Synapse
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
Dopamnine‐Immunoreactive axon varicosities form nonrandom contacts with GABA‐immunoreactive neurons of rat medial prefrontal cortexAbstract Recent postmortem studies have suggested that reduced γ‐aminobutyric acid (GABA)ergic activity in limbic cortex may be one component to the pathophysiology of schizophrenia. This hypothesis has underscored the importance of knowing whether midbrain dopamine afferents interact extensively enough with inhibitory interneurons to suggest a direct functional rel... ... hiện toàn bộ
Synapse - Tập 15 Số 4 - Trang 285-295 - 1993
Cellular colocalization of dopamine D1 and D2 receptors in rat medial prefrontal cortexAbstract In a recent study in rat medial prefrontal cortex (mPFC), a fluorescently coupled, high‐affinity ligand for the D1 receptor subtype was localized to nonpyramidal neurons, while a ligand selective for the D2 subtype was found on neurons with a size distribution overlapping with both small pyramidal and large nonpyram... ... hiện toàn bộ
Synapse - Tập 19 Số 2 - Trang 112-120 - 1995
Cytoplasmic structure in organotypic cultures of rat hippocampus prepared by rapid freezing and freeze‐substitution fixationAbstract We have compared rapid freezing followed by freeze‐substitution fixation with conventional aldehyde fixation as preparative methods for the electron microscopic study of organotypic cultures of neonatal rat hippocampus. Rapid freezing by contact with a copper block chilled by liquid helium was accomplished without mechanical distortion of superficial struct... ... hiện toàn bộ
Synapse - Tập 13 Số 3 - Trang 195-205 - 1993
Endogenous cannabinoid, anandamide, acts as a noncompetitive inhibitor on 5‐HT3 receptor‐mediated responses in Xenopus oocytesAbstract The cloned 5‐HT3 receptor from NCB‐20 neuroblastoma cells was expressed in Xenopus oocytes and the effect of the endogenous cannabinoid ligand, anandamide, was investigated on the function of this receptor. The oocytes expressing the cloned 5‐HT3 receptors were voltage‐clamped at −70 mV. A... ... hiện toàn bộ
Synapse - Tập 46 Số 3 - Trang 150-156 - 2002
Distinct patterns of ΔFosB induction in brain by drugs of abuseAbstract The transcription factor ΔFosB accumulates and persists in brain in response to chronic stimulation. This accumulation after chronic exposure to drugs of abuse has been demonstrated previously by Western blot most dramatically in striatal regions, including dorsal striatum (caudate/putamen) and nucleus accumbens. In the present study, we used immunohistoche... ... hiện toàn bộ
Synapse - Tập 62 Số 5 - Trang 358-369 - 2008
Cocaine: An in vivo microdialysis evaluation of its acute action on dopamine transmission in rat striatumAbstract The effects of cocaine on dopamine (DA) neurotransmission were evaluated by in vivo microdialysis in the striatum of halothane‐anesthetized rats. Intravenous cocaine produced a dose‐dependent, transient increase of the extracellular concentration of DA, with a peak response within 10 min and a return to control level by 30 min. The sharp DA response pattern... ... hiện toàn bộ
Synapse - Tập 3 Số 1 - Trang 48-54 - 1989
Combined subunit‐specific and unspecific inhibition of NMDA receptors triggers distinct cortical c‐fos expression patterns
Synapse - Tập 66 Số 8 - Trang 752-754 - 2012
Regulation of neuronal cdc20 (p55cdc) expression by the plasticity‐related transcription factor zif268Abstract Most forms of neuronal plasticity are associated with induction of the transcription factor zif268 (egr1). Down‐regulation of cdc20 (p55cdc )—a regulatory protein for the anaphase‐promoting complex, which controls access of specific substrates to the proteasome—was observed after transfection of a neuronal cell line with zif268. Treatmen... ... hiện toàn bộ
Synapse - Tập 61 Số 6 - Trang 463-468 - 2007
Spatial learning‐induced increase in agmatine levels at hippocampal CA1 synapsesAbstract Agmatine, a metabolite of L ‐arginine, is considered as a novel putative neurotransmitter. It has been detected in axon terminals that synapse with pyramidal cells in the hippocampus, a brain region that is critically involved in spatial learning and memory. However, the role of agmatine in learning and memory is poorly understood. Recentl... ... hiện toàn bộ
Synapse - Tập 65 Số 2 - Trang 146-153 - 2011
Increased cortical nitric oxide release after phencyclidine administrationAbstract Phencyclidine exerts psychotomimetic effects in humans and is used as a pharmacological animal model for schizophrenia. We, and others, have demonstrated that phencyclidine induces cognitive deficits in rats that are associated with schizophrenia. These cognitive deficits can be normalized by inhibition of nitric oxide synthase. The development of selective... ... hiện toàn bộ
Synapse - Tập 63 Số 12 - Trang 1083-1088 - 2009
Tổng số: 71
- 1
- 2
- 3
- 4
- 5
- 6
- 8