High Susceptibility to Hepatocellular Carcinoma Development in LEC Rats with Hereditary Hepatitis

Wiley - Tập 79 Số 7 - Trang 828-835 - 1988
Ryuichi Masuda1,2, Michihiro C. Yoshida1, Motomichi Sasaki1, Kimimaro Dempo3, Michio Mori3
1Chromosome Research Unit, Faculty of Science, Hokkaido University, Kita-10-jo, Nishi-8-chome, Kita-ku, Sapporo 060
2Recipient of a Fellowship for Japanese Junior Scientists from the Japan Society for the Promotion of Science.
3Department of Pathology, Sapporo Medical College, Minami-I-jo, Nishi-17-chome, Chuo-ku, Sapporo 060

Tóm tắt

A remarkably high incidence of hepatocellular carcinomas was observed in long‐surviving LEC rats with hereditary hepatitis. Among the 60 LEC rats examined between 12 and 28 months of age from F29, and F30, 55 (92%) developed putative preneoplastic and neoplastic lesions such as hyperplastic foci and nodules, and hepatocellular carcinomas. Of these, hepatocellular carcinomas were observed with a high frequency (46/55; 84%). All rats of advanced age that survived more than 18 months developed hepatocellular carcinomas. These results suggest that the development of liver tumors in LEC rats is an age‐associated phenomenon with serial hepatic alterations after the subsidence of acute hepatitis. The long‐surviving rats had no normal tissue and showed chronic hepatitis in nontumorous tissues of the liver. Cholangiofibrosis was also found in most rats with hepatic lesions. Metastasis of hepatocellular carcinomas was found in four rats. Histologically, the hepatocellular carcinomas were of a well‐differentiated type with a typical trabecular structure. Thus, LEC rats seem to be a promising animal model for studying the pathogenesis of hepatitis and hepatocellular carcinoma.

Từ khóa


Tài liệu tham khảo

Sasaki M., 1985, Spontaneous hepatitis in an inbred strain of Long‐Evans rats, Rat News Lett., 14, 4

10.1093/oxfordjournals.jhered.a110416

10.1258/002367788780864402

10.1111/j.1349-7006.1988.tb01584.x

Popper H., 1982, The relation of hepatocellular carcinoma to infection with hepatitis B and related viruses in man and animals, Hepatology (Suppl.), 2, 1S

10.1038/317489a0

10.1073/pnas.75.9.4533

10.1073/pnas.83.12.4543

10.1016/0016-5085(83)90309-8

Sato K., 1984, The placental form of glutathione S‐transferase as a new marker protein for preneoplasia in rat chemical hepatocarcinogenesis, Gann, 75, 199

10.1073/pnas.82.12.3964

10.1111/j.1349-7006.1988.tb00002.x

Dempo K., 1975, Immunofluorescent studies on alpha‐fetoprotein‐producing cells in the early stage of 3′‐methyl‐4‐dimethylaminoazobenzene carcinogenesis, Cancer Res., 35, 1282

Squire R. A., 1975, Report of a workshop on classification of specific hepatocellular lesions in rats, Cancer Res., 35, 3214

10.1007/BF00496563

Maekawa A., 1983, Spontaneous tumors in F‐344/ DuCrj rats, Gann, 74, 365

Solleveld H. A., 1984, Natural history of body weight gain, survival, and neoplasia in the F344 rat, J. Natl. Cancer Inst., 72, 929

Pollard M., 1979, Spontaneous liver tumors in aged germfree Wistar rats. Lab, Anim. Sci., 29, 74

Heston W. E., 1968, C3H‐Avy— A high hepatoma and high mammary tumor strain of mice, J. Natl. Cancer Inst., 40, 1161

Ward J. M., 1978, Evaluation of hepatocellular neoplasms in mice, J. Natl. Cancer Inst., 61, 807

Reuber M. D., 1969, Influence of hormones on N‐2‐fluorenyldiacetamide‐induced hyperplastic hepatic nodules in rats, J. Natl. Cancer Inst., 43, 445

Mitaka T., 1987, Sexual difference in the histochemical characteristics of “altered cell foci” in the liver of aged Fischer 344 rats, Jpn. J. Cancer Res. (Gann), 78, 785

Thông tin
Thông tin xuất bản

Wiley

Tập 79 Số 7

828-835

Thông tin tác giả