The Protective Effects of Melatonin on Aluminum-Induced Hepatotoxicity and Nephrotoxicity in Rats

Oxidative Medicine and Cellular Longevity - Tập 2020 - Trang 1-12 - 2020
Mohamed S. Othman1,2, Mohamed A. Fareid3,4, Reda S. Abdel Hameed3,5, Ahmed E. Abdel Moneim6
1Chemistry Dept., Faculty of Biotechnology, October University for Modern Science and Arts (MSA), Giza
2Chemistry Dept., Faculty of Biotechnology, October University for Modern Science and Arts (MSA), Giza, Egypt
3Basic Sciences Department, Preparatory Year, University of Ha’il, Ha’il, Saudi Arabia
4Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Cairo, Egypt
5Chemistry Department, Faculty of Science, Al-Azhar University, Cairo, Egypt
6Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo 11795, Egypt

Tóm tắt

Aluminum (Al) is a ubiquitous element with known toxicity for both humans and animals. Herein, we aimed to investigate the potential role of melatonin (MEL) in hepatotoxicity and nephrotoxicity following aluminum chloride (AlCl3) treatment in rats. Adult male rats were treated with AlCl3 (34 mg/kg bwt) for eight weeks. Exposure to AlCl3 enhanced the serum activities of the liver transaminases (alanine aminotransferase and aspartate aminotransferase) and increased the level of bilirubin, in addition to the serum kidney function markers urea and creatinine. AlCl3 intoxication boosted oxidative stress, as evidenced by increases in the levels of lipid peroxidation (LPO) and nitric oxide (NO) along with simultaneous decreases in the levels of glutathione (GSH), various antioxidant enzymes, and Nrf2 mRNA expression. MEL (5 mg/kg bwt) treatment repressed LPO and NO levels, whereas it augmented GSH content. The activities of the antioxidant enzymes GPx, SOD, CAT, and GR were also restored concomitantly when MEL was administered before AlCl3. MEL also suppressed the apoptotic effect of AlCl3 by enhancing Bcl-2 protein expression in the liver and kidney and decreasing the expression levels of proinflammatory cytokines. Histopathological findings in the liver and kidney tissues confirmed the beneficial effect of MEL against AlCl3 toxicity. These findings indicate that MEL prevents AlCl3 toxicity by enhancing the antioxidant defense system.

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Oxidative Medicine and Cellular Longevity

Tập 2020

1-12

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