Tác động của kích thước MWCNT, carboxyl hóa và tinh chế đến độc tính, viêm nhiễm và bệnh lý phổi in vitro và in vivo
Tóm tắt
Nhiều tính chất của ống nanot carbon nhiều lớp (MWCNT) có khả năng ảnh hưởng đến hoạt tính sinh học của chúng. Nghiên cứu này đã xem xét các kết quả
Ba loại MWCNT ‘nhận nguyên bản’ khác nhau về kích thước (đường kính và chiều dài) đã được tinh chế và chức năng hóa bằng cách carboxyl hóa. Các MWCNT thu được đã được đặc trưng và kiểm tra tính độc tế bào cũng như sự kích hoạt inflammasome
Các nghiên cứu với đại thực bào THP-1 cho thấy rằng chiều dài hoặc đường kính lớn hơn tương ứng với hoạt tính sinh học tăng lên như đã đo bằng sự kích hoạt inflammasome. Việc tinh chế không ảnh hưởng nhiều đến các MWCNT nguyên bản, và quá trình chức năng hóa đã hoàn toàn loại bỏ hoạt tính sinh học. Kết quả tương tự cũng thu được khi sử dụng đại thực bào phế nang tách biệt từ chuột C57BL/6. Các nghiên cứu
Từ khóa
#ống nanot carbon nhiều lớp #hoạt tính sinh học #độc tính #viêm nhiễm #carboxyl hóa #tinh chếTài liệu tham khảo
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