Wiley
0910-5050
Cơ quản chủ quản: N/A
Các bài báo tiêu biểu
Expression Profile of Histone Deacetylase 1 in Gastric Cancer Tissues
Tập 92 Số 12 - Trang 1300-1304 - 2001
Although histone deacetylases (HDACs) appear to play a crucial role in
carcinogenesis, the expression status of HDACs in primary human cancer tissues
has not yet been reported. In this study, we investigated the expression level
of HDAC1 in 25 paired primary human gastric cancer (GC) tissues and
corresponding normal tissues through semi‐quantitative RT‐PCR and immunoblot
analysis. The HDAC1 expres...
Detection and Typing of Multiple Genital Human Papillomaviruses by DNA Amplification with Consensus Primers
Tập 82 Số 5 - Trang 524-531 - 1991
Many types of human papillomavirus (HPV) are associated with genital lesions. In
order to develop simple and sensitive diagnostic procedures for HPV infection,
we took advantage of the polymerase chain reaction (PCR). We compared the
published nucleotide sequences of the LI region from six genital HPV types and
designed a pair of consensus primers for LI region. The PCR with the consensus
primers ...
A Comparative Case‐Control Study of Colorectal Cancer and Adenoma
Tập 81 Số 11 - Trang 1101-1108 - 1990
We conducted a comparative case‐control study of colorectal cancer and adenoma
involving 221 cases with colorectal cancer, 525 cases with colorectal adenoma
and 578 neighborhood controls. Daily vegetables intake was associated with lower
risks of distal colon adenoma (relative risk (RR)=0.59, 95% confidence interval
(CI): 0.39–0.89) and rectal cancer (RR=0.46, 95% CI: 0.25–0.84). Daily beans
intak...
In vitro Augmentation of Natural Killer Cell Activity and Production of Interferon‐α/β and ‐γ with Deoxyribonucleic Acid Fraction from Mycobacterium bovis BCG
Tập 79 Số 7 - Trang 866-873 - 1988
A nucleic acid‐rich fraction extracted and purified from BCG (MY‐1) augmented
natural killer (NK) cell activity of mouse spleen cells in vitro, and produced
factor(s) which showed anti‐viral activity and rendered normal macrophages
cytotoxic towards tumor cells. These cellular responses were induced by the MY‐1
digested preliminarily with RNase, but not by the MY‐1 digested with DNase,
indicating ...
Suppression by Flavonoids of Cyclooxygenase‐2 Promoter‐dependent Transcriptional Activity in Colon Cancer Cells: Structure‐Activity Relationship
Tập 91 Số 7 - Trang 686-691 - 2000
Cyclooxygenase‐2 (COX‐2) plays an important role in carcinogenesis.
Investigation of the suppressive action of twelve flavonoids of different
chemical classes on the transcriptional activity of the COX‐2 gene in human
colon cancer DLD‐1 cells using a reporter gene assay have revealed quercetin to
be the most potent suppressor of COX‐2 transcription (IC50=10.5 μM), while
catechin and epicatechin sh...
High Susceptibility to Hepatocellular Carcinoma Development in LEC Rats with Hereditary Hepatitis
Tập 79 Số 7 - Trang 828-835 - 1988
A remarkably high incidence of hepatocellular carcinomas was observed in
long‐surviving LEC rats with hereditary hepatitis. Among the 60 LEC rats
examined between 12 and 28 months of age from F29, and F30, 55 (92%) developed
putative preneoplastic and neoplastic lesions such as hyperplastic foci and
nodules, and hepatocellular carcinomas. Of these, hepatocellular carcinomas were
observed with a hi...
Chemoprevention by Nimesulide, a Selective Cyclooxygenase‐2 Inhibitor, of 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP)‐induced Mammary Gland Carcinogenesis in Rats
Tập 91 Số 9 - Trang 886-892 - 2000
Breast cancer is common in women all over the world, and exploration of
chemopreventive approaches to this cancer is very important. Nimesulide, a
selective inhibitor of cyclooxygenase‐2 (COX‐2), is a good candidate as a
chemopreventive agent with low toxicity. We examined its effects on mammary
tumor development in female Sprague‐Dawley rats induced with the environmental
carcinogen 2‐amino‐1‐met...
Inhibitory Effects of (—)‐Epigallocatechin Gallate on Spontaneous Hepatoma in C3H/HeNCrj Mice and Human Hepatoma‐derived PLC/PRF/5 Cells
Tập 85 Số 3 - Trang 221-225 - 1994
The inhibitory effect of (—)‐epigallocatechin gallate (EGCG), a main constituent
of Japanese green tea, on spontaneous hepatoma in C3H/HeNCrj mice was
investigated. A total of 72 mice were divided into three groups; the control
group without EGCG, and two experimental groups receiving 0.05% (w/w) or 0.1%
EGCG in drinking water. EGCG reduced the incidence of hepatoma‐bearing mice from
83.3% (contro...
Wakame Seaweed Suppresses the Proliferation of 7,12‐Dimethylbenz(a)‐anthracene‐induced Mammary Tumors in Rats
Tập 90 Số 9 - Trang 922-927 - 1999
We examined the anti‐tumor proliferation effects of wakame seaweed on
7,12‐dimethylbenz(a)‐anthracene (DMBA)‐induced rat mammary tumor. DMBA was
administered to 8‐week‐old female Sprague‐Dawley rats, and rats which developed
mammary tumors were assigned randomly to three groups. Commercial rat feed was
used in a control group (group I‐A), and two feed mixtures were prepared, which
contained commer...
Selective Inhibitory Effect of Bufalin on Growth of Human Tumor Cells in vitro: Association with the Induction of Apoptosis in Leukemia HL‐60 Cells
Tập 85 Số 6 - Trang 645-651 - 1994
We found that bufalin, an active principle of the Chinese medicine chan'su, has
selective inhibitory effects on the growth of various human cancer cells. In
order to examine whether the growth‐inhibitory effect of bufalin on human cancer
cells is associated with apoptosis, human leukemia cells were treated with
bufalin. HL‐60, ML1, and U937 leukemia cells treated with bufalin at 10−8M and
above ha...