Current perspectives and challenges in understanding the role of nitrite as an integral player in nitric oxide biology and therapy

Zweier, 1995, Enzyme-independent formation of nitric oxide in biological tissues, Nat. Med., 1, 804, 10.1038/nm0895-804 Modin, 2001, Nitrite-derived nitric oxide: a possible mediator of 'acidic-metabolic' vasodilation, Acta Physiol. Scand., 171, 9 Benjamin, 1994, Stomach NO synthesis, Nature, 368, 502, 10.1038/368502a0 Lundberg, 1994, Intragastric nitric oxide production in humans: measurements in expelled air, Gut, 35, 1543, 10.1136/gut.35.11.1543 van Faassen, 2009, Nitrite as regulator of hypoxic signaling in mammalian physiology, Med. Res. Rev., 29, 683, 10.1002/med.20151 Lundberg, 2009, Nitrate and nitrite in biology, nutrition and therapeutics, Nat. Chem. Biol., 5, 865, 10.1038/nchembio.260 Lundberg, 2008, The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics, Nat. Rev. Drug Discov., 7, 156, 10.1038/nrd2466 Raat, 2009, Effects of nitrite on modulating ROS generation following ischemia and reperfusion, Adv. Drug Deliv. Rev., 61, 339, 10.1016/j.addr.2009.02.002 Dezfulian, 2007, Role of the anion nitrite in ischemia–reperfusion cytoprotection and therapeutics, Cardiovasc. Res., 75, 327, 10.1016/j.cardiores.2007.05.001 Calvert, 2009, Myocardial protection by nitrite, Cardiovasc. Res., 83, 195, 10.1093/cvr/cvp079 Calvert, 2010, Clinical translation of nitrite therapy for cardiovascular diseases, Nitric Oxide, 22, 91, 10.1016/j.niox.2009.11.001 Butler, 2008, Therapeutic uses of inorganic nitrite and nitrate: from the past to the future, Circulation, 117, 2151, 10.1161/CIRCULATIONAHA.107.753814 Kapil, 2010, Inorganic nitrate and the cardiovascular system, Heart, 96, 1703, 10.1136/hrt.2009.180372 Gladwin, 2009, The new chemical biology of nitrite reactions with hemoglobin: R-state catalysis, oxidative denitrosylation, and nitrite reductase/anhydrase, Acc. Chem. Res., 42, 157, 10.1021/ar800089j Gladwin, 2006, Nitrite as a vascular endocrine nitric oxide reservoir that contributes to hypoxic signaling, cytoprotection, and vasodilation, Am. J. Physiol. Heart Circ. Physiol., 291, H2026, 10.1152/ajpheart.00407.2006 Patel, 2011, The potential role of the red blood cell in nitrite-dependent regulation of blood flow, Cardiovasc. Res., 89, 507, 10.1093/cvr/cvq323 Shiva, 2010, Mitochondria as metabolizers and targets of nitrite, Nitric Oxide, 22, 64, 10.1016/j.niox.2009.09.002 Tang, 2011, Nitrite and nitrate: cardiovascular risk–benefit and metabolic effect, Curr. Opin. Lipidol., 22, 11, 10.1097/MOL.0b013e328341942c Weitzberg, 2010, Nitrate–nitrite–nitric oxide pathway: implications for anesthesiology and intensive care, Anesthesiology, 113, 1460, 10.1097/ALN.0b013e3181fcf3cc Kevil, 2011, Review focus on inorganic nitrite and nitrate in cardiovascular health and disease, Cardiovasc. Res., 89, 489, 10.1093/cvr/cvq409 Zhang, 1998, Generation of nitric oxide by a nitrite reductase activity of xanthine oxidase: a potential pathway for nitric oxide formation in the absence of nitric oxide synthase activity, Biochem. Biophys. Res. Commun., 249, 767, 10.1006/bbrc.1998.9226 Zhang, 1997, Human xanthine oxidase converts nitrite ions into nitric oxide (NO), Biochem. Soc. Trans., 25, 524S, 10.1042/bst025524s Millar, 1998, Xanthine oxidoreductase catalyses