Regulation of obesity and insulin resistance by nitric oxide
Tài liệu tham khảo
Roger, 2012, Heart disease and stroke statistics—2012 update: a report from the American Heart Association, Circulation, 125, e2, 10.1161/CIR.0b013e31823ac046
Calle, 1999, Body-mass index and mortality in a prospective cohort of U.S. adults, N. Engl. J. Med., 341, 1097, 10.1056/NEJM199910073411501
Tseng, 2010, Cellular bioenergetics as a target for obesity therapy, Nat. Rev. Drug Discovery, 9, 465, 10.1038/nrd3138
Kant, 2004, Eating out in America, 1987–2000: trends and nutritional correlates, Prev. Med., 38, 243, 10.1016/j.ypmed.2003.10.004
Nielsen, 2003, Patterns and trends in food portion sizes, 1977–1998, JAMA, 289, 450, 10.1001/jama.289.4.450
Briefel, 2004, Secular trends in dietary intake in the United States, Annu. Rev. Nutr., 24, 401, 10.1146/annurev.nutr.23.011702.073349
Hill, 1998, Environmental contributions to the obesity epidemic, Science, 280, 1371, 10.1126/science.280.5368.1371
Jones, 2008, Environmental pollution and diabetes: a neglected association, Lancet, 371, 287, 10.1016/S0140-6736(08)60147-6
Smink, 2008, Exposure to hexachlorobenzene during pregnancy increases the risk of overweight in children aged 6 years, Acta Paediatr., 97, 1465, 10.1111/j.1651-2227.2008.00937.x
Sun, 2009, Ambient air pollution exaggerates adipose inflammation and insulin resistance in a mouse model of diet-induced obesity, Circulation, 119, 538, 10.1161/CIRCULATIONAHA.108.799015
Xu, 2010, Effect of early particulate air pollution exposure on obesity in mice: role of p47phox, Arterioscler. Thromb. Vasc. Biol., 30, 2518, 10.1161/ATVBAHA.110.215350
Yan, 2011, Enhanced insulin resistance in diet-induced obese rats exposed to fine particles by instillation, Inhalation Toxicol, 23, 507, 10.3109/08958378.2011.587472
Bolton, 2012, Prenatal air pollution exposure induces neuroinflammation and predisposes offspring to weight gain in adulthood in a sex-specific manner, FASEB J, 26, 4743, 10.1096/fj.12-210989
Rundle, 2012, Association of childhood obesity with maternal exposure to ambient air polycyclic aromatic hydrocarbons during pregnancy, Am. J. Epidemiol., 175, 1163, 10.1093/aje/kwr455
Cupul-Uicab, 2012, In utero exposure to maternal tobacco smoke and subsequent obesity, hypertension, and gestational diabetes among women in the MoBa cohort, Environ. Health Perspect., 120, 355, 10.1289/ehp.1103789
Langer, 2014, Obesogenic and diabetogenic impact of high organochlorine levels (HCB, p,p′-DDE, PCBs) on inhabitants in the highly polluted Eastern Slovakia, Endocr. Regul., 48, 17, 10.4149/endo_2014_01_17
Sallis, 2012, Role of built environments in physical activity, obesity, and cardiovascular disease, Circulation, 125, 729, 10.1161/CIRCULATIONAHA.110.969022
Ding, 2011, Neighborhood environment and physical activity among youth: a review, Am. J. Prevent. Med, 41, 442, 10.1016/j.amepre.2011.06.036
Durand, 2011, A systematic review of built environment factors related to physical activity and obesity risk: implications for smart growth urban planning, Obes. Rev., 12, e173, 10.1111/j.1467-789X.2010.00826.x
Antunes, 2010, Obesity and shift work: chronobiological aspects, Nutr. Res. Rev., 23, 155, 10.1017/S0954422410000016
Garaulet, 2010, The chronobiology, etiology and pathophysiology of obesity, Int. J. Obes., 34, 1667, 10.1038/ijo.2010.118
Challet, 2013, Circadian clocks, food intake, and metabolism, Prog. Mol. Biol. Transl. Sci, 119, 105, 10.1016/B978-0-12-396971-2.00005-1
Widen, 1995, Association of a polymorphism in the beta 3-adrenergic-receptor gene with features of the insulin resistance syndrome in Finns, N. Engl. J. Med., 333, 348, 10.1056/NEJM199508103330604
Bouchard, 1990, The response to long-term overfeeding in identical twins, N. Engl. J. Med., 322, 1477, 10.1056/NEJM199005243222101
Wells, 2009, Thrift: a guide to thrifty genes, thrifty phenotypes and thrifty norms, Int. J. Obes., 33, 1331, 10.1038/ijo.2009.175
Redman, 2009, Metabolic and behavioral compensations in response to caloric restriction: implications for the maintenance of weight loss, PLoS One, 4, e4377, 10.1371/journal.pone.0004377
Leibel, 1995, Changes in energy expenditure resulting from altered body weight, N. Engl. J. Med., 332, 621, 10.1056/NEJM199503093321001
Spiegelman, 2001, Obesity and the regulation of energy balance, Cell, 104, 531, 10.1016/S0092-8674(01)00240-9
Stanley, 1986, Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity, Peptides, 7, 1189, 10.1016/0196-9781(86)90149-X
Beck, 2013, Ghrelin, neuropeptide Y, and other feeding-regulatory peptides active in the hippocampus: role in learning and memory, Nutr. Rev., 71, 541, 10.1111/nure.12045
Rueda-Clausen, 2013, New pharmacological approaches for obesity management, Nat. Rev. Endocrinol, 9, 467, 10.1038/nrendo.2013.113
Suzuki, 2010, The role of gut hormones and the hypothalamus in appetite regulation, Endocr. J., 57, 359, 10.1507/endocrj.K10E-077
Delzenne, 2007, Modulation of glucagon-like peptide 1 and energy metabolism by inulin and oligofructose: experimental data, J. Nutr., 137, 2547S, 10.1093/jn/137.11.2547S
Harper, 2008, The efficiency of cellular energy transduction and its implications for obesity, Annu. Rev. Nutr., 28, 13, 10.1146/annurev.nutr.28.061807.155357
Cutting, 1934, Relationship between blood cholesterol and increased metabolism from dinitrophenol and thyroid, J. Clin. Invest., 13, 547, 10.1172/JCI100604
Tainter, 1934, Use of dinitrophenol in nutritional disorders: a critical survey of clinical results, Am. J. Public Health Nations Health, 24, 1045, 10.2105/AJPH.24.10.1045
Colman, 2007, Dinitrophenol and obesity: an early twentieth-century regulatory dilemma, Regul. Toxicol. Pharmacol., 48, 115, 10.1016/j.yrtph.2007.03.006
Li, 2000, Skeletal muscle respiratory uncoupling prevents diet-induced obesity and insulin resistance in mice, Nat. Med, 6, 1115, 10.1038/80450
Rothwell, 1983, Luxuskonsumption, diet-induced thermogenesis and brown fat: the case in favour, Clin. Sci. (London), 64, 19, 10.1042/cs0640019
Lowell, 1997, Brown adipose tissue, beta 3-adrenergic receptors, and obesity, Annu. Rev. Med, 48, 307, 10.1146/annurev.med.48.1.307
