Wiley

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Soluble Interleukin‐6 Receptor Is Released from Receptor‐bearing Cell Linesin vitro
Wiley - Tập 83 Số 4 - Trang 373-378 - 1992
Toshiharu Nakajima, Shinji Yamamoto, Ming Cheng, Kiyoshi Yasukawa, Toshio Hirano, Tadamitsu Kishimoto, Tohru Tokunaga, Mitsuo Honda
Soluble interleukin‐6 receptor (sIL‐6R) was found to be spontaneously released from human myeloma cell line U266 cells into culture supernatant, and was quantitatively measured with a fluorescence sandwich enzyme‐linked immunosorbent assay employing antibodies specific to IL‐6R. The supernatant IL‐6R was generated only from IL‐6R‐positive cell lines; myeloma cell lines RPMI8226 and RPMI178...... hiện toàn bộ
Interaction of Interleukin‐1 and Interferon‐γ on Fibroblast Growth Factor‐induced Angiogenesis
Wiley - Tập 85 Số 5 - Trang 522-529 - 1994
K Norioka, Toshihiro Mitaka, Yohichi Mochizuki, Masako Hara, Mitsuhiro Kawagoe, Haruo Nakamura
The interaction of interleukin‐1 (IL‐1) and interferon‐γ (IFN‐γ) actions on several aspects of angiogenesis in vitro and in vivo was studied. The proliferation and migration of human umbilical vein endothelial cells cultured with basic fibroblast growth factor (bFGF) were synergistically inhibited by cotreatment with IL‐1 and IFN‐γ. End...... hiện toàn bộ
Selective Inhibitory Effect of Bufalin on Growth of Human Tumor Cells in vitro: Association with the Induction of Apoptosis in Leukemia HL‐60 Cells
Wiley - Tập 85 Số 6 - Trang 645-651 - 1994
Yongkui Jing, Hidekazu Ohizumi, Nobuko Kawazoe, Sachiko Hashimoto, Yutaka Masuda, Shigeo Nakajo, Takemi Yoshida, Yukio Kuroiwa, Kazuyasu Nakaya
We found that bufalin, an active principle of the Chinese medicine chan'su, has selective inhibitory effects on the growth of various human cancer cells. In order to examine whether the growth‐inhibitory effect of bufalin on human cancer cells is associated with apoptosis, human leukemia cells were treated with bufalin. HL‐60, ML1, and U937 leukemia cells treated...... hiện toàn bộ
In situ mRNA Hybridization Technique for Analysis of Human Telomerase RNA in Gastric Precancerous and Cancerous Lesions
Wiley - Tập 89 Số 11 - Trang 1187-1194 - 1998
Toru Hiyama, Hiroshi Yokozaki, Yasuhiko Kitadai, Eiichi Tahara, Hiroko Tahara, Ken Haruma, Wataru Yasui, Goro Kajiyama
Telomerase, the ribonucleoprotein enzyme that elongates telomeres, is repressed in normal somatic cells but is reactivated during tumor progression. The purpose of this study was to investigate the localization of human telomerase RNA (hTR) expression in human gastric precancerous and cancerous lesions by using in situ mRNA hybridization (ISH) with avidin‐biotin ...... hiện toàn bộ
In vitro Augmentation of Natural Killer Cell Activity and Production of Interferon‐α/β and ‐γ with Deoxyribonucleic Acid Fraction from Mycobacterium bovis BCG
Wiley - Tập 79 Số 7 - Trang 866-873 - 1988
Saburo Yamamoto, Etsuro Kuramoto, Shizuo Shimada, Tohru Tokunaga
A nucleic acid‐rich fraction extracted and purified from BCG (MY‐1) augmented natural killer (NK) cell activity of mouse spleen cells in vitro, and produced factor(s) which showed anti‐viral activity and rendered normal macrophages cytotoxic towards tumor cells. These cellular responses were induced by the MY‐1 digested preliminarily with RNase, but not by the MY...... hiện toàn bộ
