Garcimultiflorone G, a Novel Benzoylphloroglucinol Derivative from Garcinia multiflora with Inhibitory Activity on Neutrophil Pro‐Inflammatory Responses

Wiley - Tập 11 Số 5 - Trang 819-824 - 2014
Chia‐Wei Ting1, Tsong‐Long Hwang2, Yu‐Chang Chen1, Ming‐Jen Cheng3, Ping‐Jyun Sung4, Ming‐Hong Yen1,5,6,7, Jih‐Jung Chen8,5,6,7,7
1Faculty of Pharmacy, Kaohsiung Medical University, Kaohsiung, 807, Taiwan
2Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Tao-Yuan 333, Taiwan
3Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu, 300, Taiwan
4National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan
5Jih-Jung Chen, Graduate Institute of Pharmaceutical Technology & Department of Pharmacy, Tajen University, Pingtung 907, Taiwan, (phone: +886-8-7624002 ext. 2827
6Ming-Hong Yen, Faculty of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan===
7fax: +886-8-7624002 ext. 5121)===
8Graduate Institute of Pharmaceutical Technology & Department of Pharmacy, Tajen University, Pingtung 907, Taiwan, (phone: +886-8-7624002 ext. 2827

Tóm tắt

AbstractA novel benzoylphloroglucinol derivative, garcimultiflorone G (1), was isolated from the fruits of Garcinia multiflora. The structure of 1 was determined through extensive 1D‐ and 2D‐NMR, and MS analyses. Garcimultiflorone G (1) showed inhibitory effects against superoxide anion (O$\rm{{_{2}^{{^\cdot} -}}}$) generation and elastase release by human neutrophils in response to formyl‐L‐methionyl‐L‐leucyl‐L‐phenylalanine/cytochalasin B (fMLP/CB), with IC50 values of 6.97±1.56 and 11.70±1.58 μM, respectively.

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Wiley

Tập 11 Số 5

819-824

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