The Involution of the Ageing Human Thymic Epithelium is Independent of Puberty Tập 22 Số 5 - Trang 563-575 - 1985
Gerhard Steinmann, Beate Klaus, H. K. Müller-Hermelink
One hundred and thiriy‐six thymuses completely removed; il autopsy from persons suffering a sudden death were examined by stereological and morphomelrical meihods. Adding biopsy material from immunologically healthy cardiac patients we obtained relative volumes from 204 persons ranging in age from 1 month to 107 years. The size of the human thymus remains unchanged during ageing under norm...... hiện toàn bộ
Mesenchymal Stem Cells Inhibit the Expression of CD25 (Interleukin‐2 Receptor) and CD38 on Phytohaemagglutinin‐Activated Lymphocytes Tập 60 Số 3 - Trang 307-315 - 2004
Katarina Le Blanc, Ida Rasmusson, Cecilia Götherström, Catharina D. Seidel, Berit Sundberg, Mikael Sundin, Ingvar Rosendahl, Charlotte Tammik, Olle Ringdén
AbstractMesenchymal stem cells (MSC) are immunomodulatory and inhibit lymphocyte proliferation. We studied surface expression of lymphocyte activation markers and secreted cytokines, when lymphocytes were activated in the presence of MSC. MSC suppressed the proliferation of phytohaemagglutinin (PHA)‐stimulated CD3+, CD4+ an...... hiện toàn bộ
Endotoxin‐Stimulated Human Monocyte Secretion of Interleukin 1, Tumour Necrosis Factor Alpha, and Prostaglandin E2 Shows Stable Interindividual Differences Tập 27 Số 6 - Trang 705-716 - 1988
Jens Mølvig, L. Bæk, Preben Christensen, Kirk R. Manogue, Helen Vlassara, P. Platz, Lene Nielsen, A. Svejgaard, Jørn Nerup
The secretions of interleukin 1 (IL‐1), tumour necrosis factor α (TNF), and prostaglandin E2 (PGE2) of low‐dose E. coli lipopolysaccharide (LPSJ‐stimulated human monocytes (Mø) were investigated in an endotoxin (ET)‐free milieu (<1.6 pg LPS/ml). Human Mø cultures from nine healthy men were stimulated with 0, 12.5–500, ...... hiện toàn bộ
T Lymphocytes in Collagen II‐Induced Arthritis in Mice Tập 22 Số 3 - Trang 295-306 - 1985
Rikard Holmdahl, Lars Klareskog, Kristofer Rubin, E Larsson, Hans Wigzell
Collagen type II‐spedfic long‐term cultured T helper cells, derived from the DBA/1 mouse, have been established and characterized. Clones from these T‐cell lines could he shown to recognize either species‐specific or species‐nonspecific determinants on the collagen type II molecule, including determinants on autologous mouse collagen. Induction of arthritis via transfer to both irradiated ...... hiện toàn bộ
The Antigens of Mycobacterium bovis, Strain BCG, Studied by Crossed Immunoelectrophoresis: a Reference System Tập 12 Số 3 - Trang 249-263 - 1980
O Closs, M Harboe, N. H. Axelsen, K. Bunch‐Christensen, M Magnusson
A reference system for the soluble antigen of Mycobacterium bovis, strain BCG is described. The system is based on crossed immunoelectrophoresis with intermediate gel. A Commercially available immunoglobulin preparation made from rabbit anti‐BCG hyperimmune serum was used as reference antibodies, while a concentrated BCG culture filtrate was used as reference ant...... hiện toàn bộ