A Case‐Control Study of Biliary Tract Cancer in Niigata Prefecture, Japan
Wiley - Tập 80 Số 10 - Trang 932-938 - 1989
Kazúo Kato, S Akai, Sumio Tominaga, Ikuko Kato
A case‐control study of biliary tract cancer was conducted in Niigata prefecture where the mortality of the cancer is the highest in Japan. The cases were 109 patients with gallbladder cancer and 84 with bile duct cancer, and the controls were 386 sex‐ and age‐matched neighborhood controls. For gallbladder cancer, a past history of biliary tract disease, a positive family history of cholel...... hiện toàn bộ
Wakame Seaweed Suppresses the Proliferation of 7,12‐Dimethylbenz(a)‐anthracene‐induced Mammary Tumors in Rats
Wiley - Tập 90 Số 9 - Trang 922-927 - 1999
Hiroomi Funahashi, Tomoaki Imai, Yuji Tanaka, Kyosuke Tsukamura, Yasusyuki Hayakawa, Toyone Kikumori, T. Mase, Takahiro Itoh, Masaya Nishikawa, H. Hayashi, Arihiro Shibata, Yatsuka Hibi, Masahide Takahashi, Tatsuhiko Narita
We examined the anti‐tumor proliferation effects of wakame seaweed on 7,12‐dimethylbenz(a)‐anthracene (DMBA)‐induced rat mammary tumor. DMBA was administered to 8‐week‐old female Sprague‐Dawley rats, and rats which developed mammary tumors were assigned randomly to three groups. Commercial rat feed was used in a control group (group I‐A), and two feed mixtures were prepared, which containe...... hiện toàn bộ
Augmented Adriamycin Sensitivity in Cells Transduced with an Antisense Tumor Necrosis Factor Gene Is Mediated by Caspase‐3 Downstream from Reactive Oxygen Species
Wiley - Tập 92 Số 9 - Trang 983-988 - 2001
Motomasa SASAKI, Daisuke Kobayashi, Naoki Watanabe
While transduction of an antisense tumor necrosis factor (TNF) gene sequence can augment the cytotoxicity of adriamycin (ADM) in human cancer cells, the specific effect of introducing this sequence on the signal transduction pathway leading to cell death remains unclear. In ADM‐resistant pancreatic carcinoma (PANC‐1) cells, both the antioxidant N‐acetyl‐L‐cystein...... hiện toàn bộ
Acquisition of Invasive Phenotype in Gallbladder Cancer Cells via Mutual Interaction of Stromal Fibroblasts and Cancer Cells as Mediated by Hepatocyte Growth Factor
Wiley - Tập 87 Số 7 - Trang 702-710 - 1996
Kunio Matsumoto, Kazuhiko Date, Hideo Shimura, Toshikazu Nakamura
Growth and motility of carcinoma cells are regulated through their interactions with host stromal cells, i. e., tumor‐stromal interactions. Hepatocyte growth factor (HGF), a ligand for c‐Met tyrosine kinase, is a stromal‐derived regulator of growth, motility, and morphogenesis. HGF stimulated proliferation and motility of GB‐d1 gallbladder carcinoma cells from a patient with gallbladder ca...... hiện toàn bộ
Reversal of Cisplatin Resistance with Amphotericin B in a Non‐small Cell Lung Cancer Cell Line
Wiley - Tập 82 Số 6 - Trang 747-751 - 1991
T Morikage, M Bungo, Motoko Inomata, Mitsuzi Yoshida, Tohru Ohmori, Yasuhiro Fujiwara, Kazuto Nishio, Nagahiro Saijo
The potentiation of anticancer agents by non‐anticancer drugs is one of the possible strategies for overcoming cellular resistance to chemotherapy. In order to overcome cis‐diamminedichloroplatinum‐(II) (CDDP) resistance, we evaluated the sensitizing effect on CDDP‐induced cytotoxicity of various non‐anticancer agents which might alter membrane transport, by mean...... hiện toàn bộ
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