Cypess, 2009, Identification and importance of brown adipose tissue in adult humans, N. Engl. J. Med., 360, 1509, 10.1056/NEJMoa0810780
Virtanen, 2009, Functional brown adipose tissue in healthy adults, N. Engl. J. Med., 360, 1518, 10.1056/NEJMoa0808949
Kozak, 2000, Mitochondrial uncoupling proteins in energy expenditure, Annu. Rev. Nutr., 20, 339, 10.1146/annurev.nutr.20.1.339
Vidal-Puig, 1997, UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue, Biochem. Biophys. Res. Commun., 235, 79, 10.1006/bbrc.1997.6740
Puigserver, 1998, A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis, Cell, 92, 829, 10.1016/S0092-8674(00)81410-5
Handschin, 2006, Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism, Endocr. Rev., 27, 728, 10.1210/er.2006-0037
Serra, 2013, Mitochondrial fatty acid oxidation in obesity, Antioxid. Redox Signaling, 19, 269, 10.1089/ars.2012.4875
Bostrom, 2012, A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis, Nature, 481, 463, 10.1038/nature10777
Hill, 2010, What part of NO don׳t you understand? Some answers to the cardinal questions in nitric oxide biology, J. Biol. Chem., 285, 19699, 10.1074/jbc.R110.101618
Sprigge, 2002, Humphry Davy; his researches in respiratory physiology and his debt to Antoine Lavoisier, Anaesthesia, 57, 357, 10.1046/j.1365-2044.2002.02414.x
Alderton, 2001, Nitric oxide synthases: structure, function and inhibition, Biochem. J., 357, 593, 10.1042/0264-6021:3570593
Dudzinski, 2007, Life history of eNOS: partners and pathways, Cardiovasc. Res., 75, 247, 10.1016/j.cardiores.2007.03.023
Shen, 2011, Lipoamide or lipoic acid stimulates mitochondrial biogenesis in 3T3-L1 adipocytes via the endothelial NO synthase–cGMP–protein kinase G signalling pathway, Br. J. Pharmacol., 162, 1213, 10.1111/j.1476-5381.2010.01134.x
Tedesco, 2008, Cannabinoid type 1 receptor blockade promotes mitochondrial biogenesis through endothelial nitric oxide synthase expression in white adipocytes, Diabetes, 57, 2028, 10.2337/db07-1623
Mei, 2011, Endothelial nitric oxide synthase is a key mediator of hepatocyte proliferation in response to partial hepatectomy in mice, Hepatology, 54, 1777, 10.1002/hep.24560
Vazquez-Chantada, 2009, Evidence for LKB1/AMP-activated protein kinase/endothelial nitric oxide synthase cascade regulated by hepatocyte growth factor, S-adenosylmethionine, and nitric oxide in hepatocyte proliferation, Hepatology, 49, 608, 10.1002/hep.22660
Oess, 2006, Subcellular targeting and trafficking of nitric oxide synthases, Biochem. J., 396, 401, 10.1042/BJ20060321
Balligand, 2009, eNOS activation by physical forces: from short-term regulation of contraction to chronic remodeling of cardiovascular tissues, Physiol. Rev., 89, 481, 10.1152/physrev.00042.2007
Kone, 2003, Protein interactions with nitric oxide synthases: controlling the right time, the right place, and the right amount of nitric oxide, Am. J. Physiol. Renal Physiol, 285, F178, 10.1152/ajprenal.00048.2003
Finocchietto, 2009, Mitochondrial nitric oxide synthase: a masterpiece of metabolic adaptation, cell growth, transformation, and death, Exp. Biol. Med. (Maywood), 234, 1020, 10.3181/0902-MR-81
Kato, 2006, Critical overview of mitochondrial nitric-oxide synthase, Front. Biosci., 11, 2725, 10.2741/2002
Lundberg, 2009, Nitrate and nitrite in biology, nutrition and therapeutics, Nat. Chem. Biol., 5, 865, 10.1038/nchembio.260
Thomas, 2001, The biological lifetime of nitric oxide: implications for the perivascular dynamics of NO and O2, Proc. Natl. Acad. Sci. USA, 98, 355, 10.1073/pnas.98.1.355
Pacher, 2007, Nitric oxide and peroxynitrite in health and disease, Physiol. Rev., 87, 315, 10.1152/physrev.00029.2006
Trujillo, 2008, Peroxynitrite detoxification and its biologic implications, Antioxid. Redox Signaling, 10, 1607, 10.1089/ars.2008.2060
Szabo, 2007, Peroxynitrite: biochemistry, pathophysiology and development of therapeutics, Nat. Rev. Drug Discovery, 6, 662, 10.1038/nrd2222
Beckman, 2009, Understanding peroxynitrite biochemistry and its potential for treating human diseases, Arch. Biochem. Biophys., 484, 114, 10.1016/j.abb.2009.03.013
Xu, 2006, Detection of sequence-specific tyrosine nitration of manganese SOD and SERCA in cardiovascular disease and aging, Am. J. Physiol. Heart Circ. Physiol, 290, H2220, 10.1152/ajpheart.01293.2005
Koeck, 2005, Mitochondria and regulated tyrosine nitration, Biochem. Soc. Trans., 33, 1399, 10.1042/BST20051399
Aulak, 2001, Proteomic method identifies proteins nitrated in vivo during inflammatory challenge, Proc. Natl. Acad. Sci. USA, 98, 12056, 10.1073/pnas.221269198
Halliwell, 1998
Hogg, 2002, The biochemistry and physiology of S-nitrosothiols, Annu. Rev. Pharmacol. Toxicol., 42, 585, 10.1146/annurev.pharmtox.42.092501.104328
Hill, 2007, Role of glutathiolation in preservation, restoration and regulation of protein function, IUBMB Life, 59, 21, 10.1080/15216540701196944
Forstermann, 2012, Nitric oxide synthases: regulation and function, Eur. Heart J., 33, 829, 10.1093/eurheartj/ehr304
Furchgott, 1980, The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine, Nature, 288, 373, 10.1038/288373a0
Rapoport, 1983, Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation, Nature, 306, 174, 10.1038/306174a0
Rapoport, 1983, Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP, Circ. Res., 52, 352, 10.1161/01.RES.52.3.352
Forstermann, 1986, Stimulation of soluble guanylate cyclase by an acetylcholine-induced endothelium-derived factor from rabbit and canine arteries, Circ. Res., 58, 531, 10.1161/01.RES.58.4.531
Rajfer, 1992, Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission, N. Engl. J. Med., 326, 90, 10.1056/NEJM199201093260203
Moncada, 1986, Mechanism of action of some inhibitors of endothelium-derived relaxing factor, Proc. Natl. Acad. Sci. USA, 83, 9164, 10.1073/pnas.83.23.9164
Gryglewski, 1986, Bioassay of prostacyclin and endothelium-derived relaxing factor (EDRF) from porcine aortic endothelial cells, Br. J. Pharmacol., 87, 685, 10.1111/j.1476-5381.1986.tb14586.x
Palmer, 1987, Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor, Nature, 327, 524, 10.1038/327524a0
