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Sealing of Transected Neurites of Rat B104 Cells Requires a Diacylglycerol PKC-Dependent Pathway and a PKA-Dependent Pathway
Springer Science and Business Media LLC - Tập 33 - Trang 31-46 - 2012
Aleksej Zuzek, Jerry D. Fan, Christopher S. Spaeth, George D. Bittner
To survive, neurons and other eukaryotic cells must rapidly repair (seal) plasmalemmal damage. Such repair occurs by an accumulation of intracellular vesicles at or near the plasmalemmal disruption. Diacylglycerol (DAG)-dependent and cAMP-dependent proteins are involved in many vesicle trafficking pathways. Although recent studies have implicated the signaling molecule cAMP in sealing, no study ha...... hiện toàn bộ
Repression of SIRT1 Promotes the Differentiation of Mouse Induced Pluripotent Stem Cells into Neural Stem Cells
Springer Science and Business Media LLC - Tập 34 - Trang 905-912 - 2014
Bin Hu, Ye Guo, Chunyuan Chen, Qing Li, Xin Niu, Shangchun Guo, Aijun Zhang, Yang Wang, Zhifeng Deng
The use of transplanting functional neural stem cells (NSCs) derived from induced pluripotent stem cells (iPSCs) has increased for the treatment of brain diseases. As such, it is important to understand the molecular mechanisms that promote NSCs differentiation of iPSCs for future NSC-based therapies. Sirtuin 1 (SIRT1), a NAD+-dependent protein deacetylase, has attracted significant attention over...... hiện toàn bộ
XVth National Meeting of the Argentine Society for Neurochemistry
Springer Science and Business Media LLC - - 2001
Francisco J. Barrantes
Identification of Circulating MicroRNAs as Potential Biomarkers for Detecting Acute Ischemic Stroke
Springer Science and Business Media LLC - - 2015
Pengfei Li, Fei Teng, Feng Gao, Mingshun Zhang, Jinping Wu, Chunbing Zhang
Capsaicin-Induced Activation of ERK1/2 and Its Involvement in GAP-43 Expression and CGRP Depletion in Organotypically Cultured DRG Neurons
Springer Science and Business Media LLC - Tập 33 - Trang 433-441 - 2013
Yunfeng Li, Guixiang Liu, Hao Li, Youzheng Xu, Hong Zhang, Zhen Liu
Low concentrations of capsaicin (CAP) stimulate and high concentrations of CAP can be toxic to the primary sensory neurons of the dorsal root ganglion (DRG). CAP induces the phosphorylation of extracellular signal-regulated protein kinases 1/2 (ERK1/2) in DRG neurons. The effect of the activation of ERK1/2 by different concentrations of CAP on growth-associated protein 43 (GAP-43) expression and c...... hiện toàn bộ
Donepezil in a Narrow Concentration Range Augments Control and Impaired by Beta-Amyloid Peptide Hippocampal LTP in NMDAR-Independent Manner
Springer Science and Business Media LLC - Tập 32 - Trang 219-226 - 2011
Nadezhda A. Kapai, Julia V. Bukanova, Elena I. Solntseva, Vladimir G. Skrebitsky
Acetylcholinesterase (AChE) inhibitor donepezil is widely used for the treatment of Alzheimer’s disease (AD). The mechanisms of therapeutic effects of the drug are not well understood. The ability of donepezil to reverse a known pathogenic effect of β-amyloid peptide (Abeta), namely, the impairment of hippocampal long-term potentiation (LTP), was not studied yet. The goal of the present study was ...... hiện toàn bộ
Functional Coupling of G Proteins to Endothelin Receptors Is Ligand and Receptor Subtype Specific
Springer Science and Business Media LLC - Tập 20 - Trang 305-317 - 2000
Zurit Shraga-Levine, Mordechai Sokolovsky
1. The aims of the present study were (a) to determine the identity of the G proteins with which the endothelin receptor interacts and whether this interaction is subtype specific and (b) to determine whether agonist exposure can result in specific coupling between the endothelin receptor and G proteins. 2. Coupling between endothelin A (ETA) or endothelin B (ETB) receptors and G proteins was asse...... hiện toàn bộ
Erratum: Differential Somatostatin Receptor Subtype Expression in Human Normal Pineal Gland and Pineal Parenchymal Tumors
Springer Science and Business Media LLC - Tập 23 - Trang 875-876 - 2003
J. Champier, A. Jouvet, C. Rey, J. Guyotat, M. Fevre-Montange
Gender-Specific Steroid Metabolism in Neural Differentiation
Springer Science and Business Media LLC - Tập 17 - Trang 603-626 - 1997
John B. Hutchison
Effect of Inorganic and Organic Tin Compounds on ACh- and Voltage-Activated Na Currents
Springer Science and Business Media LLC - Tập 20 - Trang 591-604 - 2000
János Györi, Olexandr Platoshyn, David O. Carpenter, János Salánki
1. Inorganic tin and organotin compounds, occurring in aquatic ecosystems, are toxic and can cause behavioral abnormalities in living organisms. To determine the possible neuronal basis of these actions, the effects of both forms of Sn were studied on identified neurones of the mollusk, Lymnaea stagnalis L. 2. SnCl2 caused a dose-dependent decrease in the acetylcholine (Ach)-induced inward current...... hiện toàn bộ
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