Oxidative Medicine and Cellular Longevity

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Effects of Resveratrol on Vitrified Porcine Oocytes
Oxidative Medicine and Cellular Longevity - Tập 2013 - Trang 1-7 - 2013
Elisa Giaretta, Marcella Spinaci, Diego Bucci, Carlo Tamanini, Giovanna Galeati
Vitrified MII porcine oocytes are characterized by reduced developmental competence, associated with the activation of the apoptotic pathway. Resveratrol (R), a polyphenolic compound present in several vegetal sources, has been reported to exert, among all its other biological effects, an antiapoptotic one. The aim of this study was to determine the effects of R (2 µ... hiện toàn bộ
Melatonin Ameliorates Valproic Acid‐Induced Neurogenesis Impairment: The Role of Oxidative Stress in Adult Rats
Oxidative Medicine and Cellular Longevity - Tập 2021 Số 1 - 2021
Anusara Aranarochana, Apiwat Sirichoat, Wanassanun Pannangrong, Peter Wigmore, Jariya Umka Welbat
Background. Valproic acid (anticonvulsant medication) has been found to inhibit histone deacetylase activity and suppress hippocampal neurogenesis, which causes memory impairment in both humans and rodents. The neurohormone melatonin, which regulates mammalian seasonal and circadian physiology, has recently been shown to have neuroprotective properties, counterac...... hiện toàn bộ
[Retracted] Protective Effect of D‐Limonene against Oxidative Stress‐Induced Cell Damage in Human Lens Epithelial Cells via the p38 Pathway
Oxidative Medicine and Cellular Longevity - Tập 2016 Số 1 - 2016
Jie Bai, Yi Zheng, Gang Wang, Ping Liu
Oxidative stress, as mediated by ROS, is a significant factor in initiating the development of age‐associated cataracts; D‐limonene is a common natural terpene with powerful antioxidative properties which occurs naturally in a wide variety of living organisms. It has been shown to have antioxidant effect; we found that D‐limonene can effectively prevent the oxidative damage caused by H... hiện toàn bộ
The Effect of Leonurus sibiricus Plant Extracts on Stimulating Repair and Protective Activity against Oxidative DNA Damage in CHO Cells and Content of Phenolic Compounds
Oxidative Medicine and Cellular Longevity - Tập 2016 Số 1 - 2016
Przemysław Sitarek, Ewa Skała, Halina Wysokińska, Marzena Wielanek, Janusz Szemraj, Monika M. Toma, Tomasz Śliwiński
Leonurus sibiricus L. has been used as a traditional and medicinal herb for many years in Asia and Europe. This species is known to have antibacterial, anti‐inflammatory, and antioxidant activity and has demonstrated a reduction of intracellular reactive oxygen species. All tested extracts of L. sibiricus showed protective and DNA repai...... hiện toàn bộ
Cross Talk of Proteostasis and Mitostasis in Cellular Homeodynamics, Ageing, and Disease
Oxidative Medicine and Cellular Longevity - Tập 2016 Số 1 - 2016
Sentiljana Gumeni, Ioannis P. Trougakos
Mitochondria are highly dynamic organelles that provide essential metabolic functions and represent the major bioenergetic hub of eukaryotic cell. Therefore, maintenance of mitochondria activity is necessary for the proper cellular function and survival. To this end, several mechanisms that act at different levels and time points have been developed to ensure mitochondria quality control. ...... hiện toàn bộ
The Protective Effects of Melatonin on Aluminum-Induced Hepatotoxicity and Nephrotoxicity in Rats
Oxidative Medicine and Cellular Longevity - Tập 2020 - Trang 1-12 - 2020
Mohamed S. Othman, Mohamed A. Fareid, Reda S. Abdel Hameed, Ahmed E. Abdel Moneim
Aluminum (Al) is a ubiquitous element with known toxicity for both humans and animals. Herein, we aimed to investigate the potential role of melatonin (MEL) in hepatotoxicity and nephrotoxicity following aluminum chloride (AlCl3) treatment in rats. Adult male rats were treated with AlCl3 (34 mg/kg bwt) for eight weeks. Exposure to AlCl3 enhanced the serum activities of the liver transamina...... hiện toàn bộ
Interactions between CYP3A4 and Dietary Polyphenols
Oxidative Medicine and Cellular Longevity - Tập 2015 - Trang 1-15 - 2015
Loai Basheer, Zohar Kerem
The human cytochrome P450 enzymes (P450s) catalyze oxidative reactions of a broad spectrum of substrates and play a critical role in the metabolism of xenobiotics, such as drugs and dietary compounds. CYP3A4 is known to be the main enzyme involved in the metabolism of drugs and most other xenobiotics. Dietary compounds, of which polyphenolics are the most studied, have been shown to intera...... hiện toàn bộ
Antioxidant and Vasodilator Activity of Ugni molinae Turcz. (Murtilla) and Its Modulatory Mechanism in Hypotensive Response
Oxidative Medicine and Cellular Longevity - Tập 2016 Số 1 - 2016
Ignacio Jofré, Cesar Pezoa, Magdalena E. Cuevas, Erick Scheuermann, Irlan Almeida Freires, Pedro Luiz Rosalen, Severino Matias de Alencar, Fernando Romero
Hypertension is a systemic condition with high morbidity and mortality rates worldwide, which poses an increased risk for cardiovascular diseases. In this study, we demonstrated the antioxidant and vasodilator activity of Ugni molinae Turcz. (Murtilla) fruit, a berry native to Chile and proposed models to explain its modulatory mechanism in hypotensive response. ...... hiện toàn bộ
Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox?
Oxidative Medicine and Cellular Longevity - Tập 2016 Số 1 - 2016
Subrata Kumar Biswas
Oxidative stress has been implicated in many chronic diseases. However, antioxidant trials are so far largely unsuccessful as a preventive or curative measure. Chronic low‐grade inflammatory process, on the other hand, plays a central role in the pathogenesis of a number of chronic diseases. Oxidative stress and inflammation are closely related pathophysiological processes, one of which ca...... hiện toàn bộ
The Signaling of Cellular Senescence in Diabetic Nephropathy
Oxidative Medicine and Cellular Longevity - Tập 2019 - Trang 1-16 - 2019
Yabing Xiong, Lili Zhou
Diabetic nephropathy is the leading cause of chronic kidney disease (CKD) in western countries. Notably, it has a rapidly rising prevalence in China. The patients, commonly complicated with cardiovascular diseases and neurologic disorders, are at high risk to progress into end-stage renal disease (ESRD) and death. However, the pathogenic mechanisms of diabetic nephropathy have not been det...... hiện toàn bộ
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