Russian Journal of Genetics

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Genetic Homogeneity of the Population of Male Rhesus Macaques by the Polymorphisms of Genes oprm1, npy, maoa, crh, 5-htt as Determined by Cluster Analysis of Blood Count Data
Russian Journal of Genetics - - 2022
L. E. Pavlova, Al. V. Panchenko, M. F. Timina, T. E. Gvozdik, V. V. Kovalenko, A. A. Agumava, An. V. Panchenko
Genetic heterogeneity of the population used in the experimental studies with living organisms as model objects is one of the reasons for the poor replicability of the results. Nonhuman primates represent the phylogenetically closest model to humans and it is possible to use it in the studies of genetic basis of diseases with a hereditary predisposition. However, primates represent a population th...... hiện toàn bộ
Genetic Archeological Perspective on the Origin of Yakuts
Russian Journal of Genetics - Tập 40 - Trang 450-453 - 2004
I. P. Gouriev
Published data on two cases of linkage disequilibrium in Yakuts are analyzed. These are the disequilibria between loci HLA-A and HLA-Band between the mutation of gene SCA1 responsible for type 1 spinocerebellar ataxia and its flanking microsatellites D6S274 andD6S89. Both cases are regarded as consequences of the founder effect. The genetic archeological approach has been used to calculate the his...... hiện toàn bộ
Expression of Carotenoid Biosynthesis Genes during the Long-Term Cold Storage of Potato Tubers
Russian Journal of Genetics - - 2023
А. В. Кулакова, А. В. Щенникова, Е. З. Кочиева
Epigenetic silencing of genomic structural variations
Russian Journal of Genetics - Tập 53 - Trang 1072-1079 - 2017
N. A. Skryabin, S. A. Vasilyev, I. N. Lebedev
A great amount of copy number variations (CNVs) are identified in the human genome. Most of them are neutral; nevertheless, the role of CNVs in the pathogenesis of hereditary diseases is still significant. Especially, this is important for neuropsychiatric disorders, such as intellectual disability and autism. When analyzing the CNV-associated diseases, the controversial question is to distinguish...... hiện toàn bộ
The intrinsic antibiotic resistance to β-lactams, macrolides, and fluoroquinolones of mycobacteria is mediated by the whiB7 and tap genes
Russian Journal of Genetics - Tập 53 - Trang 1006-1015 - 2017
K. V. Shur, D. A. Maslov, N. E. Mikheecheva, N. I. Akimova, O. B. Bekker, V. N. Danilenko
The M. tuberculosis resistome includes a number of genes involved in intrinsic drug resistance. One of the major members of this system is the whiB7 gene encoding a transcription factor, which regulates expression of a number of genes—its regulon. In this study, we analyze the impact on intrinsic drug resistance levels of the whiB7 and tap genes and their prevalent mutants. The mutations found wit...... hiện toàn bộ
Các hiện tượng epimutations của các gen được ghi dấu trong bộ gen người: Phân loại, nguyên nhân và mối liên hệ với bệnh lý di truyền Dịch bởi AI
Russian Journal of Genetics - Tập 44 - Trang 1176-1190 - 2008
I. N. Lebedev, E. A. Sazhenova
Ghi dấu gen là một hiện tượng di truyền biểu hiện phụ thuộc vào nguồn gốc di truyền, được đặc trưng bởi sự biểu hiện đơn bội của các gen. Cơ sở phân tử của sự biểu hiện này là các sửa đổi cộng hóa trị của DNA và histon được hình thành trong quá trình trưởng thành của các tế bào dòng sinh dục. Những bất thường trong việc thiết lập ghi dấu gen trong quá trình tạo giao tử hoặc duy trì ghi dấu ở các g...... hiện toàn bộ
#Ghi dấu gen #epimutations #methyl hóa DNA #bệnh lý di truyền #di truyền học.
Allelic variants of polymorphic genes associated with a higher frequency of chromosome aberrations
Russian Journal of Genetics - Tập 47 - Trang 1364-1371 - 2011
L. E. Sal’nikova, A. G. Chumachenko, N. Sh. Lapteva, I. N. Vesnina, G. I. Kuznetsova, A. V. Rubanovich
Genotypic associations were studied for the frequency of chromosome aberrations in human peripheral blood lymphocytes. Cytogenetic analysis (1000 metaphase plate per individual) and genotyping at 19 sites of genes involved in detoxification and DNA repair were performed in a sample of 83 Chernobyl liquidators and a matched control sample of 96 volunteers. In either sample, the frequency of chromos...... hiện toàn bộ
Analysis of the α-synuclein gene dosage variation associated with autosomal dominant form of Parkinson’s disease
Russian Journal of Genetics - Tập 45 - Trang 504-506 - 2009
E. V. Semenova, M. I. Shadrina, P. A. Slominsky, S. N. Illarioshkin, G. Kh. Bagyeva, A. V. Karabanov, I. A. Ivanova-Smolenskaia, S. A. Limborska
Fifty-two patients that had Parkinson’s disease with autosomal dominant type of inheritance were analyzed for the presence of duplications and triplications in exons 4–6 of α-synuclein gene using real-time PCR with TaqMan probes. No mutations involving the examined exons dosage were revealed in α-synuclein gene. Thus, mutations modifying copy number of α-synuclein gene do not significantly affect ...... hiện toàn bộ
RAPD Analysis of the Genome in Species of the Genus Hordeum
Russian Journal of Genetics - Tập 37 - Trang 905-910 - 2001
E. Z. Kochieva, S. V. Goryunova, A. A. Pomortsev
Random amplification of polymorphic DNA (RAPD) was used to analyze six species, three populations, and seven regional cultivars of barley. A unique pattern of amplified DNA products was obtained for each species of the genus Hordeum.High polymorphism of barley species was revealed. Specific fragments were found in most RAPD patterns; the fragments can be used as molecular markers of corresponding ...... hiện toàn bộ
Two novel meiotic restitution mechanisms in haploid maize (Zea mays L.)
Russian Journal of Genetics - Tập 47 - Trang 438-445 - 2011
N. V. Shamina, O. A. Shatskaya
Two original mechanisms of nuclear restitution related to different processes of meiotic division of pollen mother cells (PMCs) have been found in male meiosis of the lines of maize haploids no. 2903 and no. 2904. The first mechanism, which is characteristic of haploid no. 2903, consists in spindle deformation (bend) in the conventional metaphase-anaphase I. This leads to asymmetric incomplete cyt...... hiện toàn bộ
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