Doxorubicin loaded zinc oxide nanoflowers – Surmounting drug-induced toxicity

Karthika, 2022, Multidrug resistance in cancer cells: focus on a possible strategy plan to address colon carcinoma cells, Life, 12, 811, 10.3390/life12060811

Hasan, 2022, Mitigative impact of bradykinin potentiating factor isolated from Androctonus amoreuxi scorpion venom and low doses of γ-irradiation on doxorubicin induced hepatotoxicity through ang II/AMPK crosstalk, Toxicol. Mech. Methods, 1

Chen, 2009, Synergistic effect of magnetic nanoparticles of Fe3O4 with gambogic acid on apoptosis of K562 leukemia cells, Int. J. Nanomed., 4, 251, 10.2147/IJN.S7932

Angsutararux, 2015, Chemotherapy-induced cardiotoxicity: overview of the roles of oxidative stress, Oxid. Med. Cell. Longev., 2015

Fornari, 1994, Interference by doxorubicin with DNA unwinding in MCF-7 breast tumor cells, Mol. Pharmacol., 45, 649

Deavall, 2012, Drug-induced oxidative stress and toxicity, J. Toxicol., 2012

Renu, 2022, Toxic effects and molecular mechanism of doxorubicin on different organs–an update, Toxin Rev., 41, 650, 10.1080/15569543.2021.1912099

Schirone, 2000, Mitochondria and doxorubicin-induced cardiomyopathy: a complex interplay, Cells, 11

Kourie, 1998, Interaction of reactive oxygen species with ion transport mechanisms, Am. J. Physiol. Cell Physiol., 275, C1, 10.1152/ajpcell.1998.275.1.C1

Podyacheva, 2021, Analysis of models of doxorubicin-induced cardiomyopathy in rats and mice. A modern view from the perspective of the pathophysiologist and the clinician, Front. Pharmacol., 12, 10.3389/fphar.2021.670479

Renu, 2018, Molecular mechanism of doxorubicin-induced cardiomyopathy–An update, Eur. J. Pharmacol., 818, 241, 10.1016/j.ejphar.2017.10.043

Pugazhendhi, 2018, Toxicity of Doxorubicin (Dox) to different experimental organ systems, Life Sci., 200, 26, 10.1016/j.lfs.2018.03.023

Parker, 2001, Nuclear magnetic resonance study of doxorubicin binding to cardiolipin containing magnetically oriented phospholipid bilayers, Biochim. Biophys. Acta, Biomembr., 1514, 206, 10.1016/S0005-2736(01)00371-6

El-Sheikh, 2012, Effect of coenzyme-Q10 on doxorubicin-induced nephrotoxicity in rats, Adv. Pharmacol. Sci., 2012

Hu, 2022, Dexrazoxane alleviated doxorubicin-induced nephropathy in rats, Pharmacology, 107, 206, 10.1159/000521220

Sheibani, 2022, Doxorubicin-induced cardiotoxicity: an overview on pre-clinical therapeutic approaches, Cardiovasc. Toxicol., 1

Kassner, 2008, Carbonyl reductase 1 is a predominant doxorubicin reductase in the human liver, Drug Metabol. Dispos., 36, 2113, 10.1124/dmd.108.022251

Xiao, 2019, The true colors of autophagy in doxorubicin-induced cardiotoxicity, Oncol. Lett., 18, 2165

Kanwal, 2019, Doxorubicin-loaded quaternary ammonium palmitoyl glycol chitosan polymeric nanoformulation: uptake by cells and organs, Int. J. Nanomed., 14, 1, 10.2147/IJN.S176868

Shafei, 2017, A review on the efficacy and toxicity of different doxorubicin nanoparticles for targeted therapy in metastatic breast cancer, Biomed. Pharmacother., 95, 1209, 10.1016/j.biopha.2017.09.059

Martschick, 2009, The pathogenetic mechanism of anthracycline-induced palmar-plantar erythrodysesthesia, Anticancer Res., 29, 2307

Manil, 1995, Acute renal toxicity of doxorubicin (adriamycin)-loaded cyanoacrylate nanoparticles, Pharmaceut. Res., 12, 85, 10.1023/A:1016290704772

Badkoobeh, 2013, Effect of nano-zinc oxide on doxorubicin-induced oxidative stress and sperm disorders in adult male Wistar rats, Iran. J. Reproductive Med., 11, 355

Czyżowska, 2022, A review: zinc oxide nanoparticles–friends or enemies?, Int. J. Environ. Health Res., 32, 885, 10.1080/09603123.2020.1805415

Espitia, 2012, Zinc oxide nanoparticles: synthesis, antimicrobial activity and food packaging applications, Food Bioprocess Technol., 5, 1447, 10.1007/s11947-012-0797-6

