Natállia A. Parreira1,2, Lizandra Guidi Magalhães3, Danielle Barcellos Morais1,2, Soraya C. Caixeta1,2, João Paulo Barreto de Sousa4, Jairo Kenupp Bastos4, Wilson Roberto Cunha1,2, Márcio Luís Andrade e Silva1,2, N. P. Dhammika Nanayakkara5, Vanderlei Rodrigues3, Ademar Alves da Silva Filho1,2
1Laboratório de Produtos Naturais, Núcleo de Pesquisa em Ciências Exatas e Tecnológicas, Universidade de Franca, Av. Dr. Armando Salles de Oliveira, 201, 14404-600, Franca, São Paulo, Brazil, (phone: +55-16-3711-8871
2fax: +55-16-3711-8878).
3Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil
4Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil
5National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, Oxford, Mississippi, USA
Tóm tắt
AbstractBaccharis dracunculifolia DC. (Asteraceae), popularly known as ‘alecrim do campo’, is a native plant from Brazil used in folk medicine as febrifuge, anti‐inflammatory, antiseptic, and to treat skin sores. Also, B. dracunculifolia is the most important plant source of the Brazilian green propolis, which is recognized for its antiseptic and antiprotozoal activities. This study aimed at investigating the in vitro antiprotozoal, schistosomicidal, and antimicrobial activities of the essential oil from the leaves of B. dracunculifolia. The essential oil was obtained by hydrodistillation and analyzed by GC and GC/MS, which allowed the identification of 14 compounds, mainly oxygenated sesquiterpenes, such as (E)‐nerolidol (33.51%) and spathulenol (16.24%). The essential oil showed activity against promastigote forms of Leishmania donovani, with IC50 values of 42 μg/ml. The essential oil displayed high activity in the schistosomicidal assay, since all pairs of Schistosoma mansoni adult worms were dead after incubation with the essential oil (10, 50, and 100 μg/ml). B. dracunculifolia essential oil was neither cytotoxic against Vero cells, nor active in the antimicrobial and antiplasmodial assays.
