T Lymphocytes in Collagen II‐Induced Arthritis in Mice

Scandinavian Journal of Immunology - Tập 22 Số 3 - Trang 295-306 - 1985
Rikard Holmdahl1, Lars Klareskog1, Kristofer Rubin1, E Larsson1, Hans Wigzell1
1Department of Medical and Physiological Chemistry, Biomedical Center, and Department of Pathology, University of Uppsala, Uppsala, and Department of Immunology, Karolinska Institute, Stockholm, Sweden

Tóm tắt

Collagen type II‐spedfic long‐term cultured T helper cells, derived from the DBA/1 mouse, have been established and characterized. Clones from these T‐cell lines could he shown to recognize either species‐specific or species‐nonspecific determinants on the collagen type II molecule, including determinants on autologous mouse collagen. Induction of arthritis via transfer to both irradiated and normal syngeneic recipient mice was obtained with both collagen type II‐specific T‐cell lines and an autoreactive and collagen type II‐specific T‐cell clone. Fewer cells were needed to evoke arthritis in normal than in irradiated recipients. Cells from lines and the clone used for transfer were by immunocytochemistry shown to have T helper phenotype.

Từ khóa


Tài liệu tham khảo

Ben Nun A., 1982, Experimental autoimmune encephalomyelitis (EAE) mediated by T cell lines: process of selection of lines and characterizations of the cells, J. Immunol., 129, 303, 10.4049/jimmunol.129.1.303

10.1126/science.183.4130.1200

10.1038/283666a0

10.1111/j.1600-065X.1982.tb00426.x

10.1016/S0022-2836(66)80106-7

10.1159/000229438

10.1016/0090-1229(84)90092-8

10.1111/j.1365-3083.1985.tb01421.x

10.1172/JCI111193

10.1126/science.6336851

10.1177/29.4.6166661

Rang A.H., 1976, Handbook of Biochemistry and Molecular Biology

10.1093/ajcp/63.3.451

10.1016/0022-1759(83)90386-1

Klareskog L., 1983, Role of T‐lymphocytes in collagen II induced arthritis in rats, Clin. exp. Immunol., 51, 117

10.1021/bi00776a005

Nowack H., 1975, Specificity of the antibody response in inbred mice to bovine type I and type II collagen, Immunology, 29, 621

10.3181/00379727-91-22179

Rosenwasser L.F., 1980, Genetic control of the murine T lymphocyte proliferate response to collagen: analysis of the molecular and cellular contributions to immunogenicity, J. Immunol., 124, 2854, 10.4049/jimmunol.124.6.2854

10.1016/0003-9861(75)90378-1

10.1084/jem.158.2.378

10.1172/JCI110495

10.1016/0008-8749(83)90325-8

10.1172/JCI109136

10.1084/jem.146.3.857

10.1172/JCI108929

10.1111/j.1432-1033.1982.tb05905.x

10.1084/jem.154.3.688

Thông tin
Thông tin xuất bản

Scandinavian Journal of Immunology

Tập 22 Số 3

295-306

Thông tin tác giả