Psychosis pathways converge via D2High dopamine receptors

Synapse - Tập 60 Số 4 - Trang 319-346 - 2006
Philip Seeman1,2, Johannes Schwarz3, Jiang‐Fan Chen4, Henry Szechtman5, Melissa L. Perreault5, G. Stanley McKnight6, John Roder7, Rémi Quirion8, Patricia Boksa8, Lalit K. Srivastava8, Kazuhiko Yanai9, David Weinshenker10, Tomiki Sumiyoshi11
1Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada, M5S 1A8
2Department of Psychiatry, University of Toronto, Toronto, Ontario Canada M5S 1A8
3Department of Neurology, University of Leipzig, Leipzig 04103, Germany
4Molecular Neuropharmacology Laboratory, Department of Neurology, Boston University School of Medicine, Boston, Massachusetts 02118
5Department of Psychiatry and Behavioural Neuroscience, McMaster University, Hamilton, Ontario, Canada L8N 3Z5
6Department of Pharmacology, University of Washington, Seattle, Washington 98195
7Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5
8Douglas Hospital Research Center, Verdun, Quebec, Canada H4H 1R3
9Department of Pharmacology, Tohoku University School of Medicine, Sendai 980-8575, Japan
10Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322
11Department of Neuropsychiatry, Toyama University School of Medicine, Toyama 930-0194, Japan

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Abi-Dargham, 2004, Int J Neuropsychopharmacol, 7, s1, 10.1017/S1461145704004110

