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Intracellular Membrane Transport Systems in Trypanosoma brucei
Traffic - Tập 5 Số 12 - Trang 905-913 - 2004
Trypanosomes belong to the order kinetoplastida, an early diverging group of
organisms in the eukaryotic lineage. The principal reasons for interest in these
organisms are twofold; they provide a superb distant triangulation point from
which to assess global features of eukaryotic biology and, more importantly,
they are representative of a number of pathogenic parasitic protozoa with a huge
public...
LDL Receptor‐Related Proteins in Neurodevelopment
Traffic - Tập 4 Số 5 - Trang 291-301 - 2003
Low‐density lipoprotein receptor‐related proteins (LRPs) are evolutionarily
ancient cell‐surface receptors with diverse biological functions. All are
expressed in the central nervous system and, for most receptors, animal models
have shown that they are indispensable for successful neurodevelopment. The
mechanisms by which they regulate the formation of the nervous system are varied
and include th...
The Calcium Channel Mucolipin‐3 is a Novel Regulator of Trafficking Along the Endosomal Pathway
Traffic - Tập 10 Số 8 - Trang 1143-1156 - 2009
The varitint‐waddler phenotype in mice is caused by gain‐of‐function mutations
in mucolipin‐3 (MCOLN3), a member of the mucolipin family of ion channels. These
mice are characterized by defects in pigmentation, hearing loss and vestibular
defects, suggesting that MCOLN3 might play a role in melanosome trafficking and
hair cell maturation. Recent evidence has shown that MCOLN3 is a Ca2+–permeable
c...
The Ca2+ Channel TRPML3 Regulates Membrane Trafficking and Autophagy
Traffic - Tập 10 Số 8 - Trang 1157-1167 - 2009
TRPML3 is an inward rectifying Ca2+ channel that is regulated by extracytosolic
H+. Although gain‐of‐function mutation in TRPML3 causes the varitint‐waddler
phenotype, the role of TRPML3 in cellular physiology is not known. In this
study, we report that TRPML3 is a prominent regulator of endocytosis, membrane
trafficking and autophagy. Gradient fractionation and confocal localization
reveal that T...
Mucolipin‐2 Localizes to the Arf6‐Associated Pathway and Regulates Recycling of GPI‐APs
Traffic - Tập 8 Số 10 - Trang 1404-1414 - 2007
In mammals, the mucolipin family includes three members mucolipin‐1,
mucolipin‐2, and mucolipin‐3 (MCOLN1–3). While mutations in MCOLN1 and MCOLN3
have been associated with mucolipidosis type IV and the varitint‐waddlermouse
phenotype, respectively, little is known about the function and cellular
distribution of MCOLN2. Here we show that MCOLN2 traffics via the
Arf6‐associated pathway and colocali...
Two Di‐Leucine Motifs Regulate Trafficking of Mucolipin‐1 to Lysosomes
Traffic - Tập 7 Số 3 - Trang 337-353 - 2006
Mutations in the mucolipin‐1 gene have been linked to mucolipidosis type IV, a
lysosomal storage disorder characterized by severe neurological and
ophthalmologic abnormalities. Mucolipin‐1 is a membrane protein containing six
putative transmembrane domains with both its N‐ and C‐termini localized facing
the cytosol. To gain information on the sorting motifs that mediate the
trafficking of this pro...
An Unconventional NLS is Critical for the Nuclear Import of the Influenza A Virus Nucleoprotein and Ribonucleoprotein
Traffic - Tập 6 Số 3 - Trang 205-213 - 2005
Replication of the RNAs of influenza virus occurs in the nucleus of infected
cells. The nucleoprotein (NP) has been shown to be important for the import of
the viral RNA into the nucleus and has been proposed to contain at least three
different nuclear localization signals (NLSs). Here, an import assay in
digitonin‐permeabilized cells was used to further define the contribution of
these NLSs. Muta...
The Role of Galectins in Protein Trafficking
Traffic - Tập 10 Số 10 - Trang 1405-1413 - 2009
The galectins, a family of lectins, modulate distinct cellular processes, such
as cancer progression, immune response and cellular development, through their
specific binding to extracellular or intracellular ligands. In the past few
years, research has unravelled interactions of different galectins with lipids
and glycoproteins in the outer milieu or in the secretory pathway of cells.
Interesting...
Fluorescence Correlation Spectroscopy Measures Molecular Transport in Cells
Traffic - Tập 2 Số 11 - Trang 789-796 - 2001
Fluorescence correlation spectroscopy (FCS) can measure dynamics of fluorescent
molecules in cells. FCS measures the fluctuations in the number of fluorescent
molecules in a small volume illuminated by a thin beam of excitation light.
These fluctuations are processed statistically to yield an autocorrelation
function from which rates of diffusion, convection, chemical reaction, and other
processes...
A Glut4‐Vesicle Marker Protein, Insulin‐Responsive Aminopeptidase, is Localized in a Novel Vesicular Compartment in PC12 Cells
Traffic - Tập 2 Số 8 - Trang 577-587 - 2001
Glut4‐containing vesicles represent a regulated recycling compartment in
insulin‐sensitive fat and skeletal muscle cells, the nature and origin of which
are not fully understood. In addition to Glut4 itself, these vesicles
compartmentalize a number of proteins, at least one of which, insulin‐responsive
aminopeptidase, or IRAP, is completely colocalized with Glut4 in
insulin‐sensitive tissues. Howe...
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