the reduction of nitrates and nitrite to nitric oxide under hypoxic conditions, FEBS Lett., 427, 225, 10.1016/S0014-5793(98)00430-X Keszler, 2008, The reaction between nitrite and oxyhemoglobin: a mechanistic study, J. Biol. Chem., 283, 9615, 10.1074/jbc.M705630200 Cosby, 2003, Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation, Nat. Med., 9, 1498, 10.1038/nm954 Crawford, 2006, Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation, Blood, 107, 566, 10.1182/blood-2005-07-2668 Huang, 2005, Enzymatic function of hemoglobin as a nitrite reductase that produces NO under allosteric control, J. Clin. Invest., 115, 2099, 10.1172/JCI24650 Shiva, 2007, Deoxymyoglobin is a nitrite reductase that generates nitric oxide and regulates mitochondrial respiration, Circ. Res., 100, 654, 10.1161/01.RES.0000260171.52224.6b Cassoly, 1975, Conformation, co-operativity and ligand binding in human hemoglobin, J. Mol. Biol., 91, 301, 10.1016/0022-2836(75)90382-4 Herold, 2001, Kinetic and mechanistic studies of the NO*-mediated oxidation of oxymyoglobin and oxyhemoglobin, Biochemistry, 40, 3385, 10.1021/bi002407m Bekedam, 2009, Myoglobin concentration in skeletal muscle fibers of chronic heart failure patients, J. Appl. Physiol., 107, 1138, 10.1152/japplphysiol.00149.2009 Wittenberg, 2003, Myoglobin function reassessed, J. Exp. Biol., 206, 2011, 10.1242/jeb.00243 Hendgen-Cotta, 2008, Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia–reperfusion injury, Proc. Natl Acad. Sci. U. S. A., 105, 10256, 10.1073/pnas.0801336105 Nagababu, 2007, Intermediates detected by visible spectroscopy during the reaction of nitrite with deoxyhemoglobin: the effect of nitrite concentration and diphosphoglycerate, Biochemistry, 46, 11650, 10.1021/bi700364e Rifkind, 2006, Nitric oxide redox reactions and red cell biology, Antioxid. Redox Signal., 8, 1193, 10.1089/ars.2006.8.1193 Rifkind, 2011, The quaternary hemoglobin conformation regulates the formation of the nitrite-induced bioactive intermediate and the dissociation of nitric oxide from this intermediate, Nitric Oxide, 24, 102, 10.1016/j.niox.2011.01.001 Rifkind, 2009, Nitrite-induced improved blood circulation associated with an increase in a pool of RBC-NO with no bioactivity, Adv. Exp. Med. Biol., 645, 27, 10.1007/978-0-387-85998-9_5 Salgado, 2009, Quantification of intermediates formed during the reduction of nitrite by deoxyhemoglobin, J. Biol. Chem., 284, 12710, 10.1074/jbc.M808647200 Lancaster, 1997, A tutorial on the diffusibility and reactivity of free nitric oxide, Nitric Oxide, 1, 18, 10.1006/niox.1996.0112 Vaughn, 2000, Erythrocytes possess an intrinsic barrier to nitric oxide consumption, J. Biol. Chem., 275, 2342, 10.1074/jbc.275.4.2342 Jeffers, 2005, Hemoglobin mediated nitrite activation of soluble guanylyl cyclase, Comp. Biochem. Physiol. A Mol. Integr. Physiol., 142, 130, 10.1016/j.cbpb.2005.04.016 Robinson, 2005, Hemoglobin-mediated, hypoxia-induced vasodilation via nitric oxide: mechanism(s) and physiologic versus pathophysiologic relevance, Am. J. Respir. Cell Mol. Biol., 32, 257, 10.1165/rcmb.F292 Basu, 2007, Catalytic generation of N2O3 by the concerted nitrite reductase and anhydrase activity of hemoglobin, Nat. Chem. Biol., 3, 785, 10.1038/nchembio.2007.46 Fernandez, 2003, Nitrite catalyzes ferriheme protein