Reversal of Cisplatin Resistance with Amphotericin B in a Non‐small Cell Lung Cancer Cell Line

Wiley - Tập 82 Số 6 - Trang 747-751 - 1991
T Morikage1,2,3, M Bungo4,2,3, Motoko Inomata2, Mitsuzi Yoshida2, Tohru Ohmori2,3, Yasuhiro Fujiwara2, Kazuto Nishio2,3, Nagahiro Saijo2
1First Department of Internal Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-01
2Pharmacology Division, National Cancer Center Research Institute and Department of Internal Medicine, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104
3Recipients of Research Resident Fellowships from the Foundation for Promotion of Cancer Research.
4First Department of Internal Medicine, Kagawa Medical School, 1750-1 Ikenobe, Miki-cho, Kagawa 761-01

Tóm tắt

The potentiation of anticancer agents by non‐anticancer drugs is one of the possible strategies for overcoming cellular resistance to chemotherapy. In order to overcome cis‐diamminedichloroplatinum‐(II) (CDDP) resistance, we evaluated the sensitizing effect on CDDP‐induced cytotoxicity of various non‐anticancer agents which might alter membrane transport, by means of a colorimetric [3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyItetrazolium bromide] (MTT) assay. Drugs which have previously been demonstrated to modify multidrug resistance did not show a sensitizing effect to cisplatin. Only amphotericin B (AmB) selectively conquered CDDP resistance in the CDDP‐resistant cell line. A drug accumulation study done by the atomic absorption method demonstrated that the accumulation of CDDP in the resistant cell line recovered to the level of the parental cell line after treatment with AmB. Thus, AmB might overcome CDDP resistance by increasing the accumulation of CDDP.

Từ khóa


Tài liệu tham khảo

10.1007/BF00254240

Andrews P. A., 1988, cis‐Diamminedichloroplatinum(II) accumulation in sensitive and resistant human overian carcinoma cells, Cancer Res., 48, 68

Bungo M., 1990, Decreased accumulation as a mechanism of resistance to cis‐diamminedichloroplatinum(II) in human non‐small cell lung cancer cell lines: relation to DNA damage and repair, Cancer Res., 50, 2549

Kraker A. J., 1988, Accumulation of cis‐diamminedichloroplatinum(II) and platinum analogues by platinum‐resistant murine leukemia cells in vitro, Cancer Res., 48, 9

10.1126/science.3175622

10.1093/jnci/81.7.535

Nakagawa K., 1990, Glutathione‐S‐transferase as a determinant of drug resistance in transfectant cell lines, J. Biol. Chem., 265, 4296, 10.1016/S0021-9258(19)39562-6

Tsuruo T., 1982, Increased accumulation of vincristine and adriamycin in drug resistant tumor cells following incubation with calcium antagonists and calmodulin inhibitors, Cancer Res., 42, 4730

Hamada H., 1987, Phosphorylation of the Mr 170,000 to 180,000 glycoprotein specific to multidrug‐resistant tumor cells: effects of verapamil, trifluoparazine, and phorbol esters, Cancer Res., 47, 2860

10.1016/0305-7372(89)90002-9

Onoda J. M., 1989, In vivo Characterization of combination antitumor chemotherapy with calcium channel blockers and cis‐diamminedichloroplatinum(II), Cancer Res., 49, 2844

10.1016/0304-3835(89)90024-4

Hunter K. J., 1990, Effect of 2‐difluoromethylornithine on 1,3‐bis(2‐chloroethyl)‐l‐nitrosourea and cis‐diamminedichloroplatinum(II) cytotoxicity, DNA interstrand cross‐linking, and growth in human brain tumor cell lines in vitro, Cancer Res., 50, 2769

10.7326/0003-4819-100-5-704

10.1111/j.1349-7006.1990.tb02602.x

Hospers G. A. P., 1988, Characterization of a human small cell lung carcinoma cell line with acquired resistance to cis‐diamminedichloroplatinum(II), in vitro. Cancer Res., 48, 6803

Medoff G., 1981, Potentiation of anticancer agents by amphotericin B, J. Natl. Cancer Inst., 67, 131

Presant C. A., 1984, Effects of amphotericin B with combination chemotherapy on response rates and on survival in non‐small cell carcinoma of the lung, Cancer Treat. Rep., 68, 651

Valeriote P., 1984, Amphotericin B potentiation of the cytotoxicity of anti‐cancer agents against both normal hematopoietic and leukemia cells in mice, J. Natl. Cancer Inst., 73, 475, 10.1093/jnci/73.2.475

Krishan A., 1987, Effect of amphotericin B on adriamycin transport in P388 cells, Cancer Res., 45, 4097

10.1016/0277-5379(88)90241-6

10.1016/S0277-5379(98)90033-5

10.1002/ijc.2910410325

Carmichael J., 1987, Evaluation of a tetrazolium based semiautomated colorimetric assay: assessment of chemosensitivity testing, Cancer Res., 47, 936

Hon S., 1976, Platinum determination in blood and biological tissues by flameless atomic absorption, Clin. Chem., 22, 1211

Richon V. M., 1987, Multiple mechanisms of resistance to cis‐diamminedichloroplatinum(II) in murine leukemia L1210 cells, Cancer Res., 47, 2056

Thông tin
Thông tin xuất bản

Wiley

Tập 82 Số 6

747-751

Thông tin tác giả