Synapse
SCIE-ISI SCOPUS (1987-2023)
0887-4476
1098-2396
Mỹ
Cơ quản chủ quản: WILEY , Wiley-Liss Inc.
Lĩnh vực:
Cellular and Molecular Neuroscience
Các bài báo tiêu biểu
Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusersAbstract Decreased dopaminergic function has been postulated to underlie cocaine addiction. To examine the possibility that dysfunction of brain regions subserved by the dopamine system could promote cocaine self‐administration, positron emission tomography and a dual‐tracer approach was used to examine dopamine D2 receptor availability and regi... ... hiện toàn bộ
Tập 14 Số 2 - Trang 169-177 - 1993
Systemic nicotine‐induced dopamine release in the rat nucleus accumbens is regulated by nicotinic receptors in the ventral tegmental areaAbstract Stimulation of the mesolimbic dopamine (DA) system is considered of major importance for the rewarding and dependence producing properties of nicotine (NIC). To identify the site of this stimulatory action, simultaneous microdialysis was performed in the ventral tegmental area (VTA) and the ipsilateral nucleus accumbens (NAC) of awake rats. Extracellular co... ... hiện toàn bộ
Tập 16 Số 1 - Trang 36-44 - 1994
Intracellular studies in the facial nucleus illustrating a simple new method for obtaining viable motoneurons in adult rat brain slicesAbstract In general, it has been difficult to preserve electrophysiologically viable motoneurons in brain slices from adult mammals. The present study describes a new method for obtaining viable motoneurons in the facial nucleus of adult rat brain slices. The essence of the method was to use a modified artificial cerebrospinal fluid (ACSF) in which NaCl was replaced... ... hiện toàn bộ
Tập 3 Số 4 - Trang 331-338 - 1989
“Nonhedonic” food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effectAbstract The drive for food is one of the most powerful of human and animal behaviors. Dopamine, a neurotransmitter involved with motivation and reward, its believed to regulate food intake in laboratory animals by modulating its rewarding effects through the nucleus accumbens (NA). Here we assess the involvement of dopamine in “nonhedonic” food motivation in humans... ... hiện toàn bộ
Tập 44 Số 3 - Trang 175-180 - 2002
The serotoninergic innervation of cerebral cortex: Different classes of axon terminals arise from dorsal and median raphe nucleiAbstract The objective of the present study was to characterize the morphology of serotoninergic axons in cerebral cortex of the rat and to determine whether dissimilar axon terminals arise from the dorsal vs. the median raphe nuclei. The anterograde tracer PHA‐L was administered by iontophoresis into the dorsal (DR) and median (MR) raphe nuclei, and the morphologic... ... hiện toàn bộ
Tập 1 Số 2 - Trang 153-168 - 1987
Molecular alterations in the neostriatum of human cocaine addictsAbstract Molecular changes in the neostriatum of human subjects who died with a history of cocaine abuse were revealed in discrete cell populations by means of the techniques of in situ hybridization histochemistry and in vitro receptor binding and autoradiography. Cocaine subjects had a history of repeated cocaine use and had cocaine and/or cocaine metabolites on b... ... hiện toàn bộ
Tập 13 Số 4 - Trang 357-369 - 1993
Relationship between blockade of dopamine transporters by oral methylphenidate and the increases in extracellular dopamine: Therapeutic implicationsAbstract Methylphenidate (Ritalin) is an effective drug in the treatment of attention deficit hyperactivity disorder. However, the doses required therapeutically vary significantly between subjects and it is not understood what determines these differences. Since methylphenidate's therapeutic effects are in part due to increases in extracellular DA secondary to bloc... ... hiện toàn bộ
Tập 43 Số 3 - Trang 181-187 - 2002
Brain imaging of 18F‐fallypride in normal volunteers: Blood analysis, distribution, test‐retest studies, and preliminary assessment of sensitivity to aging effects on dopamine D‐2/D‐3 receptorsAbstract Human studies of dopamine D2/D3 receptors using 18 F‐fallypride‐PET in normal volunteers were performed to evaluate brain distribution in striatal and extrastriatal regions, evaluate metabolites in blood plasma, establish PET imaging protocol for this new radiotracer, evaluate graphical methods of analysis to quantitate D2/D3 receptors, ... ... hiện toàn bộ
Tập 46 Số 3 - Trang 170-188 - 2002
Cocaine: An in vivo microdialysis evaluation of its acute action on dopamine transmission in rat striatumAbstract The effects of cocaine on dopamine (DA) neurotransmission were evaluated by in vivo microdialysis in the striatum of halothane‐anesthetized rats. Intravenous cocaine produced a dose‐dependent, transient increase of the extracellular concentration of DA, with a peak response within 10 min and a return to control level by 30 min. The sharp DA response pattern... ... hiện toàn bộ
Tập 3 Số 1 - Trang 48-54 - 1989