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The Calcium Channel Mucolipin‐3 is a Novel Regulator of Trafficking Along the Endosomal Pathway
Traffic - Tập 10 Số 8 - Trang 1143-1156 - 2009
José A. Martina, Benjamin Lelouvier, Rosa Puertollano
The varitint‐waddler phenotype in mice is caused by gain‐of‐function mutations in mucolipin‐3 (MCOLN3), a member of the mucolipin family of ion channels. These mice are characterized by defects in pigmentation, hearing loss and vestibular defects, suggesting that MCOLN3 might play a role in melanosome trafficking and hair cell maturation. Recent evidence has shown that MCOLN3 i...... hiện toàn bộ
Mucolipin‐2 Localizes to the Arf6‐Associated Pathway and Regulates Recycling of GPI‐APs
Traffic - Tập 8 Số 10 - Trang 1404-1414 - 2007
Claudia Karacsonyi, Anitza San Miguel, Rosa Puertollano
In mammals, the mucolipin family includes three members mucolipin‐1, mucolipin‐2, and mucolipin‐3 (MCOLN1–3). While mutations in MCOLN1 and MCOLN3 have been associated with mucolipidosis type IV and the varitint‐waddlermouse phenotype, respectively, little is known about the function and cellular distribution of MCOLN2. Here we show that MCOLN2 traffic...... hiện toàn bộ
The Role of Galectins in Protein Trafficking
Traffic - Tập 10 Số 10 - Trang 1405-1413 - 2009
Delphine Delacour, Annett Koch, Ralf Jacob
The galectins, a family of lectins, modulate distinct cellular processes, such as cancer progression, immune response and cellular development, through their specific binding to extracellular or intracellular ligands. In the past few years, research has unravelled interactions of different galectins with lipids and glycoproteins in the outer milieu or in the secretory pathway o...... hiện toàn bộ
Myosins, Actin and Autophagy
Traffic - Tập 17 Số 8 - Trang 878-890 - 2016
Antonina J. Kruppa, John Kendrick‐Jones, Folma Buß
Myosin motor proteins working together with the actin cytoskeleton drive a wide range of cellular processes. In this review, we focus on their roles in autophagy – the pathway the cell uses to ensure homeostasis by targeting pathogens, misfolded proteins and damaged organelles for degradation. The actin cytoskeleton regulated by a host of nucleating, anchoring and stabilizing proteins prov...... hiện toàn bộ
A Sorting Nexin 17‐Binding Domain Within the LRP1 Cytoplasmic Tail Mediates Receptor Recycling Through the Basolateral Sorting Endosome
Traffic - Tập 14 Số 7 - Trang 823-838 - 2013
Pamela Farfán, Jiyeon Lee, Jorge Larios, Pablo H. Sotelo, Guojun Bu, María‐Paz Marzolo
Sorting nexin 17 (SNX17) is an adaptor protein present in early endosomal antigen 1 (EEA1)‐positive sorting endosomes that promotes the efficient recycling of low‐density lipoprotein receptor‐related protein 1 (LRP1... hiện toàn bộ
Fission of Biological Membranes: Interplay Between Dynamin and Lipids
Traffic - Tập 2 Số 1 - Trang 51-65 - 2001
Michael M. Kozlov
Membrane budding and fission are the key stages of ubiquitous processes of formation of intracellular transport vesicles. We present a theoretical consideration of one of the most important types of fission machinery, which is mediated by GTPase dynamin and controlled by lipid composition of the membrane. We suggest a mechanism for collapse of a membrane neck driven by interplay between th...... hiện toàn bộ
RhoGDIs Revisited: Novel Roles in Rho Regulation
Traffic - Tập 6 Số 11 - Trang 957-966 - 2005
Estelle Dransart, Birgitta Olofsson, Jacqueline Cherfils
Small GTP‐binding proteins of the Rho/Rac/Cdc42 family combine their GDP/GTP cycle, regulated by guanine nucleotide‐exchange factors and GTPase‐activating proteins, to a cytosol/membrane cycle, regulated by guanine nucleotide dissociation inhibitors (rhoGDIs). RhoGDIs are endowed with dual functions in the cytosol where they form soluble complexes with geranylgeranylated GDP‐bou...... hiện toàn bộ
The Polymerization Motor
Traffic - Tập 1 Số 1 - Trang 19-28 - 2000
Julie A. Theriot
Polymerization and depolymerization of actin filaments and microtubules are thought to generate force for movement in various kinds of cell motility, ranging from lamellipodial protrusion to chromosome segregation. This article reviews the thermodynamic and physical theories of how a nonequilibrium polymerization reaction can be used to transduce chemical energy into mechanical energy, and...... hiện toàn bộ
Touch, Grasp, Deliver and Control: Functional Cross‐Talk Between Microtubules and Cell Adhesions
Traffic - Tập 10 Số 3 - Trang 268-274 - 2009
Anna Akhmanova, Samantha J. Stehbens, Alpha S. Yap
Cross‐talk between microtubule networks and sites of cell–matrix and cell–cell adhesion has profound impact on these structures and is essential for proper cell organization, polarization and motility. Components of adhesion sites can interact directly with microtubules or with proteins that specifically associate with microtubule plus ends and minus ends and in this way captur...... hiện toàn bộ
On the Trail of the Glucocorticoid Receptor: Into the Nucleus and Back
Traffic - Tập 13 Số 3 - Trang 364-374 - 2012
Sofie Vandevyver, Lien Dejager, Claude Libert
The glucocorticoid receptor (GR) belongs to the superfamily of steroid receptors and is an important regulator of physiological and metabolic processes. In its inactive state, GR is unbound by ligand and resides in the cytoplasm in a chaperone complex. When...... hiện toàn bộ
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