Oxidative Medicine and Cellular Longevity

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Melatonin Ameliorates Valproic Acid‐Induced Neurogenesis Impairment: The Role of Oxidative Stress in Adult Rats
Oxidative Medicine and Cellular Longevity - Tập 2021 Số 1 - 2021
Anusara Aranarochana, Apiwat Sirichoat, Wanassanun Pannangrong, Peter Wigmore, Jariya Umka Welbat
Background. Valproic acid (anticonvulsant medication) has been found to inhibit histone deacetylase activity and suppress hippocampal neurogenesis, which causes memory impairment in both humans and rodents. The neurohormone melatonin, which regulates mammalian seasonal and circadian physiology, has recently been shown to have neuroprotective properties, counterac...... hiện toàn bộ
[Retracted] Protective Effect of D‐Limonene against Oxidative Stress‐Induced Cell Damage in Human Lens Epithelial Cells via the p38 Pathway
Oxidative Medicine and Cellular Longevity - Tập 2016 Số 1 - 2016
Jie Bai, Yi Zheng, Gang Wang, Ping Liu
Oxidative stress, as mediated by ROS, is a significant factor in initiating the development of age‐associated cataracts; D‐limonene is a common natural terpene with powerful antioxidative properties which occurs naturally in a wide variety of living organisms. It has been shown to have antioxidant effect; we found that D‐limonene can effectively prevent the oxidative damage caused by H... hiện toàn bộ
Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease
Oxidative Medicine and Cellular Longevity - Tập 2016 Số 1 - 2016
Sentiljana Gumeni, Ioannis P. Trougakos
Mitochondria are highly dynamic organelles that provide essential metabolic functions and represent the major bioenergetic hub of eukaryotic cell. Therefore, maintenance of mitochondria activity is necessary for the proper cellular function and survival. To this end, several mechanisms that act at different levels and time points have been developed to ensure mitochondria quality control. ...... hiện toàn bộ
The Protective Effects of Melatonin on Aluminum-Induced Hepatotoxicity and Nephrotoxicity in Rats
Oxidative Medicine and Cellular Longevity - Tập 2020 - Trang 1-12 - 2020
Mohamed S. Othman, Mohamed A. Fareid, Reda S. Abdel Hameed, Ahmed E. Abdel Moneim
Aluminum (Al) is a ubiquitous element with known toxicity for both humans and animals. Herein, we aimed to investigate the potential role of melatonin (MEL) in hepatotoxicity and nephrotoxicity following aluminum chloride (AlCl3) treatment in rats. Adult male rats were treated with AlCl3 (34 mg/kg bwt) for eight weeks. Exposure to AlCl3 enhanced the serum activities of the liver transamina...... hiện toàn bộ
Antioxidant and Vasodilator Activity of Ugni molinae Turcz. (Murtilla) and Its Modulatory Mechanism in Hypotensive Response
Oxidative Medicine and Cellular Longevity - Tập 2016 Số 1 - 2016
Ignacio Jofré, Cesar Pezoa, Magdalena E. Cuevas, Erick Scheuermann, Irlan Almeida Freires, Pedro Luiz Rosalen, Severino Matias de Alencar, Fernando Romero
Hypertension is a systemic condition with high morbidity and mortality rates worldwide, which poses an increased risk for cardiovascular diseases. In this study, we demonstrated the antioxidant and vasodilator activity of Ugni molinae Turcz. (Murtilla) fruit, a berry native to Chile and proposed models to explain its modulatory mechanism in hypotensive response. ...... hiện toàn bộ
Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox?
Oxidative Medicine and Cellular Longevity - Tập 2016 Số 1 - 2016
Subrata Kumar Biswas
Oxidative stress has been implicated in many chronic diseases. However, antioxidant trials are so far largely unsuccessful as a preventive or curative measure. Chronic low‐grade inflammatory process, on the other hand, plays a central role in the pathogenesis of a number of chronic diseases. Oxidative stress and inflammation are closely related pathophysiological processes, one of which ca...... hiện toàn bộ
The Signaling of Cellular Senescence in Diabetic Nephropathy
Oxidative Medicine and Cellular Longevity - Tập 2019 - Trang 1-16 - 2019
Yabing Xiong, Lili Zhou
Diabetic nephropathy is the leading cause of chronic kidney disease (CKD) in western countries. Notably, it has a rapidly rising prevalence in China. The patients, commonly complicated with cardiovascular diseases and neurologic disorders, are at high risk to progress into end-stage renal disease (ESRD) and death. However, the pathogenic mechanisms of diabetic nephropathy have not been det...... hiện toàn bộ
Metforminium Decavanadate as a Potential Metallopharmaceutical Drug for the Treatment of Diabetes Mellitus
Oxidative Medicine and Cellular Longevity - Tập 2016 Số 1 - 2016
Samuel Treviño, Denisse Velázquez-Vázquez, Eduardo Sánchez‐Lara, Alfonso Díaz, José Ángel Flores-Hernández, Aarón Pérez-Benı́tez, Eduardo Brambila-Colombres, Enrique González‐Vergara
New potential drugs based on vanadium are being developed as possible treatments for diabetes mellitus (DM) and its complications. In this regard, our working group developed metforminium decavanadate (MetfDeca), a compound with hypoglycemic and hypolipidemic properties. MetfDeca was evaluated in models of type 1 and type 2 diabetes mellitus, on male Wistar rats. Alloxan‐induction was empl...... hiện toàn bộ
Decavanadate Toxicology and Pharmacological Activities: V10 or V1, Both or None?
Oxidative Medicine and Cellular Longevity - Tập 2016 Số 1 - 2016
Manuel Aureliano
This review covers recent advances in the understanding of decavanadate toxicology and pharmacological applications. Toxicological in vivo studies point out that V10 induces several changes in several oxidative stress parameters, different from the ones observed for vanadate (V1). In in vitro st...... hiện toàn bộ
Tribulus terrestris Protects against Male Reproductive Damage Induced by Cyclophosphamide in Mice
Oxidative Medicine and Cellular Longevity - Tập 2018 Số 1 - 2018
Natasha Frasson Pavin, Aryele Pinto Izaguirry, Melina Bucco Soares, Cristiano Chiapinotto Spiazzi, Andreas Sebastian Loureiro Mendez, Fábio Gallas Leivas, Daniela dos Santos Brum, Francielli Weber Santos Cibin
Tribulus terrestris (TT) has been considered as a potential stimulator of testosterone production, which has been related with steroidal saponins prevailing in this plant. Cyclophosphamide (CP) is the most commonly used anticancer and immunosuppressant drug, which causes several toxic effects, especially on the reproductive system. Patients who need to use CP the...... hiện toàn bộ
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