Roy, 2013, Zinc and male reproduction in domestic animals: a review, Indian J. Anim. Nutr., 30, 339

Marreiro, 2017, Zinc and oxidative stress: current mechanisms, Antioxidants, 6, 24, 10.3390/antiox6020024

Eftekhari, 2020, Hepatoprotective role of berberine against paraquat-induced liver toxicity in rat, Environ. Sci. Pollut. Control Ser., 27, 4969, 10.1007/s11356-019-07232-1

El-Maddawy, 2019, Protective effects of zinc oxide nanoparticles against doxorubicin induced testicular toxicity and DNA damage in male rats, Toxicol. Res., 8, 654, 10.1039/c9tx00052f

Deng, 2013, The synergistic effect and mechanism of doxorubicin-ZnO nanocomplexes as a multimodal agent integrating diverse anticancer therapeutics, Int. J. Nanomed., 8, 1835

Zhang, 2011, A strategy for ZnO nanorod mediated multi-mode cancer treatment, Biomaterials, 32, 906, 10.1016/j.biomaterials.2010.11.027

Srivastav, 2016, A comprehensive toxicity study of zinc oxide nanoparticles versus their bulk in Wistar rats: toxicity study of zinc oxide nanoparticles, Hum. Exp. Toxicol., 35, 1286, 10.1177/0960327116629530

Rahdar, 2020, Synthesis, characterization, and intraperitoneal biochemical studies of zinc oxide nanoparticles in Rattus norvegicus, Appl. Phys. A, 126, 1

Pandurangan, 2015, In vitro toxicity of zinc oxide nanoparticles: a review, J. Nanoparticle Res., 17, 1, 10.1007/s11051-015-2958-9

AbouAitah, 2021, Enhanced activity and sustained release of protocatechuic acid, a natural antibacterial agent, from hybrid nanoformulations with zinc oxide nanoparticles, Int. J. Mol. Sci., 22, 5287, 10.3390/ijms22105287

Ijaz, 2023, Development and DoE-ANN based optimization of novel swellable matrix-diffusible doxorubicin loaded zinc oxide nanoflowers using sonochemical-precipitation method, Int. J. Pharm., 633, 1, 10.1016/j.ijpharm.2023.122584

Naeem, 2020, HF-based surface modification for enhanced photobiological and photochemical performance of ZnO and ZnO/CdS hierarchical structures, Mater. Chem. Phys., 252, 10.1016/j.matchemphys.2020.123190

Ahmadian, 2020, Effects of quercetin loaded nanostructured lipid carriers on the paraquat-induced toxicity in human lymphocytes, Pestic. Biochem. Physiol., 167, 10.1016/j.pestbp.2020.104586

Wang, 2014, Superior antibacterial activity of zinc oxide/graphene oxide composites originating from high zinc concentration localized around bacteria, ACS Appl. Mater. Interfaces, 6, 2791, 10.1021/am4053317

Percie du Sert, 2020, The ARRIVE guidelines 2.0: updated guidelines for reporting animal research, J. Cerebr. Blood Flow Metabol., 40, 1769, 10.1177/0271678X20943823

Wen, 2017, Acute toxicity and genotoxicity of silver nanoparticle in rats, PLoS One, 12, 10.1371/journal.pone.0185554

Dong, 2022, Safety assessment of MPTA: an oral acute and 90-day sub-chronic toxicity study in Sprague-Dawley rats, Regul. Toxicol. Pharmacol., 10.1016/j.yrtph.2022.105188

Khan, 2022, Toxicological impact of sodium benzoate on inflammatory cytokines, oxidative stress and biochemical markers in male Wistar rats, Drug Chem. Toxicol., 45, 1345, 10.1080/01480545.2020.1825472

Mohamed, 2022, TGF-β1, NAG-1, and antioxidant enzymes expression alterations in Cisplatin-induced nephrotoxicity in a rat model: comparative modulating role of Melatonin, Vit. E and Ozone, Gene., 820

Kumral, 2015, Effect of olive leaf extract treatment on doxorubicin-induced cardiac, hepatic and renal toxicity in rats, Pathophysiology, 22, 117, 10.1016/j.pathophys.2015.04.002

El Okle, 2022, Ornipural® mitigates malathion-induced hepato-renal damage in rats via amelioration of oxidative stress biomarkers, restoration of antioxidant activity, and attenuation of inflammatory response, Antioxidants, 11, 757, 10.3390/antiox11040757

Esmaeilbeigi, 2021, Intra and extracellular effects of benzo [α] pyrene on liver, gill and blood of Caspian White fish (Rutilus frissi kutum): cyto-genotoxicity and histopathology approach, Mar. Pollut. Bull., 163, 10.1016/j.marpolbul.2020.111942

