Association between CD8+ T-cell infiltration and breast cancer survival in 12 439 patients

Annals of Oncology - Tập 25 - Trang 1536-1543 - 2014
H.R. Ali1,2,3, E. Provenzano1,3, S.-J. Dawson1,3,4, F.M. Blows4, B. Liu1,3,4, M. Shah3,4,5, H.M. Earl3,4, C.J. Poole6, L. Hiller6, J.A. Dunn6, S.J. Bowden7, C. Twelves8, J.M.S. Bartlett9,10, S.M.A. Mahmoud11, E. Rakha11, I.O. Ellis11, S. Liu12, D. Gao12, T.O. Nielsen12, P.D.P. Pharoah3,4,5
1Cancer Research UK Cambridge Institute
2Departments of Pathology
3Oncology, University of Cambridge, Cambridge
4Cambridge Experimental Cancer Medicine Centre and NIHR Cambridge Biomedical Research Centre, Cambridge
5Strangeways Research Laboratory, Cambridge
6Warwick Clinical Trials Unit, University of Warwick, Coventry
7Cancer Research UK Clinical Trials Unit, Institute for Cancer Studies, The University of Birmingham, Birmingham
8University of Leeds and Leeds Cancer Research UK Centre, St James' Institute of Oncology, Leeds, UK
9Ontario Institute for Cancer Research, Toronto, Canada and Biomarker and Companion Diagnostics, Edinburgh Cancer Research Centre, Edinburgh
10Department of Histopathology and School of Molecular Medical Sciences, The University of Nottingham and Nottingham University Hospitals NHS Trust, Nottingham, UK
11Department of Pathology and Laboratory Medicine, University of British Columbia; Integrative Oncology Department, British Columbia Cancer Agency, Vancouver
12Genetic Pathology Evaluation Centre, Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada

Tài liệu tham khảo

Zhang, 2003, Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer, N Engl J Med, 348, 203, 10.1056/NEJMoa020177

Topalian, 2012, Safety, activity, and immune correlates of anti-PD-1 antibody in cancer, N Engl J Med, 366, 2443, 10.1056/NEJMoa1200690

Mahmoud, 2011, Tumor-infiltrating CD8+ lymphocytes predict clinical outcome in breast cancer, J Clin Oncol, 29, 1949, 10.1200/JCO.2010.30.5037

Denkert, 2010, Tumor-associated lymphocytes as an independent predictor of response to neoadjuvant chemotherapy in breast cancer, J Clin Oncol, 28, 105, 10.1200/JCO.2009.23.7370

Loi, 2013, Prognostic and predictive value of tumor-infiltrating lymphocytes in a phase III randomized adjuvant breast cancer trial in node-positive breast cancer comparing the addition of docetaxel to doxorubicin with doxorubicin-based chemotherapy: BIG 02-98, J Clin Oncol, 31, 860, 10.1200/JCO.2011.41.0902

Hoppin, 2002, Potential for selection bias with tumor tissue retrieval in molecular epidemiology studies, Ann Epidemiol, 12, 1, 10.1016/S1047-2797(01)00250-2

Bates, 2006, Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse, J Clin Oncol, 24, 5373, 10.1200/JCO.2006.05.9584

Ignatiadis, 2012, Gene modules and response to neoadjuvant chemotherapy in breast cancer subtypes: a pooled analysis, J Clin Oncol, 30, 1996, 10.1200/JCO.2011.39.5624