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Immunosenescence: deficits in adaptive immunity in the elderly
Wiley - Tập 70 Số 3 - Trang 179-189 - 2007
Frances T. Hakim, Ronald E. Gress
AbstractAging is associated clinically with increases in the frequency and severity of infectious diseases and an increased incidence of cancer, chronic inflammatory disorders and autoimmunity. These age‐associated immune dysfunctions are the consequence of declines in both the generation of new naïve T and B lymphocytes and the functional competence of memory populations. These alterations collec... hiện toàn bộ
HLA‐DR4 Antigen and IgA Nephropathy
Wiley - Tập 16 Số 5 - Trang 405-410 - 1980
R Fauchet, P. Le Pogamp, B Genetet, D Chevet, M. Guéguen, Pierre Simon, M P Ramee, F Cartier
HLA‐A, B and DR antigens were tested in 45 unrelated patients with IgA nephropathy (Berger's disease). A significant association with HLA‐DR4 was noted. An unusual finding was a secondary association with the A2‐B12 antigen combination.
HLA Antigens and Berger's Disease
Wiley - Tập 16 Số 1 - Trang 108-111 - 1980
Jean‐Denis Bignon, A Houssin, Jean‐Paul Soulillou, J Denis, J Guimbretière, J Guénel
We have studied the frequencies of HLA–A, –B antigens in 73 Berger's disease patients, plus HLA–DR antigens in 35 of them, and compared the percentages of antigens frequencies with those of a local and national panel. This study does not confirm the positive associations with HLA–Bw35 or HLA–B12 which have been previously reported. The HLA–DR typing only showed increased frequency of blanks in the... hiện toàn bộ
Genetic investigation in mesangial IgA nephropathy
Wiley - Tập 19 Số 2 - Trang 108-114 - 1982
Jean‐Claude Petit, M. H. Gazes, F Berthoux, Erna van Loghem, Jane Goguen, J Séger, C. Chapuis‐Chllier, M. Marcelin, Gerda de Lange, Marvin R. Garovoy, J. L. Serre, C.P. Brizard, Charles B. Carpenter
HLA—A, B. C. DR, MB, Bf, Gm, Am, Pi and Km genes (and 12 erythrocyte genetic systems) have been analyzed and correlated with clinical or biological features in 88 mesangial IgA glomerulonephritis.These data pointed out 2 gene frequency modifications: a significant MB1 specificity decrease in the total patient group and a significant Km I increase in the chronic renal failure mesangial IgA nephropa... hiện toàn bộ
HLA‐A, ‐B and ‐DR antigens in IgA nephropathy
Wiley - Tập 23 Số 5 - Trang 270-273 - 1984
Patrick J. Hanly, P. Garrett, Sharon Spencer, W. F. O’Dwyer
Fifty‐six Irish patients with IgA Nephropathy were typed for HLA‐A and ‐B antigens. Forty‐six were typed for HLA‐DR antigens. The frequencies of these antigens did not differ significantly from the frequency in the general population. The influence of genetic factors in the pathogenesis of this disease remains uncertain.
HLA‐DRB1 and DQB1 genotypes in patients with insulin‐dependent neonatal diabetes mellitus. A study of 13 cases
Wiley - Tập 56 Số 3 - Trang 217-222 - 2000
Eve Marquis, I. Le Monnier de Gouville, Claire Bouvattier, Jacques Beltrand, Claudine Junien, Dominique Charron, J Hors, C. Diatloff‐Zito
Abstract:Insulin‐dependent neonatal diabetes mellitus (NDM) is a rare form of diabetes with a heterogeneous genetic background. The HLA‐DRB1 and DQB1 genotypes were determined for 13 patients with NDM, from 9 unrelated families. Four patients had permanent NDM (PNDM) and 9 patients had transient NDM (TNDM). No excess of HLA susceptibility markers for type 1 diabetes (IDDM) was observed in this ser... hiện toàn bộ
Expression of HLA class I/II antigens and T cell immune response in human neuroendocrine tumors of the pancreas
Wiley - Tập 62 Số 1 - Trang 48-54 - 2003
Eduard Ryschich, Frank Autschbach, Sven Eisold, Ernst Klar, M W Büchler, Julien Schmidt
Abstract:  Peptide presentation by HLA class I and II antigens regulates specific antigen recognition by T cells. The present study aimed to investigate T cell infiltration and its relation to HLA antigen expression in pancreatic neuroendocrine tumors. Fresh tissue samples were collected from five insulinomas and six other neuroendocrine tumors (one gastrinoma, one glucagonoma, two carcinoid, and ... hiện toàn bộ
Molecular typing for HLA class I using ARMS‐PCR: Further developments following the 12th International Histocompatibility Workshop
Wiley - Tập 53 Số 2 - Trang 175-183 - 1999
Susan Tonks, Steven G.E. Marsh, M. Bunce M, Walter F. Bodmer
Molecular typing for HLA class I was introduced in the 12th International Histocompatibility Workshop. Following a pilot study using three methods, sequence specific oligotyping (SSO), reverse dot blot and amplification refractory mutation system (ARMS)‐PCR, the ARMS‐PCR method was selected for use. A great advantage of an ARMS‐PCR method is that, unlike the other two methods, it can determine whe... hiện toàn bộ
Population of the HLA Ligand Database
Wiley - Tập 61 Số 1 - Trang 12-19 - 2003
Muthuraman Sathiamurthy, Heather D. Hickman, J. W. Cavett, Ameer Fawad Zahoor, Kiley R. Prilliman, Stephen A. Metcalf, Marcelo Fernández-Viña, William H. Hildebrand
Abstract: We have established an HLA ligand database to provide scientists and clinicians with access to Major Histocompatibility Complex (MHC) class I and II motif and ligand data. The HLA Ligand Database is available on the world wide web at http://hlaligand.ouhsc.edu and contains ligands that have been published in peer‐reviewed journals. HLA peptide datasets prove useful in several areas: liga... hiện toàn bộ
An update of the HLA genomic region, locus information and disease associations: 2004
Wiley - Tập 64 Số 6 - Trang 631-649 - 2004
Takashi Shiina, Hidetoshi Inoko, Jerzy K. Kulski
Abstract:  The human major histocompatibility (MHC) genomic region at chromosomal position 6p21 encodes the six classical transplantation HLA genes and many other genes that have important roles in the regulation of the immune system as well as in some fundamental cellular processes. This small segment of the human genome has been associated with more than 100 diseases, including common diseases –... hiện toàn bộ
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