Scandinavian Journal of Immunology

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Preferential Expression of VH5 and VH6 Immunoglobulin Genes in Early Human B‐Cell Ontogeny
Scandinavian Journal of Immunology - Tập 30 Số 4 - Trang 493-497 - 1989
Anne‐Marie Cuisinier, V. Guigou, L. Boubli, M. Fougereau, Cécile Tonnelle
Analysis of Ig transcripts by dot blot hybridization revealed that VH5 and VH6 RNA first occurred during the 7th week of gestation in human fetal liver. At the same time, a Cλ or Cλ‐like chain was also expressed, in the absence of detectable K chains. In adult B cells, VH3 appears to be the dominant f...... hiện toàn bộ
Naïve Donor Responses to Schistosoma mansoni Soluble Egg Antigens
Scandinavian Journal of Immunology - Tập 66 Số 6 - Trang 662-670 - 2007
Edna Afonso Reis, T. M. Azevedo, Alan J. A. McBride, Donald A. Harn, Mitermayer Galvão dos Reis
AbstractSchistosome infection induces profound Th‐biasing and immune suppression. Although much has been examined in mice, few studies have examined responses of naïve humans to schistosome antigens. In this study, we examined the response of naïve human peripheral blood mononuclear cells (nPBMC) to stimulation with Schistosoma mansoni so...... hiện toàn bộ
Spiegelmer Inhibition of MCP‐1/CCR2 – Potential as an Adjunct Immunosuppressive Therapy in Transplantation
Scandinavian Journal of Immunology - Tập 82 Số 2 - Trang 102-109 - 2015
Aivars Kalnins, Michael Thomas, M. Andrassy, Sebastian Müller, Alexandra Wagner, Sebastian Pratschke, Markus Rentsch, JP Klußmann, Teresa Kauke, Martin K. Angele, Alexandr V. Bazhin, Michael Fischereder, Jens Werner, Markus Guba, Joachim Andrassy
AbstractThe rejection process remains the key unsolved issue after transplantation of disparate tissue. The CC chemokine monocyte chemoattractant protein‐1 (MCP‐1/CCL2) has been reported to be involved in the process of alloimmune interaction. Spiegelmers are l‐oligonucleotides that can be designed to bind to pharmacologically relevant target mol...... hiện toàn bộ
A Common Epitope Identified by a Monoclonal Antibody, MID 2, Present on All Leucocytes and Associated with a Group of High Molecular Weight Glycopeptides
Scandinavian Journal of Immunology - Tập 19 Số 1 - Trang 11-21 - 1984
J. Paul Banga, Gabriella Guarnotta, A. Harte, Gareth Pryce, Mary E. Campbell, Ruby Quartey‐Papafio, Peter M. Lydyard, Ivan M. Roitt
A monoclonal antibody, MID 2, which reacts with an epitope common to all human leucocytes, was used to show that the leucocyte common antigen can be resolved into four glycoprotein components with molecular weights of 220 K. 200 K, 180 K and 160 K. The 200, 180 and 160 K peptides were all present to various extents in the T and B lymphoblastoid cell lines examined, but the 220 K component ...... hiện toàn bộ
Sharing of Ia Antigens between Species
Scandinavian Journal of Immunology - Tập 10 Số 5 - Trang 403-413 - 1979
Joan K. Lunney, Dean Mann, David H. Sachs
Certain mouse alloantisera have been found to detect immunologic cross‐reactions between human and murine Ia antigens. Almost every anti‐Iaa, ‐Iak and ‐Iad serum tested exhibited such cross‐reactions. Sera prepared against the products of limited segments of the mouse I region and tested on human B cells revealed that anti‐I‐E/...... hiện toàn bộ
Experimental Infections of Rana esculenta with Aeromonas hydrophila: A Molecular Mechanism for the Control of the Normal Flora
Scandinavian Journal of Immunology - Tập 48 Số 4 - Trang 357-363 - 1998
Simmaco, Maria Luisa Mangoni, Boman, Barra
Frogs can be useful models for studying the mechanisms that may regulate their natural microbial flora. Their skin glands produce a secretion containing 20–30 different peptides, some antimicrobial some neurotrophic. As they often live in soil or silt that is rich in microbes, they can be expected to be able to prevent or eliminate infections in very short peroids of time. The bacterium ... hiện toàn bộ
Two Nuclear Dot‐Associated Proteins, PML and SplOO, are Often Co‐Autoimmunogenic in Patients with Primary Biliary Cirrhosis
Scandinavian Journal of Immunology - Tập 42 Số 2 - Trang 257-268 - 1995
Thomas Sternsdorf, H H Guldner, Carin Szostecki, Thilo Grötzinger, Hans Will
The nucleoproteins Sp100 and PML, the first an autoantigen predominant in patients with primary biliary cirrhosis (PBC) and the second a transformation and cell growth suppressing protein aberrantly expressed in promyelocytic leukaemia ceils, were recently shown to colocalize in dot‐like nuclear domains. Here we analysed whether PML, like Sp100, is also an autoantigen in patients with PBC ...... hiện toàn bộ
Autoantibodies to the Nuclear Sp100 Protein in Primary Biliary Cirrhosis and Associated Diseases: Epitope Specificity and Immunoglobulin Class Distribution
Scandinavian Journal of Immunology - Tập 36 Số 4 - Trang 555-564 - 1992
Carin Szostecki, Hans Will, Hans Netter, H H Guldner
Sp100, a protein with a dot‐like intranuclear localization in immunofluorescence microscopy, is a major target for patient autoantibodies in primary biliary cirrhosis (PBC) and occasionally in rheumatic disorders. The human Sp 100 cDNA has recently been cloned, and the deduced amino acid sequence was found to contain sequence similarities with an MHC class I domain and several transacting ...... hiện toàn bộ
Induction of Natural Killer Cell Activity and Allocytotoxicity in Human Peripheral Blood Lymphocytes after Mixed Lymphocyte Culture
Scandinavian Journal of Immunology - Tập 13 Số 5 - Trang 401-412 - 1981
R. L. H. Bolhuis, Huub Schellekens
The k‐562 tumour cell is a highly susceptible target for natural killer (NK) cell lysis by lymphocytes of human peripheral blood. We have studied the antigenic relationship between the recognition sites for lysis or lymphoid and various tumour target cell by cytolytic T lymphocytes (CTL) and NK cells induced in mixed lymphocyte cultures (MLC). The characteristics of these two effector cell...... hiện toàn bộ
Chloroquine Enhances the Number of IL‐10 Producing Cells and the Expression of B7‐2 and ICAM‐1 in In Vitro‐Cultured PBMC
Scandinavian Journal of Immunology - Tập 55 Số 4 - Trang 399-408 - 2002
Elisabeth Hugosson, Anders Björkman, Marita Troye‐Blomberg
Chloroquine is prescribed as both an anti‐malarial and an anti‐inflammatory drug. However, its immuno‐modulating effects remain largely unclear. Previous studies have shown that chloroquine inhibits antigen‐induced proliferation, implying immuno‐suppressive effects. In this study, we examined whether the inhibition of the proliferation reflects changes in the surface molecules that are imp...... hiện toàn bộ
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