Melikian, 2009, Neuronal nitric oxide synthase and human vascular regulation, Trends Cardiovasc. Med, 19, 256, 10.1016/j.tcm.2010.02.007
Sakuma, 1992, NG-methyl-L-arginine, an inhibitor of L-arginine-derived nitric oxide synthesis, stimulates renal sympathetic nerve activity in vivo: a role for nitric oxide in the central regulation of sympathetic tone?, Circ. Res., 70, 607, 10.1161/01.RES.70.3.607
el Karib, 1993, The central effects of a nitric oxide synthase inhibitor (N omega-nitro-L-arginine) on blood pressure and plasma renin, Clin. Exp. Hypertens., 15, 819, 10.3109/10641969309041644
Toda, 2009, Control of systemic and pulmonary blood pressure by nitric oxide formed through neuronal nitric oxide synthase, J. Hypertens., 27, 1929, 10.1097/HJH.0b013e32832e8ddf
Kim, 1991, A nitric oxide-like factor mediates nonadrenergic-noncholinergic neurogenic relaxation of penile corpus cavernosum smooth muscle, J. Clin. Invest., 88, 112, 10.1172/JCI115266
Shiva, 2005, Nitroxia: the pathological consequence of dysfunction in the nitric oxide–cytochrome c oxidase signaling pathway, Free Radic. Biol. Med., 38, 297, 10.1016/j.freeradbiomed.2004.10.037
Cooper, 2007, Nitric oxide regulation of mitochondrial oxygen consumption. II. Molecular mechanism and tissue physiology, Am. J. Physiol. Cell Physiol, 292, C1993, 10.1152/ajpcell.00310.2006
Wolzt, 1999, Biochemical characterization of S-nitrosohemoglobin: mechanisms underlying synthesis, no release, and biological activity, J. Biol. Chem., 274, 28983, 10.1074/jbc.274.41.28983
Kelly, 2004, Transcriptional regulatory circuits controlling mitochondrial biogenesis and function, Genes Dev., 18, 357, 10.1101/gad.1177604
Nisoli, 2003, Mitochondrial biogenesis in mammals: the role of endogenous nitric oxide, Science, 299, 896, 10.1126/science.1079368
Nisoli, 2004, Mitochondrial biogenesis by NO yields functionally active mitochondria in mammals, Proc. Natl. Acad. Sci. USA, 101, 16507, 10.1073/pnas.0405432101
Bender, 2007, Diet-induced obesity and diabetes reduce coronary responses to nitric oxide due to reduced bioavailability in isolated mouse hearts, Diabetes Obes. Metab., 9, 688, 10.1111/j.1463-1326.2006.00650.x
Kim, 2008, Vascular inflammation, insulin resistance, and reduced nitric oxide production precede the onset of peripheral insulin resistance, Arterioscler. Thromb. Vasc. Biol., 28, 1982, 10.1161/ATVBAHA.108.169722
Higashi, 2001, Effect of obesity on endothelium-dependent, nitric oxide-mediated vasodilation in normotensive individuals and patients with essential hypertension, Am. J. Hypertens., 14, 1038, 10.1016/S0895-7061(01)02191-4
Gruber, 2008, Obesity reduces the bioavailability of nitric oxide in juveniles, Int. J. Obes., 32, 826, 10.1038/sj.ijo.0803795
Georgescu, 2011, Dysfunction of human subcutaneous fat arterioles in obesity alone or obesity associated with type 2 diabetes, Clin. Sci., 120, 463, 10.1042/CS20100355
Perez-Matute, 2009, Transcriptional control of human adipose tissue blood flow, Obesity, 17, 681, 10.1038/oby.2008.606
Sansbury, 2012, Overexpression of endothelial nitric oxide synthase prevents diet-induced obesity and regulates adipocyte phenotype, Circ. Res., 111, 1176, 10.1161/CIRCRESAHA.112.266395
Valerio, 2006, TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents, J. Clin. Invest., 116, 2791, 10.1172/JCI28570.
Kraus, 2012, Obesity, insulin resistance, and skeletal muscle nitric oxide synthase, J. Appl. Physiol. (1985), 113, 758, 10.1152/japplphysiol.01018.2011
Awolesi, 1995, Cyclic strain upregulates nitric oxide synthase in cultured bovine aortic endothelial cells, J. Clin. Invest., 96, 1449, 10.1172/JCI118181
Hirata, 1995, Low concentration of oxidized low-density lipoprotein and lysophosphatidylcholine upregulate constitutive nitric oxide synthase mRNA expression in bovine aortic endothelial cells, Circ. Res., 76, 958, 10.1161/01.RES.76.6.958
Zeng, 2000, Roles for insulin receptor, PI3-kinase, and Akt in insulin-signaling pathways related to production of nitric oxide in human vascular endothelial cells, Circulation, 101, 1539, 10.1161/01.CIR.101.13.1539
Hambrecht, 2000, Effect of exercise on coronary endothelial function in patients with coronary artery disease, N. Engl. J. Med., 342, 454, 10.1056/NEJM200002173420702
Hotamisligil, 1993, Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance, Science, 259, 87, 10.1126/science.7678183
Michel, 1992, Molecular cloning of constitutive endothelial nitric oxide synthase: evidence for a family of related genes, J. Cardiovasc. Pharmacol., 20, S45, 10.1097/00005344-199204002-00014
Lai, 2003, Downregulation of eNOS mRNA expression by TNFalpha: identification and functional characterization of RNA–protein interactions in the 3′UTR, Cardiovasc. Res., 59, 160, 10.1016/S0008-6363(03)00296-7
Neumann, 2004, TNF-alpha induces a decrease in eNOS promoter activity, Am. J. Physiol. Lung Cell Mol. Physiol, 286, L452, 10.1152/ajplung.00378.2002
Anderson, 2004, Tumor necrosis factor-alpha inhibits endothelial nitric-oxide synthase gene promoter activity in bovine aortic endothelial cells, J. Biol. Chem., 279, 963, 10.1074/jbc.M309552200
Alonso, 1997, Endothelial cytosolic proteins bind to the 3′ untranslated region of endothelial nitric oxide synthase mRNA: regulation by tumor necrosis factor alpha, Mol. Cell. Biol., 17, 5719, 10.1128/MCB.17.10.5719
Sanchez de Miguel, 1999, Evidence that an endothelial cytosolic protein binds to the 3′-untranslated region of endothelial nitric oxide synthase mRNA, J. Vasc. Res., 36, 201, 10.1159/000025643
Yoshizumi, 1993, Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life, Circ. Res., 73, 205, 10.1161/01.RES.73.1.205
Yan, 2008, Tumor necrosis factor-alpha downregulates endothelial nitric oxide synthase mRNA stability via translation elongation factor 1-alpha 1, Circ. Res., 103, 591, 10.1161/CIRCRESAHA.108.173963
Bulotta, 2001, Activation of the endothelial nitric-oxide synthase by tumor necrosis factor-alpha: a novel feedback mechanism regulating cell death, J. Biol. Chem., 276, 6529, 10.1074/jbc.M006535200
Kawanaka, 2002, Activation of eNOS in rat portal hypertensive gastric mucosa is mediated by TNF-alpha via the PI 3-kinase-Akt signaling pathway, Hepatology, 35, 393, 10.1053/jhep.2002.30958
