Oxidative Medicine and Cellular Longevity

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Quá Trình Oxy Hóa Lipid: Quá Trình Sản Sinh, Chuyển Hóa và Cơ Chế Tín Hiệu của Malondialdehyde và 4-Hydroxy-2-Nonenal Dịch bởi AI
Oxidative Medicine and Cellular Longevity - Tập 2014 - Trang 1-31 - 2014
Antonio Ayala, Mario Muñoz, Sandro Argüelles
Quá trình oxi hóa lipid có thể được mô tả chung là một quá trình mà các chất oxi hóa như các gốc tự do tấn công các lipid có chứa liên kết đôi carbon-carbon, đặc biệt là các axit béo không bão hòa đa (PUFAs). Trong bốn thập kỷ qua, một lượng lớn tư liệu về quá trình oxi hóa lipid đã cho thấy vai trò quan trọng của nó trong sinh học tế bào và sức khỏe con người. Từ đầu những năm 1970, tổng số bài b... hiện toàn bộ
#Oxy hóa lipid #malondialdehyde #4-hydroxy-2-nonenal #axit béo không bão hòa đa #gốc tự do #sinh lý tế bào #chết tế bào.
Effects of Resveratrol on Vitrified Porcine Oocytes
Oxidative Medicine and Cellular Longevity - Tập 2013 - Trang 1-7 - 2013
Elisa Giaretta, Marcella Spinaci, Diego Bucci, Carlo Tamanini, Giovanna Galeati
Vitrified MII porcine oocytes are characterized by reduced developmental competence, associated with the activation of the apoptotic pathway. Resveratrol (R), a polyphenolic compound present in several vegetal sources, has been reported to exert, among all its other biological effects, an antiapoptotic one. The aim of this study was to determine the effects of R (2 µM) on the apoptotic status of p... hiện toàn bộ
The Triggering Receptor Expressed on Myeloid Cells 2: “TREM-ming” the Inflammatory Component Associated with Alzheimer's Disease
Oxidative Medicine and Cellular Longevity - Tập 2013 - Trang 1-8 - 2013
Troy T. Rohn
Alzheimer's disease (AD) is an age-related neurodegenerative disorder characterized by a progressive loss of memory and cognitive skills. Although much attention has been devoted concerning the contribution of the microscopic lesions, senile plaques, and neurofibrillary tangles to the disease process, inflammation has long been suspected to play a major role in the etiology of AD. Recently, a nove... hiện toàn bộ
The Tumorigenic Roles of the Cellular REDOX Regulatory Systems
Oxidative Medicine and Cellular Longevity - Tập 2016 Số 1 - 2016
Stéphanie A. Castaldo, Juliana Crês de Freitas, Nadine V. Conchinha, Patrícia A. Madureira
The cellular REDOX regulatory systems play a central role in maintaining REDOX homeostasis that is crucial for cell integrity, survival, and proliferation. To date, a substantial amount of data has demonstrated that cancer cells typically undergo increasing oxidative stress as the tumor develops, upregulating these important antioxidant systems in order to survive, proliferate, and metastasize und... hiện toàn bộ
Unraveling the Potential Role of Glutathione in Multiple Forms of Cell Death in Cancer Therapy
Oxidative Medicine and Cellular Longevity - Tập 2019 - Trang 1-16 - 2019
Huanhuan Lv, Chenxiao Zhen, Junyu Liu, Pengfei Yang, Lijiang Hu, Peng Shang
Glutathione is the principal intracellular antioxidant buffer against oxidative stress and mainly exists in the forms of reduced glutathione (GSH) and oxidized glutathione (GSSG). The processes of glutathione synthesis, transport, utilization, and metabolism are tightly controlled to maintain intracellular glutathione homeostasis and redox balance. As for cancer cells, they exhibit a greater ROS l... hiện toàn bộ
A Metabonomics Investigation into the Therapeutic Effects of BuChang NaoXinTong Capsules on Reversing the Amino Acid-Protein Interaction Network of Cerebral Ischemia
Oxidative Medicine and Cellular Longevity - Tập 2019 - Trang 1-14 - 2019
Jing Xu, Xin Liu, Liyu Luo, Liying Tang, Na Guo, Mengting Liu, Hongmei Li, Fangbo Zhang, Yi Zhang, Defeng Li, Ye Zhao, Hongwei Wu, Hongjun Yang
Background. Amino acids (AAs) in cerebrospinal fluid (CSF) play a pivotal role in cerebral ischemia (CI). BuChang NaoXinTong Capsules (BNC) are widely prescribed in Chinese medicine for the treatment of cerebrovascular and cardiovascular diseases. Methods. In order to investigate the therapeutic effects and pharmacological mechanisms of BNC on reversing CI from a system level, an amino acid-protei... hiện toàn bộ
TPEN Induces Apoptosis Independently of Zinc Chelator Activity in a Model of Acute Lymphoblastic Leukemia andEx VivoAcute Leukemia Cells through Oxidative Stress and Mitochondria Caspase-3- and AIF-Dependent Pathways
Oxidative Medicine and Cellular Longevity - Tập 2012 - Trang 1-14 - 2012
Miguel Mendivil‐Perez, Carlos Velez‐Pardo, Marlene Jiménez-Del-Río
Increased Oxidative Stress as a Selective Anticancer Therapy
Oxidative Medicine and Cellular Longevity - Tập 2015 - Trang 1-12 - 2015
Jiahui Liu, Zhichong Wang
Reactive oxygen species (ROS) are closely related to tumorgenesis. Under hypoxic environment, increased levels of ROS induce the expression of hypoxia inducible factors (HIFs) in cancer stem cells (CSCs), resulting in the promotion of the upregulation of CSC markers, and the reduction of intracellular ROS level, thus facilitating CSCs survival and proliferation. Although the ROS level is regulated... hiện toàn bộ
The Essential Element Manganese, Oxidative Stress, and Metabolic Diseases: Links and Interactions
Oxidative Medicine and Cellular Longevity - Tập 2018 Số 1 - 2018
Longman Li, Xiaobo Yang
Manganese (Mn) is an essential element that is involved in the synthesis and activation of many enzymes and in the regulation of the metabolism of glucose and lipids in humans. In addition, Mn is one of the required components for Mn superoxide dismutase (MnSOD) that is mainly responsible for scavenging reactive oxygen species (ROS) in mitochondrial oxidative stress. Both Mn deficiency and intoxic... hiện toàn bộ
Hemin Attenuates Cisplatin-Induced Acute Renal Injury in Male Rats
Oxidative Medicine and Cellular Longevity - Tập 2014 - Trang 1-9 - 2014
Mohamed A. Al‐Kahtani, Ashraf M. Abdel‐Moneim, Omar M. Elmenshawy, Mohamed A. Elkersh
Background.The aim of this study is to investigate the protective effects of hemin (the heme oxygenase-1 [OH-1] inducer) against nephrotoxic effects induced by cisplatin [cis-diamminedichloroplatinum II (CP)] in male rats.Methods.The evaluation was performed through monitoring renal redox parameters: lipid peroxidation (LPO), glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione re... hiện toàn bộ
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