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Mechanisms of action of inhaled fibers, particles and nanoparticles in lung and cardiovascular diseases
Springer Science and Business Media LLC - Tập 4 - Trang 1-10 - 2007
Brooke T Mossman, Paul J Borm, Vincent Castranova, Daniel L Costa, Kenneth Donaldson, Steven R Kleeberger
A symposium on the mechanisms of action of inhaled airborne particulate matter (PM), pathogenic particles and fibers such as silica and asbestos, and nanomaterials, defined as synthetic particles or fibers less than 100 nm in diameter, was held on October 27 and 28, 2005, at the Environmental Protection Agency (EPA) Conference Center in Research Triangle Park, North Carolina. The meeting was the e... hiện toàn bộ
Tác động của kích thước MWCNT, carboxyl hóa và tinh chế đến độc tính, viêm nhiễm và bệnh lý phổi in vitro và in vivo Dịch bởi AI
Springer Science and Business Media LLC - - 2013
Raymond F. Hamilton, Zheqiong Wu, Somenath Mitra, Pamela Shaw, Andrij Holian
Tóm tắt Giới thiệu Nhiều tính chất của ống nanot carbon nhiều lớp (MWCNT) có khả năng ảnh hưởng đến hoạt tính sinh học của chúng. Nghiên cứu này đã xem xét các kết quả in vitro và in vivo của ảnh hưởng của đường kính, chiều dài, tinh chế và carboxyl hóa (chỉ thử nghiệm in vitro) của MWCNT. Phương pháp Ba loại MWCNT ‘nhận nguyên bản’ khác nhau về kích thước (đường kính và chiều dài) đã được tinh ch... hiện toàn bộ
#ống nanot carbon nhiều lớp #hoạt tính sinh học #độc tính #viêm nhiễm #carboxyl hóa #tinh chế
Role of oxidative stress on diesel-enhanced influenza infection in mice
Springer Science and Business Media LLC - Tập 7 - Trang 1-15 - 2010
Kymberly M Gowdy, Quentin T Krantz, Charly King, Elizabeth Boykin, Ilona Jaspers, William P Linak, M Ian Gilmour
Numerous studies have shown that air pollutants, including diesel exhaust (DE), reduce host defenses, resulting in decreased resistance to respiratory infections. This study sought to determine if DE exposure could affect the severity of an ongoing influenza infection in mice, and examine if this could be modulated with antioxidants. BALB/c mice were treated by oropharyngeal aspiration with 50 pla... hiện toàn bộ
Comparison of cellular toxicity caused by ambient ultrafine particles and engineered metal oxide nanoparticles
Springer Science and Business Media LLC - Tập 12 - Trang 1-12 - 2015
Senlin Lu, Wenchao Zhang, Rui Zhang, Pinwei Liu, Qiangxiang Wang, Yu Shang, Minghong Wu, Ken Donaldson, Qingyue Wang
The development of nanotechnology has spurred concerns about the health effects of exposure to nanoparticles (NPs) and ultrafine particles (UFPs). Toxicological data on NPs and UFPs may provide evidence to support the development of regulations to reduce the risk of particle exposure. We tried to provide fundamental data to determine differences in cytotoxicity induced by ambient UFPs and engineer... hiện toàn bộ
The pulmonary toxicity of carboxylated or aminated multi-walled carbon nanotubes in mice is determined by the prior purification method
Springer Science and Business Media LLC - Tập 17 - Trang 1-18 - 2020
Alexia J. Taylor-Just, Mark D. Ihrie, Katherine S. Duke, Ho Young Lee, Dorothy J. You, Salik Hussain, Vamsi K. Kodali, Christina Ziemann, Otto Creutzenberg, Adriana Vulpoi, Flaviu Turcu, Monica Potara, Milica Todea, Sybille van den Brule, Dominique Lison, James C. Bonner
Inhalation of multi-walled carbon nanotubes (MWCNTs) poses a potential risk to human health. In order to safeguard workers and consumers, the toxic properties of MWCNTs need to be identified. Functionalization has been shown to either decrease or increase MWCNT-related pulmonary injury, depending on the type of modification. We, therefore, investigated both acute and chronic pulmonary toxicity of ... hiện toàn bộ