reductive nitrosylation, J. Am. Chem. Soc., 125, 10510, 10.1021/ja036693b Ford, 2010, Reactions of NO and nitrite with heme models and proteins, Inorg. Chem., 49, 6226, 10.1021/ic902073z Angelo, 2006, An S-nitrosothiol (SNO) synthase function of hemoglobin that utilizes nitrite as a substrate, Proc. Natl Acad. Sci. U. S. A., 103, 8366, 10.1073/pnas.0600942103 Basu, 2008, Nitrite reductase activity of cytochrome c, J. Biol. Chem., 283, 32590, 10.1074/jbc.M806934200 Crawford, 2004, Transduction of NO-bioactivity by the red blood cell in sepsis: novel mechanisms of vasodilation during acute inflammatory disease, Blood, 104, 1375, 10.1182/blood-2004-03-0880 Nagababu, 2006, S-nitrosohemoglobin: a mechanism for its formation in conjunction with nitrite reduction by deoxyhemoglobin, Nitric Oxide, 15, 20, 10.1016/j.niox.2006.01.012 Bryan, 2005, Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues, Nat. Chem. Biol., 1, 290, 10.1038/nchembio734 Feelisch, 2002, Concomitant S-, N-, and heme-nitros(yl)ation in biological tissues and fluids: implications for the fate of NO in vivo, FASEB J., 16, 1775, 10.1096/fj.02-0363com Duranski, 2005, Cytoprotective effects of nitrite during in vivo ischemia–reperfusion of the heart and liver, J. Clin. Invest., 115, 1232, 10.1172/JCI22493 Rassaf, 2007, Nitrite reductase function of deoxymyoglobin: oxygen sensor and regulator of cardiac energetics and function, Circ. Res., 100, 1749, 10.1161/CIRCRESAHA.107.152488 Schwab, 2009, Nitrite–methemoglobin inadequate for hypoxic vasodilation, Nat. Chem. Biol., 5, 366, 10.1038/nchembio0609-366 Yi, 2008, The nitrite anion binds to human hemoglobin via the uncommon O-nitrito mode, Biochemistry, 47, 8247, 10.1021/bi801015c Rodkey, 1976, A mechanism for the conversion of oxyhemoglobin to methemoglobin by nitrite, Clin. Chem., 22, 1986, 10.1093/clinchem/22.12.1986 Goetz, 2010, An electron paramagnetic resonance study of the affinity of nitrite for methemoglobin, Nitric Oxide, 22, 149, 10.1016/j.niox.2009.10.009 Keshive, 1996, Kinetics of S-nitrosation of thiols in nitric oxide solutions, Chem. Res. Toxicol., 9, 988, 10.1021/tx960036y Grubina, 2007, Concerted nitric oxide formation and release from the simultaneous reactions of nitrite with deoxy- and oxyhemoglobin, J. Biol. Chem., 282, 12916, 10.1074/jbc.M700546200 Hendgen-Cotta, 2010, A highlight of myoglobin diversity: the nitrite reductase activity during myocardial ischemia–reperfusion, Nitric Oxide, 22, 75, 10.1016/j.niox.2009.10.003 Allen, 2009, Hemoglobin, nitric oxide and molecular mechanisms of hypoxic vasodilation, Trends Mol. Med., 15, 452, 10.1016/j.molmed.2009.08.002 Li, 2009, Characterization of the magnitude and mechanism of aldehyde oxidase-mediated nitric oxide production from nitrite, J. Biol. Chem., 284, 33850, 10.1074/jbc.M109.019125 Petersen, 2008, Reactions of ferrous neuroglobin and cytoglobin with nitrite under anaerobic conditions, J. Inorg. Biochem., 102, 1777, 10.1016/j.jinorgbio.2008.05.008 Tiso, 2011, Human neuroglobin functions as a redox-regulated nitrite reductase, J. Biol. Chem., 286, 18277, 10.1074/jbc.M110.159541 Gautier, 2006, Endothelial nitric oxide synthase reduces nitrite anions to NO under anoxia, Biochem. Biophys. Res. Commun., 341, 816, 10.1016/j.bbrc.2006.01.031 Aamand, 2009, Generation of nitric oxide from nitrite