Wiley
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Antimicrobial and Cytotoxic Activities of Neolignans from Magnolia officinalis
Wiley - Tập 1 Số 3 - Trang 530-537 - 2004
AbstractIn the light of the steady increase of infections related to
vancomycin‐resistant enterococci (VRE) and methicillin‐resistant Staphylococcus
aureus (MRSA), the medicinal plant Magnolia officinalis was subjected to
bioassay‐directed fractionation, which led to the isolation of the known
neolignans piperitylmagnolol (1), magnolol (2), and honokiol (3) from the MeOH
extract. In broth‐microdil...
Limonoids with an Oxygen Bridge between C(1) and C(29) from the Seeds of a Krishna Mangrove, Xylocarpus granatum
Wiley - Tập 11 Số 2 - Trang 262-275 - 2014
AbstractTen limonoids, named granatumins L–U (1–10, resp.), were isolated from
the seeds of an Indian mangrove, Xylocarpus granatum, collected in the estuary
of Krishna, Andhra Pradesh. The structures of these compounds were established
on the basis of spectroscopic data. The relative configuration of granatumin L
(1) was confirmed by a single‐crystal X‐ray diffraction analysis. Granatumins
L–T (1...
Cancer Chemopreventive Effect of Bergenin from Peltophorum pterocarpum Wood
Wiley - Tập 10 Số 10 - Trang 1866-1875 - 2013
AbstractThe aqueous extract of Peltophorum pterocarpum (Fabaceae) wood exhibited
potent inhibitory effects against EpsteinBarr virus early antigen (EBV‐EA)
activation induced with 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA) in Raji cells
and against melanogenesis in α‐melanocyte‐stimulating hormone (α‐MSH)‐stimulated
B16 melanoma cells, as well as potent 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) free
r...
New Limonoids from the Seeds of a Krishna Mangrove, Xylocarpus granatum
Wiley - Tập 10 Số 4 - Trang 612-620 - 2013
AbstractTwo new mexicanolides, named granatumins H and I (1 and 2, resp.), and
two phragmalins, named granatumins J and K (3 and 4, resp.), were isolated from
the seeds of an Indian mangrove, Xylocarpus moluccensis, collected from the
swamps of Krishna estuary, Andhra Pradesh. The structures of these limonoids
were established on the basis of spectroscopic data. Granatumin J (3) is a
highly oxidiz...
Production of the Inaccessible Sesquiterpene (−)‐5‐Epieremophilene by Metabolically Engineered Escherichia coli
Wiley - Tập 17 Số 7 - 2020
Abstract(−)‐5‐Epieremophilene, an epimer of the versatile sesquiterpene
(+)‐valencene, is an inaccessible natural product catalyzed by three
sesquiterpene synthases (SmSTPSs1‐3) of the Chinese medicinal herb Salvia
miltiorrhiza, and its biological activity remains less explored. In this study,
three metabolically engineered Escherichia coli strains were constructed for
(−)‐5‐epieremophilene produc...
Garcimultiflorone G, a Novel Benzoylphloroglucinol Derivative from Garcinia multiflora with Inhibitory Activity on Neutrophil Pro‐Inflammatory Responses
Wiley - Tập 11 Số 5 - Trang 819-824 - 2014
AbstractA novel benzoylphloroglucinol derivative, garcimultiflorone G (1), was
isolated from the fruits of Garcinia multiflora. The structure of 1 was
determined through extensive 1D‐ and 2D‐NMR, and MS analyses. Garcimultiflorone
G (1) showed inhibitory effects against superoxide anion (O$\rm{{_{2}^{{^\cdot}
-}}}$) generation and elastase release by human neutrophils in response to
formyl‐L‐methi...
Heat Shock Factor 1 Inducers from the Bark of Eucommia ulmoides as Cytoprotective Agents
Wiley - Tập 10 Số 7 - Trang 1322-1327 - 2013
AbstractThe barks of Eucommia ulmoides (Eucommiae Cortex, Eucommiaceae) have
been used as a traditional medicine in Korea, Japan, and China to treat
hypertension, reinforce the muscles and bones, and recover the damaged liver and
kidney functions. Among these traditional uses, to establish the recovery
effects on the damaged organs on the basis of phytochemistry, the barks of E.
ulmoides have been...
Fungal Transformation and Schistosomicidal Effects of Pimaradienoic Acid
Wiley - Tập 9 Số 8 - Trang 1465-1474 - 2012
AbstractThe schistosomicidal effects of pimaradienoic acid (PA) and two
derivatives, obtained by fungal transformation in the presence of Aspergillus
ochraceus, were investigated. PA was the only compound with antischistosomal
activity among the three diterpenes studied, with the ability to significantly
reduce the viability of the parasites at concentrations ranging from 25 to
100 μM. PA also pro...
Antiprotozoal, Schistosomicidal, and Antimicrobial Activities of the Essential Oil from the Leaves of Baccharis dracunculifolia
Wiley - Tập 7 Số 4 - Trang 993-1001 - 2010
AbstractBaccharis dracunculifolia DC. (Asteraceae), popularly known as ‘alecrim
do campo’, is a native plant from Brazil used in folk medicine as febrifuge,
anti‐inflammatory, antiseptic, and to treat skin sores. Also, B. dracunculifolia
is the most important plant source of the Brazilian green propolis, which is
recognized for its antiseptic and antiprotozoal activities. This study aimed at
inves...
Addressing Central Nervous System (CNS) Penetration in Drug Discovery: Basics and Implications of the Evolving New Concept
Wiley - Tập 6 Số 11 - Trang 2030-2049 - 2009
AbstractDespite enormous efforts, achieving a safe and efficacious concentration
profile in the brain remains one of the big challenges in central nervous system
(CNS) drug discovery and development. Although there are multiple reasons, many
failures are due to underestimating the complexity of the brain, also in terms
of pharmacokinetics (PK).To this day, PK support of CNS drug discovery heavily
...
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