Barsacchi, 2003, Activation of endothelial nitric-oxide synthase by tumor necrosis factor-alpha: a novel pathway involving sequential activation of neutral sphingomyelinase, phosphatidylinositol-3′ kinase, and Akt, Mol. Pharmacol., 63, 886, 10.1124/mol.63.4.886
De Palma, 2006, Endothelial nitric oxide synthase activation by tumor necrosis factor alpha through neutral sphingomyelinase 2, sphingosine kinase 1, and sphingosine 1 phosphate receptors: a novel pathway relevant to the pathophysiology of endothelium, Arterioscler. Thromb. Vasc. Biol., 26, 99, 10.1161/01.ATV.0000194074.59584.42
Vaziri, 1999, cGMP-mediated negative-feedback regulation of endothelial nitric oxide synthase expression by nitric oxide, Hypertension, 34, 1237, 10.1161/01.HYP.34.6.1237
Zhang, 2005, Regulation of endothelial nitric oxide synthase by small RNA, Proc. Natl. Acad. Sci. USA, 102, 16967, 10.1073/pnas.0503853102
Shimabukuro, 1997, Role of nitric oxide in obesity-induced beta cell disease, J. Clin. Invest., 100, 290, 10.1172/JCI119534
Noronha, 2005, Inducible nitric oxide synthase has divergent effects on vascular and metabolic function in obesity, Diabetes, 54, 1082, 10.2337/diabetes.54.4.1082
Sugita, 2005, Inducible nitric-oxide synthase and NO donor induce insulin receptor substrate-1 degradation in skeletal muscle cells, J. Biol. Chem., 280, 14203, 10.1074/jbc.M411226200
Mantena, 2009, High fat diet induces dysregulation of hepatic oxygen gradients and mitochondrial function in vivo, Biochem. J., 417, 183, 10.1042/BJ20080868
Fujimoto, 2005, A role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice, Diabetes, 54, 1340, 10.2337/diabetes.54.5.1340
Weisberg, 2003, Obesity is associated with macrophage accumulation in adipose tissue, J. Clin. Invest., 112, 1796, 10.1172/JCI200319246
Lumeng, 2007, Obesity induces a phenotypic switch in adipose tissue macrophage polarization, J. Clin. Invest., 117, 175, 10.1172/JCI29881
Lumeng, 2007, Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity, Diabetes, 56, 16, 10.2337/db06-1076
Merial, 2000, Nitric oxide-dependent downregulation of adipocyte UCP-2 expression by tumor necrosis factor-alpha, Am. J. Physiol. Cell Physiol, 279, C1100, 10.1152/ajpcell.2000.279.4.C1100
Sadler, 2004, Reduced ventromedial hypothalamic neuronal nitric oxide synthase and increased sensitivity to NOS inhibition in dietary obese rats: further evidence of a role for nitric oxide in the regulation of energy balance, Brain Res., 1016, 222, 10.1016/j.brainres.2004.05.007
Benkhoff, 2012, Leptin potentiates endothelium-dependent relaxation by inducing endothelial expression of neuronal NO synthase, Arterioscler. Thromb. Vasc. Biol., 32, 1605, 10.1161/ATVBAHA.112.251140
Huang, 2009, metabolic syndrome and cardiovascular disease, Trends Endocrinol. Metab., 20, 295, 10.1016/j.tem.2009.03.005
Rafikov, 2011, eNOS activation and NO function: structural motifs responsible for the posttranslational control of endothelial nitric oxide synthase activity, J. Endocrinol., 210, 271, 10.1530/JOE-11-0083
Ju, 1997, Direct interaction of endothelial nitric-oxide synthase and caveolin-1 inhibits synthase activity, J. Biol. Chem., 272, 18522, 10.1074/jbc.272.30.18522
Yang, 2007, High-fat diet up-regulates caveolin-1 expression in aorta of diet-induced obese but not in diet-resistant rats, Cardiovasc. Res., 76, 167, 10.1016/j.cardiores.2007.05.028
Bikman, 2011, Ceramides as modulators of cellular and whole-body metabolism, J. Clin. Invest., 121, 4222, 10.1172/JCI57144
Zhang, 2012, Ceramide mediates vascular dysfunction in diet-induced obesity by PP2A-mediated dephosphorylation of the eNOS–Akt complex, Diabetes, 61, 1848, 10.2337/db11-1399
Gratton, 2000, Reconstitution of an endothelial nitric-oxide synthase (eNOS), hsp90, and caveolin-1 complex in vitro: evidence that hsp90 facilitates calmodulin stimulated displacement of eNOS from caveolin-1, J. Biol. Chem., 275, 22268, 10.1074/jbc.M001644200
Elrod, 2006, eNOS gene therapy exacerbates hepatic ischemia–reperfusion injury in diabetes: a role for eNOS uncoupling, Circ. Res., 99, 78, 10.1161/01.RES.0000231306.03510.77
Zhong, 2007, Apelin modulates aortic vascular tone via endothelial nitric oxide synthase phosphorylation pathway in diabetic mice, Cardiovasc. Res., 74, 388, 10.1016/j.cardiores.2007.02.002
Li, 2013, Deficient eNOS phosphorylation is a mechanism for diabetic vascular dysfunction contributing to increased stroke size, Stroke, 44, 3183, 10.1161/STROKEAHA.113.002073
Taguchi, 2011, Dysfunction of endothelium-dependent relaxation to insulin via PKC-mediated GRK2/Akt activation in aortas of ob/ob mice, Am. J. Physiol. Heart Circ. Physiol, 301, H571, 10.1152/ajpheart.01189.2010
Kim, 2007, Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity, Circ. Res., 100, 1589, 10.1161/CIRCRESAHA.106.142851
Symons, 2009, Contribution of insulin and Akt1 signaling to endothelial nitric oxide synthase in the regulation of endothelial function and blood pressure, Circ. Res., 104, 1085, 10.1161/CIRCRESAHA.108.189316
Naruse, 2006, Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance, Diabetes, 55, 691, 10.2337/diabetes.55.03.06.db05-0771
Zecchin, 2007, Defective insulin and acetylcholine induction of endothelial cell-nitric oxide synthase through insulin receptor substrate/Akt signaling pathway in aorta of obese rats, Diabetes, 56, 1014, 10.2337/db05-1147
Park, 2013, Serine phosphorylation sites on IRS2 activated by angiotensin II and protein kinase C to induce selective insulin resistance in endothelial cells, Mol. Cell. Biol., 33, 3227, 10.1128/MCB.00506-13
Dimmeler, 1999, Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation, Nature, 399, 601, 10.1038/21224
Hermann, 2000, Insulin-mediated stimulation of protein kinase Akt: a potent survival signaling cascade for endothelial cells, Arterioscler. Thromb. Vasc. Biol., 20, 402, 10.1161/01.ATV.20.2.402
Duncan, 2008, Effect of endothelium-specific insulin resistance on endothelial function in vivo, Diabetes, 57, 3307, 10.2337/db07-1111
Kubota, 2011, Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle, Cell Metab., 13, 294, 10.1016/j.cmet.2011.01.018
