Wiley
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In vitro Augmentation of Natural Killer Cell Activity and Production of Interferon‐α/β and ‐γ with Deoxyribonucleic Acid Fraction from Mycobacterium bovis BCGA nucleic acid‐rich fraction extracted and purified from BCG (MY‐1) augmented natural killer (NK) cell activity of mouse spleen cells in vitro , and produced factor(s) which showed anti‐viral activity and rendered normal macrophages cytotoxic towards tumor cells. These cellular responses were induced by the MY‐1 digested preliminarily with RNase, but not by the MY... ... hiện toàn bộ
Wiley - Tập 79 Số 7 - Trang 866-873 - 1988
Reconstitution of Anti‐tumor Effects of Lentinan in Nude Mice: Roles of Delayed‐type Hypersensitivity Reaction Triggered by CD4‐positive T Cell Clone in the Infiltration of Effector Cells into TumorLentinan, an antitumor polysaccharide used clinically in Japan, requires the intact T cell compartment to manifest its antitumor effects. The aim of the current study was to clarify the mechanisms playing crucial roles in the T cell requirement in the expression of antitumor effects of lentinan. Lentinan treatment of BDF1 mice transplanted intradermally with FBL‐3 induced complete tumor re... ... hiện toàn bộ
Wiley - Tập 85 Số 4 - Trang 409-417 - 1994
Acquisition of Invasive Phenotype in Gallbladder Cancer Cells via Mutual Interaction of Stromal Fibroblasts and Cancer Cells as Mediated by Hepatocyte Growth FactorGrowth and motility of carcinoma cells are regulated through their interactions with host stromal cells, i. e., tumor‐stromal interactions. Hepatocyte growth factor (HGF), a ligand for c‐Met tyrosine kinase, is a stromal‐derived regulator of growth, motility, and morphogenesis. HGF stimulated proliferation and motility of GB‐d1 gallbladder carcinoma cells from a patient with gallbladder ca... ... hiện toàn bộ
Wiley - Tập 87 Số 7 - Trang 702-710 - 1996
In vitro Anti‐tumor Activity of Anti‐c‐erbB‐2 × Anti‐CD3ɛ Bifunctional Monoclonal AntibodyWith the aim of developing an effective cancer immunotherapy for common epithelial cancer, a new class of bifunctional antibody (BFA) was developed; one arm of this BFA recognized c‐erb B‐2 gene product, and the other arm recognized CD3ɛ, a T‐cell specific surface antigen. Application of this BFA with human peripheral blood lymphocytes exhibited specific anti‐tumo... ... hiện toàn bộ
Wiley - Tập 83 Số 6 - Trang 563-567 - 1992
Soluble Interleukin‐6 Receptor Is Released from Receptor‐bearing Cell Linesin vitroSoluble interleukin‐6 receptor (sIL‐6R) was found to be spontaneously released from human myeloma cell line U266 cells into culture supernatant, and was quantitatively measured with a fluorescence sandwich enzyme‐linked immunosorbent assay employing antibodies specific to IL‐6R. The supernatant IL‐6R was generated only from IL‐6R‐positive cell lines; myeloma cell lines RPMI8226 and RPMI178... ... hiện toàn bộ
Wiley - Tập 83 Số 4 - Trang 373-378 - 1992
Expression Profile of Histone Deacetylase 1 in Gastric Cancer TissuesAlthough histone deacetylases (HDACs) appear to play a crucial role in carcinogenesis, the expression status of HDACs in primary human cancer tissues has not yet been reported. In this study, we investigated the expression level of HDAC1 in 25 paired primary human gastric cancer (GC) tissues and corresponding normal tissues through semi‐quantitative RT‐PCR and immunoblot analysis. The HDAC... ... hiện toàn bộ
Wiley - Tập 92 Số 12 - Trang 1300-1304 - 2001
CELL‐LINE SPECIFIC ACTIVATION OF SV40 TRANSCRIPTIONAL ENHANCER BY p40tax OF HTLV‐1A transcriptional trans ‐activator P40tax of HTLV‐1 was reported to activate HTLV‐1 enhancer, but not SV40 or Rous sarcoma virus enhancer. However, in certain cell lines, we found that SV40 enhancer was activated by p40tax . These cell lines were mostly T cells, where the SV40 enhancer showed only low activity without p40... hiện toàn bộ
Wiley - Tập 79 Số 7 - Trang 800-804 - 1988
Selective Inhibitory Effect of Bufalin on Growth of Human Tumor Cells in vitro: Association with the Induction of Apoptosis in Leukemia HL‐60 CellsWe found that bufalin, an active principle of the Chinese medicine chan'su , has selective inhibitory effects on the growth of various human cancer cells. In order to examine whether the growth‐inhibitory effect of bufalin on human cancer cells is associated with apoptosis, human leukemia cells were treated with bufalin. HL‐60, ML1, and U937 leukemia cells treated... ... hiện toàn bộ
Wiley - Tập 85 Số 6 - Trang 645-651 - 1994
Prevention of Mammary Tumorigenesis in Acatalasemic Mice by Vitamin E SupplementationAdult male and female acatalasemic (C3H/AnLCsb Csb ), hypocatalasemic (C3H/AnLCsc Csc ) and normal mice of C3H strain fed on regular laboratory chow for 15 months showed an increased incidence of spontaneous mammary tumor in the decreasing order of female acatalasemic, male acatalasemic, female hypocatalasemic ... ... hiện toàn bộ
Wiley - Tập 87 Số 7 - Trang 680-684 - 1996
Interaction of Interleukin‐1 and Interferon‐γ on Fibroblast Growth Factor‐induced AngiogenesisThe interaction of interleukin‐1 (IL‐1) and interferon‐γ (IFN‐γ) actions on several aspects of angiogenesis in vitro and in vivo was studied. The proliferation and migration of human umbilical vein endothelial cells cultured with basic fibroblast growth factor (bFGF) were synergistically inhibited by cotreatment with IL‐1 and IFN‐γ. End... ... hiện toàn bộ
Wiley - Tập 85 Số 5 - Trang 522-529 - 1994
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