Preferential Expression of VH5 and VH6 Immunoglobulin Genes in Early Human B‐Cell Ontogeny

Scandinavian Journal of Immunology - Tập 30 Số 4 - Trang 493-497 - 1989
Anne‐Marie Cuisinier1, V. Guigou1, L. Boubli1, M. Fougereau1, Cécile Tonnelle1
1Centre d'Immunologie de Marseille-Luminy, Marseilles, and Hôpital de la Conception Marseilles, France

Tóm tắt

Analysis of Ig transcripts by dot blot hybridization revealed that VH5 and VH6 RNA first occurred during the 7th week of gestation in human fetal liver. At the same time, a Cλ or Cλ‐like chain was also expressed, in the absence of detectable K chains. In adult B cells, VH3 appears to be the dominant family expressed. Because VH5 and VH6 were located as the most proximal V genes to the JH cluster, the orderly expression of human VH genes seems to resemble the situation reported for the mouse.

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Tài liệu tham khảo

10.1111/j.1600-065X.1986.tb01470.x

10.1111/j.1432-1033.1980.tb06030.x

10.1002/j.1460-2075.1988.tb02869.x

10.1002/eji.1830181130

10.1089/dna.1983.2.329

10.1084/jem.163.2.425

10.1073/pnas.84.24.9074

10.1016/0003-2697(83)90418-9

10.1002/eji.1830071112

10.1016/0092-8674(80)90168-3

10.1038/331446a0

10.1093/nar/13.18.6515

10.1093/nar/12.18.6995

10.1093/nar/13.18.6499

10.1038/309073a0

10.1016/0022-2836(86)90239-1

Kudo A., 1987, Organization of the murine Ig‐related λ5 gene transcribed selectively in pre‐B lymphocytes, EMBO J., 6, 103, 10.1002/j.1460-2075.1987.tb04725.x

10.1038/300760a0

10.1126/science.3975629

10.1126/science.3118465

10.1073/pnas.85.21.8196

10.1038/311727a0

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Thông tin xuất bản

Scandinavian Journal of Immunology

Tập 30 Số 4

493-497

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