Kim, 2005, Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta, Arterioscler. Thromb. Vasc. Biol., 25, 989, 10.1161/01.ATV.0000160549.60980.a8
Edirisinghe, 2006, Effect of fatty acids on endothelium-dependent relaxation in the rabbit aorta, Clin. Sci., 111, 145, 10.1042/CS20060001
Du, 2006, Insulin resistance reduces arterial prostacyclin synthase and eNOS activities by increasing endothelial fatty acid oxidation, J. Clin. Invest., 116, 1071, 10.1172/JCI23354
Steinberg, 2000, Free fatty acid elevation impairs insulin-mediated vasodilation and nitric oxide production, Diabetes, 49, 1231, 10.2337/diabetes.49.7.1231
Steinberg, 1997, Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation, J. Clin. Invest., 100, 1230, 10.1172/JCI119636
Jang, 2013, Toll-like receptor 2 mediates high-fat diet-induced impairment of vasodilator actions of insulin, Am. J. Physiol. Endocrinol. Metab., 304, E1077, 10.1152/ajpendo.00578.2012
Du, 2001, Hyperglycemia inhibits endothelial nitric oxide synthase activity by posttranslational modification at the Akt site, J. Clin. Invest., 108, 1341, 10.1172/JCI11235
Calnek, 2003, Peroxisome proliferator-activated receptor gamma ligands increase release of nitric oxide from endothelial cells, Arterioscler. Thromb. Vasc. Biol., 23, 52, 10.1161/01.ATV.0000044461.01844.C9
Polikandriotis, 2005, Peroxisome proliferator-activated receptor gamma ligands stimulate endothelial nitric oxide production through distinct peroxisome proliferator-activated receptor gamma-dependent mechanisms, Arterioscler. Thromb. Vasc. Biol., 25, 1810, 10.1161/01.ATV.0000177805.65864.d4
Goya, 2006, The thiazolidinedione drug troglitazone up-regulates nitric oxide synthase expression in vascular endothelial cells, J. Diabetes Complications, 20, 336, 10.1016/j.jdiacomp.2005.08.003
Davis, 2006, Activation of the AMP-activated kinase by antidiabetes drug metformin stimulates nitric oxide synthesis in vivo by promoting the association of heat shock protein 90 and endothelial nitric oxide synthase, Diabetes, 55, 496, 10.2337/diabetes.55.02.06.db05-1064
Li, 2000, Peroxisome proliferator-activated receptor gamma-dependent repression of the inducible nitric oxide synthase gene, Mol. Cell. Biol., 20, 4699, 10.1128/MCB.20.13.4699-4707.2000
Maggi, 2000, Anti-inflammatory actions of 15-deoxy-delta 12,14-prostaglandin J2 and troglitazone: evidence for heat shock-dependent and -independent inhibition of cytokine-induced inducible nitric oxide synthase expression, Diabetes, 49, 346, 10.2337/diabetes.49.3.346
Heneka, 2000, Peroxisome proliferator-activated receptor-gamma ligands reduce neuronal inducible nitric oxide synthase expression and cell death in vivo, J. Neurosci., 20, 6862, 10.1523/JNEUROSCI.20-18-06862.2000
Konturek, 2003, Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, accelerates gastric ulcer healing in rat, Eur. J. Pharmacol., 472, 213, 10.1016/S0014-2999(03)01932-0
Mendez, 2003, PPARgamma inhibition of cyclooxygenase-2, PGE2 synthase, and inducible nitric oxide synthase in cardiac myocytes, Hypertension, 42, 844, 10.1161/01.HYP.0000085332.69777.D1
Crosby, 2005, Peroxisome proliferation-activated receptor (PPAR)gamma is not necessary for synthetic PPARgamma agonist inhibition of inducible nitric-oxide synthase and nitric oxide, J. Pharmacol. Exp. Ther., 312, 69, 10.1124/jpet.104.074005
Alp, 2004, Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease, Arterioscler. Thromb. Vasc. Biol., 24, 413, 10.1161/01.ATV.0000110785.96039.f6
Zweier, 2011, S-glutathionylation reshapes our understanding of endothelial nitric oxide synthase uncoupling and nitric oxide/reactive oxygen species-mediated signaling, Antioxid. Redox Signaling, 14, 1769, 10.1089/ars.2011.3904
Channon, 2012, Tetrahydrobiopterin: a vascular redox target to improve endothelial function, Curr. Vasc. Pharmacol, 10, 705, 10.2174/157016112803520819
Chander, 2004, Nephropathy in Zucker diabetic fat rat is associated with oxidative and nitrosative stress: prevention by chronic therapy with a peroxynitrite scavenger ebselen, J. Am. Soc. Nephrol., 15, 2391, 10.1097/01.ASN.0000135971.88164.2C
Shinozaki, 1999, Abnormal biopterin metabolism is a major cause of impaired endothelium-dependent relaxation through nitric oxide/O2− imbalance in insulin-resistant rat aorta, Diabetes, 48, 2437, 10.2337/diabetes.48.12.2437
Pannirselvam, 2002, Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (db/db −/−) mice: role of decreased tetrahydrobiopterin bioavailability, Br. J. Pharmacol., 136, 255, 10.1038/sj.bjp.0704683
Cai, 2005, Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells, Cardiovasc. Res., 65, 823, 10.1016/j.cardiores.2004.10.040
Crabtree, 2008, Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS, Am. J. Physiol. Heart Circ. Physiol, 294, H1530, 10.1152/ajpheart.00823.2007
Forstermann, 2011, Therapeutic effect of enhancing endothelial nitric oxide synthase (eNOS) expression and preventing eNOS uncoupling, Br. J. Pharmacol., 164, 213, 10.1111/j.1476-5381.2010.01196.x
Kietadisorn, 2012, Tackling endothelial dysfunction by modulating NOS uncoupling: new insights into its pathogenesis and therapeutic possibilities, Am. J. Physiol. Endocrinol. Metab., 302, E481, 10.1152/ajpendo.00540.2011
Sanchez, 2012, Role of neural NO synthase (nNOS) uncoupling in the dysfunctional nitrergic vasorelaxation of penile arteries from insulin-resistant obese Zucker rats, PLoS One, 7, e36027, 10.1371/journal.pone.0036027
Molnar, 2005, Diabetes induces endothelial dysfunction but does not increase neointimal formation in high-fat diet fed C57BL/6J mice, Circ. Res., 96, 1178, 10.1161/01.RES.0000168634.74330.ed
Brodsky, 2004, Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen, Circ. Res., 94, 377, 10.1161/01.RES.0000111802.09964.EF
Cassuto, 2014, Belin de Chantemele, E.; Feher, A.; Romero, M. J.; Bagi, Z. Peroxynitrite disrupts endothelial caveolae leading to eNOS uncoupling and diminished flow-mediated dilation in coronary arterioles of diabetic patients, Diabetes, 63, 1381, 10.2337/db13-0577
Landmesser, 2003, Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension, J. Clin. Invest., 111, 1201, 10.1172/JCI200314172
