Uncoupling of endothelial NO synthase in atherosclerosis and vascular disease

Current Opinion in Pharmacology - Tập 13 - Trang 161-167 - 2013
Huige Li1, Ulrich Förstermann1
1Department of Pharmacology, Johannes Gutenberg University Medical Center, 55131 Mainz, Germany

Tài liệu tham khảo

Li, 2009, Prevention of atherosclerosis by interference with the vascular nitric oxide system, Curr Pharm Des, 15, 3133, 10.2174/138161209789058002 Forstermann, 2012, Nitric oxide synthases: regulation and function, Eur Heart J, 33, 829, 10.1093/eurheartj/ehr304 Crabtree, 2011, Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency, Free Radic Biol Med, 50, 1639, 10.1016/j.freeradbiomed.2011.03.010 Pritchard, 1995, Native low-density lipoprotein increases endothelial cell nitric oxide synthase generation of superoxide anion, Circ Res, 77, 510, 10.1161/01.RES.77.3.510 Stepp, 2002, Native ldl and minimally oxidized ldl differentially regulate superoxide anion in vascular endothelium in situ, Am J Physiol Heart Circ Physiol, 283, H750, 10.1152/ajpheart.00029.2002 Alp, 2004, Increased endothelial tetrahydrobiopterin synthesis by targeted transgenic GTP-cyclohydrolase i overexpression reduces endothelial dysfunction and atherosclerosis in apoe-knockout mice, Arterioscler Thromb Vasc Biol, 24, 445, 10.1161/01.ATV.0000115637.48689.77 Wohlfart, 2008, Antiatherosclerotic effects of small-molecular-weight compounds enhancing endothelial nitric-oxide synthase (enos) expression and preventing enos uncoupling, J Pharmacol Exp Ther, 325, 370, 10.1124/jpet.107.128009 Xia, 2010, Resveratrol reverses endothelial nitric-oxide synthase uncoupling in apolipoprotein e knockout mice, J Pharmacol Exp Ther, 335, 149, 10.1124/jpet.110.168724 Heinloth, 2000, Stimulation of NADPH oxidase by oxidized low-density lipoprotein induces proliferation of human vascular endothelial cells, J Am Soc Nephrol, 11, 1819, 10.1681/ASN.V11101819 Rueckschloss, 2001, Induction of nad(p)h oxidase by oxidized low-density lipoprotein in human endothelial cells: antioxidative potential of hydroxymethylglutaryl coenzyme a reductase inhibitor therapy, Circulation, 104, 1767, 10.1161/hc4001.097056 Steffen, 2012, Cigarette smoke and ldl cooperate in reducing nitric oxide bioavailability in endothelial cells via effects on both enos and NADPH oxidase, Nitric Oxide, 27, 176, 10.1016/j.niox.2012.06.006 Drummond, 2011, Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets, Nat Rev Drug Discov, 10, 453, 10.1038/nrd3403 Sorescu, 2002, Superoxide production and expression of nox family proteins in human atherosclerosis, Circulation, 105, 1429, 10.1161/01.CIR.0000012917.74432.66 Guzik, 2006, Coronary artery superoxide production and nox isoform expression in human coronary artery disease, Arterioscler Thromb Vasc Biol, 26, 333, 10.1161/01.ATV.0000196651.64776.51 Douglas, 2012, Endothelial-specific nox2 overexpression increases vascular superoxide and macrophage recruitment in apoe(−)/(−) mice, Cardiovasc Res, 94, 20, 10.1093/cvr/cvs026 Dikalova, 2010, Upregulation of nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via enos uncoupling, Am J Physiol Heart Circ Physiol, 299, H673, 10.1152/ajpheart.00242.2010 Forstermann, 2011, Therapeutic effect of enhancing endothelial nitric oxide synthase (enos) expression and preventing enos uncoupling, Br J Pharmacol, 164, 213, 10.1111/j.1476-5381.2010.01196.x Nickenig, 1999, Statin-sensitive dysregulated at1 receptor function and density in hypercholesterolemic men, Circulation, 100, 2131, 10.1161/01.CIR.100.21.2131 Chalupsky, 2005, Endothelial dihydrofolate reductase: critical for nitric oxide bioavailability and role in angiotensin II uncoupling of endothelial nitric oxide synthase, Proc