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Three-dimensional super-resolution microscopy of the inactive X chromosome territory reveals a collapse of its active nuclear compartment harboring distinct Xist RNA foci
Springer Science and Business Media LLC - Tập 7 - Trang 1-27 - 2014
Daniel Smeets, Yolanda Markaki, Volker J Schmid, Felix Kraus, Anna Tattermusch, Andrea Cerase, Michael Sterr, Susanne Fiedler, Justin Demmerle, Jens Popken, Heinrich Leonhardt, Neil Brockdorff, Thomas Cremer, Lothar Schermelleh, Marion Cremer
A Xist RNA decorated Barr body is the structural hallmark of the compacted inactive X territory in female mammals. Using super-resolution three-dimensional structured illumination microscopy (3D-SIM) and quantitative image analysis, we compared its ultrastructure with active chromosome territories (CTs) in human and mouse somatic cells, and explored the spatio-temporal process of Barr body formati... hiện toàn bộ
Activation of the alpha-globin gene expression correlates with dramatic upregulation of nearby non-globin genes and changes in local and large-scale chromatin spatial structure
Springer Science and Business Media LLC - Tập 10 - Trang 1-19 - 2017
Sergey V. Ulianov, Aleksandra A. Galitsyna, Ilya M. Flyamer, Arkadiy K. Golov, Ekaterina E. Khrameeva, Maxim V. Imakaev, Nezar A. Abdennur, Mikhail S. Gelfand, Alexey A. Gavrilov, Sergey V. Razin
In homeotherms, the alpha-globin gene clusters are located within permanently open genome regions enriched in housekeeping genes. Terminal erythroid differentiation results in dramatic upregulation of alpha-globin genes making their expression comparable to the rRNA transcriptional output. Little is known about the influence of the erythroid-specific alpha-globin gene transcription outburst on adj... hiện toàn bộ
A combined HM-PCR/SNuPE method for high sensitive detection of rare DNA methylation
Springer Science and Business Media LLC - Tập 3 - Trang 1-8 - 2010
Sascha Tierling, Matthias Schuster, Reimo Tetzner, Jörn Walter
DNA methylation changes are widely used as early molecular markers in cancer detection. Sensitive detection and classification of rare methylation changes in DNA extracted from circulating body fluids or complex tissue samples is crucial for the understanding of tumor etiology, clinical diagnosis and treatment. In this paper, we describe a combined method to monitor the presence of methylated tumo... hiện toàn bộ
Correlations between DNA methylation levels and nucleosome enrichment in the human genome
Springer Science and Business Media LLC - - 2013
Clayton K. Collings, J.C. Anderson
Molecular mechanism of the priming by jasmonic acid of specific dehydration stress response genes in Arabidopsis
Springer Science and Business Media LLC - Tập 9 Số 1 - 2016
Ning Liu, Zoya Avramova
A closer look into DNase I hypersensitivity
Springer Science and Business Media LLC - Tập 6 - Trang 1-1 - 2013
Housheng Hansen He, Clifford A Meyer, Henry Long, X Shirley Liu, Myles Brown
The fungus Neurospora crassa displays telomeric silencing mediated by multiple sirtuins and by methylation of histone H3 lysine 9
Springer Science and Business Media LLC - Tập 1 Số 1 - 2008
Kristina Smith, Gregory O. Kothe, Cindy Matsen, Tamir K. Khlafallah, Keyur K. Adhvaryu, Melissa Hemphill, Michael Freitag, Maryam Motamedi, Eric U. Selker
Abstract Background Silencing of genes inserted near telomeres provides a model to investigate the function of heterochromatin. We initiated a study of telomeric silencing in Neurospora crassa, a fungus that sports DNA methylation, unlike most other organisms in which telomeric silencing has been characterized. Results The selectable marker, hph, was inserted at the subtelomere of Linkage Group VR... hiện toàn bộ
Abstract not submitted for online publication
Springer Science and Business Media LLC - Tập 6 - Trang 1-1 - 2013
Application of dual reading domains as novel reagents in chromatin biology reveals a new H3K9me3 and H3K36me2/3 bivalent chromatin state
Springer Science and Business Media LLC - Tập 10 - Trang 1-19 - 2017
Rebekka Mauser, Goran Kungulovski, Corinna Keup, Richard Reinhardt, Albert Jeltsch
Histone post-translational modifications (PTMs) play central roles in chromatin-templated processes. Combinations of two or more histone PTMs form unique interfaces for readout and recruitment of chromatin interacting complexes, but the genome-wide mapping of coexisting histone PTMs remains an experimentally difficult task. We introduce here a novel type of affinity reagents consisting of two fuse... hiện toàn bộ
Histone H3.5 forms an unstable nucleosome and accumulates around transcription start sites in human testis
Springer Science and Business Media LLC - Tập 9 Số 1 - 2016
Takashi Urahama, Akihito Harada, Kazuhira Maehara, Naoki Horikoshi, Koichi Sato, Yuko Sato, Koji Shiraishi, Norihiro Sugino, Akihisa Osakabe, Hiroaki Tachiwana, Wataru Kagawa, Hiroshi Kimurâ, Yasuyuki Ohkawa, Hitoshi Kurumizaka
Tổng số: 639   
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