Satoh, 2005, NAD(P)H oxidase and uncoupled nitric oxide synthase are major sources of glomerular superoxide in rats with experimental diabetic nephropathy, Am. J. Physiol. Renal Physiol, 288, F1144, 10.1152/ajprenal.00221.2004
Bitar, 2005, Nitric oxide dynamics and endothelial dysfunction in type II model of genetic diabetes, Eur. J. Pharmacol., 511, 53, 10.1016/j.ejphar.2005.01.014
Xu, 2006, Uncoupling of endothelial nitric oxidase synthase by hypochlorous acid: role of NAD(P)H oxidase-derived superoxide and peroxynitrite, Arterioscler. Thromb. Vasc. Biol., 26, 2688, 10.1161/01.ATV.0000249394.94588.82
Dikalova, 2010, Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling, Am. J. Physiol. Heart Circ. Physiol, 299, H673, 10.1152/ajpheart.00242.2010
Zhang, 2008, Paradoxical activation of endothelial nitric oxide synthase by NADPH oxidase, Arterioscler. Thromb. Vasc. Biol., 28, 1627, 10.1161/ATVBAHA.108.168278
Koppenol, 2001, 100 years of peroxynitrite chemistry and 11 years of peroxynitrite biochemistry, Redox Rep., 6, 339, 10.1179/135100001101536517
Toutouzas, 2008, Asymmetric dimethylarginine (ADMA) and other endogenous nitric oxide synthase (NOS) inhibitors as an important cause of vascular insulin resistance, Horm. Metab. Res., 40, 655, 10.1055/s-0028-1083814
Risbano, 2013, Therapeutics targeting of dysregulated redox equilibrium and endothelial dysfunction, Handb. Exp. Pharmacol, 218, 315, 10.1007/978-3-662-45805-1_13
Chen, 2010, S-glutathionylation uncouples eNOS and regulates its cellular and vascular function, Nature, 468, 1115, 10.1038/nature09599
Williams, 2002, Obesity, atherosclerosis and the vascular endothelium: mechanisms of reduced nitric oxide bioavailability in obese humans, Int. J. Obes. Relat. Metab. Disord, 26, 754, 10.1038/sj.ijo.0801995
Steinberg, 1996, Obesity/insulin resistance is associated with endothelial dysfunction: implications for the syndrome of insulin resistance, J. Clin. Invest., 97, 2601, 10.1172/JCI118709
Laine, 1998, Insulin resistance of glucose uptake in skeletal muscle cannot be ameliorated by enhancing endothelium-dependent blood flow in obesity, J. Clin. Invest., 101, 1156, 10.1172/JCI1065
Van Guilder, 2008, Impaired endothelium-dependent vasodilation in overweight and obese adult humans is not limited to muscarinic receptor agonists, Am. J. Physiol. Heart Circ. Physiol, 294, H1685, 10.1152/ajpheart.01281.2007
Arcaro, 1999, Body fat distribution predicts the degree of endothelial dysfunction in uncomplicated obesity, Int. J. Obes. Relat. Disord, 23, 936, 10.1038/sj.ijo.0801022
Westerbacka, 1999, Marked resistance of the ability of insulin to decrease arterial stiffness characterizes human obesity, Diabetes, 48, 821, 10.2337/diabetes.48.4.821
Sturm, 2009, Influence of visceral obesity and liver fat on vascular structure and function in obese subjects, Obesity, 17, 1783, 10.1038/oby.2009.81
Parikh, 2009, Visceral and subcutaneous adiposity and brachial artery vasodilator function, Obesity, 17, 2054, 10.1038/oby.2009.60
Grassi, 2010, Structural and functional alterations of subcutaneous small resistance arteries in severe human obesity, Obesity, 18, 92, 10.1038/oby.2009.195
Weil, 2011, Enhanced endothelin-1 system activity with overweight and obesity, Am. J. Physiol. Heart Circ. Physiol, 301, H689, 10.1152/ajpheart.00206.2011
Lambert, 2010, Sympathetic nervous system activity is associated with obesity-induced subclinical organ damage in young adults, Hypertension, 56, 351, 10.1161/HYPERTENSIONAHA.110.155663
Han, 2011, Contributions of dysglycaemia, obesity, and insulin resistance to impaired endothelium-dependent vasodilation in humans, Diabetes Metab. Res. Rev, 27, 354, 10.1002/dmrr.1183
Andersson, 2010, Dysregulation of subcutaneous adipose tissue blood flow in overweight postmenopausal women, Menopause, 17, 365, 10.1097/gme.0b013e3181c12b26
Miadi-Messaoud, 2010, Obesity-induced impairment of endothelium-dependent vasodilation in Tunisian women, Int. J. Obes., 34, 273, 10.1038/ijo.2009.231
Bhattacharjee, 2012, Endothelial dysfunction in children without hypertension: potential contributions of obesity and obstructive sleep apnea, Chest, 141, 682, 10.1378/chest.11-1777
Czernichow, 2010, Microvascular dysfunction in healthy insulin-sensitive overweight individuals, J. Hypertens., 28, 325, 10.1097/HJH.0b013e328333d1fc
Calapai, 1998, Effects of intracerebroventricular leptin administration on food intake, body weight gain and diencephalic nitric oxide synthase activity in the mouse, Br. J. Pharmacol., 125, 798, 10.1038/sj.bjp.0702121
Iuras, 2005, Central administration of a nitric oxide precursor abolishes both the hypothalamic serotonin release and the hypophagia induced by interleukin-1beta in obese Zucker rats, Regul. Pept., 124, 145, 10.1016/j.regpep.2004.07.007
Squadrito, 1994, Central serotoninergic system involvement in the anorexia induced by NG-nitro-L-arginine, an inhibitor of nitric oxide synthase, Eur. J. Pharmacol., 255, 51, 10.1016/0014-2999(94)90081-7
Tsuchiya, 2007, Chronic blockade of nitric oxide synthesis reduces adiposity and improves insulin resistance in high fat-induced obese mice, Endocrinology, 148, 4548, 10.1210/en.2006-1371
Shankar, 1998, Central nervous system nitric oxide synthase activity regulates insulin secretion and insulin action, J. Clin. Invest., 102, 1403, 10.1172/JCI3030
Rodin, 1985, Insulin levels, hunger, and food intake: an example of feedback loops in body weight regulation, Health Psychol., 4, 1, 10.1037/0278-6133.4.1.1
Rodin, 1985, Effect of insulin and glucose on feeding behavior, Metabolism, 34, 826, 10.1016/0026-0495(85)90106-4
Louis-Sylvestre, 1984, Meal size: role of reflexly induced insulin release, J. Auton. Nerv. Syst., 10, 317, 10.1016/0165-1838(84)90029-8
Woods, 1989, The regulation of food intake by peptides, Ann. N. Y. Acad. Sci., 575, 236, 10.1111/j.1749-6632.1989.tb53246.x
Pliquett, 2006, The effects of insulin on the central nervous system—focus on appetite regulation, Horm. Metab. Res., 38, 442, 10.1055/s-2006-947840
Sugimoto, 1999, A neuronal nitric oxide synthase inhibitor 7-nitroindazole reduces the 5-HT1A receptor against 8-OH-DPAT-elicited hyperphagia in rats, Eur. J. Pharmacol., 376, 1, 10.1016/S0014-2999(99)00378-7