Abi-Dargham, 2000, Proc Natl Acad Sci USA, 97, 8104, 10.1073/pnas.97.14.8104

Accili, 1996, Proc Natl Acad Sci USA, 93, 1945, 10.1073/pnas.93.5.1945

Aiba, 1999, Nihon Shinkei Seishin Yakurigaku Zasshi, 19, 251

Akiyama, 1994, Schizophr Res, 12, 251, 10.1016/0920-9964(94)90035-3

Alburges, 1993, Synapse, 14, 314, 10.1002/syn.890140409

Allen, 1978, Am J Psychiatry, 135, 1081, 10.1176/ajp.135.9.1081

Andersen, 2001, Psychopharmacology (Berl), 156, 291, 10.1007/s002130100818

Arnold, 1991, Arch Gen Psychiatry, 48, 625, 10.1001/archpsyc.1991.01810310043008

Arnold, 1995, Am J Psychiatry, 152, 738, 10.1176/ajp.152.5.738

Atkinson, 2001, Mol Pharmacol, 60, 1414, 10.1124/mol.60.6.1414

Badner, 2002, Mol Psychiatry, 7, 405, 10.1038/sj.mp.4001012

Bai, 2004, Biol Psychiatry, 56, 427, 10.1016/j.biopsych.2004.06.022

Bast, 2000, Pharmacol Biochem Behav, 67, 647, 10.1016/S0091-3057(00)00409-3

Bast, 2001, Neuroscience, 103, 325, 10.1016/S0306-4522(00)00589-3

Bastia, 2005, Neuropsychopharmacology, 30, 891, 10.1038/sj.npp.1300630

Beaulieu, 2004, Proc Natl Acad Sci USA, 101, 5099, 10.1073/pnas.0307921101

Beaulieu, 2005, Cell, 122, 261, 10.1016/j.cell.2005.05.012

Benson, 2004, Trends Neurosci, 27, 516, 10.1016/j.tins.2004.06.004

Beraki, 2005, Mol Psychiatry, 10, 299, 10.1038/sj.mp.4001545

Bergson, 2003, Trends Pharmacol Sci, 24, 486, 10.1016/S0165-6147(03)00232-3

Bhardwaj, 2003, Neuroscience, 122, 669, 10.1016/j.neuroscience.2003.08.016

Birdsall, 1977, Adv Behav Biol, 24, 25, 10.1007/978-1-4684-3096-7_2

Blackwood, 2001, Am J Hum Genet, 69, 428, 10.1086/321969

Blumer, 2004, Nature, 427, 20, 10.1038/427020a

Boksa, 2003, Neurosci Biobehav Rev, 27, 91, 10.1016/S0149-7634(03)00012-5

Boksa, 2002, Exp Neurol, 175, 388, 10.1006/exnr.2002.7896

Bondy, 1987, J Psychiatr Res, 21, 521, 10.1016/0022-3956(87)90101-4

Brady, 1991, J Clin Psychiatry, 52, 509

Braff, 2005, Biol Psychiatry, 57, 817, 10.1016/j.biopsych.2004.12.030

Brandon, 1998, J Neurosci, 18, 3639, 10.1523/JNEUROSCI.18-10-03639.1998

Brody, 2004a, Psychopharmacology (Berl), 172, 187, 10.1007/s00213-003-1635-3

Brody, 2004b, Mol Psychiatry, 9, 35, 10.1038/sj.mp.4001404

Bronsert, 2001, Behav Pharmacol, 12, 549, 10.1097/00008877-200111000-00017

Brown, 2004, Arch Gen Psychiatry, 61, 774, 10.1001/archpsyc.61.8.774

Brzustowicz, 2000, Science, 288, 678, 10.1126/science.288.5466.678

Burchett, 1998, J Neurochem, 70, 2216, 10.1046/j.1471-4159.1998.70052216.x

Burchett, 1999, J Neurochem, 72, 1529, 10.1046/j.1471-4159.1999.721529.x

Butkerait, 1994, J Pharmacol Exp Ther, 271, 422

Cabrera-Vera, 2004, Proc Natl Acad Sci USA, 101, 16339, 10.1073/pnas.0407416101

Cadenhead, 2000, Am J Psychiatry, 157, 1660, 10.1176/appi.ajp.157.10.1660

Cardno, 2001, Am J Med Genet, 105, 439, 10.1002/ajmg.1404

Carey, 1999, Am J Med Genet, 89, 7, 10.1002/(SICI)1096-8628(19990326)89:1<7::AID-AJMG4>3.0.CO;2-#

Carrasco, 2004, J Pharmacol Exp Ther, 311, 349, 10.1124/jpet.104.069807

Carta, 2000, Neuroreport, 11, 2395, 10.1097/00001756-200008030-00012

Chartoff, 2005, Neuropsychopharmacology, 30, 1324, 10.1038/sj.npp.1300678

, , , , , et al. 2004. Behavioral deficits of ERK1 knockout mice in mood disorder-related animal tests [Abstracts]. In: The 43rd Annual Meeting of American College of Neuropsychopharmacology, San Juan, Puerto Rico, December 12–16, 2004.

, . 2005. New genetic mouse models of schizophrenia: Mimicking cognitive dysfunction by altering susceptibility gene expression (Program No. TUAM65). Abstract viewer. Waikoloa, HI: American College of Neuropsychopharmacology.

Chen, 2000, Neuroscience, 97, 195, 10.1016/S0306-4522(99)00604-1

Chen, 2003, Neuropsychopharmacology, 28, 1086, 10.1038/sj.npp.1300152

Chiamulera, 2001, Nat Neurosci, 4, 873, 10.1038/nn0901-873

Chidiac, 1997, Biochemistry, 36, 7361, 10.1021/bi961939t

Chouinard, 1991, Schizophr Res, 5, 21, 10.1016/0920-9964(91)90050-2

Chouinard, 1978, Am J Psychiatry, 135, 1409, 10.1176/ajp.135.11.1409

Chowdari, 2002, Hum Mol Genet, 11, 1373, 10.1093/hmg/11.12.1373

Chumakov, 2002, Proc Natl Acad Sci USA, 99, 13675, 10.1073/pnas.182412499

Coccini, 1991, Immunopharmacology, 22, 93, 10.1016/0162-3109(91)90034-V

Collier, 2003, Eur J Pharmacol, 480, 177, 10.1016/j.ejphar.2003.08.105

Colussi-Mas, 2005, Int J Neuropsychopharmacol, 8, 569, 10.1017/S1461145705005298

Corripio, 2006, Neuroimage, 29, 662, 10.1016/j.neuroimage.2005.07.038

Craddock, 2005, J Med Genet, 42, 193, 10.1136/jmg.2005.030718

Crawford, 1997, Neuroreport, 8, 2523, 10.1097/00001756-199707280-00021

Curran, 2004, Br J Psychiatry, 185, 196, 10.1192/bjp.185.3.196

De Lean, 1980, J Biol Chem, 255, 7108, 10.1016/S0021-9258(20)79672-9

DeLisi, 1997, Psychiatry Res, 74, 129, 10.1016/S0925-4927(97)00012-7

Depoortère, 2005, Neuropsychopharmacology, 30, 1963, 10.1038/sj.npp.1300772

Deroche, 1995, J Neurosci, 15, 7181, 10.1523/JNEUROSCI.15-11-07181.1995

Dewey, 1983, Naunyn-Schmiedebergs Arch Pharmacol, 322, 261, 10.1007/BF00508341

Doudet, 2000, Synapse, 38, 105, 10.1002/1098-2396(200011)38:2<105::AID-SYN1>3.0.CO;2-S