Compositional and structural analysis of engineered stones and inorganic particles in silicotic nodules of exposed workers
Springer Science and Business Media LLC - Tập 18 - Trang 1-16 - 2021
Antonio León-Jiménez, José M. Mánuel, Marcial García-Rojo, Marina G. Pintado-Herrera, José Antonio López-López, Antonio Hidalgo-Molina, Rafael García, Pedro Muriel-Cueto, Nieves Maira-González, Daniel Del Castillo-Otero, Francisco M. Morales
Engineered stone silicosis is an emerging disease in many countries worldwide produced by the inhalation of respirable dust of engineered stone. This silicosis has a high incidence among young workers, with a short latency period and greater aggressiveness than silicosis caused by natural materials. Although the silica content is very high and this is the key factor, it has been postulated that ot... hiện toàn bộ
Circulatory metabolites trigger ex vivo arterial endothelial cell dysfunction in population chronically exposed to diesel exhaust
Springer Science and Business Media LLC - Tập 19 - Trang 1-14 - 2022
Wenting Cheng, Huanhuan Pang, Matthew J. Campen, Jianzhong Zhang, Yanting Li, Jinling Gao, Dunqiang Ren, Xiaoya Ji, Nathaniel Rothman, Qing Lan, Yuxin Zheng, Shuguang Leng, Zeping Hu, Jinglong Tang
Chronic exposure to diesel exhaust has a causal link to cardiovascular diseases in various environmental and occupational settings. Arterial endothelial cell function plays an important role in ensuring proper maintenance of cardiovascular homeostasis and the endothelial cell dysfunction by circulatory inflammation is a hallmark in cardiovascular diseases. Acute exposure to diesel exhaust in contr... hiện toàn bộ
Multi-walled carbon nanotubes induce human microvascular endothelial cellular effects in an alveolar-capillary co-culture with small airway epithelial cells
Springer Science and Business Media LLC - Tập 10 - Trang 1-14 - 2013
Brandi N Snyder-Talkington, Diane Schwegler-Berry, Vincent Castranova, Yong Qian, Nancy L Guo
Nanotechnology, particularly the use of multi-walled carbon nanotubes (MWCNT), is a rapidly growing discipline with implications for advancement in a variety of fields. A major route of exposure to MWCNT during both occupational and environmental contact is inhalation. While many studies showed adverse effects to the vascular endothelium upon MWCNT exposure, in vitro results often do not correlate... hiện toàn bộ
Controlled exposure to particulate matter from urban street air is associated with decreased vasodilation and heart rate variability in overweight and older adults
Springer Science and Business Media LLC - Tập 12 - Trang 1-10 - 2015
Jette G Hemmingsen, Jenny Rissler, Jens Lykkesfeldt, Gerd Sallsten, Jesper Kristiansen, Peter Møller P, Steffen Loft
Exposure to particulate matter (PM) is generally associated with elevated risk of cardiovascular morbidity and mortality. Elderly and obese subjects may be particularly susceptible, although short-term effects are poorly described. Sixty healthy subjects (25 males, 35 females, age 55 to 83 years, body mass index > 25 kg/m2) were included in a cross-over study with 5 hours of exposure to particle- ... hiện toàn bộ
Putative adverse outcome pathways for silver nanoparticle toxicity on mammalian male reproductive system: a literature review
Springer Science and Business Media LLC - Tập 20 - Trang 1-23 - 2023
Ozge Kose, Paride Mantecca, Anna Costa, Marie Carrière
Adverse outcome pathways (AOPs) are conceptual frameworks that organize knowledge about biological interactions and toxicity mechanisms. They present a sequence of events commencing with initial interaction(s) of a stressor, which defines the perturbation in a biological system (molecular initiating event, MIE), and a dependent series of key events (KEs), ending with an adverse outcome (AO). AOPs ... hiện toàn bộ
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