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Abstract not submitted for online publication
Springer Science and Business Media LLC - - 2013
Telomere shortening and telomere position effect in mild ring 17 syndrome
Springer Science and Business Media LLC - Tập 7 - Trang 1-9 - 2014
Cecilia Surace, Francesco Berardinelli, Andrea Masotti, Maria Cristina Roberti, Letizia Da Sacco, Gemma D’Elia, Pietro Sirleto, Maria Cristina Digilio, Raffaella Cusmai, Simona Grotta, Stefano Petrocchi, May El Hachem, Elisa Pisaneschi, Laura Ciocca, Serena Russo, Francesca Romana Lepri, Antonella Sgura, Adriano Angioni
Ring chromosome 17 syndrome is a rare disease that arises from the breakage and reunion of the short and long arms of chromosome 17. Usually this abnormality results in deletion of genetic material, which explains the clinical features of the syndrome. Moreover, similar phenotypic features have been observed in cases with complete or partial loss of the telomeric repeats and conservation of the eu...... hiện toàn bộ
Sự tri-methyl hóa ATF7IP bởi G9a/GLP thu hút protein chromodomain MPP8 Dịch bởi AI
Springer Science and Business Media LLC - Tập 11 - Trang 1-16 - 2018
Takeshi Tsusaka, Masaki Kikuchi, Tadahiro Shimazu, Takehiro Suzuki, Yoshihiro Sohtome, Mai Akakabe, Mikiko Sodeoka, Naoshi Dohmae, Takashi Umehara, Yoichi Shinkai
G9a và enzyme liên quan GLP ban đầu được xác định là các histone lysine methyltransferases và sau đó được chỉ ra rằng cũng methyl hóa một số protein phi-histone khác. Ở đây, chúng tôi đã thực hiện một sàng lọc toàn diện để xác định các cơ chất của chúng trong tế bào gốc phôi chuột (mESCs). Chúng tôi đã xác định 59 protein, bao gồm histones và các cơ chất đã biết khác. Một trong những cơ chất được ...... hiện toàn bộ
#G9a #GLP #ATF7IP #methyl hóa lysine #tế bào gốc phôi chuột #SETDB1 #MPP8 #làm lặng tiếng gen
RNA:DNA hybrids in the human genome have distinctive nucleotide characteristics, chromatin composition, and transcriptional relationships
Springer Science and Business Media LLC - Tập 8 - Trang 1-19 - 2015
Julie Nadel, Rodoniki Athanasiadou, Christophe Lemetre, N. Ari Wijetunga, Pilib Ó Broin, Hanae Sato, Zhengdong Zhang, Jeffrey Jeddeloh, Cristina Montagna, Aaron Golden, Cathal Seoighe, John M. Greally
RNA:DNA hybrids represent a non-canonical nucleic acid structure that has been associated with a range of human diseases and potential transcriptional regulatory functions. Mapping of RNA:DNA hybrids in human cells reveals them to have a number of characteristics that give insights into their functions. We find RNA:DNA hybrids to occupy millions of base pairs in the human genome. A directional seq...... hiện toàn bộ
Locus-specific biochemical epigenetics/chromatin biochemistry by insertional chromatin immnoprecipitation (iChIP)
Springer Science and Business Media LLC - Tập 6 - Trang 1-2 - 2013
Toshitsugu Fujita, Hodaka Fujii
Establishment of regulatory elements during erythro-megakaryopoiesis identifies hematopoietic lineage-commitment points
Springer Science and Business Media LLC - Tập 11 Số 1 - 2018
Elisabeth F. Heuston, Cheryl A. Keller, Jens Lichtenberg, Belinda Giardine, Stacie M. Anderson, Ross C. Hardison, David M. Bodine
A novel methyl-binding domain protein enrichment method for identifying genome-wide tissue-specific DNA methylation from nanogram DNA samples
Springer Science and Business Media LLC - Tập 6 Số 1 - 2013
Verity F. Oliver, Jun Wan, Saurabh Agarwal, Donald J. Zack, Jiang Qian, Shannath L. Merbs
Abstract Background Growing evidence suggests that DNA methylation plays a role in tissue-specific differentiation. Current approaches to methylome analysis using enrichment with the methyl-binding domain protein (MBD) are restricted to large (≥1 μg) DNA samples, limiting the analysis of small ti...... hiện toàn bộ
How is epigenetic information maintained through DNA replication?
Springer Science and Business Media LLC - Tập 6 - Trang 1-7 - 2013
Varija N Budhavarapu, Myrriah Chavez, Jessica K Tyler
DNA replication is a highly conserved process that accurately copies the genetic information from one generation to the next. The processes of chromatin disassembly and reassembly during DNA replication also have to be precisely regulated to ensure that the genetic material is compactly packaged to fit into the nucleus while also maintaining the epigenetic information that is carried by the histon...... hiện toàn bộ
The histone chaperone DAXX maintains the structural organization of heterochromatin domains
Springer Science and Business Media LLC - Tập 8 - Trang 1-14 - 2015
Lindsy M. Rapkin, Kashif Ahmed, Stanimir Dulev, Ren Li, Hiroshi Kimura, Alexander M. Ishov, David P. Bazett-Jones
The death domain-associated protein (DAXX) collaborates with accessory proteins to deposit the histone variant H3.3 into mouse telomeric and pericentromeric repeat DNA. Pericentromeric repeats are the main genetic contributor to spatially discrete, compact, constitutive heterochromatic structures called chromocentres. Chromocentres are enriched in the H3K9me3 histone modification and serve as inte...... hiện toàn bộ
Profiling of chromatin accessibility and identification of general cis-regulatory mechanisms that control two ocular lens differentiation pathways
Springer Science and Business Media LLC - Tập 12 - Trang 1-23 - 2019
Yilin Zhao, Deyou Zheng, Ales Cvekl
Promoters and enhancers are cis-regulatory DNA sequences that control specificity and quantity of transcription. Both are rich on clusters of cis-acting sites that interact with sequence-specific DNA-binding transcription factors (TFs). At the level of chromatin, these regions display increased nuclease sensitivity, reduced nucleosome density, including nucleosome-free regions, and specific combin...... hiện toàn bộ
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