Oxidative Medicine and Cellular Longevity
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Hemin Attenuates Cisplatin-Induced Acute Renal Injury in Male RatsBackground. The aim of this study is to investigate the protective effects of hemin (the heme oxygenase-1 [OH-1] inducer) against nephrotoxic effects induced by cisplatin [cis-diamminedichloroplatinum II (CP)] in male rats.Methods. The evaluation was performed through monitoring renal redox parameters: lipid peroxidation (LPO), glutathion...
Oxidative Medicine and Cellular Longevity - Tập 2014 - Trang 1-9 - 2014
Quá Trình Oxy Hóa Lipid: Quá Trình Sản Sinh, Chuyển Hóa và Cơ Chế Tín Hiệu của Malondialdehyde và 4-Hydroxy-2-Nonenal Dịch bởi AI Quá trình oxi hóa lipid có thể được mô tả chung là một quá trình mà các chất oxi hóa như các gốc tự do tấn công các lipid có chứa liên kết đôi carbon-carbon, đặc biệt là các axit béo không bão hòa đa (PUFAs). Trong bốn thập kỷ qua, một lượng lớn tư liệu về quá trình oxi hóa lipid đã cho thấy vai trò quan trọng của nó trong sinh học tế bào và sức khỏe con người. Từ đầu những năm 1970, tổng ... ... hiện toàn bộ
Oxidative Medicine and Cellular Longevity - Tập 2014 - Trang 1-31 - 2014
#Oxy hóa lipid #malondialdehyde #4-hydroxy-2-nonenal #axit béo không bão hòa đa #gốc tự do #sinh lý tế bào #chết tế bào.
Relationship between Human Aging Muscle and Oxidative System PathwayAgeing is a complex process that in muscle is usually associated with a decrease in mass, strength, and velocity of contraction. One of the most striking effects of ageing on muscle is known as sarcopenia. This inevitable biological process is characterized by a general decline in the physiological and biochemical functions of the major systems. At the cellular level, aging is caused by a ... ... hiện toàn bộ
Oxidative Medicine and Cellular Longevity - Tập 2012 - Trang 1-13 - 2012
Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox?Oxidative stress has been implicated in many chronic diseases. However, antioxidant trials are so far largely unsuccessful as a preventive or curative measure. Chronic low‐grade inflammatory process, on the other hand, plays a central role in the pathogenesis of a number of chronic diseases. Oxidative stress and inflammation are closely related pathophysiological processes, one of which ca... ... hiện toàn bộ
Oxidative Medicine and Cellular Longevity - Tập 2016 Số 1 - 2016
Exosomes Derived from TIMP2-Modified Human Umbilical Cord Mesenchymal Stem Cells Enhance the Repair Effect in Rat Model with Myocardial Infarction Possibly by the Akt/Sfrp2 PathwayExosomes derived from human umbilical cord mesenchymal stem cells (hucMSCs) are a promising new therapeutic option for myocardial infarction (MI). The tissue matrix metalloproteinase inhibitor 2, also known as TIMP2, is a member of the tissue inhibitor family of metalloproteinases. Since TIMP2-mediated inhibition of matrix metalloproteinases (MMPs) is a key determinant of post-MI remodelin... ... hiện toàn bộ
Oxidative Medicine and Cellular Longevity - Tập 2019 - Trang 1-19 - 2019
The Triggering Receptor Expressed on Myeloid Cells 2: “TREM-ming” the Inflammatory Component Associated with Alzheimer's DiseaseAlzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by a progressive loss of memory and cognitive skills. Although much attention has been devoted concerning the contribution of the microscopic lesions, senile plaques, and neurofibrillary tangles to the disease process, inflammation has long been suspected to play a major role in the etiology of AD. Recently... ... hiện toàn bộ
Oxidative Medicine and Cellular Longevity - Tập 2013 - Trang 1-8 - 2013
Antidiabetic Potency, Antioxidant Effects, and Mode of Actions ofCitrus reticulataFruit Peel Hydroethanolic Extract, Hesperidin, and Quercetin in Nicotinamide/Streptozotocin-Induced Wistar Diabetic RatsThis study is aimed at assessing the antihyperglycemic, antihyperlipidemic, and antioxidant effects ofCitrus reticulata (C. reticulata ) fruit peel hydroethanolic extract and two flavonoids, hesperidin and quercetin, in nicotinamide (NA)/streptozotocin- (STZ-) induced type 2 diabetic rats. In addition, GC-MS and HPLC-MS analyses of the ex... ... hiện toàn bộ
Oxidative Medicine and Cellular Longevity - Tập 2020 - Trang 1-21 - 2020
Oxidative Stress Contributes to Endothelial Dysfunction in Mouse Models of Hereditary Hemorrhagic TelangiectasiaHereditary hemorrhagic telangiectasia (HHT) is a vascular dysplasia caused by mutations in endoglin (ENG ; HHT1) or activin receptor-like kinase (ALK1 ; HHT2) genes, coding for transforming growth factor- hiện toàn bộ
Oxidative Medicine and Cellular Longevity - Tập 2012 - Trang 1-9 - 2012
Pentaerythritol Tetranitrate In Vivo Treatment Improves Oxidative Stress and Vascular Dysfunction by Suppression of Endothelin‐1 Signaling in Monocrotaline‐Induced Pulmonary HypertensionObjective . Oxidative stress and endothelial dysfunction contribute to pulmonary arterial hypertension (PAH). The role of the nitrovasodilator pentaerythritol tetranitrate (PETN) on endothelial function and oxidative stress in PAH has not yet been defined. Methods and Results . PAH was induced by monocrotaline (MCT, i.v.) in Wistar rats. ...
Oxidative Medicine and Cellular Longevity - Tập 2017 Số 1 - 2017
Exercise in the Metabolic SyndromeThe metabolic syndrome is a clustering of obesity, diabetes, hyperlipidemia, and hypertension that is occurring in increasing frequency across the global population. Although there is some controversy about its diagnostic criteria, oxidative stress, which is defined as imbalance between the production and inactivation of reactive oxygen species, has a major pathophysiological role in all t... ... hiện toàn bộ
Oxidative Medicine and Cellular Longevity - Tập 2012 - Trang 1-13 - 2012
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