Dubertret, 2004, Schizophr Res, 67, 75, 10.1016/S0920-9964(03)00220-2

Dulawa, 2000, Neuropsychopharmacology, 22, 650, 10.1016/S0893-133X(99)00164-5

Duncan, 2003a, Psychopharmacology (Berl), 167, 63, 10.1007/s00213-002-1372-z

Duncan, 2003b, Psychiatry Res, 120, 1, 10.1016/S0165-1781(03)00161-6

Egan, 1997, Curr Opin Neurobiol, 7, 701, 10.1016/S0959-4388(97)80092-X

Egan, 2004, Proc Natl Acad Sci USA, 101, 12604, 10.1073/pnas.0405077101

Ekelund, 2001, Hum Mol Genet, 10, 1611, 10.1093/hmg/10.15.1611

El-Ghundi, 2001, Brain Res, 892, 86, 10.1016/S0006-8993(00)03234-0

El-Khodor, 1998, Neuroscience, 87, 893, 10.1016/S0306-4522(98)00194-8

Emamian, 2004, Nat Genet, 36, 131, 10.1038/ng1296

Feifel, 1999, Psychopharmacology (Berl), 146, 175, 10.1007/s002130051103

Feifel, 2004, Neuropsychopharmacology, 29, 731, 10.1038/sj.npp.1300378

Ferguson, 2001, Pharmacol Rev, 53, 1

Flores, 1996a, J Neurosci, 16, 2020, 10.1523/JNEUROSCI.16-06-02020.1996

Flores, 1996b, J Neurosci, 16, 7366, 10.1523/JNEUROSCI.16-22-07366.1996

Friberg, 1998, Brain Res Mol Brain Res, 54, 298, 10.1016/S0169-328X(97)00346-X

Fritts, 1997, Pharmacol Biochem Behav, 58, 1015, 10.1016/S0091-3057(97)00308-0

Gabriel, 2002, Nat Genet, 31, 89, 10.1038/ng868

Gainetdinov, 2003, Neuron, 38, 291, 10.1016/S0896-6273(03)00192-2

Gainetdinov, 2004, Annu Rev Neurosci, 27, 107, 10.1146/annurev.neuro.27.070203.144206

George, 1985, Endocrinology, 117, 690, 10.1210/endo-117-2-690

Geuze, 2005, Mol Psychiatry, 10, 160, 10.1038/sj.mp.4001579

Giannini, 1984, J Clin Pharmacol, 24, 202, 10.1002/j.1552-4604.1984.tb01831.x

Giannini, 1984–85, J Toxicol Clin Toxicol, 22, 573, 10.3109/15563658408992586

Glatt, 2006, Am J Med Genet B Neuropsychiatr Genet, 141, 149, 10.1002/ajmg.b.30273

Glatt, 2003, Mol Psychiatry, 8, 911, 10.1038/sj.mp.4001321

, , , , , , , . 2005. Frontal dopamine D2 receptor binding in neuroleptic-naïve first-episode schizophrenic patients correlates with positive psychotic symptoms and predicts treatment outcome (Program No. 19). Abstract viewer. Waikoloa, HI: American College of Neuropsychopharmacology.

Glickstein, 2001, Pharmacol Ther, 91, 63, 10.1016/S0163-7258(01)00145-0

Goff, 2001, Am J Psychiatry, 158, 1367, 10.1176/appi.ajp.158.9.1367

Gold, 1997, J Neurosci, 17, 8024, 10.1523/JNEUROSCI.17-20-08024.1997

Gourianov, 2005, Biochemistry, 44, 14989, 10.1021/bi0513812

Graham, 2004, J Psychopharmacol, 18, 173, 10.1177/0269881104042615

Green, 1997, Biochemistry, 36, 7380, 10.1021/bi961940s

Greenberg, 1985, Pharmacol Biochem Behav, 23, 99, 10.1016/0091-3057(85)90137-6

Grillet, 2005, Mol Cell Biol, 25, 4221, 10.1128/MCB.25.10.4221-4228.2005

Guillin, 2001, Nature, 411, 86, 10.1038/35075076

Hall, 1987, Pharmacol Toxicol, 60, 359, 10.1111/j.1600-0773.1987.tb01527.x

Harrison, 2003, Lancet, 361, 417, 10.1016/S0140-6736(03)12379-3

Harrison, 2005, Mol Psychiatry, 10, 40, 10.1038/sj.mp.4001558

Hashimoto, 2004, Curr Med Chem Cent Nerv Syst Agents, 4, 147, 10.2174/1568015043357011

, , . 2005. Identification and characterization of D2 dopamine receptor-interacting proteins. (Program No. 33.9). Abstract viewer/Itinerary planner. Washington, DC: Society for Neuroscience.

Heldt, 2004, Neuropsychopharmacology, 29, 1610, 10.1038/sj.npp.1300468

Herrmann, 2004, J Biol Chem, 279, 24283, 10.1074/jbc.M311166200

Hersch, 1995, J Neurosci, 15, 5222, 10.1523/JNEUROSCI.15-07-05222.1995

Hirvonen, 2005, Arch Gen Psychiatry, 62, 371, 10.1001/archpsyc.62.4.371

Holmes, 2001, Behav Neurosci, 115, 1129, 10.1037/0735-7044.115.5.1129

Holmes, 2004, Neuropharmacology, 47, 1117, 10.1016/j.neuropharm.2004.07.034

Holzman, 1988, Arch Gen Psychiatry, 45, 641, 10.1001/archpsyc.1988.01800310049006

Houchi, 2005, Neuropsychopharmacology, 30, 339, 10.1038/sj.npp.1300568

Hu, 2002, Proc Natl Acad Sci USA, 99, 9755, 10.1073/pnas.152094799

Huotari, 2002, Eur J Neurosci, 15, 246, 10.1046/j.0953-816x.2001.01856.x

Huotari, 2004, Psychopharmacology, 172, 1, 10.1007/s00213-003-1627-3

Ikeda, 2005, Am J Med Genet B Neuropsychiatr Genet, 134, 90, 10.1002/ajmg.b.30155

