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Response of NADPH-Diaphorase-Exhibiting Neurons in the Medullar Reticular Formation to High Spinal Cord Injury
Springer Science and Business Media LLC - Tập 24 - Trang 865-872 - 2004
1. The effect of hemisection of the cervical spinal cord on NADPH-diaphorase staining in the reticular nuclei of the rabbit medulla was investigated using histochemical technique. 2. A quantitative assessment of somal and neuropil NADPH-diaphorase staining was made by an image analyzer in a selected area of each reticular nucleus of the rabbit medulla. 3. On the 7th postsurgery day, the highest up...... hiện toàn bộ
Brain Insulin: Regulation, Mechanisms of Action and Functions
Springer Science and Business Media LLC - - 2003
1. While many questions remain unanswered, it is now well documented that, contrary to earlier views, insulin is an important neuromodulator, contributing to neurobiological processes, in particular energy homeostasis and cognition. A specific role on cognitive functions related to feeding is proposed, and it is suggested that brain insulin from different sources might be involved in the above vit...... hiện toàn bộ
In the Rat Midbrain, SG2NA and DJ-1 have Common Interactome, Including Mitochondrial Electron Transporters that are Comodulated Under Oxidative Stress
Springer Science and Business Media LLC - Tập 43 - Trang 3061-3080 - 2023
Scaffold proteins Striatin and SG2NA assemble kinases and phosphatases into the signalling complexes called STRIPAK. Dysfunctional STRIPAKs cause cancer, cerebral cavernous malformations, etc. DJ-1, a sensor for oxidative stress, has long been associated with the Parkinson’s disease, cancer, and immune disorders. SG2NA interacts with DJ-1 and Akt providing neuroprotection under oxidative stress. T...... hiện toàn bộ
Tetrodotoxin-resistant sodium channels
Springer Science and Business Media LLC - Tập 14 - Trang 227-244 - 1994
1. Tetrodotoxin (TTX) has been widely used as a chemical tool for blocking Na+ channels. However, reports are accumulating that some Na+ channels are resistant to TTX in various tissues and in different animal species. Studying the sensitivity of Na+ channels to TTX may provide us with an insight into the evolution of Na+ channels. 2. Na+ channels present in TTX-carrying animals such as pufferfish...... hiện toàn bộ
Mapping of Rat Hippocampal Neurons With NeuN After Ischemia/Reperfusion and Ginkgo Biloba Extract (EGb 761) Pretreatment
Springer Science and Business Media LLC - Tập 26 - Trang 1191-1202 - 2006
1. The neuroprotective effect of Ginkgo biloba extract (EGb 761) against transient forebrain ischemia following 7 days of reperfusion was studied in male Wistar rats after four-vessel occlusion for 20 min. 2. NeuN, a neuronal specific nuclear protein was used for immunohistochemical detection of surviving pyramidal neurons in the hippocampus, as well as counterstaining with hematoxylin in the same...... hiện toàn bộ
The Effect of an Endogenous Na+, K+-ATPase Inhibitor on Rat Lens Transparency and Ultrastructure
Springer Science and Business Media LLC - Tập 23 - Trang 131-141 - 2003
1. The purpose of the present study was to analyze the possible effect of ouabain and an endogenous ouabain-like substance (endobain E), on lenses of 100- and 400-g body weight rats. 2. Lenses were incubated with ouabain or endobain E for 120 min, either at room temperature or in the cold; opalescence was checked by gross examination and ultrastructure by electron microscopy. 3. Lenses from 400-g ...... hiện toàn bộ
Effect of Chronic Treatment with Conventional and Organic Purple Grape Juices (Vitis labrusca) on Rats Fed with High-Fat Diet
Springer Science and Business Media LLC - Tập 33 - Trang 1123-1133 - 2013
Serra Gaucha is described as the most important wine region of Brazil. Regarding cultivars widespread in the Serra Gaucha, about 90 % of the area is occupied by vines of Vitis labrusca that is the most important specie used in grape juice production. The objective of this study was to investigate the antioxidant and neuroprotective effect of chronic intake of purple grape juice (organic and conven...... hiện toàn bộ
Retinoic Acid-Induced Protein 14 (RAI14) Promotes mTOR-Mediated Inflammation Under Inflammatory Stress and Chemical Hypoxia in a U87 Glioblastoma Cell Line
Springer Science and Business Media LLC - - 2019
The Blood–Brain Barrier Permeability of Geissoschizine Methyl Ether in Uncaria Hook, a Galenical Constituent of the Traditional Japanese Medicine Yokukansan
Springer Science and Business Media LLC - Tập 31 - Trang 787-793 - 2011
Geissoschizine methyl ether (GM) in Uncaria hook, a galenical constituent of yokukansan is thought to be one of active components in the psychotropic effect of yokukansan, a traditional Japanese medicine (kampo medicine). However, there is no data on the blood–brain barrier (BBB) permeability of Uncaria hook-derived alkaloids containing GM. In this study, we investigated the BBB permeability of se...... hiện toàn bộ
Oxycodone in the Opioid Epidemic: High ‘Liking’, ‘Wanting’, and Abuse Liability
Springer Science and Business Media LLC - Tập 41 - Trang 899-926 - 2020
It is estimated that nearly a third of people who abuse drugs started with prescription opioid medicines. Approximately, 11.5 million Americans used prescription drugs recreationally in 2016, and in 2018, 46,802 Americans died as the result of an opioid overdose, including prescription opioids, heroin, and illicitly manufactured fentanyl (National Institutes on Drug Abuse (2020) Opioid Overdose Cr...... hiện toàn bộ
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