Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR

Nature - Tập 483 Số 7387 - Trang 100-103 - 2012
Anirudh Prahallad1, Chong Sun1, Sidong Huang1, Federica Di Nicolantonio2, Ramón Salazar3, Davide Zecchin2, Roderick L. Beijersbergen1, Alberto Bardelli4, René Bernards1
1Division of Molecular Carcinogenesis, Center for Biomedical Genetics and Cancer Genomics Centre, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands,
2Laboratory of Molecular Genetics, Institute for Cancer Research and Treatment, University of Torino, Medical School, Str prov 142 Km 3.95, 10060 Candiolo, Torino, Italy,
3IDIBELL, Institut Català d’Oncologia L’Hospitalet de Llobregat, Gran Via s/n, km 2, 7 08907 L’Hospitalet-Barcelona, Spain,
4FIRC-IFOM Institute for Molecular Oncology, Via Adamello 16, 20100 Milan, Italy,

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