Running wheel exercise ameliorates methamphetamine‐induced damage to dopamine and serotonin terminals

Synapse - Tập 66 Số 1 - Trang 71-80 - 2012
Steven J. O’Dell1, Bryan Galvez1, Alexander Ball1, John F. Marshall1
1Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California 92697

Tóm tắt

AbstractRepeated administration of methamphetamine (mAMPH) to rodents in a single‐day “binge” produces long‐lasting damage to dopaminergic and serotonergic terminals. Because previous research has demonstrated that physical activity can ameliorate nigrostriatal injury, this study investigated whether voluntary exercise in rats can alter the monoaminergic damage resulting from a neurotoxic mAMPH binge. Adult male rats were allowed constant access to running wheels or kept in nonwheel cages for three weeks, then given a binge dosing regimen of mAMPH or saline. The rats were returned to their original environments for three additional weeks post‐mAMPH. [125I]RTI‐55 binding and autoradiography was used to quantify dopamine transporters (DAT), and radioimmunocytochemistry was used to quantify striatal tyrosine hydroxylase (TH). Binge mAMPH treatment significantly reduced striatal DAT and TH in a regionally specific pattern; with greatest effects in ventral caudate‐putamen (CP) and relative sparing of the nucleus accumbens septi (NAc). The effects of mAMPH on striatal DAT and TH were ameliorated in the running, compared to the sedentary, animals. Also, mAMPH was found to reduce [125I]RTI‐55 binding to serotonin transporters (SERT) in frontoparietal cortex, and this too was significantly attenuated by exercise. Additional correlational analyses showed that the post‐mAMPH running of individual animals predicted the amelioration of striatal DAT and TH as well as frontoparietal SERT. Overall, voluntary exercise significantly diminished mAMPH‐induced forebrain monoaminergic damage. The significant correlations between post‐mAMPH exercise and markers of monoaminergic terminal integrity provide novel evidence that voluntary exercise may exert beneficial effects on behavior in recovering mAMPH addicts. Synapse, 2012. © 2011 Wiley Periodicals, Inc.

Từ khóa


Tài liệu tham khảo

10.1007/s11064-007-9485-8

Albers DS, 1995, Methamphetamine‐induced hyperthermia and dopaminergic neurotoxicity in mice: Pharmacological profile of protective and nonprotective agents, J Pharmacol Exp Ther, 275, 1104

10.1002/syn.890090405

10.1046/j.1471-4159.2003.01867.x

10.1038/sj.npp.1301510

10.1038/sj.npp.1300771

10.1016/j.beproc.2004.12.006

10.1002/syn.890120104

10.1016/j.freeradbiomed.2007.08.015

Bowyer JF, 1994, Further studies of the role of hyperthermia in methamphetamine neurotoxicity, J Pharmacol Exp Ther, 268, 1571

10.1196/annals.1432.005

10.1002/syn.890110404

10.1046/j.1471-4159.2000.0741079.x

10.1523/JNEUROSCI.19-17-07653.1999

10.1046/j.1471-4159.2003.01657.x

10.1016/S0166-2236(02)02143-4

10.1097/00003677-200204000-00006

Deng X, 1999, Null mutation of c‐fos causes exacerbation of methamphetamine‐induced neurotoxicity, J Neurosci, 19, 10107, 10.1523/JNEUROSCI.19-22-10107.1999

10.1523/JNEUROSCI.15-10-06377.1995

10.1016/0006-8993(92)90201-J

10.1002/(SICI)1098-2396(199603)22:3<217::AID-SYN3>3.0.CO;2-F

10.1126/science.26975

10.1016/S0892-0362(97)00094-9

10.1046/j.1471-4159.1995.64041819.x

10.1016/S0006-8993(97)00375-2

10.1016/j.bbr.2010.05.009

10.1007/s12640-009-9106-1

10.1016/S0006-8993(00)02439-2

10.1016/0024-3205(79)90414-4

10.1016/S0006-8993(97)01356-5

10.1017/S1461145705005699

10.1523/JNEUROSCI.16-15-04776.1996

10.1371/journal.pone.0019179

10.1046/j.1471-4159.1999.0732546.x

10.1016/j.biopsych.2005.04.039

10.1523/JNEUROSCI.18-20-08417.1998

10.1016/j.expneurol.2004.05.012

10.1038/373109a0

10.1016/j.neuroscience.2006.10.042

10.1093/brain/124.4.784

10.1523/JNEUROSCI.1069-07.2007

10.1016/0006-8993(82)90198-6

10.1016/0006-8993(80)90952-X

10.1016/S0006-8993(97)00173-X

10.1002/syn.10210

10.1124/jpet.109.155770

10.1007/BF03033456

10.1111/j.1749-6632.1988.tb42104.x

10.1016/0376-8716(76)90030-2

10.1001/archpsyc.63.1.90

10.1016/j.expneurol.2003.08.017

Sonsalla PK, 1986, Roles of D1 and D2 dopamine receptor subtypes in mediating the methamphetamine‐induced changes in monoamine systems, J Pharmacol Exp Ther, 238, 932

10.1111/j.1749-6632.1992.tb24542.x

10.1046/j.1471-4159.1998.71020613.x

10.1016/j.pbb.2007.10.004

10.1111/j.1471-4159.2009.06094.x

10.1523/JNEUROSCI.0713-04.2004

10.1016/S0306-4522(03)00096-4

Tillerson JL, 2002, Forced nonuse in unilateral parkinsonian rats exacerbates injury, J Neurosci, 22, 6790, 10.1523/JNEUROSCI.22-15-06790.2002

Tillerson JL, 2001, Forced limb‐use effects on the behavioral and neurochemical effects of 6‐hydroxydopamine, J Neurosci, 21, 4427, 10.1523/JNEUROSCI.21-12-04427.2001

10.1176/appi.ajp.158.12.2015

10.1523/JNEUROSCI.21-23-09414.2001

10.1176/appi.ajp.158.3.383

10.1176/appi.ajp.158.3.377

10.1016/0006-8993(80)91265-2

10.1155/2005/105341

Thông tin
Thông tin xuất bản

Synapse

Tập 66 Số 1

71-80

Thông tin tác giả