Ingi, 1998, J Neurosci, 18, 7178, 10.1523/JNEUROSCI.18-18-07178.1998

Itzhak, 2000, Psychopharmacology (Berl), 151, 226, 10.1007/s002130000394

Iwabuchi, 2004, Ann N Y Acad Sci, 1025, 129, 10.1196/annals.1316.016

Jacob, 1986, J Neural Transm, 65, 303, 10.1007/BF01249090

Jacob, 1994, J Neural Transm, 98, 83, 10.1007/BF01277013

James, 2004, Mol Cell Neurosci, 26, 112, 10.1016/j.mcn.2004.01.013

Janowsky, 1977, Arch Gen Psychiatry, 34, 189, 10.1001/archpsyc.1977.01770140079009

Jaskiw, 1990, Brain Res, 534, 263, 10.1016/0006-8993(90)90138-2

Jenner, 1982, Biochem Pharmacol, 31, 325, 10.1016/0006-2952(82)90178-2

Jonsson, 1999, Schizophr Res, 40, 31, 10.1016/S0920-9964(99)00033-X

Jonsson, 2003, Am J Med Genet B Neuropsychiatr Genet, 119, 28, 10.1002/ajmg.b.20004

Juárez, 2005, Synapse, 58, 236, 10.1002/syn.20203

Juhila, 2005, Eur J Pharmacol, 517, 74, 10.1016/j.ejphar.2005.05.022

Kabbani, 2002, J Neurosci, 22, 8476, 10.1523/JNEUROSCI.22-19-08476.2002

Kapur, 2002, Mol Psychiatry, 7, 837, 10.1038/sj.mp.4001093

Kapur, 2003, J Pharmacol Exp Ther, 305, 625, 10.1124/jpet.102.046987

Karasinska, 2005, Eur J Neurosci, 22, 1741, 10.1111/j.1460-9568.2005.04353.x

Karper, 2002, Psychopharmacology, 159, 407, 10.1007/s00213-001-0936-7

Kathmann, 2003, Am J Psychiatry, 160, 696, 10.1176/appi.ajp.160.4.696

Kellendonk, 2006, Neuron, 49, 603, 10.1016/j.neuron.2006.01.023

Kim, 2000, J Neurosci, 20, 4405, 10.1523/JNEUROSCI.20-12-04405.2000

Kim, 2002, Pharmacol Biochem Behav, 73, 333, 10.1016/S0091-3057(02)00827-4

King, 1994, J Pharmacol Exp Ther, 269, 743

Kirkpatrick, 1992, J Nerv Ment Dis, 180, 265, 10.1097/00005053-199204000-00009

Ko, 2002, Neuroreport, 13, 1017, 10.1097/00001756-200206120-00007

Koh, 2003, Proc Natl Acad Sci USA, 100, 313, 10.1073/pnas.232693499

Kovoor, 2005, J Neurosci, 25, 2157, 10.1523/JNEUROSCI.2840-04.2005

Kruzich, 2004, Synapse, 53, 131, 10.1002/syn.20043

Krystal, 2005, Arch Gen Psychiatry, 62, 985, 10.1001/archpsyc.62.9.985

Kubota, 2002, J Neurochem, 83, 837, 10.1046/j.1471-4159.2002.01189.x

Kumari, 1998, Behav Pharmacol, 9, 567, 10.1097/00008877-199811000-00012

Kumari, 2004, Schizophr Res, 69, 219, 10.1016/j.schres.2003.09.010

Kuribara, 1995, Psychopharmacology (Berl), 119, 34, 10.1007/BF02246051

Lähdesmäki, 2004, Neuropsychopharmacology, 29, 1282, 10.1038/sj.npp.1300428

LaHoste, 1992, Synapse, 12, 14, 10.1002/syn.890120103

Lahti, 2001, Neuropsychopharmacology, 25, 455, 10.1016/S0893-133X(01)00243-3

Lawford, 2005, Schizophr Res, 73, 31, 10.1016/j.schres.2004.08.020

Le Moine, 1995, J Comp Neurol, 355, 418, 10.1002/cne.903550308

Le Pen, 2002, Neuropsychopharmacology, 27, 1, 10.1016/S0893-133X(01)00383-9

Lee, 2004, J Biol Chem, 279, 35671, 10.1074/jbc.M401923200

Levinson, 2002, Science, 296, 739, 10.1126/science.1069914

Lewis, 2003, Am J Hum Genet, 73, 34, 10.1086/376549

Lieberman, 1987, Psychopharmacology, 91, 415, 10.1007/BF00216006

Lieberman, 1990, Schizophr Bull, 16, 97, 10.1093/schbul/16.1.97

Lieberman, 2001, Biol Psychiatry, 49, 487, 10.1016/S0006-3223(01)01067-8

Lillrank, 1999, Neurochem Int, 34, 235, 10.1016/S0197-0186(99)00008-X

Lipska, 1993, Brain Res Dev Brain Res, 75, 213, 10.1016/0165-3806(93)90026-7

Lipska, 1991, Pharmacol Biochem Behav, 40, 181, 10.1016/0091-3057(91)90342-Y

