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Erratum: Differential Somatostatin Receptor Subtype Expression in Human Normal Pineal Gland and Pineal Parenchymal Tumors
Springer Science and Business Media LLC - Tập 23 - Trang 875-876 - 2003
Decreased Glucose Metabolism and Glutamine Synthesis in the Retina of a Transgenic Mouse Model of Alzheimer’s Disease
Springer Science and Business Media LLC - Tập 42 - Trang 291-303 - 2021
Visual changes are some of the earliest symptoms that patients with Alzheimer’s disease (AD) experience. Pathophysiological processes such as amyloid-β plaque formation, vascular changes, neuroinflammation, and loss of retinal ganglion cells (RGCs) have been detected in the retina of AD patients and animal models. However, little is known about the molecular processes that underlie retinal neurode......
Neuropeptides, Growth Factors, and Cytokines: A Cohort of Informational Molecules Whose Expression Is Up-Regulated by the Stress-Associated Slow Transmitter PACAP in Chromaffin Cells
Springer Science and Business Media LLC - Tập 30 - Trang 1441-1449 - 2010
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a co-transmitter with acetylcholine at the adrenomedullary synapse, mediating sustained hormone secretion and regulation of cellular plasticity in response to stress at the level of gene transcription. Here we have extended our investigation of PACAP-regulated neuroendocrine cell-specific genes from PC12 cells to PC12 cells expressing p......
Cardiac Neural Crest Cells: Their Rhombomeric Specification, Migration, and Association with Heart and Great Vessel Anomalies
Springer Science and Business Media LLC - Tập 41 - Trang 403-429 - 2020
Outflow tract abnormalities are the most frequent congenital heart defects. These are due to the absence or dysfunction of the two main cell types, i.e., neural crest cells and secondary heart field cells that migrate in opposite directions at the same stage of development. These cells directly govern aortic arch patterning and development, ascending aorta dilatation, semi-valvular and coronary ar......
Oxidative Stress in Phenylketonuria: What is the Evidence?
Springer Science and Business Media LLC - Tập 31 - Trang 653-662 - 2011
Phenylketonuria (PKU) is an inborn error of amino acid metabolism caused by severe deficiency of phenylalanine hydroxylase activity, leading to the accumulation of phenylalanine and its metabolites in blood and tissues of affected patients. Phenylketonuric patients present as the major clinical feature mental retardation, whose pathomechanisms are poorly understood. In recent years, mounting evide......
Neuroprotective Effect of Hydrogen Sulfide Subchronic Treatment Against TBI-Induced Ferroptosis and Cognitive Deficits Mediated Through Wnt Signaling Pathway
Springer Science and Business Media LLC - Tập 43 - Trang 4117-4140 - 2023
Emerging evidence shows that targeting ferroptosis may be a potential therapeutic strategy for treating traumatic brain injury (TBI). Hydrogen sulfide (H2S) has been proven to play a neuroprotective role in TBI, but little is known about the effects of H2S on TBI-induced ferroptosis. In addition, it is reported that the Wnt signaling pathway can also actively regulate ferroptosis. However, whether......
In Vitro and In Vivo Magnetic Resonance Tracking of Sinerem-Labeled Human Umbilical Mesenchymal Stromal Cell-Derived Schwann Cells
Springer Science and Business Media LLC - Tập 31 - Trang 365-375 - 2010
Tracking of ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles-labeled embryonic stem cells, neural stem cells, or adult mesenchymal stem cells in vitro and in vivo by using magnetic resonance (MR) imaging have been reported. However, whether the transdifferentiated cells can be effectively labeled by USPIO has not yet been investigated. The requirement for nerve donor material evokes a......
Tầm quan trọng của các biến thể splice của thụ thể mu-opioid và tính linh hoạt của các hệ quả tín hiệu của chúng đối với sự tolérance thuốc giảm đau opioid Dịch bởi AI
Springer Science and Business Media LLC - Tập 41 Số 5 - Trang 855-862 - 2021
Việc tăng liều opioid để kiểm soát hiệu quả cơn đau thường gắn liền với đại dịch lạm dụng opioid hiện nay. Điều này tạo ra những yêu cầu xã hội cũng như y tế để hiểu rõ hơn về các cơ chế cơ bản của sự tolérance opioid nhằm phát triển các can thiệp làm giảm thiểu tình trạng này, qua đó tối đa hóa hiệu quả giảm đau của opioid. Sự tolérance giảm đau opioid sâu sắc có thể được quan sát thấy mà không c......
#thuốc giảm đau opioid #thụ thể mu-opioid #tolérance opioid #tín hiệu thụ thể #biến thể splice
Adoptive Regulatory T-cell Therapy Attenuates Perihematomal Inflammation in a Mouse Model of Experimental Intracerebral Hemorrhage
Springer Science and Business Media LLC - Tập 37 - Trang 919-929 - 2016
The CD4+CD25+ regulatory T cells (Tregs), an innate immunomodulator, suppress cerebral inflammation and maintain immune homeostasis in multiple central nervous system injury, but its role in intracerebral hemorrhage (ICH) has not been fully characterized. This study investigated the effect of Tregs on brain injury using the mouse ICH model, which is established by autologous blood infusion. The re......
Polymorphic Cytochromes P450 and Drugs Used in Psychiatry
Springer Science and Business Media LLC - Tập 19 - Trang 325-354 - 1999
1. The cytochrome P450 monooxygenases, CYP2D6, CYP2C19, and CYP2C9, display polymorphism. CYP2D6 and CYP2C19 have been studied extensively, and despite their low abundance in the liver, they catalyze the metabolism of many drugs. 2. CYP2D6 has numerous allelic variants, whereas CYP2C19 has only two. Most variants are translated into inactive, truncated protein or fail to express protein. 3. CYP2C9......
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