, 2013, Control of autophagic cell death by caspase-10 in multiple myeloma, Cancer Cell, 23, 435, 10.1016/j.ccr.2013.02.017

Shaffer, 2008, IRF4 addiction in multiple myeloma, Nature, 454, 226, 10.1038/nature07064

Bassik, 2013, A systematic mammalian genetic interation map reveals pathways underlying ricin susceptibility, Cell, 152, 1, 10.1016/j.cell.2013.01.030

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Drug Discovery Today: Technologies

Tập 11

11-18

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