Lipska, 1993, Neuropsychopharmacology, 9, 67, 10.1038/npp.1993.44

Lipska, 2003, Eur J Neurosci, 18, 3097, 10.1111/j.1460-9568.2003.03047.x

Lomanowska, 2004, Pharmacol Biochem Behav, 77, 617, 10.1016/j.pbb.2003.12.018

Lu, 2002, Ann Pharmacother, 36, 1387, 10.1345/aph.1A440

Ludewig, 2003, Biol Psychiatry, 54, 121, 10.1016/S0006-3223(02)01925-X

Macey, 2004, Mol Pharmacol, 66, 1635, 10.1124/mol.104.001495

MacKenzie, 1984, J Neurochem, 43, 1310, 10.1111/j.1471-4159.1984.tb05388.x

Mackeprang, 2002, Biol Psychiatry, 52, 863, 10.1016/S0006-3223(02)01409-9

Mandel, 1993, Behav Brain Res, 59, 53, 10.1016/0166-4328(93)90151-F

Martin, 2000, Eur J Neurosci, 12, 4038, 10.1046/j.1460-9568.2000.00287.x

Martinez, 2002, Psychopharmacology (Berl), 161, 38, 10.1007/s00213-001-0977-y

Matthysse, 2004, Am J Med Genet B Neuropsychiatr Genet, 128, 30, 10.1002/ajmg.b.30030

Mattingly, 1996, Pharmacol Biochem Behav, 53, 481, 10.1016/0091-3057(95)02101-9

Mattsson, 2004, Neuroscience, 127, 579, 10.1016/j.neuroscience.2004.05.038

Maziade, 2001, Mol Psychiatry, 6, 684, 10.1038/sj.mp.4000915

McDonald, 1984, Mol Cell Endocrinol, 36, 201, 10.1016/0303-7207(84)90037-6

McGorry, 2002, Arch Gen Psychiatry, 59, 921, 10.1001/archpsyc.59.10.921

McGuffin, 2003, Curr Psychiatry Rep, 5, 121, 10.1007/s11920-003-0028-y

McNeil, 2000, Am J Psychiatry, 157, 203, 10.1176/appi.ajp.157.2.203

Meincke, 2004a, Psychiatry Res, 126, 51, 10.1016/j.psychres.2004.01.003

Meincke, 2004b, Eur Arch Psychiatry Clin Neurosci, 254, 415, 10.1007/s00406-004-0523-0

Meller, 1996, Neuropharmacology, 35, 1785, 10.1016/S0028-3908(96)00119-0

Meng, 1998, Brain Res Mol Brain Res, 61, 39, 10.1016/S0169-328X(98)00196-X

Mileson, 1991, Brain Res, 561, 1, 10.1016/0006-8993(91)90742-E

Millar, 2000, Hum Mol Genet, 9, 1415, 10.1093/hmg/9.9.1415

Millar, 2003, Genetics, 163, 833, 10.1093/genetics/163.2.833

Mirnics, 2001, Mol Psychiatry, 6, 293, 10.1038/sj.mp.4000866

Miyakawa, 2003, Proc Natl Acad Sci USA, 100, 8987, 10.1073/pnas.1432926100

Miyamoto, 2005, Mol Psychiatry, 10, 79, 10.1038/sj.mp.4001556

Morishima, 2005, Proc Natl Acad Sci USA, 102, 4170, 10.1073/pnas.0500914102

Morris, 2005, Curr Opin Pharmacol, 5, 101, 10.1016/j.coph.2004.08.008

Morris, 2003, Schizophr Res, 60, 167, 10.1016/S0920-9964(02)00527-3

Mowry, 2004, Mol Psychiatry, 9, 784, 10.1038/sj.mp.4001481

Mueller, 2004, Schizophr Res, 71, 361, 10.1016/j.schres.2004.02.016

Naber, 1982, Biochem Biophys Res Commun, 107, 374, 10.1016/0006-291X(82)91714-4

Nadri, 2004, Schizophr Res, 71, 377, 10.1016/j.schres.2004.02.020

Nelson, 1998, Arch Gen Psychiatry, 55, 433, 10.1001/archpsyc.55.5.433

Neubig, 2002, J Peptide Res, 60, 312, 10.1034/j.1399-3011.2002.21064.x

Neubig, 2002, Nat Rev Drug Discov, 11, 187, 10.1038/nrd747

Neves-Pereira, 2005, Mol Psychiatry, 10, 208, 10.1038/sj.mp.4001575

Nishiguchi, 2004, Nature, 427, 75, 10.1038/nature02170

Nordström, 1995, Psychiatry Res, 61, 67, 10.1016/0925-4927(95)02732-D

Ögren, 1994, Neuropsychopharmacology, 11, 167, 10.1038/sj.npp.1380103

Oranje, 2002, JClin Psychopharmacol, 22, 359, 10.1097/00004714-200208000-00005

. 1984. Neurons containing or accumulating transmitter amino acids. In: , , editors. Handbook of chemical neuroanatomy, Vol. 3. Amsterdam: Elsevier. pp 141–286.

