Open Biology
SCOPUS (2011-2023)SCIE-ISI
2046-2441
Anh Quốc
Cơ quản chủ quản: The Royal Society , ROYAL SOC
Lĩnh vực:
Neuroscience (miscellaneous)Biochemistry, Genetics and Molecular Biology (miscellaneous)Immunology
Các bài báo tiêu biểu
Targeting BCL-2 regulated apoptosis in cancerThe ability of a cell to undergo mitochondrial apoptosis is governed by pro- and anti-apoptotic members of the BCL-2 protein family. The equilibrium of pro- versus anti-apoptotic BCL-2 proteins ensures appropriate regulation of programmed cell death during development and maintains organismal health. When unbalanced, the BCL-2 family can act as a barrier to apoptosis and facilitate tumour ... ... hiện toàn bộ
Tập 8 Số 5 - Trang 180002 - 2018
Neuron–glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stageAn essential aspect of normal brain function is the bidirectional interaction and communication between neurons and neighbouring glial cells. To this end, the brain has evolved ligand–receptor partnerships that facilitate crosstalk between different cell types. The chemokine, fractalkine (FKN), is expressed on neuronal cells, and its receptor, CX3 CR1, is predominantly ... ... hiện toàn bộ
Tập 3 Số 12 - Trang 130181 - 2013
A toolkit enabling efficient, scalable and reproducible gene tagging in trypanosomatids
One of the first steps in understanding a protein's function is to determine its localization; however, the methods for localizing proteins in some systems have not kept pace with the developments in other fields, creating a bottleneck in the analysis of the large datasets that are generated in the post-genomic era. To address this, we developed tools for tagging proteins in t... ... hiện toàn bộ
Tập 5 Số 1 - Trang 140197 - 2015
Heterotrimeric G protein signalling in the plant kingdom
In animals, heterotrimeric G proteins, comprising α-, β-and γ-subunits, perceive extracellular stimuli through cell surface receptors, and transmit signals to ion channels, enzymes and other effector proteins to affect numerous cellular behaviours. In plants, G proteins have structural similarities to the corresponding molecules in animals but transmit signals by atypical mech... ... hiện toàn bộ
Tập 3 Số 3 - Trang 120186 - 2013
Biosynthesis and biology of mammalian GPI-anchored proteinsAt least 150 human proteins are glycosylphosphatidylinositol-anchored proteins (GPI-APs). The protein moiety of GPI-APs lacking transmembrane domains is anchored to the plasma membrane with GPI covalently attached to the C-terminus. The GPI consists of the conserved core glycan, phosphatidylinositol and glycan side chains. The entire GPI-AP is anchored to the outer leaflet of the lipid bil... ... hiện toàn bộ
Tập 10 Số 3 - 2020
The ANGPTL3-4-8 model, a molecular mechanism for triglyceride traffickingLipoprotein lipase (LPL) is a rate-limiting enzyme for hydrolysing circulating triglycerides (TG) into free fatty acids that are taken up by peripheral tissues. Postprandial LPL activity rises in white adipose tissue (WAT), but declines in the heart and skeletal muscle, thereby directing circulating TG to WAT for storage; the reverse is true during fasting. However, the mechanism for the t... ... hiện toàn bộ
Tập 6 Số 4 - Trang 150272 - 2016
Cancer drug pan-resistance: pumps, cancer stem cells, quiescence, epithelial to mesenchymal transition, blocked cell death pathways, persisters or what?Although chemotherapy of tumours has scored successes, drug resistance remains the major cause of death of cancer patients. Initial treatment often leaves residual disease, from which the tumour regrows. Eventually, most tumours become resistant to all available chemotherapy. I call this pan-resistance to distinguish it from multi-drug resistance, usually describing resistance caused by up... ... hiện toàn bộ
Tập 2 Số 5 - Trang 120066 - 2012
Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouseTo address the long-known relationship between supernumerary centrosomes and cancer, we have generated a transgenic mouse that permits inducible expression of the master regulator of centriole duplication, Polo-like-kinase-4 (Plk4). Over-expression of Plk4 from this transgene advances the onset of tumour formation that occurs in the absence of the tumour suppressor p53. Plk4 over-expressio... ... hiện toàn bộ
Tập 5 Số 12 - Trang 150209 - 2015
RETRACTED: Long non-coding RNA LINC00152 promotes gallbladder cancer metastasis and epithelial–mesenchymal transition by regulating HIF-1α via miR-138
Long non-coding RNA LINC00152 had been reported as an oncogene in gastric and hepatocellular cancer. In this study, we show that LINC00152 is overexpressed in gallbladder cancer (GBC) tissue samples and cell lines. The high LINC00152 levels correlated negatively with the overall survival time in GBC patients. Functionally, LINC00152 dramatically promoted cell migration, invasi... ... hiện toàn bộ
Tập 7 Số 1 - 2017
MicroRNA-independent roles of the RNase III enzymes Drosha and DicerThe ribonuclease III enzymes Drosha and Dicer are renowned for their central roles in the biogenesis of microRNAs (miRNAs). For many years, this has overshadowed the true versatility and importance of these enzymes in the processing of other RNA substrates. For example, Drosha also recognizes and cleaves messenger RNAs (mRNAs), and potentially ribosomal RNA. The cleavage of mRNAs occurs vi... ... hiện toàn bộ
Tập 3 Số 10 - Trang 130144 - 2013