Fouda, 2022, Evaluation of the diagnostic performances of tissue inhibitors of metalloproteinase-1 and fibronectin for heart failure, J. Biosci. Appl. Res., 8, 107, 10.21608/jbaar.2022.246476

Chang, 2022, Glycogen synthase kinase 3 beta inhibitor SB216763 improves Kir2. 1 expression after myocardia infraction in rats, J. Intervent. Card Electrophysiol., 63, 239, 10.1007/s10840-021-00963-7

Kocaman, 2021, Crocin attenuates oxidative and inflammatory stress-related periodontitis in cardiac tissues in rats, vol. 30

Adegbola, 2021, Combined ginger and garlic extract improves serum lipid profile, oxidative stress markers and reduced IL-6 in diet induced obese rats, Obesity Med., 23, 10.1016/j.obmed.2021.100336

Abid, 2021, Atherogenic indices in clinical practice and biomedical research: a short review, Baghdad J. Biochem. Appl. Biol. Sci., 2, 60, 10.47419/bjbabs.v2i02.52

Alatawi, 2021, Coconut products alleviate hyperglycaemic, hyperlipidimic and nephropathy indices in streptozotocin-induced diabetic wistar rats, Saudi J. Biol. Sci., 28, 4224, 10.1016/j.sjbs.2021.06.060

Benzer, 2018, Chemoprotective effects of curcumin on doxorubicin-induced nephrotoxicity in wistar rats: by modulating inflammatory cytokines, apoptosis, oxidative stress and oxidative DNA damage, Arch. Physiol. Biochem., 124, 448, 10.1080/13813455.2017.1422766

Ahmed, 2022, Thyme oil and thymol counter doxorubicin-induced hepatotoxicity via modulation of inflammation, apoptosis, and oxidative stress, Oxid. Med. Cell. Longev., 2022

Díaz-Antón, 2022, Early detection of anthracycline‐and trastuzumab‐induced cardiotoxicity: value and optimal timing of serum biomarkers and echocardiographic parameters, ESC Heart Failure, 9, 1127, 10.1002/ehf2.13782

Esmat, 2015, Aloin: a natural antitumor anthraquinone glycoside with iron chelating and non-atherogenic activities, Pharmaceut. Biol., 53, 138, 10.3109/13880209.2014.912239

Emara, 2022, Detection of hypokalemia disorder and its relation with hypercalcemia in blood serum using LIBS technique for patients of colorectal cancer grade I and grade II, Laser Med. Sci., 37, 1081, 10.1007/s10103-021-03355-5

Liu, 2017, Low toxicity and accumulation of zinc oxide nanoparticles in mice after 270-day consecutive dietary supplementation, Toxicol. Res., 6, 134, 10.1039/C6TX00370B

Ratnaparkhi, 2013, Sustained release oral drug delivery system-an overview, Terminology, 3, 10

Pei, 2019, Effects of dietary zinc oxide nanoparticles supplementation on growth performance, zinc status, intestinal morphology, microflora population, and immune response in weaned pigs, J. Sci. Food Agric., 99, 1366, 10.1002/jsfa.9312

El-Maddawy, 2019, Protective effects of zinc oxide nanoparticles against doxorubicin induced testicular toxicity and DNA damage in male rats, Toxicol. Res., 8, 654, 10.1039/c9tx00052f

Suh, 2009, Weight gain after adjuvant TAC (docetaxel, doxorubicin, and cyclophosphamide) chemotherapy for node-positive breast cancer, J. Clin. Oncol., 27

Abdel-Moniem, 2022, Iron supplementation ameliorates aloin-induced iron deficiency anemia in rats, Exp. Mol. Pathol., 124, 10.1016/j.yexmp.2021.104740

Helmy, 2022, Novel doxorubicin/folate-targeted trans-ferulic acid-loaded PLGA nanoparticles combination: in-vivo superiority over standard chemotherapeutic regimen for breast cancer treatment, Biomed. Pharmacother., 145, 10.1016/j.biopha.2021.112376

do Nascimento Marreiro, 2022, Antiviral and immunological activity of zinc and possible role in COVID-19, Br. J. Nutr., 127, 1172, 10.1017/S0007114521002099

Mohamed, 2022, Anti-inflammatory, anti-apoptotic, and antioxidant roles of honey, royal jelly, and propolis in suppressing nephrotoxicity induced by doxorubicin in male albino rats, Antioxidants, 11, 1029, 10.3390/antiox11051029

Afsar, 2020, Doxorubicin-induced alterations in kidney functioning, oxidative stress, DNA damage, and renal tissue morphology; Improvement by Acacia hydaspica tannin-rich ethyl acetate fraction, Saudi J. Biol. Sci., 27, 2251, 10.1016/j.sjbs.2020.07.011

