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The Role of TNF-α and its Receptors in the Production of β-1,4-galactosyltransferase I mRNA by Rat Primary Type-2 Astrocytes
Springer Science and Business Media LLC - - 2008
Ming Yan, Chunlin Xia, Shuqiong Niu, Chun Cheng, Xiaorong Shao, Aiguo Shen
Elucidating Critical Proteinopathic Mechanisms and Potential Drug Targets in Neurodegeneration
Springer Science and Business Media LLC - Tập 40 - Trang 313-345 - 2019
Khalid Bashir Dar, Aashiq Hussain Bhat, Shajrul Amin, Bilal Ahmad Reshi, Mohammad Afzal Zargar, Akbar Masood, Showkat Ahmad Ganie
Neurodegeneration entails progressive loss of neuronal structure as well as function leading to cognitive failure, apathy, anxiety, irregular body movements, mood swing and ageing. Proteomic dysregulation is considered the key factor for neurodegeneration. Mechanisms involving deregulated processing of proteins such as amyloid beta (Aβ) oligomerization; tau hyperphosphorylation, prion misfolding; ... hiện toàn bộ
Human acetylcholinesterase and butyrylcholinesterase are encoded by two distinct genes
Springer Science and Business Media LLC - Tập 11 - Trang 91-104 - 1991
Averell Gnatt, Dalia Ginzberg, Judy Lieman-Hurwitz, Ronit Zamir, Haim Zakut, Hermona Soreq
Identification of Up-Regulated Genes After Complete Spinal Cord Transection in Adult Rats
Springer Science and Business Media LLC - - 2006
Zhuo Ma, Tao Liu, Xin Li, Tao Zhou, Lin Xiao, Haiping Que, Dan Tian, Shuqian Jing, Shaojun Liu
Hyperhomocysteinemia-Induced Oxidative Stress Exacerbates Cortical Traumatic Brain Injury Outcomes in Rats
Springer Science and Business Media LLC - Tập 41 - Trang 487-503 - 2020
Flaubert Tchantchou, Molly Goodfellow, Fengying Li, Lyric Ramsue, Catriona Miller, Adam Puche, Gary Fiskum
Traumatic brain injury (TBI) is a leading cause of morbidity and mortality among military service members and civilians in the United States. Despite significant advances in the understanding of TBI pathophysiology, several clinical reports indicate that multiple genetic and epigenetic factors can influence outcome. Homocysteine (HCY) is a non-proteinogenic amino acid, the catabolism of which can ... hiện toàn bộ
Prognostic Value of Plasma Trimethylamine N-Oxide Levels in Patients with Acute Ischemic Stroke
Springer Science and Business Media LLC - Tập 39 - Trang 1201-1206 - 2019
Qijin Zhai, Xiang Wang, Chun Chen, Yan Tang, Yuqian Wang, Jisha Tian, Ying Zhao, Xinfeng Liu
Trimethylamine N-oxide (TMAO) has emerged as a newly identified gut microbiota-dependent metabolite contributing to a variety of diseases, such as diabetes, atherosclerosis, and cardiovascular diseases. The aim of our study was to determine whether a relatively high TMAO level is associated with an increased risk of poor outcome in ischemic stroke patients. From June 2018 to December 2018, we pros... hiện toàn bộ
Neutralization of BDNF Attenuates the in vitro Protective Effects of Olfactory Ensheathing Cell-Conditioned Medium on Scratch-Insulted Retinal Ganglion Cells
Springer Science and Business Media LLC - Tập 31 - Trang 357-364 - 2010
Tao Wang, Rui Cong, Hao Yang, Ming-Mei Wu, Na Luo, Fang Kuang, Si-Wei You
Transplantation of olfactory ensheathing cells (OECs) becomes one of the promising strategies in restoring lost functions of injured central nervous system. Elevated level of expressed brain-derived neurotrophic factor (BDNF) was revealed in the previous studies to be related to the protective effects of OECs on injured cortical and brain stem neurons as well as retinal ganglion cells (RGCs), but ... hiện toàn bộ
Introduction
Springer Science and Business Media LLC - Tập 28 - Trang 5-7 - 2007
Ji-Sheng Han
The edition of a special issue entitled “Neuroscience in China” provides a unique opportunity to introduce neuroscience research undertakings in China today. Among the biological sciences at large, neuroscience is one of the most advanced fields in China. To take two examples, more than 70% of the articles published in the Chinese Journal of Physiology were in the category of neuroscience; among t... hiện toàn bộ
Sealing of Transected Neurites of Rat B104 Cells Requires a Diacylglycerol PKC-Dependent Pathway and a PKA-Dependent Pathway
Springer Science and Business Media LLC - Tập 33 - Trang 31-46 - 2012
Aleksej Zuzek, Jerry D. Fan, Christopher S. Spaeth, George D. Bittner
To survive, neurons and other eukaryotic cells must rapidly repair (seal) plasmalemmal damage. Such repair occurs by an accumulation of intracellular vesicles at or near the plasmalemmal disruption. Diacylglycerol (DAG)-dependent and cAMP-dependent proteins are involved in many vesicle trafficking pathways. Although recent studies have implicated the signaling molecule cAMP in sealing, no study ha... hiện toàn bộ
Repression of SIRT1 Promotes the Differentiation of Mouse Induced Pluripotent Stem Cells into Neural Stem Cells
Springer Science and Business Media LLC - Tập 34 - Trang 905-912 - 2014
Bin Hu, Ye Guo, Chunyuan Chen, Qing Li, Xin Niu, Shangchun Guo, Aijun Zhang, Yang Wang, Zhifeng Deng
The use of transplanting functional neural stem cells (NSCs) derived from induced pluripotent stem cells (iPSCs) has increased for the treatment of brain diseases. As such, it is important to understand the molecular mechanisms that promote NSCs differentiation of iPSCs for future NSC-based therapies. Sirtuin 1 (SIRT1), a NAD+-dependent protein deacetylase, has attracted significant attention over... hiện toàn bộ
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