by carbonic anhydrase: a possible link between metabolic activity and vasodilation, Am. J. Physiol. Heart Circ. Physiol., 297, H2068, 10.1152/ajpheart.00525.2009 Castello, 2006, Mitochondrial cytochrome oxidase produces nitric oxide under hypoxic conditions: implications for oxygen sensing and hypoxic signaling in eukaryotes, Cell Metab., 3, 277, 10.1016/j.cmet.2006.02.011 Kozlov, 1999, Nitrite reductase activity is a novel function of mammalian mitochondria, FEBS Lett., 454, 127, 10.1016/S0014-5793(99)00788-7 Li, 2006, Characterization of the mechanism of cytochrome P450 reductase–cytochrome P450-mediated nitric oxide and nitrosothiol generation from organic nitrates, J. Biol. Chem., 281, 12546, 10.1074/jbc.M511803200 Li, 2004, Characterization of the effects of oxygen on xanthine oxidase-mediated nitric oxide formation, J. Biol. Chem., 279, 16939, 10.1074/jbc.M314336200 Li, 2001, Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrite reduction: evaluation of its role in nitric oxide generation in anoxic tissues, J. Biol. Chem., 276, 24482, 10.1074/jbc.M011648200 Webb, 2004, Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia–reperfusion damage, Proc. Natl Acad. Sci. U. S. A., 101, 13683, 10.1073/pnas.0402927101 Tripatara, 2007, Nitrite-derived nitric oxide protects the rat kidney against ischemia/reperfusion injury in vivo: role for xanthine oxidoreductase, J. Am. Soc. Nephrol., 18, 570, 10.1681/ASN.2006050450 Zuckerbraun, 2010, Nitrite potently inhibits hypoxic and inflammatory pulmonary arterial hypertension and smooth muscle proliferation via xanthine oxidoreductase-dependent nitric oxide generation, Circulation, 121, 98, 10.1161/CIRCULATIONAHA.109.891077 Feelisch, 2008, Tissue processing of nitrite in hypoxia: an intricate interplay of nitric oxide-generating and -scavenging systems, J. Biol. Chem., 283, 33927, 10.1074/jbc.M806654200 Li, 2003, Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrate reduction: evaluation of its role in nitrite and nitric oxide generation in anoxic tissues, Biochemistry, 42, 1150, 10.1021/bi026385a Chen, 2002, Protein oxidation of cytochrome c by reactive halogen species enhances its peroxidase activity, J. Biol. Chem., 277, 29781, 10.1074/jbc.M200709200 Cassina, 2000, Cytochrome c nitration by peroxynitrite, J. Biol. Chem., 275, 21409, 10.1074/jbc.M909978199 Basova, 2007, Cardiolipin switch in mitochondria: shutting off the reduction of cytochrome c and turning on the peroxidase activity, Biochemistry, 46, 3423, 10.1021/bi061854k Hamdane, 2003, The redox state of the cell regulates the ligand binding affinity of human neuroglobin and cytoglobin, J. Biol. Chem., 278, 51713, 10.1074/jbc.M309396200 Hamdane, 2004, Coupling of the heme and an internal disulfide bond in human neuroglobin, Micron, 35, 59, 10.1016/j.micron.2003.10.019 Nicolis, 2007, Reactivity and endogenous modification by nitrite and hydrogen peroxide: does human neuroglobin act only as a scavenger?, Biochem. J., 407, 89, 10.1042/BJ20070372 Dejam, 2007, Nitrite infusion in humans and nonhuman primates: endocrine effects, pharmacokinetics, and tolerance formation, Circulation, 116, 1821, 10.1161/CIRCULATIONAHA.107.712133 Bryan, 2007, Dietary nitrite supplementation protects against myocardial ischemia–reperfusion injury, Proc. Natl Acad. Sci. U. S. A., 104, 