Scandinavian Journal of Immunology
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Preferential Expression of VH5 and VH6 Immunoglobulin Genes in Early Human B‐Cell Ontogeny
Scandinavian Journal of Immunology - Tập 30 Số 4 - Trang 493-497 - 1989
Analysis of Ig transcripts by dot blot hybridization revealed that VH5 and VH6
RNA first occurred during the 7th week of gestation in human fetal liver. At the
same time, a Cλ or Cλ‐like chain was also expressed, in the absence of
detectable K chains. In adult B cells, VH3 appears to be the dominant family
expressed. Because VH5 and VH6 were located as the most proximal V genes to the
JH cluster, ...
Naïve Donor Responses to Schistosoma mansoni Soluble Egg Antigens
Scandinavian Journal of Immunology - Tập 66 Số 6 - Trang 662-670 - 2007
AbstractSchistosome infection induces profound Th‐biasing and immune
suppression. Although much has been examined in mice, few studies have examined
responses of naïve humans to schistosome antigens. In this study, we examined
the response of naïve human peripheral blood mononuclear cells (nPBMC) to
stimulation with Schistosoma mansoni soluble egg antigen (SEA) using a priming
in vitro (PIV) assay...
Spiegelmer Inhibition of MCP‐1/CCR2 – Potential as an Adjunct Immunosuppressive Therapy in Transplantation
Scandinavian Journal of Immunology - Tập 82 Số 2 - Trang 102-109 - 2015
AbstractThe rejection process remains the key unsolved issue after
transplantation of disparate tissue. The CC chemokine monocyte chemoattractant
protein‐1 (MCP‐1/CCL2) has been reported to be involved in the process of
alloimmune interaction. Spiegelmers are l‐oligonucleotides that can be designed
to bind to pharmacologically relevant target molecules. Here, we tested a
high‐affinity Spiegelmer‐b...
A Common Epitope Identified by a Monoclonal Antibody, MID 2, Present on All Leucocytes and Associated with a Group of High Molecular Weight Glycopeptides
Scandinavian Journal of Immunology - Tập 19 Số 1 - Trang 11-21 - 1984
A monoclonal antibody, MID 2, which reacts with an epitope common to all human
leucocytes, was used to show that the leucocyte common antigen can be resolved
into four glycoprotein components with molecular weights of 220 K. 200 K, 180 K
and 160 K. The 200, 180 and 160 K peptides were all present to various extents
in the T and B lymphoblastoid cell lines examined, but the 220 K component was
only...
Sharing of Ia Antigens between Species
Scandinavian Journal of Immunology - Tập 10 Số 5 - Trang 403-413 - 1979
Certain mouse alloantisera have been found to detect immunologic cross‐reactions
between human and murine Ia antigens. Almost every anti‐Iaa, ‐Iak and ‐Iad serum
tested exhibited such cross‐reactions. Sera prepared against the products of
limited segments of the mouse I region and tested on human B cells revealed that
anti‐I‐E/Ck cross‐reactions were more readily detectable than anti‐I‐A,B,Jk
cros...
Experimental Infections of Rana esculenta with Aeromonas hydrophila: A Molecular Mechanism for the Control of the Normal Flora
Scandinavian Journal of Immunology - Tập 48 Số 4 - Trang 357-363 - 1998
Frogs can be useful models for studying the mechanisms that may regulate their
natural microbial flora. Their skin glands produce a secretion containing 20–30
different peptides, some antimicrobial some neurotrophic. As they often live in
soil or silt that is rich in microbes, they can be expected to be able to
prevent or eliminate infections in very short peroids of time. The bacterium
Aeromonas ...
Two Nuclear Dot‐Associated Proteins, PML and SplOO, are Often Co‐Autoimmunogenic in Patients with Primary Biliary Cirrhosis
Scandinavian Journal of Immunology - Tập 42 Số 2 - Trang 257-268 - 1995
The nucleoproteins Sp100 and PML, the first an autoantigen predominant in
patients with primary biliary cirrhosis (PBC) and the second a transformation
and cell growth suppressing protein aberrantly expressed in promyelocytic
leukaemia ceils, were recently shown to colocalize in dot‐like nuclear domains.
Here we analysed whether PML, like Sp100, is also an autoantigen in patients
with PBC and othe...
Autoantibodies to the Nuclear Sp100 Protein in Primary Biliary Cirrhosis and Associated Diseases: Epitope Specificity and Immunoglobulin Class Distribution
Scandinavian Journal of Immunology - Tập 36 Số 4 - Trang 555-564 - 1992
Sp100, a protein with a dot‐like intranuclear localization in immunofluorescence
microscopy, is a major target for patient autoantibodies in primary biliary
cirrhosis (PBC) and occasionally in rheumatic disorders. The human Sp 100 cDNA
has recently been cloned, and the deduced amino acid sequence was found to
contain sequence similarities with an MHC class I domain and several transacting
regulato...
Induction of Natural Killer Cell Activity and Allocytotoxicity in Human Peripheral Blood Lymphocytes after Mixed Lymphocyte Culture
Scandinavian Journal of Immunology - Tập 13 Số 5 - Trang 401-412 - 1981
The k‐562 tumour cell is a highly susceptible target for natural killer (NK)
cell lysis by lymphocytes of human peripheral blood. We have studied the
antigenic relationship between the recognition sites for lysis or lymphoid and
various tumour target cell by cytolytic T lymphocytes (CTL) and NK cells induced
in mixed lymphocyte cultures (MLC). The characteristics of these two effector
cell types h...
Chloroquine Enhances the Number of IL‐10 Producing Cells and the Expression of B7‐2 and ICAM‐1 in In Vitro‐Cultured PBMC
Scandinavian Journal of Immunology - Tập 55 Số 4 - Trang 399-408 - 2002
Chloroquine is prescribed as both an anti‐malarial and an anti‐inflammatory
drug. However, its immuno‐modulating effects remain largely unclear. Previous
studies have shown that chloroquine inhibits antigen‐induced proliferation,
implying immuno‐suppressive effects. In this study, we examined whether the
inhibition of the proliferation reflects changes in the surface molecules that
are important f...
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