Type, Density, and Location of Immune Cells Within Human Colorectal Tumors Predict Clinical Outcome

American Association for the Advancement of Science (AAAS) - Tập 313 Số 5795 - Trang 1960-1964 - 2006
Jérôme Galon1,2,3,4,5, Anne Costes1,2,3,4,5, Fátima Sánchez‐Cabo1,2,3,4,5, Amos Kirilovsky1,2,3,4,5, Bernhard Mlecnik1,2,3,4,5, F Paraf1,2,3,4,5, Marie Tosolini1,2,3,4,5, Matthieu Camus1,2,3,4,5, Anne Berger1,2,3,4,5, Philippe Wind1,2,3,4,5, Franck Zinzindohoué1,2,3,4,5, Patrick Bruneval1,2,3,4,5, Paul-Henri Cugnenc1,2,3,4,5, Zlatko Trajanoski1,2,3,4,5, Wolf H. Fridman1,2,6,4,5, Franck Pagès1,2,6,4,5
1Department of Digestive Surgery, Avicenne Hospital, Bobigny, 93017 France.
2Department of General and Digestive Surgery, Georges Pompidou European Hospital, AP-HP, Paris, 75015 France.
3Department of Pathology, Avicenne Hospital, Bobigny, 93017 France.
4INSERM U 255, Paris, 75006 France; Université Paris-Descartes Paris 5, Faculté de Médecine, Paris, 75006 France; and Université Pierre et Marie Curie Paris 6, Institut des Cordeliers, Paris, 75006 France.
5Institute for Genomics and Bioinformatics, Graz University of Technology, Graz, Austria
6Department of Immunology, Georges Pompidou European Hospital, AP-HP, Paris, 75015 France.

Tóm tắt

The role of the adaptive immune response in controlling the growth and recurrence of human tumors has been controversial. We characterized the tumor-infiltrating immune cells in large cohorts of human colorectal cancers by gene expression profiling and in situ immunohistochemical staining. Collectively, the immunological data (the type, density, and location of immune cells within the tumor samples) were found to be a better predictor of patient survival than the histopathological methods currently used to stage colorectal cancer. The results were validated in two additional patient populations. These data support the hypothesis that the adaptive immune response influences the behavior of human tumors. In situ analysis of tumor-infiltrating immune cells may therefore be a valuable prognostic tool in the treatment of colorectal cancer and possibly other malignancies.

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We thank A. Rodi and M. Pelegrin for expert technical assistance; I. Gresser for helpful comments and critical review of the manuscript; and D. Frucht C. Anderson and T. Pokrovska for critically reading the manuscript. Supported by the Association pour la Recherche sur le Cancer (ARC) through the Alliance pour la Recherche sur le Cancer network (ARECA) INSERM Action Concertée Incitative ACI IMPBio Université Paris-Descartes Paris 5 and the Austrian Federal Ministry of Education Science and Culture (GBN-AU project Bioinformatics Integration Network).

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American Association for the Advancement of Science (AAAS)

Tập 313 Số 5795

1960-1964

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