Synthetic Lethal Interaction between Oncogenic KRAS Dependency and STK33 Suppression in Human Cancer Cells

Cell - Tập 137 - Trang 821-834 - 2009
Claudia Scholl1, Stefan Fröhling1, Ian F. Dunn2,3,4,5,6, Anna C. Schinzel3,4,5,6, David A. Barbie3,4,5,6,7, So Young Kim3,4,5,6, Serena J. Silver6, Pablo Tamayo6, Raymond C. Wadlow7,8, Sridhar Ramaswamy6,7,8,9, Konstanze Döhner10, Lars Bullinger10, Peter Sandy11, Jesse S. Boehm6, David E. Root6, Tyler Jacks6,11,12, William C. Hahn1,3,4,5,6, D. Gary Gilliland1,3,6,9,13,14
1Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
2Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
3Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
4Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
5Center for Cancer Systems Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
6Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA
7Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
8Center for Cancer Research and Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
9Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA
10Department of Internal Medicine III, University Hospital of Ulm, 89081, Ulm, Germany
11David H. Koch Institute for Integrative Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
12Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
13Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA
14Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA

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