HLA class II‐associated genetic susceptibility in multiple sclerosis: A critical evaluation
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Abstract: Multiple sclerosis (MS) has, since the 1970s, been known to be associated with the HLA‐Dw2 and ‐DR2 specificities in Caucasian Europeans and North Americans. By the use of genomic typing techniques, the association has been specified to be with the DRwlS,DQw6,Dw2, i.e. the DRBI* 1501‐DQAI*0102‐DQBl*0602 haplotype. A significant DPw4 association in Scandinavian MS patients has been described in one report. However, this association has not been confirmed in several subsequent studies with patients from the same and other ethnic groups. During the last few years several reports, based on serological, RFLP and PCR‐SSO data, have suggested that the HLA class II‐associated MS susceptibility gene(s) may be more closely associated with the
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