Wiley

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Presence of Streptococcus DNA Sequence in Surgical Specimens of Gastric Cancer
Wiley - Tập 86 Số 9 - Trang 791-794 - 1995
Hiroki Sasaki, Hiroyasu Igaki, Tomoki Ishizuka, Yukiko Kogoma, Takashi Sügimura, Masaaki Terada
In Southern blot analysis using Mycoplasma16S ribosomal DNA (rDNA) as a probe, positive signals were detected in DNA samples from surgical specimens of gastric cancers. The DNA that hybridized to Mycoplasma 16S rDNA was eluted from the gel, cloned and sequenced. The cloned sequence was identical to 16S rDNA of Streptococcus...... hiện toàn bộ
Soluble Interleukin‐6 Receptor Is Released from Receptor‐bearing Cell Linesin vitro
Wiley - Tập 83 Số 4 - Trang 373-378 - 1992
Toshiharu Nakajima, Shinji Yamamoto, Ming Cheng, Kiyoshi Yasukawa, Toshio Hirano, Tadamitsu Kishimoto, Tohru Tokunaga, Mitsuo Honda
Soluble interleukin‐6 receptor (sIL‐6R) was found to be spontaneously released from human myeloma cell line U266 cells into culture supernatant, and was quantitatively measured with a fluorescence sandwich enzyme‐linked immunosorbent assay employing antibodies specific to IL‐6R. The supernatant IL‐6R was generated only from IL‐6R‐positive cell lines; myeloma cell lines RPMI8226 and RPMI178...... hiện toàn bộ
CELL‐LINE SPECIFIC ACTIVATION OF SV40 TRANSCRIPTIONAL ENHANCER BY p40tax OF HTLV‐1
Wiley - Tập 79 Số 7 - Trang 800-804 - 1988
Jun‐ichi Fujisawa, Motoharu Seiki, M Toita, Shoichiro Miyatake, Ken‐ichi Arai, Mitsuaki Yoshida
A transcriptional trans‐activator P40tax of HTLV‐1 was reported to activate HTLV‐1 enhancer, but not SV40 or Rous sarcoma virus enhancer. However, in certain cell lines, we found that SV40 enhancer was activated by p40tax. These cell lines were mostly T cells, where the SV40 enhancer showed only low activity without p40... hiện toàn bộ
Detection and Typing of Multiple Genital Human Papillomaviruses by DNA Amplification with Consensus Primers
Wiley - Tập 82 Số 5 - Trang 524-531 - 1991
Hiroyuki Yoshikawa, Takashi Kawana, Kyoko Kitagawa, Masahiko Mizuno, Hiroshi Yoshikura, Aikichi Iwamoto
Many types of human papillomavirus (HPV) are associated with genital lesions. In order to develop simple and sensitive diagnostic procedures for HPV infection, we took advantage of the polymerase chain reaction (PCR). We compared the published nucleotide sequences of the LI region from six genital HPV types and designed a pair of consensus primers for LI region. The PCR with the consensus ...... hiện toàn bộ
Replication of Hepatitis C Virus in Cultured Non‐neoplastic Human Hepatocytes
Wiley - Tập 87 Số 8 - Trang 787-792 - 1996
Naoya Kato, Nobuyuki Kato, Tetsuya Mizutani, Kazuo Sugiyama, Masayuki Noguchi, S Hirohashi, Kunitada Shimotohno
We established a replication system for hepatitis C virus (HCV) using the PH5CH non‐neoplastic human hepatocyte line that had been immortalized with simian virus 40 large T antigen. In cells inoculated with sera derived from two HCV‐positive blood donors, positive‐stranded HCV RNA was detected up to 30 days postinoculation (p.i.). Semi‐quantitative analysis of HCV RNA revealed that HCV mul...... hiện toàn bộ
Interaction of Interleukin‐1 and Interferon‐γ on Fibroblast Growth Factor‐induced Angiogenesis
Wiley - Tập 85 Số 5 - Trang 522-529 - 1994