19144, 10.1073/pnas.0706579104 Bryan, 2008, Dietary nitrite restores NO homeostasis and is cardioprotective in endothelial nitric oxide synthase-deficient mice, Free Radic. Biol. Med., 45, 468, 10.1016/j.freeradbiomed.2008.04.040 Raat, 2009, Dietary nitrate and nitrite modulate blood and organ nitrite and the cellular ischemic stress response, Free Radic. Biol. Med., 47, 510, 10.1016/j.freeradbiomed.2009.05.015 Kapil, 2010, Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO, Hypertension, 56, 274, 10.1161/HYPERTENSIONAHA.110.153536 Larsen, 2006, Effects of dietary nitrate on blood pressure in healthy volunteers, N. Engl. J. Med., 355, 2792, 10.1056/NEJMc062800 Webb, 2008, Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite, Hypertension, 51, 784, 10.1161/HYPERTENSIONAHA.107.103523 Tsai, 2004, Oxygen distribution and respiration by the microcirculation, Antioxid. Redox Signal., 6, 1011, 10.1089/ars.2004.6.1011 Bertuglia, 2005, Role of nitric oxide in capillary perfusion and oxygen delivery regulation during systemic hypoxia, Am. J. Physiol. Heart Circ. Physiol., 288, H525, 10.1152/ajpheart.00426.2005 Webb, 2008, Mechanisms underlying erythrocyte and endothelial nitrite reduction to nitric oxide in hypoxia: role for xanthine oxidoreductase and endothelial nitric oxide synthase, Circ. Res., 103, 957, 10.1161/CIRCRESAHA.108.175810 Badejo, 2010, Mitochondrial aldehyde dehydrogenase mediates vasodilator responses of glyceryl trinitrate and sodium nitrite in the pulmonary vascular bed of the rat, Am. J. Physiol. Heart Circ. Physiol., 299, H819, 10.1152/ajpheart.00959.2009 Blood, 2011, Inhaled nitrite reverses hemolysis-induced pulmonary vasoconstriction in newborn lambs without blood participation, Circulation, 123, 605, 10.1161/CIRCULATIONAHA.110.001073 Dejam, 2007, Nitrite infusion in humans and nonhuman primates: endocrine effects, pharmacokinetics, and tolerance formation, Circulation, 116, 1821, 10.1161/CIRCULATIONAHA.107.712133 Bryan, 2004, Cellular targets and mechanisms of nitros(yl)ation: an insight into their nature and kinetics in vivo, Proc. Natl Acad. Sci. U. S. A., 101, 4308, 10.1073/pnas.0306706101 Samouilov, 2007, Magnetic resonance study of the transmembrane nitrite diffusion, Nitric Oxide, 16, 362, 10.1016/j.niox.2006.12.006 Jensen, 2010, Comparative analysis of nitrite uptake and hemoglobin–nitrite reactions in erythrocytes: sorting out uptake mechanisms and oxygenation dependencies, Am. J. Physiol. Regul. Integr. Comp. Physiol., 298, R972, 10.1152/ajpregu.00813.2009 Vitturi, 2009, Regulation of nitrite transport in red blood cells by hemoglobin oxygen fractional saturation, Am. J. Physiol. Heart Circ. Physiol., 296, H1398, 10.1152/ajpheart.01303.2008 Kumar, 2008, Chronic sodium nitrite therapy augments ischemia-induced angiogenesis and arteriogenesis, Proc. Natl Acad. Sci. U. S. A., 105, 7540, 10.1073/pnas.0711480105 Cauwels, 2009, Nitrite protects against morbidity and mortality associated with TNF- or LPS-induced shock in a soluble guanylate cyclase-dependent manner, J. Exp. Med., 206, 2915, 10.1084/jem.20091236 Veselik, 2008, Activation of estrogen receptor-α by the anion nitrite, Cancer Res., 68, 3950, 10.1158/0008-5472.CAN-07-2783 Larsen, 2011, Dietary inorganic nitrate improves mitochondrial efficiency in humans, Cell Metab., 13, 149, 