Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers Tập 14 Số 2 - Trang 169-177 - 1993
N D Volkow, Joanna S. Fowler, G. J. Wang, Robert Hitzemann, Jean Logan, David Schlyer, S L Dewey, Alfred P. Wolf
AbstractDecreased dopaminergic function has been postulated to underlie cocaine addiction. To examine the possibility that dysfunction of brain regions subserved by the dopamine system could promote cocaine self‐administration, positron emission tomography and a dual‐tracer approach was used to examine dopamine D2 receptor availability and regi...... hiện toàn bộ “Nonhedonic” food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect Tập 44 Số 3 - Trang 175-180 - 2002
Nora D. Volkow, G. J. Wang, Joanna S. Fowler, Jean Logan, Millard Jayne, Dinko Franceschi, Cristopher Wong, S. John Gatley, Andrew N. Gifford, Yu‐Shin Ding, Naomi Pappas
AbstractThe drive for food is one of the most powerful of human and animal behaviors. Dopamine, a neurotransmitter involved with motivation and reward, its believed to regulate food intake in laboratory animals by modulating its rewarding effects through the nucleus accumbens (NA). Here we assess the involvement of dopamine in “nonhedonic” food motivation in humans...... hiện toàn bộ Psychosis pathways converge via D2High dopamine receptors Tập 60 Số 4 - Trang 319-346 - 2006
Philip Seeman, Johannes Schwarz, Jiang‐Fan Chen, Henry Szechtman, Melissa L. Perreault, G. Stanley McKnight, John Roder, Rémi Quirion, Patricia Boksa, Lalit K. Srivastava, Kazuhiko Yanai, David Weinshenker, Tomiki Sumiyoshi
Molecular alterations in the neostriatum of human cocaine addicts Tập 13 Số 4 - Trang 357-369 - 1993
Yasmin L. Hurd, Miles Herkenham
AbstractMolecular changes in the neostriatum of human subjects who died with a history of cocaine abuse were revealed in discrete cell populations by means of the techniques of in situ hybridization histochemistry and in vitro receptor binding and autoradiography. Cocaine subjects had a history of repeated cocaine use and had cocaine and/or cocaine metabolites on b...... hiện toàn bộ Relationship between blockade of dopamine transporters by oral methylphenidate and the increases in extracellular dopamine: Therapeutic implications Tập 43 Số 3 - Trang 181-187 - 2002
Nora D. Volkow, Gene‐Jack Wang, Joanna S. Fowler, Jean Logan, Dinko Franceschi, Laurence Maynard, Yu‐Shin Ding, S. John Gatley, Andrew J. Gifford, Wei Zhu, James M. Swanson
AbstractMethylphenidate (Ritalin) is an effective drug in the treatment of attention deficit hyperactivity disorder. However, the doses required therapeutically vary significantly between subjects and it is not understood what determines these differences. Since methylphenidate's therapeutic effects are in part due to increases in extracellular DA secondary to bloc...... hiện toàn bộ Brain imaging of 18F‐fallypride in normal volunteers: Blood analysis, distribution, test‐retest studies, and preliminary assessment of sensitivity to aging effects on dopamine D‐2/D‐3 receptors Tập 46 Số 3 - Trang 170-188 - 2002
Jogeshwar Mukherjee, Bradley T. Christian, Kelly Dunigan, Bingzhi Shi, Tanjore K. Narayanan, Martin Satter, Joseph Mantil
AbstractHuman studies of dopamine D2/D3 receptors using 18F‐fallypride‐PET in normal volunteers were performed to evaluate brain distribution in striatal and extrastriatal regions, evaluate metabolites in blood plasma, establish PET imaging protocol for this new radiotracer, evaluate graphical methods of analysis to quantitate D2/D3 receptors, ...... hiện toàn bộ