Synapse
SCIE-ISI SCOPUS (1987-2025)
0887-4476
1098-2396
Mỹ
Cơ quản chủ quản: WILEY , Wiley-Liss Inc.
Lĩnh vực:
Cellular and Molecular Neuroscience
Các bài báo tiêu biểu
Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers
Tập 14 Số 2 - Trang 169-177 - 1993
AbstractDecreased dopaminergic function has been postulated to underlie cocaine
addiction. To examine the possibility that dysfunction of brain regions
subserved by the dopamine system could promote cocaine self‐administration,
positron emission tomography and a dual‐tracer approach was used to examine
dopamine D2 receptor availability and regional brain glucose metabolism in
cocaine abusers. When...
Systemic nicotine‐induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental area
Tập 16 Số 1 - Trang 36-44 - 1994
AbstractStimulation of the mesolimbic dopamine (DA) system is considered of
major importance for the rewarding and dependence producing properties of
nicotine (NIC). To identify the site of this stimulatory action, simultaneous
microdialysis was performed in the ventral tegmental area (VTA) and the
ipsilateral nucleus accumbens (NAC) of awake rats. Extracellular concentrations
of DA and its metabo...
Intracellular studies in the facial nucleus illustrating a simple new method for obtaining viable motoneurons in adult rat brain slices
Tập 3 Số 4 - Trang 331-338 - 1989
AbstractIn general, it has been difficult to preserve electrophysiologically
viable motoneurons in brain slices from adult mammals. The present study
describes a new method for obtaining viable motoneurons in the facial nucleus of
adult rat brain slices. The essence of the method was to use a modified
artificial cerebrospinal fluid (ACSF) in which NaCl was replaced initially by
sucrose; the modifi...
“Nonhedonic” food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect
Tập 44 Số 3 - Trang 175-180 - 2002
AbstractThe drive for food is one of the most powerful of human and animal
behaviors. Dopamine, a neurotransmitter involved with motivation and reward, its
believed to regulate food intake in laboratory animals by modulating its
rewarding effects through the nucleus accumbens (NA). Here we assess the
involvement of dopamine in “nonhedonic” food motivation in humans. Changes in
extracellular dopami...
The serotoninergic innervation of cerebral cortex: Different classes of axon terminals arise from dorsal and median raphe nuclei
Tập 1 Số 2 - Trang 153-168 - 1987
AbstractThe objective of the present study was to characterize the morphology of
serotoninergic axons in cerebral cortex of the rat and to determine whether
dissimilar axon terminals arise from the dorsal vs. the median raphe nuclei. The
anterograde tracer PHA‐L was administered by iontophoresis into the dorsal (DR)
and median (MR) raphe nuclei, and the morphologic features of the respective
axona...
Molecular alterations in the neostriatum of human cocaine addicts
Tập 13 Số 4 - Trang 357-369 - 1993
AbstractMolecular changes in the neostriatum of human subjects who died with a
history of cocaine abuse were revealed in discrete cell populations by means of
the techniques of in situ hybridization histochemistry and in vitro receptor
binding and autoradiography. Cocaine subjects had a history of repeated cocaine
use and had cocaine and/or cocaine metabolites on board at the time of death.
These ...
Relationship between blockade of dopamine transporters by oral methylphenidate and the increases in extracellular dopamine: Therapeutic implications
Tập 43 Số 3 - Trang 181-187 - 2002
AbstractMethylphenidate (Ritalin) is an effective drug in the treatment of
attention deficit hyperactivity disorder. However, the doses required
therapeutically vary significantly between subjects and it is not understood
what determines these differences. Since methylphenidate's therapeutic effects
are in part due to increases in extracellular DA secondary to blockade of
dopamine transporters (DA...
Brain imaging of 18F‐fallypride in normal volunteers: Blood analysis, distribution, test‐retest studies, and preliminary assessment of sensitivity to aging effects on dopamine D‐2/D‐3 receptors
Tập 46 Số 3 - Trang 170-188 - 2002
AbstractHuman studies of dopamine D2/D3 receptors using 18F‐fallypride‐PET in
normal volunteers were performed to evaluate brain distribution in striatal and
extrastriatal regions, evaluate metabolites in blood plasma, establish PET
imaging protocol for this new radiotracer, evaluate graphical methods of
analysis to quantitate D2/D3 receptors, and assess the ability of 18F‐fallypride
to measure ch...
Cocaine: An in vivo microdialysis evaluation of its acute action on dopamine transmission in rat striatum
Tập 3 Số 1 - Trang 48-54 - 1989
AbstractThe effects of cocaine on dopamine (DA) neurotransmission were evaluated
by in vivo microdialysis in the striatum of halothane‐anesthetized rats.
Intravenous cocaine produced a dose‐dependent, transient increase of the
extracellular concentration of DA, with a peak response within 10 min and a
return to control level by 30 min. The sharp DA response pattern was abolished
in a calcium‐free ...