10.1016/j.cmet.2011.01.004 Shiva, 2007, Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer, J. Exp. Med., 204, 2089, 10.1084/jem.20070198 Brown, 2004, Inhibition of mitochondrial respiratory complex I by nitric oxide, peroxynitrite and S-nitrosothiols, Biochim. Biophys. Acta, 1658, 44, 10.1016/j.bbabio.2004.03.016 Dezfulian, 2009, Nitrite therapy after cardiac arrest reduces reactive oxygen species generation, improves cardiac and neurological function, and enhances survival via reversible inhibition of mitochondrial complex I, Circulation, 120, 897, 10.1161/CIRCULATIONAHA.109.853267 Goldstein, 1996, Mechanism of the nitrosation of thiols and amines by oxygenated NO solutions: the nature of the nitrosating intermediates, J. Am. Chem. Soc., 118, 3419, 10.1021/ja9536680 van der Vliet, 1997, Formation of reactive nitrogen species during peroxidase-catalyzed oxidation of nitrite, J. Biol. Chem., 272, 7617, 10.1074/jbc.272.12.7617 Wu, 1999, Eosinophil peroxidase nitrates protein tyrosyl residues, J. Biol. Chem., 274, 25933, 10.1074/jbc.274.36.25933 Castro, 2004, Cytochrome c: a catalyst and target of nitrite–hydrogen peroxide-dependent protein nitration, Arch. Biochem. Biophys., 421, 99, 10.1016/j.abb.2003.08.033 Grzelak, 2001, Hemoglobin can nitrate itself and other proteins, Biochim. Biophys. Acta Gen. Subj., 1528, 97, 10.1016/S0304-4165(01)00176-3 Herold, 2004, Nitrotyrosine, dityrosine, and nitrotryptophan formation from metmyoglobin, hydrogen peroxide, and nitrite, Free Radic. Biol. Med., 36, 565, 10.1016/j.freeradbiomed.2003.10.014 Kilinc, 2001, Myoglobin-catalyzed tyrosine nitration: no need for peroxynitrite, Biochem. Biophys. Res. Commun., 285, 273, 10.1006/bbrc.2001.5168 Jung, 2006, Early intravenous infusion of sodium nitrite protects brain against in vivo ischemia–reperfusion injury, Stroke, 37, 2744, 10.1161/01.STR.0000245116.40163.1c Akaike, 2010, Cell signaling mediated by nitrated cyclic guanine nucleotide, Nitric Oxide, 23, 166, 10.1016/j.niox.2010.06.006 Khoo, 2010, Electrophilic nitro-fatty acids: anti-inflammatory mediators in the vascular compartment, Curr. Opin. Pharmacol., 10, 179, 10.1016/j.coph.2009.11.003 Kevil, 2011, Inorganic nitrite therapy: historical perspective and future directions, Free Radic. Biol. Med., 10.1016/j.freeradbiomed.2011.04.042 Tang, 2010, Nitrite and nitrate: cardiovascular risk-benefit and metabolic effect, Curr. Opin. Lipidol., 22, 11, 10.1097/MOL.0b013e328341942c Kenjale, 2011, Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease, J. Appl. Physiol., 110, 1582, 10.1152/japplphysiol.00071.2011 Lansley, 2011, Acute dietary nitrate supplementation improves cycling time trial performance, Med. Sci. Sports Exerc., 43, 1125, 10.1249/MSS.0b013e31821597b4 Lansley, 2011, Dietary nitrate supplementation reduces the O2 cost of walking and running: a placebo-controlled study, J. Appl. Physiol., 110, 591, 10.1152/japplphysiol.01070.2010 Rodriguez, 2009, Sodium nitrite therapy attenuates the hypertensive effects of HBOC-201 via nitrite reduction, Biochem. J., 422, 423, 10.1042/BJ20090735 Ingram, 2010, Low-dose sodium nitrite vasodilates hypoxic human pulmonary vasculature by a means that is not dependent on a simultaneous elevation in plasma nitrite, Am. J. Physiol. Heart Circ. Physiol., 298, H331, 10.1152/ajpheart.00583.2009