Sugimoto, 1999, Involvement of nitric oxide in the 5-HT1A autoreceptor-mediated hyperphagia in rats, Adv. Exp. Med. Biol., 467, 109, 10.1007/978-1-4615-4709-9_16
Czech, 2003, A nitric oxide synthase inhibitor, N(G)-nitro-L-arginine methyl ester, attenuates lipoprivic feeding in mice, Physiol. Behav., 80, 75, 10.1016/S0031-9384(03)00220-8
Li, 2006, The weight loss elicited by cobalt protoporphyrin is related to decreased activity of nitric oxide synthase in the hypothalamus, J. Appl. Physiol. (1985), 100, 1983, 10.1152/japplphysiol.01169.2005
Wascher, 1997, Effects of low-dose L-arginine on insulin-mediated vasodilatation and insulin sensitivity, Eur. J. Clin. Invest., 27, 690, 10.1046/j.1365-2362.1997.1730718.x
Lucotti, 2006, Beneficial effects of a long-term oral L-arginine treatment added to a hypocaloric diet and exercise training program in obese, insulin-resistant type 2 diabetic patients, Am. J. Physiol. Endocrinol. Metab., 291, E906, 10.1152/ajpendo.00002.2006
Alizadeh, 2012, Effect of L-arginine and selenium added to a hypocaloric diet enriched with legumes on cardiovascular disease risk factors in women with central obesity: a randomized, double-blind, placebo-controlled trial, Ann. Nutr. Metab., 60, 157, 10.1159/000335470
Suliburska, 2014, Changes in mineral status are associated with improvements in insulin sensitivity in obese patients following L-arginine supplementation, Eur. J. Nutr., 53, 387, 10.1007/s00394-013-0533-7
Clemmensen, 2012, L-Arginine improves multiple physiological parameters in mice exposed to diet-induced metabolic disturbances, Amino Acids, 43, 1265, 10.1007/s00726-011-1199-1
Fu, 2005, Dietary L-arginine supplementation reduces fat mass in Zucker diabetic fatty rats, J. Nutr., 135, 714, 10.1093/jn/135.4.714
Jobgen, 2009, Dietary L-arginine supplementation reduces white fat gain and enhances skeletal muscle and brown fat masses in diet-induced obese rats, J. Nutr., 139, 230, 10.3945/jn.108.096362
Ayala, 2007, Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice, Diabetes, 56, 1025, 10.2337/db06-0883
Mitschke, 2013, Increased cGMP promotes healthy expansion and browning of white adipose tissue, FASEB J, 27, 1621, 10.1096/fj.12-221580
De Toni, 2011, Effects of type 5-phosphodiesterase inhibition on energy metabolism and mitochondrial biogenesis in human adipose tissue ex vivo, J. Endocrinol. Invest., 34, 738, 10.1007/BF03346724
Wang, 2013, Nitric oxide directly promotes vascular endothelial insulin transport, Diabetes, 62, 4030, 10.2337/db13-0627
Meshkani, 2009, Hepatic insulin resistance, metabolic syndrome and cardiovascular disease, Clin. Biochem., 42, 1331, 10.1016/j.clinbiochem.2009.05.018
Meininger, 2000, Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency, Biochem. J., 349, 353, 10.1042/0264-6021:3490353
Xu, 2007, Proteasome-dependent degradation of guanosine 5′-triphosphate cyclohydrolase I causes tetrahydrobiopterin deficiency in diabetes mellitus, Circulation, 116, 944, 10.1161/CIRCULATIONAHA.106.684795
Meininger, 2004, GTP cyclohydrolase I gene transfer reverses tetrahydrobiopterin deficiency and increases nitric oxide synthesis in endothelial cells and isolated vessels from diabetic rats, FASEB J, 18, 1900, 10.1096/fj.04-1702fje
Abudukadier, 2013, Tetrahydrobiopterin has a glucose-lowering effect by suppressing hepatic gluconeogenesis in an endothelial nitric oxide synthase-dependent manner in diabetic mice, Diabetes, 62, 3033, 10.2337/db12-1242
Guarino, 2003, Hepatic glutathione and nitric oxide are critical for hepatic insulin-sensitizing substance action, Am. J. Physiol. Gastrointest. Liver Physiol., 284, G588, 10.1152/ajpgi.00423.2002
Guarino, 2006, Co-administration of glutathione and nitric oxide enhances insulin sensitivity in Wistar rats, Br. J. Pharmacol., 147, 959, 10.1038/sj.bjp.0706691
Sosa, 2011, Hepatoregenerative role of bone morphogenetic protein-9, Med. Sci. Monit., 17, HY33, 10.12659/MSM.882108
Lautt, 2004, A new paradigm for diabetes and obesity: the hepatic insulin sensitizing substance (HISS) hypothesis, J. Pharmacol. Sci., 95, 9, 10.1254/jphs.95.9
Lautt, 2005, Insulin sensitivity in skeletal muscle regulated by a hepatic hormone, HISS, Can. J. Appl. Physiol., 30, 304, 10.1139/h05-123
Ming, 2011, HISS, not insulin, causes vasodilation in response to administered insulin, J. Appl. Physiol. (1985), 110, 60, 10.1152/japplphysiol.00714.2010
Steinberg, 1994, Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent: a novel action of insulin to increase nitric oxide release, J. Clin. Invest., 94, 1172, 10.1172/JCI117433
Scherrer, 1994, Nitric oxide release accounts for insulin׳s vascular effects in humans, J. Clin. Invest., 94, 2511, 10.1172/JCI117621
Guarino, 2004, Insulin sensitivity is mediated by the activation of the ACh/NO/cGMP pathway in rat liver, Am. J. Physiol. Gastrointest. Liver Physiol., 287, G527, 10.1152/ajpgi.00085.2004
Lautt, 2001, Hepatic parasympathetic (HISS) control of insulin sensitivity determined by feeding and fasting, Am. J. Physiol. Gastrointest. Liver Physiol., 281, G29, 10.1152/ajpgi.2001.281.1.G29
Barreto, 2010, The islet–acinar axis of the pancreas: more than just insulin, Am. J. Physiol. Gastrointest. Liver Physiol., 299, G10, 10.1152/ajpgi.00077.2010
Chey, 2001, Neural hormonal regulation of exocrine pancreatic secretion, Pancreatology, 1, 320, 10.1159/000055831
Vincent, 1992, Nitric oxide and arginine-evoked insulin secretion, Science, 258, 1376, 10.1126/science.1455235
Broniowska, 2014, A. beta-Cell responses to nitric oxide, Vitam. Horm., 95, 299, 10.1016/B978-0-12-800174-5.00012-0
Laychock, 1991, L-Arginine stimulates cyclic guanosine 3′,5′-monophosphate formation in rat islets of Langerhans and RINm5F insulinoma cells: evidence for L-arginine:nitric oxide synthase, Endocrinology, 129, 3043, 10.1210/endo-129-6-3043
Schmidt, 1992, Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxides, Science, 255, 721, 10.1126/science.1371193
Spinas, 1998, The early phase of glucose-stimulated insulin secretion requires nitric oxide, Diabetologia, 41, 292, 10.1007/s001250050906
Spinas, 1999, The dual role of nitric oxide in islet beta-cells, News Physiol. Sci., 14, 49