Hazem, 2022, Pirfenidone and vitamin D mitigate renal fibrosis induced by doxorubicin in mice with Ehrlich solid tumor, Life Sci., 288, 10.1016/j.lfs.2021.120185

Kubat, 2021, The effects of mesenchymal stem cell mitochondrial transplantation on doxorubicin‐mediated nephrotoxicity in rats, J. Biochem. Mol. Toxicol., 35, 10.1002/jbt.22612

Barakat, 2020, Protective role of zinc oxide nanoparticles in kidney injury induced by cisplatin in rats, Life Sci., 262, 10.1016/j.lfs.2020.118503

Ruz, 2013, Zinc as a potential coadjuvant in therapy for type 2 diabetes, Food Nutr. Bull., 34, 215, 10.1177/156482651303400210

Prasanna, 2020, New molecular and biochemical insights of doxorubicin-induced hepatotoxicity, Life Sci., 250, 10.1016/j.lfs.2020.117599

Janssen, 2021, Population pharmacokinetics of docetaxel, paclitaxel, doxorubicin and epirubicin in pregnant women with cancer: a study from the International Network of Cancer, Infertility and Pregnancy (INCIP), Clin. Pharmacokinet., 60, 775, 10.1007/s40262-020-00961-4

Indu, 2014, Amelioration of doxorubicin induced cardio-and hepato-toxicity by carotenoids, J. Cancer Res. Therapeut., 10, 62, 10.4103/0973-1482.131370

Kalender, 2005, Doxorubicin hepatotoxicity and hepatic free radical metabolism in rats: the effects of vitamin E and catechin, Toxicology, 209, 39, 10.1016/j.tox.2004.12.003

Sajomsang, 2014, Effect of N-pyridinium positions of quaternized chitosan on transfection efficiency in gene delivery system, Carbohydr. Polym., 104, 17, 10.1016/j.carbpol.2013.12.077

Boghdady, 2013, Antioxidant and antiapoptotic effects of proanthocyanidin and ginkgo biloba extract against doxorubicin‐induced cardiac injury in rats, Cell Biochem. Funct., 31, 344, 10.1002/cbf.2907

Saleh, 2020, Pirfenidone and vitamin D ameliorate cardiac fibrosis induced by doxorubicin in Ehrlich ascites carcinoma bearing mice: modulation of monocyte chemoattractant protein-1 and Jun N-terminal kinase-1 pathways, Pharmaceuticals, 13, 348, 10.3390/ph13110348

Afsar, 2017, Acacia hydaspica R. Parker prevents doxorubicin-induced cardiac injury by attenuation of oxidative stress and structural Cardiomyocyte alterations in rats, BMC Compl. Alternative Med., 17, 554, 10.1186/s12906-017-2061-0

Al-Malky, 2020, Major obstacles to doxorubicin therapy: cardiotoxicity and drug resistance, J. Oncol. Pharm. Pract., 26, 434, 10.1177/1078155219877931

Cattel, 2003, From conventional to stealth liposomes a new frontier in cancer chemotherapy, Tumori J., 89, 237, 10.1177/030089160308900302

Karagulova, 2007, Protective role of intracellular zinc in myocardial ischemia/reperfusion is associated with preservation of protein kinase C isoforms, J. Pharmacol. Exp. Therapeut., 321, 517, 10.1124/jpet.107.119644

Knez, 2021, Zinc as a biomarker of cardiovascular health, Front. Nutr., 8, 10.3389/fnut.2021.686078

Mohammadifard, 2019, Trace minerals intake: risks and benefits for cardiovascular health, Crit. Rev. Food Sci. Nutr., 59, 1334, 10.1080/10408398.2017.1406332

Ranasinghe, 2015, Effects of zinc supplementation on serum lipids: a systematic review and meta-analysis, Nutr. Metabol., 12, 1, 10.1186/s12986-015-0023-4

Sobczuk, 2020, Anthracycline-induced cardiotoxicity and renin-angiotensin-aldosterone system—from molecular mechanisms to therapeutic applications, Heart Failure Rev., 1

Crawford, 1987, Excessive intracellular zinc accumulation in cardiac and skeletal muscles of dystrophic hamsters, Exp. Neurol., 95, 265, 10.1016/0014-4886(87)90137-3

Vizirianakis, 2011, Nanomedicine and personalized medicine toward the application of pharmacotyping in clinical practice to improve drug-delivery outcomes, Nanomed. Nanotechnol. Biol. Med., 7, 11, 10.1016/j.nano.2010.11.002

Ho, 2004, Zinc deficiency, DNA damage and cancer risk, J. Nutr. Biochem., 15, 572, 10.1016/j.jnutbio.2004.07.005