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Intracellular Membrane Transport Systems in Trypanosoma brucei
Traffic - Tập 5 Số 12 - Trang 905-913 - 2004
Mark C. Field, Mark Carrington
Trypanosomes belong to the order kinetoplastida, an early diverging group of organisms in the eukaryotic lineage. The principal reasons for interest in these organisms are twofold; they provide a superb distant triangulation point from which to assess global features of eukaryotic biology and, more importantly, they are representative of a number of pathogenic parasitic protozoa...... hiện toàn bộ
LDL Receptor‐Related Proteins in Neurodevelopment
Traffic - Tập 4 Số 5 - Trang 291-301 - 2003
Petra May, Joachim Herz
Low‐density lipoprotein receptor‐related proteins (LRPs) are evolutionarily ancient cell‐surface receptors with diverse biological functions. All are expressed in the central nervous system and, for most receptors, animal models have shown that they are indispensable for successful neurodevelopment. The mechanisms by which they regulate the formation of the nervous system are va...... hiện toàn bộ
The Calcium Channel Mucolipin‐3 is a Novel Regulator of Trafficking Along the Endosomal Pathway
Traffic - Tập 10 Số 8 - Trang 1143-1156 - 2009
José A. Martina, Benjamin Lelouvier, Rosa Puertollano
The varitint‐waddler phenotype in mice is caused by gain‐of‐function mutations in mucolipin‐3 (MCOLN3), a member of the mucolipin family of ion channels. These mice are characterized by defects in pigmentation, hearing loss and vestibular defects, suggesting that MCOLN3 might play a role in melanosome trafficking and hair cell maturation. Recent evidence has shown that MCOLN3 i...... hiện toàn bộ
The Ca2+ Channel TRPML3 Regulates Membrane Trafficking and Autophagy
Traffic - Tập 10 Số 8 - Trang 1157-1167 - 2009
Hyun Jin Kim, Abigail A. Soyombo, Sandra Tjon‐Kon‐Sang, Insuk So, Shmuel Muallem
TRPML3 is an inward rectifying Ca2+ channel that is regulated by extracytosolic H+. Although gain‐of‐function mutation in TRPML3 causes the varitint‐waddler phenotype, the role of TRPML3 in cellular physiology is not known. In this study, we report that TRPML3 is a prominent regulator of endocytosis, membrane trafficking and autophagy. ...... hiện toàn bộ
Mucolipin‐2 Localizes to the Arf6‐Associated Pathway and Regulates Recycling of GPI‐APs
Traffic - Tập 8 Số 10 - Trang 1404-1414 - 2007
Claudia Karacsonyi, Anitza San Miguel, Rosa Puertollano
In mammals, the mucolipin family includes three members mucolipin‐1, mucolipin‐2, and mucolipin‐3 (MCOLN1–3). While mutations in MCOLN1 and MCOLN3 have been associated with mucolipidosis type IV and the varitint‐waddlermouse phenotype, respectively, little is known about the function and cellular distribution of MCOLN2. Here we show that MCOLN2 traffic...... hiện toàn bộ
Two Di‐Leucine Motifs Regulate Trafficking of Mucolipin‐1 to Lysosomes
Traffic - Tập 7 Số 3 - Trang 337-353 - 2006
Silvia Vergarajauregui, Rosa Puertollano
Mutations in the mucolipin‐1 gene have been linked to mucolipidosis type IV, a lysosomal storage disorder characterized by severe neurological and ophthalmologic abnormalities. Mucolipin‐1 is a membrane protein containing six putative transmembrane domains with both its N‐ and C‐termini localized facing the cytosol. To gain information on the sorting motifs that mediate the traf...... hiện toàn bộ
An Unconventional NLS is Critical for the Nuclear Import of the Influenza A Virus Nucleoprotein and Ribonucleoprotein
Traffic - Tập 6 Số 3 - Trang 205-213 - 2005
Jérôme Cros, Adolfo Garcı́a-Sastre, Peter Palese
Replication of the RNAs of influenza virus occurs in the nucleus of infected cells. The nucleoprotein (NP) has been shown to be important for the import of the viral RNA into the nucleus and has been proposed to contain at least three different nuclear localization signals (NLSs). Here, an import assay in digitonin‐permeabilized cells was used to further define the contribution ...... hiện toàn bộ
The Role of Galectins in Protein Trafficking
Traffic - Tập 10 Số 10 - Trang 1405-1413 - 2009
Delphine Delacour, Annett Koch, Ralf Jacob
The galectins, a family of lectins, modulate distinct cellular processes, such as cancer progression, immune response and cellular development, through their specific binding to extracellular or intracellular ligands. In the past few years, research has unravelled interactions of different galectins with lipids and glycoproteins in the outer milieu or in the secretory pathway o...... hiện toàn bộ
Fluorescence Correlation Spectroscopy Measures Molecular Transport in Cells
Traffic - Tập 2 Số 11 - Trang 789-796 - 2001
Elliot L. Elson
Fluorescence correlation spectroscopy (FCS) can measure dynamics of fluorescent molecules in cells. FCS measures the fluctuations in the number of fluorescent molecules in a small volume illuminated by a thin beam of excitation light. These fluctuations are processed statistically to yield an autocorrelation function from which rates of diffusion, convection, chemical reaction, and other p...... hiện toàn bộ
A Glut4‐Vesicle Marker Protein, Insulin‐Responsive Aminopeptidase, is Localized in a Novel Vesicular Compartment in PC12 Cells
Traffic - Tập 2 Số 8 - Trang 577-587 - 2001
Galini Thoidis, Konstantin V. Kandror
Glut4‐containing vesicles represent a regulated recycling compartment in insulin‐sensitive fat and skeletal muscle cells, the nature and origin of which are not fully understood. In addition to Glut4 itself, these vesicles compartmentalize a number of proteins, at least one of which, insulin‐responsive aminopeptidase, or IRAP, is completely colocalized with Glut4 in insulin‐sensitive tissu...... hiện toàn bộ
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