Owen, 2005, Trends Genet, 21, 518, 10.1016/j.tig.2005.06.011

Palmatier, 2004, Mol Psychiatry, 9, 859, 10.1038/sj.mp.4001496

Papiol, 2005, Neuroimage, 27, 1002, 10.1016/j.neuroimage.2005.05.035

Paterlini, 2005, Nat Neurosci, 8, 1586, 10.1038/nn1562

Perreault, 2005, Neuropsychopharmacology

Perrine, 2005, Brain Res Mol Brain Res, 133, 224, 10.1016/j.molbrainres.2004.10.025

Phillips, 2001, J Pharmacol Exp Ther, 296, 905

Pierre, 1998, Psychopharmacology (Berl), 138, 159, 10.1007/s002130050658

Pippig, 1993, J Biol Chem, 268, 3201, 10.1016/S0021-9258(18)53678-4

Posner, 1994, Mol Pharmacol, 45, 65

Powell, 2004, Neuron, 42, 143, 10.1016/S0896-6273(04)00146-1

Prien, 1969, Br J Psychiatry, 115, 679, 10.1192/bjp.115.523.679

Przegalinski, 2000, J Physiol Pharmacol (Poland), 51, 193

Rahman, 2003, Neuron, 38, 941, 10.1016/S0896-6273(03)00321-0

Ralph, 1999, J Neurosci, 19, 4627, 10.1523/JNEUROSCI.19-11-04627.1999

Ralph-Williams, 2002, J Neurosci, 22, 9604, 10.1523/JNEUROSCI.22-21-09604.2002

Ralph-Williams, 2003, Neuropsychopharmacology, 28, 108, 10.1038/sj.npp.1300017

Randall, 1985, Life Sci, 37, 1419, 10.1016/0024-3205(85)90081-5

Rao, 1990, Pharmacopsychiatry, 23, 176, 10.1055/s-2007-1014503

Resnick, 1999, J Neurochem, 73, 1539, 10.1046/j.1471-4159.1999.0731539.x

Richfield, 1989, Neuroscience, 30, 767, 10.1016/0306-4522(89)90168-1

Richtand, 2000, Brain Res, 867, 239, 10.1016/S0006-8993(00)02247-2

Richtand, 2006, Neuropsychopharmacology, 31, 77, 10.1038/sj.npp.1300791

Roberts, 2004, Mol Pharmacol, 66, 1573, 10.1124/mol.104.004077

Robinson, 2004, Proc Natl Acad Sci USA, 101, 13329, 10.1073/pnas.0405084101

Robinson, 1986, Brain Res Rev, 11, 157, 10.1016/0165-0173(86)90002-0

Robinson, 2000, Addiction, 95, s91, 10.1046/j.1360-0443.95.8s2.19.x

Rubinstein, 1997, Cell, 90, 991, 10.1016/S0092-8674(00)80365-7

Russig, 2004, Psychopharmacology (Berl), 175, 143, 10.1007/s00213-004-1810-1

Schank, 2005, Neuropsychopharmacology

Schlüter, 2003, Neuroscience, 118, 985, 10.1016/S0306-4522(03)00036-8

Schooler, 1967, Am J Psychiatry, 123, 986, 10.1176/ajp.123.8.986

Schroeder, 1999, Psychopharmacology (Berl), 145, 61, 10.1007/s002130051032

Schwarting, 1996, Prog Neurobiol, 49, 215, 10.1016/S0301-0082(96)00015-9

Seeger, 1982, Psychopharmacology, 76, 182, 10.1007/BF00435275

Seeman, 1974, Fed Proc, 33, 2116

Seeman, 1980, Pharmacol Rev, 32, 229

Seeman, 1987, Synapse, 1, 133, 10.1002/syn.890010203

Seeman, 2001, Clin Neurosci Res, 1, 53, 10.1016/S1566-2772(00)00007-4

Seeman, 2002, Can J Psychiatry, 47, 27, 10.1177/070674370204700106

Seeman, 2004, Science, 305, 180, 10.1126/science.1096072

Seeman, 2005, Am J Psychiatry, 162, 1984, 10.1176/appi.ajp.162.10.1984-a

Seeman, 2000, Proc Natl Acad Sci USA, 97, 7673, 10.1073/pnas.97.14.7673

