Antioxidant and Vasodilator Activity of Ugni molinae Turcz. (Murtilla) and Its Modulatory Mechanism in Hypotensive Response

Oxidative Medicine and Cellular Longevity - Tập 2016 Số 1 - 2016
Ignacio Jofré1, Cesar Pezoa1, Magdalena E. Cuevas1, Erick Scheuermann2, Irlan Almeida Freires3, Pedro Luiz Rosalen3, Severino Matias de Alencar4, Fernando Romero1
1Center for Neurosciences and Peptides Biology, CEGIN-BIOREN-UFRO, Department of Preclinical Sciences, Faculty of Medicine, University La Frontera, Francisco Salazar 01145, 4811230 Temuco, Chile
2Department of Chemical Engineering, University La Frontera, Francisco Salazar 01145, 4811230 Temuco, Chile
3Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, 13414-903 Piracicaba, SP, Brazil
4Department of Agri-Food industry, “Luiz de Queiroz” College of Agriculture, University of São Paulo, 13418-900 Piracicaba, SP, Brazil

Tóm tắt

Hypertension is a systemic condition with high morbidity and mortality rates worldwide, which poses an increased risk for cardiovascular diseases. In this study, we demonstrated the antioxidant and vasodilator activity of Ugni molinae Turcz. (Murtilla) fruit, a berry native to Chile and proposed models to explain its modulatory mechanism in hypotensive response. Murtilla fruits were cultivated in a germplasm bank and submitted to chemical and biological analyses. The phenolic compounds gallic acid, Catechin, Quercetin‐3‐β‐D‐glucoside, Myricetin, Quercetin, and Kaempferol were identified. Murtilla extract did not generate toxic effects on human endothelial cells and had significant antioxidant activity against ROS production, lipid peroxidation, and superoxide anion production. Furthermore, it showed dose‐dependent vasodilator activity in aortic rings in the presence of endothelium, whose hypotensive mechanism is partially mediated by nitric oxide synthase/guanylate cyclase and large‐conductance calcium‐dependent potassium channels. Murtilla fruits might potentially have beneficial effects on the management of cardiovascular diseases.

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Oxidative Medicine and Cellular Longevity

Tập 2016 Số 1

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