Natl Acad Sci U S A, 102, 9056, 10.1073/pnas.0409594102 Ponnuswamy, 2012, Enos protects from atherosclerosis despite relevant superoxide production by the enzyme in apoe mice, PLoS One, 7, e30193, 10.1371/journal.pone.0030193 Kauser, 2000, Role of endogenous nitric oxide in progression of atherosclerosis in apolipoprotein e-deficient mice, Am J Physiol Heart Circ Physiol, 278, H1679, 10.1152/ajpheart.2000.278.5.H1679 Zhu, 2003, Low density lipoprotein induces enos translocation to membrane caveolae: the role of rhoa activation and stress fiber formation, Biochim Biophys Acta, 1635, 117, 10.1016/j.bbalip.2003.10.011 Feron, 1999, Hypercholesterolemia decreases nitric oxide production by promoting the interaction of caveolin and endothelial nitric oxide synthase, J Clin Invest, 103, 897, 10.1172/JCI4829 Pritchard, 2002, Native low-density lipoprotein induces endothelial nitric oxide synthase dysfunction: role of heat shock protein 90 and caveolin-1, Free Radic Biol Med, 33, 52, 10.1016/S0891-5849(02)00851-1 Chavakis, 2001, Oxidized ldl inhibits vascular endothelial growth factor-induced endothelial cell migration by an inhibitory effect on the akt/endothelial nitric oxide synthase pathway, Circulation, 103, 2102, 10.1161/01.CIR.103.16.2102 Ryoo, 2011, Oxldl-dependent activation of arginase II is dependent on the lox-1 receptor and downstream rhoa signaling, Atherosclerosis, 214, 279, 10.1016/j.atherosclerosis.2010.10.044 Sindler, 2009, Effects of ageing and exercise training on enos uncoupling in skeletal muscle resistance arterioles, J Physiol, 587, 3885, 10.1113/jphysiol.2009.172221 Imanishi, 2008, Addition of eplerenone to an angiotensin-converting enzyme inhibitor effectively improves nitric oxide bioavailability, Hypertension, 51, 734, 10.1161/HYPERTENSIONAHA.107.104299 Warnholtz, 1999, Increased nadh-oxidase-mediated superoxide production in the early stages of atherosclerosis: evidence for involvement of the renin–angiotensin system, Circulation, 99, 2027, 10.1161/01.CIR.99.15.2027 Takaya, 2006, Angiotensin II type 1 receptor blocker telmisartan suppresses superoxide production and reduces atherosclerotic lesion formation in apolipoprotein e-deficient mice, Atherosclerosis, 186, 402, 10.1016/j.atherosclerosis.2005.08.009 Wenzel, 2008, At1-receptor blockade by telmisartan upregulates GTP-cyclohydrolase i and protects enos in diabetic rats, Free Radic Biol Med, 45, 619, 10.1016/j.freeradbiomed.2008.05.009 Satoh, 2008, Angiotensin II type 1 receptor blocker ameliorates uncoupled endothelial nitric oxide synthase in rats with experimental diabetic nephropathy, Nephrol Dial Transplant, 23, 3806, 10.1093/ndt/gfn357 Oak, 2007, Attenuation of angiotensin II signaling recouples enos and inhibits nonendothelial nox activity in diabetic mice, Diabetes, 56, 118, 10.2337/db06-0288 Knorr, 2011, Nitroglycerin-induced endothelial dysfunction and tolerance involve adverse phosphorylation and s-glutathionylation of endothelial nitric oxide synthase: beneficial effects of therapy with the at1 receptor blocker telmisartan, Arterioscler Thromb Vasc Biol, 31, 2223, 10.1161/ATVBAHA.111.232058 Antonopoulos, 2012, Statins as anti-inflammatory agents in atherogenesis: Molecular mechanisms and lessons from the recent clinical trials, Curr Pharm Des, 18, 1519, 10.2174/138161212799504803 Hattori, 2003, Hmg-coa reductase inhibitor increases GTP cyclohydrolase i mrna and tetrahydrobiopterin in vascular endothelial cells, Arterioscler Thromb Vasc Biol, 23, 176, 10.1161/01.ATV.0000054659.72231.A1 Wenzel, 2008, Mechanisms underlying recoupling of enos by hmg-coa reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus, Atherosclerosis, 198, 65, 10.1016/j.atherosclerosis.2007.10.003 