K Norioka, Toshihiro Mitaka, Yohichi Mochizuki, Masako Hara, Mitsuhiro Kawagoe, Haruo Nakamura
The interaction of interleukin‐1 (IL‐1) and interferon‐γ (IFN‐γ) actions on several aspects of angiogenesis in vitro and in vivo was studied. The proliferation and migration of human umbilical vein endothelial cells cultured with basic fibroblast growth factor (bFGF) were synergistically inhibited by cotreatment with IL‐1 and IFN‐γ. End...... hiện toàn bộ
Selective Inhibitory Effect of Bufalin on Growth of Human Tumor Cells in vitro: Association with the Induction of Apoptosis in Leukemia HL‐60 Cells
Wiley - Tập 85 Số 6 - Trang 645-651 - 1994
Yongkui Jing, Hidekazu Ohizumi, Nobuko Kawazoe, Sachiko Hashimoto, Yutaka Masuda, Shigeo Nakajo, Takemi Yoshida, Yukio Kuroiwa, Kazuyasu Nakaya
We found that bufalin, an active principle of the Chinese medicine chan'su, has selective inhibitory effects on the growth of various human cancer cells. In order to examine whether the growth‐inhibitory effect of bufalin on human cancer cells is associated with apoptosis, human leukemia cells were treated with bufalin. HL‐60, ML1, and U937 leukemia cells treated...... hiện toàn bộ
In situ mRNA Hybridization Technique for Analysis of Human Telomerase RNA in Gastric Precancerous and Cancerous Lesions
Wiley - Tập 89 Số 11 - Trang 1187-1194 - 1998
Toru Hiyama, Hiroshi Yokozaki, Yasuhiko Kitadai, Eiichi Tahara, Hiroko Tahara, Ken Haruma, Wataru Yasui, Goro Kajiyama
Telomerase, the ribonucleoprotein enzyme that elongates telomeres, is repressed in normal somatic cells but is reactivated during tumor progression. The purpose of this study was to investigate the localization of human telomerase RNA (hTR) expression in human gastric precancerous and cancerous lesions by using in situ mRNA hybridization (ISH) with avidin‐biotin ...... hiện toàn bộ
In vitro Augmentation of Natural Killer Cell Activity and Production of Interferon‐α/β and ‐γ with Deoxyribonucleic Acid Fraction from Mycobacterium bovis BCG
Wiley - Tập 79 Số 7 - Trang 866-873 - 1988
Saburo Yamamoto, Etsuro Kuramoto, Shizuo Shimada, Tohru Tokunaga
A nucleic acid‐rich fraction extracted and purified from BCG (MY‐1) augmented natural killer (NK) cell activity of mouse spleen cells in vitro, and produced factor(s) which showed anti‐viral activity and rendered normal macrophages cytotoxic towards tumor cells. These cellular responses were induced by the MY‐1 digested preliminarily with RNase, but not by the MY...... hiện toàn bộ
Chemoprevention by Nimesulide, a Selective Cyclooxygenase‐2 Inhibitor, of 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP)‐induced Mammary Gland Carcinogenesis in Rats
Wiley - Tập 91 Số 9 - Trang 886-892 - 2000
Seiichi Nakatsugi, Toshihisa Ohta, Toshihiko Kawamori, Michihiro Mutoh, Toshiki Tanigawa, Kouji Watanabe, Shigeyuki Sugie, Takashi Sügimura, Keiji Wakabayashi
Breast cancer is common in women all over the world, and exploration of chemopreventive approaches to this cancer is very important. Nimesulide, a selective inhibitor of cyclooxygenase‐2 (COX‐2), is a good candidate as a chemopreventive agent with low toxicity. We examined its effects on mammary tumor development in female Sprague‐Dawley rats induced with the environmental carcinogen 2‐ami...... hiện toàn bộ
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