Seeman, 2003, Synapse, 50, 35, 10.1002/syn.10221

Seeman, 2005, Synapse, 58, 122, 10.1002/syn.20193

Seeman, 2005, Synapse, 58, 275, 10.1002/syn.20210

Seeman, 1998, Mol Psychiatry, 3, 386, 10.1038/sj.mp.4000421

Seeman, 1999, Am J Psychiatry, 156, 876, 10.1176/ajp.156.6.876

Seeman, 1973, J Cell Biol, 56, 519, 10.1083/jcb.56.2.519

Seeman, 1974, Fed Proc, 33, 246

Seeman, 1975, Proc Natl Acad Sci USA, 72, 4376, 10.1073/pnas.72.11.4376

Seeman, 1976, Nature, 261, 717, 10.1038/261717a0

Seeman, 1984, J Neurochem, 43, 221, 10.1111/j.1471-4159.1984.tb06700.x

Seeman, 1985, Mol Pharmacol, 28, 391

Seeman, 1987, Neuropsychopharmacology, 1, 5, 10.1016/0893-133X(87)90004-2

Seeman, 1989, Proc Natl Acad Sci USA, 86, 10156, 10.1073/pnas.86.24.10156

Seeman, 1993, Synapse, 14, 254, 10.1002/syn.890140403

Seeman, 2002, Synapse, 46, 235, 10.1002/syn.10139

Seeman, 2003, Synapse, 49, 209, 10.1002/syn.10232

Seeman, 2004, Synapse, 52, 77, 10.1002/syn.20005

Seeman, 2005a, Mol Psychiatry, 10, 877, 10.1038/sj.mp.4001682

Seeman, 2005b, Proc Natl Acad Sci USA, 102, 3513, 10.1073/pnas.0409766102

Sesack, 2003, Ann N Y Acad Sci, 1003, 36, 10.1196/annals.1300.066

Sharifi, 2004, Neuroreport, 15, 2433, 10.1097/00001756-200410250-00026

Sibley, 1999, Annu Rev Pharmacol Toxicol, 39, 313, 10.1146/annurev.pharmtox.39.1.313

Siderovski, 1999, Crit Rev Biochem Mol Biol, 34, 215, 10.1080/10409239991209273

Smith, 2005, J Neurosci, 25, 914, 10.1523/JNEUROSCI.4079-04.2005

Smith, 1975, Psychopharmacol Commun, 1, 285

Soyka, 1994, J Stud Alcohol, 55, 503, 10.15288/jsa.1994.55.503

Sporn, 2005, Schizophr Res, 73, 243, 10.1016/j.schres.2004.07.020

Stadel, 1981, J Cyclic Nucleotide Res, 7, 37

St Clair, 1990, Lancet, 336, 13, 10.1016/0140-6736(90)91520-K

Stefansson, 2002, Am J Hum Genet, 71, 877, 10.1086/342734

, , , , , et al. 2004. NRG1 and other genes affecting the glutamatergic system conferring susceptibility to schizophrenia (Abstracts). In: The 43rd Annual Meeting of American College of Neuropsychopharmacology, San Juan, Puerto Rico, December 12–16, 2004. Available at 43:acnp.abstractcentral.com/planner.

Steiner, 1999, Proc Natl Acad Sci USA, 96, 5786, 10.1073/pnas.96.10.5786

Stéphane, 2005, Curr Psychiatry Rev, 1, 23, 10.2174/1573400052953583

Strakowski, 1996, Biol Psychiatry, 40, 872, 10.1016/0006-3223(95)00497-1

Strakowski, 1997, Biol Psychiatry, 42, 749, 10.1016/S0006-3223(97)00052-8

Sum, 2001, Biochem Pharmacol, 62, 829, 10.1016/S0006-2952(01)00819-X

Sumiyoshi, 2004, Neurosci Lett, 364, 124, 10.1016/j.neulet.2004.04.027

Sumiyoshi, 2005, Brain Res Mol Brain Res, 140, 116, 10.1016/j.molbrainres.2005.07.001

Surmeier, 1996, J Neurosci, 16, 6579, 10.1523/JNEUROSCI.16-20-06579.1996

Suzuki, 1997, Prog Neuropsychopharmacol Biol Psychiatry, 21, 359, 10.1016/S0278-5846(97)00006-7