Laffranchi, 1995, Nitric oxide (nitrogen monoxide, NO) stimulates insulin secretion by inducing calcium release from mitochondria, Biochem. Biophys. Res. Commun., 217, 584, 10.1006/bbrc.1995.2815
Weigert, 1992, Contribution of neural intrapancreatic non-cholinergic non-adrenergic mechanisms to glucose-induced insulin release in the isolated rat pancreas, Diabetologia, 35, 1133, 10.1007/BF00401366
Yoshimura, 2003, The relationship between insulin resistance and polymorphisms of the endothelial nitric oxide synthase gene in patients with coronary artery disease, J. Atheroscler. Thromb., 10, 43, 10.5551/jat.10.43
Monti, 2003, Endothelial nitric oxide synthase polymorphisms are associated with type 2 diabetes and the insulin resistance syndrome, Diabetes, 52, 1270, 10.2337/diabetes.52.5.1270
Gonzalez-Sanchez, 2007, Endothelial nitric oxide synthase haplotypes are associated with features of metabolic syndrome, Clin. Chem., 53, 91, 10.1373/clinchem.2006.075176
Rittig, 2008, Endothelial NO-synthase intron 4 polymorphism is associated with disturbed in vivo nitric oxide production in individuals prone to type 2 diabetes, Horm. Metab. Res., 40, 13, 10.1055/s-2007-1004527
Morris, 2001, Influence of an inducible nitric oxide synthase promoter variant on clinical variables in patients with coronary artery disease, Clin. Sci., 100, 551, 10.1042/CS20000223
Bagarolli, 2010, Toll-like receptor 4 and inducible nitric oxide synthase gene polymorphisms are associated with type 2 diabetes, J. Diabetes Complications, 24, 192, 10.1016/j.jdiacomp.2009.03.003
Duplain, 2001, Insulin resistance, hyperlipidemia, and hypertension in mice lacking endothelial nitric oxide synthase, Circulation, 104, 342, 10.1161/01.CIR.104.3.342
Cook, 2004, Partial gene deletion of endothelial nitric oxide synthase predisposes to exaggerated high-fat diet-induced insulin resistance and arterial hypertension, Diabetes, 53, 2067, 10.2337/diabetes.53.8.2067
Shankar, 2000, Mice with gene disruption of both endothelial and neuronal nitric oxide synthase exhibit insulin resistance, Diabetes, 49, 684, 10.2337/diabetes.49.5.684
Nakata, 2008, Spontaneous myocardial infarction in mice lacking all nitric oxide synthase isoforms, Circulation, 117, 2211, 10.1161/CIRCULATIONAHA.107.742692
Sydow, 2008, Dimethylarginine dimethylaminohydrolase overexpression enhances insulin sensitivity, Arterioscler. Thromb. Vasc. Biol., 28, 692, 10.1161/ATVBAHA.108.162073
Le Gouill, 2007, Endothelial nitric oxide synthase (eNOS) knockout mice have defective mitochondrial beta-oxidation, Diabetes, 56, 2690, 10.2337/db06-1228
Lee-Young, 2010, Endothelial nitric oxide synthase is central to skeletal muscle metabolic regulation and enzymatic signaling during exercise in vivo, Am. J. Physiol. Regul. Integr. Comp. Physiol, 298, R1399, 10.1152/ajpregu.00004.2010
Carlstrom, 2010, Dietary inorganic nitrate reverses features of metabolic syndrome in endothelial nitric oxide synthase-deficient mice, Proc. Natl. Acad. Sci. USA, 107, 17716, 10.1073/pnas.1008872107
Khedara, 1999, Elevated body fat in rats by the dietary nitric oxide synthase inhibitor, L-N omega nitroarginine, Biosci. Biotechnol. Biochem., 63, 698, 10.1271/bbb.63.698
Recchia, 2002, Reduced synthesis of NO causes marked alterations in myocardial substrate metabolism in conscious dogs, Am. J. Physiol. Endocrinol. Metab., 282, E197, 10.1152/ajpendo.2002.282.1.E197
Garcia-Villafranca, 2003, Involvement of nitric oxide/cyclic GMP signaling pathway in the regulation of fatty acid metabolism in rat hepatocytes, Biochem. Pharmacol., 65, 807, 10.1016/S0006-2952(02)01623-4
Goto, 1999, Feeding the nitric oxide synthase inhibitor L-N(omega)nitroarginine elevates serum very low density lipoprotein and hepatic triglyceride synthesis in rats, J. Nutr. Biochem., 10, 274, 10.1016/S0955-2863(99)00008-X
Schild, 2008, Impairment of endothelial nitric oxide synthase causes abnormal fat and glycogen deposition in liver, Biochim. Biophys. Acta, 1782, 180, 10.1016/j.bbadis.2007.12.007
Lefebvre, 2006, Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis, J. Clin. Invest., 116, 571, 10.1172/JCI27989
Doulias, 2013, Nitric oxide regulates mitochondrial fatty acid metabolism through reversible protein S-nitrosylation, Sci. Signaling, 6, rs1, 10.1126/scisignal.2003252
Carvalho-Filho, 2005, S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B/Akt: a novel mechanism of insulin resistance, Diabetes, 54, 959, 10.2337/diabetes.54.4.959
Carvalho-Filho, 2006, Targeted disruption of iNOS prevents LPS-induced S-nitrosation of IRbeta/IRS-1 and Akt and insulin resistance in muscle of mice, Am. J. Physiol. Endocrinol. Metab., 291, E476, 10.1152/ajpendo.00422.2005
Pauli, 2008, Acute physical exercise reverses S-nitrosation of the insulin receptor, insulin receptor substrate 1 and protein kinase B/Akt in diet-induced obese Wistar rats, J. Physiol., 586, 659, 10.1113/jphysiol.2007.142414
Williamson, 1901, On the treatment of glycosuria and diabetes mellitus with sodium salicylate, Br. Med. J, 1, 760, 10.1136/bmj.1.2100.760
Smith, 1952, The effect of salicylate on glycosuria, blood glucose and liver glycogen of the alloxan-diabetic rat, Biochem. J., 51, 18, 10.1042/bj0510018
Hundal, 2002, Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes, J. Clin. Invest., 109, 1321, 10.1172/JCI0214955
Kim, 2001, Prevention of fat-induced insulin resistance by salicylate, J. Clin. Invest., 108, 437, 10.1172/JCI11559
Shinozaki, 2011, Liver-specific inducible nitric-oxide synthase expression is sufficient to cause hepatic insulin resistance and mild hyperglycemia in mice, J. Biol. Chem., 286, 34959, 10.1074/jbc.M110.187666
Handa, 2011, Reduced vascular nitric oxide–cGMP signaling contributes to adipose tissue inflammation during high-fat feeding, Arterioscler. Thromb. Vasc. Biol., 31, 2827, 10.1161/ATVBAHA.111.236554
Cha, 2010, Lack of inducible nitric oxide synthase does not prevent aging-associated insulin resistance, Exp. Gerontol., 45, 711, 10.1016/j.exger.2010.05.004
Taniguchi, 2006, Critical nodes in signalling pathways: insights into insulin action, Nat. Rev. Mol. Cell Biol., 7, 85, 10.1038/nrm1837