Synapse

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
Increase in matrix metalloproteinase‐9 levels in the rat medial prefrontal cortex after cocaine reinstatement of conditioned place preference
Synapse - Tập 62 Số 12 - Trang 886-889 - 2008
Travis E. Brown, Melissa R. Forquer, Joseph W. Harding, John W. Wright, Barbara A. Sorg
AbstractRecently we have shown that inhibition of matrix metalloproteinase (MMP) activity suppresses the reinstatement of cocaine‐primed conditioned place preference (CPP) in rats. Here we explored whether cocaine‐primed reinstatement was associated with increased activity of the gelatinases, MMP‐2 or MMP‐9, in the medial prefrontal cortex (mPFC) or dorsal hippocampus. Male Sprague‐Dawley rats und... hiện toàn bộ
Combined subunit‐specific and unspecific inhibition of NMDA receptors triggers distinct cortical c‐fos expression patterns
Synapse - Tập 66 Số 8 - Trang 752-754 - 2012
Dragoš Inta, Juan M. Lima‐Ojeda, Christof Dormann, Georg Köhr, Rolf Sprengel, Peter Gass
Purification and characterization of PCPP‐260: A Purkinje cell‐enriched cyclic amp‐regulated membrane phosphoprotein of Mr 260,000
Synapse - Tập 2 Số 1 - Trang 89-96 - 1988
Gerald Weeks, Marina R. Picciotto, Angus C. Nairn, S. Ivar Walaas, Paul Greengard
AbstractPCPP‐260 (Purkinje cell phosphoprotein of Mr 260,000), a substrate for cAMP‐dependent protein kinase, appears to be an integral membrane protein highly enriched in Purkinje cells of the mammalian cerebellum (Walaas et al.: J. Neurosci., 3:291–301, 1983; Walaas et al.: J. Neurosci., 6:954–961, 1986). PCPP‐260 has now been purified from a crude particulate fraction of bovine cerebellum, usin... hiện toàn bộ
Melatonin protects against amyloid-β-induced impairments of hippocampal LTP and spatial learning in rats
Synapse - Tập 67 Số 9 - Trang 626-636 - 2013
Xiaojie Liu, Li Yuan, Dong Uk Yang, Wei-Na Han, Qingshan Li, Wei Yang, Qing-song Liu, Jin‐Shun Qi
Neuroanatomic specificity and time course of alterations in rat brain serotonergic pathways induced by MDMA (3,4‐methylenedioxymethamphetamine): Assessment using quantitative autoradiography
Synapse - Tập 8 Số 4 - Trang 249-260 - 1991
George Battaglia, John Sharkey, Michael J. Kuhar, Errol B. De Souza
AbstractThe Widely abused “designer” durg MDMA (3,4‐methylenedioxymethamphetamine) has been shown to caused marked and long‐lasting changes in brain serotonergic systems. The present study uses quantitative in vitro autoradiography of 3H‐paroxetine labeled 5‐HT uptake sites to assess the time‐dependent effects of MDMA on 5‐HT neurons in specific neuroanatomic loci. Following treatment with MDMA (2... hiện toàn bộ
Effect of destruction of serotonin neurons on basal and fenfluramine‐induced serotonin release in striatum
Synapse - Tập 20 Số 2 - Trang 99-105 - 1995
Lynn G. Kirby, Deborah S. Kreiss, Ashish Singh, Irwin Lucki
AbstractThis study examined the relationship between the magnitude of tissue serotonin (5‐HT)depletion produced by treatment with the neurotoxin 5,7‐dihydroxytryptamine (5,7) and basal and fenfluramine‐induced 5‐HT release in the striatum. Separate groups of rats were treated with either vehicle or 5,7‐DHT (100μ 76% striatal 5‐HT depletion; or 200μ 93% styriatal 5‐HT depletion). four weeks after t... hiện toàn bộ
Autoradiographic localization of 3H‐paroxetine‐labeled serotonin uptake sites in rat brain
Synapse - Tập 1 Số 5 - Trang 488-496 - 1987
Errol B. De Souza, Brian L. Kuyatt
AbstractParoxetine is a potent and selective inhibitor of serotonin uptake into neurons. Serotonin uptake sites have been identified, localized, and quantified in rat brain by autoradiography with 3H‐paroxetine; 3H‐paroxetine binding in slide‐mounted sections of rat forebrain was of high affinity (KD = 10 pM) and the inhibition affinity constant (Ki) values of various drugs in competing 3H‐paroxet... hiện toàn bộ
Functional analysis of MOR‐1 splice variants of the mouse mu opioid receptor gene Oprm
Synapse - Tập 51 Số 1 - Trang 11-18 - 2004
Elizabeth Bolan, Ying‐Xian Pan, Gavril W. Pasternak
AbstractA series of mu opioid receptor gene Oprm splice variants have been reported that differ only at their C‐terminus. These variants all contain exons 1, 2, and 3 of the gene, the exons responsible for coding all seven transmembrane domains. Whereas MOR‐1 also has exon 4 that encodes for an additional 12 amino acids at the tip of the C‐terminus, the other MOR‐1 variants have unique amino acid ... hiện toàn bộ
Synaptic structural plasticity: Role of synaptic shape
Synapse - Tập 3 Số 1 - Trang 1-11 - 1989
Etan J. Markus, Ted L. Petit
AbstractRecent research has indicated that synaptic curvature is an important and potentially critical plastic feature of the synapse. Alterations in synaptic shape are related to synaptic function, being found both during maturation and in adulthood following neuronal activation. In this paper we review the evidence supporting synaptic shape as a plastic feature of synaptic structure. We also pro... hiện toàn bộ
Running wheel exercise ameliorates methamphetamine‐induced damage to dopamine and serotonin terminals
Synapse - Tập 66 Số 1 - Trang 71-80 - 2012
Steven J. O’Dell, Bryan Galvez, Alexander Ball, John F. Marshall
AbstractRepeated administration of methamphetamine (mAMPH) to rodents in a single‐day “binge” produces long‐lasting damage to dopaminergic and serotonergic terminals. Because previous research has demonstrated that physical activity can ameliorate nigrostriatal injury, this study investigated whether voluntary exercise in rats can alter the monoaminergic damage resulting from a neurotoxic mAMPH bi... hiện toàn bộ
Tổng số: 71   
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 8