Szechtman, 2001, BMC Neurosci, 2, 4, 10.1186/1471-2202-2-4

Takahashi, 1997, Proc Natl Acad Sci USA, 94, 9938, 10.1073/pnas.94.18.9938

Talbot, 2004, J Clin Invest, 113, 1353, 10.1172/JCI200420425

Tamminga, 2005, Mol Psychiatry, 10, 27, 10.1038/sj.mp.4001563

Taymans, 2003, J Neurochem, 84, 1118, 10.1046/j.1471-4159.2003.01610.x

Taymans, 2004, Eur J Neurosci, 19, 2249, 10.1111/j.0953-816X.2004.03336.x

Tenn, 2003, Schizophrenia Res, 64, 103, 10.1016/S0920-9964(03)00009-4

Tenn, 2005, Biol Psychiatry, 57, 586, 10.1016/j.biopsych.2004.12.013

Tepest, 2003, Biol Psychiatry, 54, 1234, 10.1016/S0006-3223(03)00702-9

Thiselton, 2004, Mol Psychiatry, 9, 777, 10.1038/sj.mp.4001530

Thomsen, 1988, Mol Pharmacol, 34, 814

Torrey, 2005, Biol Psychiatry, 57, 252, 10.1016/j.biopsych.2004.10.019

Traynor, 2005, Mol Interv, 5, 30, 10.1124/mi.5.1.7

Tsutsumi, 1995, Clin Neuropharmacol, 18, 64, 10.1097/00002826-199502000-00008

Tune, 1993, Psychiatry Res, 49, 219, 10.1016/0165-1781(93)90063-M

Tuominen, 2005, Schizophr Res, 72, 225, 10.1016/j.schres.2004.05.005

Uehara, 2000, Brain Res, 860, 77, 10.1016/S0006-8993(00)01985-5

Ujike, 2002, Curr Psychiatry Rep, 4, 177, 10.1007/s11920-002-0024-7

Ujike, 1990, Psychopharmacology (Berl), 102, 459, 10.1007/BF02247125

Usiello, 2000, Nature, 408, 199, 10.1038/35041572

Vekovischeva, 2001, J Neurosci, 21, 4451, 10.1523/JNEUROSCI.21-12-04451.2001

Vezina, 1996, J Neurosci, 16, 2411, 10.1523/JNEUROSCI.16-07-02411.1996

Vile, 1996, Biol Psychiatry, 40, 881, 10.1016/0006-3223(95)00498-X

Virgos, 2001, Schizophr Res, 49, 65, 10.1016/S0920-9964(00)00106-7

Volkow, 2001, Am J Psychiatry, 158, 2015, 10.1176/appi.ajp.158.12.2015

VonVoigtlander, 1975, J Pharmacol Exper Ther, 193, 88

Wan, 1997, Neuropsychopharmacology, 16, 259, 10.1016/S0893-133X(96)00217-5

Wan, 1996, Behav Brain Res, 78, 211, 10.1016/0166-4328(95)00251-0

Wang, 1997, Neuron, 19, 1285, 10.1016/S0896-6273(00)80419-5

Weinberger, 2001, Biol Psychiatry, 50, 825, 10.1016/S0006-3223(01)01252-5

Weinshenker, 2002, Proc Natl Acad Sci USA, 99, 13873, 10.1073/pnas.212519999

Whitaker, 2004, Med Hypotheses, 62, 5, 10.1016/S0306-9877(03)00293-7

Willeit, 2006, Biol Psychiatry, 59, 389, 10.1016/j.biopsych.2005.09.017

Williams, 2004, Biol Psychiatry, 55, 192, 10.1016/j.biopsych.2003.11.002

Wilson, 2005, J Med Chem, 48, 4153, 10.1021/jm050155n

Winterer, 2004, Trends Neurosci, 27, 683, 10.1016/j.tins.2004.08.002

, , , , . 2004. Deficit in prepulse inhibition and enhanced sensitivity to amphetamine in mice lacking the trace amine-1 receptor. [Abstracts]. In: The 43rd Meeting of American College of Neuropsychopharmacology, San Juan, Puerto Rico, December 12–16, 2004. Available at http://acnp.abstractcentral.com/planner.

Wong, 1997, J Cereb Blood Flow Metab, 17, 331, 10.1097/00004647-199703000-00010

Wood, 1997, Brain Res Dev Brain Res, 101, 17, 10.1016/S0165-3806(97)00050-3

Wreggett, 1995, J Biol Chem, 270, 22488, 10.1074/jbc.270.38.22488

Wyatt, 1988, Schizophr Res, 1, 3, 10.1016/0920-9964(88)90034-5

Wynn, 2004, Biol Psychiatry, 55, 518, 10.1016/j.biopsych.2003.10.018

Xu, 2000a, Nat Neurosci, 3, 465, 10.1038/74839

Xu, 1994, Cell, 79, 945, 10.1016/0092-8674(94)90026-4

Xu, 1997, Neuron, 19, 837, 10.1016/S0896-6273(00)80965-4

Xu, 1999, J Biol Chem, 274, 3549, 10.1074/jbc.274.6.3549

Xu, 2000b, Brain Res, 852, 198, 10.1016/S0006-8993(99)02258-1

Yao, 2004, Neuron, 41, 625, 10.1016/S0896-6273(04)00048-0

Yee, 2005, Proc Natl Acad Sci USA, 102, 17154, 10.1073/pnas.0508752102

Yui, 1999, Mol Psychiatry, 4, 512, 10.1038/sj.mp.4000575

Yurek, 2004, Brain Res, 1028, 116, 10.1016/j.brainres.2004.08.066

Zachariou, 2003, Proc Natl Acad Sci USA, 100, 13656, 10.1073/pnas.2232594100

Zhang, 1999, Gene, 240, 23, 10.1016/S0378-1119(99)00393-5

Zhou, 1995, Cell, 83, 1197, 10.1016/0092-8674(95)90145-0

Zhuang, 2001, Proc Natl Acad Sci USA, 98, 1982, 10.1073/pnas.98.4.1982