Antoniades, 2011, Rapid, direct effects of statin treatment on arterial redox state and nitric oxide bioavailability in human atherosclerosis via tetrahydrobiopterin-mediated endothelial nitric oxide synthase coupling, Circulation, 124, 335, 10.1161/CIRCULATIONAHA.110.985150 Antoniades, 2010, Preoperative atorvastatin treatment in cabg patients rapidly improves vein graft redox state by inhibition of rac1 and NADPH-oxidase activity, Circulation, 122, S66, 10.1161/CIRCULATIONAHA.109.927376 Carrepeiro, 2011, Effect of n−3 fatty acids and statins on oxidative stress in statin-treated hypercholestorelemic and normocholesterolemic women, Atherosclerosis, 217, 171, 10.1016/j.atherosclerosis.2010.12.013 Landmesser, 2005, Simvastatin versus ezetimibe: pleiotropic and lipid-lowering effects on endothelial function in humans, Circulation, 111, 2356, 10.1161/01.CIR.0000164260.82417.3F Munzel, 2009, Nebivolol: the somewhat-different beta-adrenergic receptor blocker, J Am Coll Cardiol, 54, 1491, 10.1016/j.jacc.2009.05.066 Mollnau, 2003, Nebivolol prevents vascular NOS III uncoupling in experimental hyperlipidemia and inhibits NADPH oxidase activity in inflammatory cells, Arterioscler Thromb Vasc Biol, 23, 615, 10.1161/01.ATV.0000065234.70518.26 Oelze, 2006, Nebivolol inhibits superoxide formation by NADPH oxidase and endothelial dysfunction in angiotensin II-treated rats, Hypertension, 48, 677, 10.1161/01.HYP.0000239207.82326.29 Oppermann, 2009, Pharmacological induction of vascular extracellular superoxide dismutase expression in vivo, J Cell Mol Med, 13, 1271, 10.1111/j.1582-4934.2008.00627.x Schuhmacher, 2011, Vascular dysfunction in experimental diabetes is improved by pentaerithrityl tetranitrate but not isosorbide-5-mononitrate therapy, Diabetes, 60, 2608, 10.2337/db10-1395 Li, 2012, Cardiovascular effects and molecular targets of resveratrol, Nitric Oxide, 26, 102, 10.1016/j.niox.2011.12.006 Do, 2008, Long-term effects of resveratrol supplementation on suppression of atherogenic lesion formation and cholesterol synthesis in apo e-deficient mice, Biochem Biophys Res Commun, 374, 55, 10.1016/j.bbrc.2008.06.113 Timmers, 2011, Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans, Cell Metab, 14, 612, 10.1016/j.cmet.2011.10.002 Klinge, 2008, Resveratrol stimulates nitric oxide production by increasing estrogen receptor alpha-src-caveolin-1 interaction and phosphorylation in human umbilical vein endothelial cells, FASEB J, 22, 2185, 10.1096/fj.07-103366 Mattagajasingh, 2007, Sirt1 promotes endothelium-dependent vascular relaxation by activating endothelial nitric oxide synthase, Proc Natl Acad Sci U S A, 104, 14855, 10.1073/pnas.0704329104 Cunnington, 2012, Systemic and vascular oxidation limits the efficacy of oral tetrahydrobiopterin treatment in patients with coronary artery disease, Circulation, 125, 1356, 10.1161/CIRCULATIONAHA.111.038919 McNeill, 2012, The role of tetrahydrobiopterin in inflammation and cardiovascular disease, Thromb Haemost, 108 Youn, 2012, Endothelium-specific sepiapterin reductase deficiency in doca-salt hypertension, Am J Physiol Heart Circ Physiol, 302, H2243, 10.1152/ajpheart.00835.2011 Westermann, 2009, Enhancement of the endothelial no synthase attenuates experimental diastolic heart failure, Basic Res Cardiol, 104, 499, 10.1007/s00395-009-0014-6 Yang, 2011, Ave3085, an enhancer of endothelial nitric oxide synthase, restores endothelial function and reduces blood pressure in spontaneously hypertensive rats, Br J Pharmacol, 163, 1078, 10.1111/j.1476-5381.2011.01308.x Cheang, 2011, Endothelial nitric oxide synthase enhancer reduces oxidative stress and restores endothelial function in db/db mice, Cardiovasc Res, 92, 267, 10.1093/cvr/cvr233