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The Calcium Channel Mucolipin‐3 is a Novel Regulator of Trafficking Along the Endosomal Pathway The varitint‐waddler phenotype in mice is caused by gain‐of‐function mutations in mucolipin‐3 (MCOLN3), a member of the mucolipin family of ion channels. These mice are characterized by defects in pigmentation, hearing loss and vestibular defects, suggesting that MCOLN3 might play a role in melanosome trafficking and hair cell maturation. Recent evidence has shown that MCOLN3 i... ...
Traffic - Tập 10 Số 8 - Trang 1143-1156 - 2009
Mucolipin‐2 Localizes to the Arf6‐Associated Pathway and Regulates Recycling of GPI‐APsIn mammals, the mucolipin family includes three members mucolipin‐1, mucolipin‐2, and mucolipin‐3 (MCOLN1–3). While mutations in MCOLN1 and MCOLN3 have been associated with mucolipidosis type IV and the varitint‐waddler mouse phenotype, respectively, little is known about the function and cellular distribution of MCOLN2. Here we show that MCOLN2 traffic...
Traffic - Tập 8 Số 10 - Trang 1404-1414 - 2007
The Role of Galectins in Protein Trafficking The galectins, a family of lectins, modulate distinct cellular processes, such as cancer progression, immune response and cellular development, through their specific binding to extracellular or intracellular ligands. In the past few years, research has unravelled interactions of different galectins with lipids and glycoproteins in the outer milieu or in the secretory pathway o... ...
Traffic - Tập 10 Số 10 - Trang 1405-1413 - 2009
Myosins, Actin and AutophagyMyosin motor proteins working together with the actin cytoskeleton drive a wide range of cellular processes. In this review, we focus on their roles in autophagy – the pathway the cell uses to ensure homeostasis by targeting pathogens, misfolded proteins and damaged organelles for degradation. The actin cytoskeleton regulated by a host of nucleating, anchoring and stabilizing proteins prov... ...
Traffic - Tập 17 Số 8 - Trang 878-890 - 2016
Fission of Biological Membranes: Interplay Between Dynamin and LipidsMembrane budding and fission are the key stages of ubiquitous processes of formation of intracellular transport vesicles. We present a theoretical consideration of one of the most important types of fission machinery, which is mediated by GTPase dynamin and controlled by lipid composition of the membrane. We suggest a mechanism for collapse of a membrane neck driven by interplay between th... ...
Traffic - Tập 2 Số 1 - Trang 51-65 - 2001
RhoGDIs Revisited: Novel Roles in Rho RegulationSmall GTP‐binding proteins of the Rho/Rac/Cdc42 family combine their GDP/GTP cycle, regulated by guanine nucleotide‐exchange factors and GTPase‐activating proteins, to a cytosol/membrane cycle, regulated by guanine nucleotide dissociation inhibitors (rhoGDIs). RhoGDIs are endowed with dual functions in the cytosol where they form soluble complexes with geranylgeranylated GDP‐bou...
Traffic - Tập 6 Số 11 - Trang 957-966 - 2005
On the Trail of the Glucocorticoid Receptor: Into the Nucleus and BackThe glucocorticoid receptor (GR ) belongs to the superfamily of steroid receptors and is an important regulator of physiological and metabolic processes. In its inactive state, GR is unbound by ligand and resides in the cytoplasm in a chaperone complex. When...
Traffic - Tập 13 Số 3 - Trang 364-374 - 2012
Spastin Couples Microtubule Severing to Membrane Traffic in Completion of Cytokinesis and Secretion Mutations in the gene encoding the microtubule (MT)‐severing protein spastin are the most common cause of hereditary spastic paraplegia, a genetic condition in which axons of the corticospinal tracts degenerate. We show that not only does endogenous spastin colocalize with MTs, but that it is also located on the early secretory pathway, can be recruited to endosomes and is pres... ...
Traffic - Tập 10 Số 1 - Trang 42-56 - 2009
Infectious Adenovirus Type 2 Transport Through Early but not Late Endosomes Receptor‐mediated endocytosis is a major gate for pathogens into cells. In this study, we analyzed the trafficking of human adenovirus type 2 and 5 (Ad2/5) and the escape‐defective temperature‐sensitive Ad2‐ts1 mutant in epithelial cancer cells. Ad2/5 and Ad2‐ts1 uptake into endosomes containing transferrin, major histocompatibility antigen 1 and the Rab5 effector early endosom... ...
Traffic - Tập 9 Số 12 - Trang 2265-2278 - 2008
Dissection of Membrane Dynamics of the ARF‐Guanine Nucleotide Exchange Factor GBF1ADP‐ribosylation factor (ARF)‐facilitated recruitment of COP I to membranes is required for secretory traffic. The guanine nucleotide exchange factor GBF1 activates ARF and regulates ARF/COP I dynamics at the endoplasmic reticulum (ER)–Golgi interface. Like ARF and coatomer, GBF1 peripherally associates with membranes. ADP‐ribosylation factor and coatomer have been shown to rapi...
Traffic - Tập 6 Số 5 - Trang 374-385 - 2005
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