Open Biology
SCOPUS (2011-2025)SCIE-ISI
2046-2441
Anh Quốc
Cơ quản chủ quản: The Royal Society , ROYAL SOC
Lĩnh vực:
Neuroscience (miscellaneous)Biochemistry, Genetics and Molecular Biology (miscellaneous)Immunology
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Targeting BCL-2 regulated apoptosis in cancer
Tập 8 Số 5 - Trang 180002 - 2018
The ability of a cell to undergo mitochondrial apoptosis is governed by pro- and
anti-apoptotic members of the BCL-2 protein family. The equilibrium of pro-
versus anti-apoptotic BCL-2 proteins ensures appropriate regulation of
programmed cell death during development and maintains organismal health. When
unbalanced, the BCL-2 family can act as a barrier to apoptosis and facilitate
tumour developm...
Neuron–glia crosstalk in health and disease: fractalkine and CX3CR1 take centre stage
Tập 3 Số 12 - Trang 130181 - 2013
An essential aspect of normal brain function is the bidirectional interaction
and communication between neurons and neighbouring glial cells. To this end, the
brain has evolved ligand–receptor partnerships that facilitate crosstalk between
different cell types. The chemokine, fractalkine (FKN), is expressed on neuronal
cells, and its receptor, CX3CR1, is predominantly expressed on microglia. This
...
A toolkit enabling efficient, scalable and reproducible gene tagging in trypanosomatids
Tập 5 Số 1 - Trang 140197 - 2015
One of the first steps in understanding a protein's function is to determine its
localization; however, the methods for localizing proteins in some systems have
not kept pace with the developments in other fields, creating a bottleneck in
the analysis of the large datasets that are generated in the post-genomic era.
To address this, we developed tools for tagging proteins in trypanosomatids. We
ma...
Heterotrimeric G protein signalling in the plant kingdom
Tập 3 Số 3 - Trang 120186 - 2013
In animals, heterotrimeric G proteins, comprising α-, β-and γ-subunits, perceive
extracellular stimuli through cell surface receptors, and transmit signals to
ion channels, enzymes and other effector proteins to affect numerous cellular
behaviours. In plants, G proteins have structural similarities to the
corresponding molecules in animals but transmit signals by atypical mechanisms
and effector p...
Biosynthesis and biology of mammalian GPI-anchored proteins
Tập 10 Số 3 - 2020
At least 150 human proteins are glycosylphosphatidylinositol-anchored proteins
(GPI-APs). The protein moiety of GPI-APs lacking transmembrane domains is
anchored to the plasma membrane with GPI covalently attached to the C-terminus.
The GPI consists of the conserved core glycan, phosphatidylinositol and glycan
side chains. The entire GPI-AP is anchored to the outer leaflet of the lipid
bilayer by ...
The ANGPTL3-4-8 model, a molecular mechanism for triglyceride trafficking
Tập 6 Số 4 - Trang 150272 - 2016
Lipoprotein lipase (LPL) is a rate-limiting enzyme for hydrolysing circulating
triglycerides (TG) into free fatty acids that are taken up by peripheral
tissues. Postprandial LPL activity rises in white adipose tissue (WAT), but
declines in the heart and skeletal muscle, thereby directing circulating TG to
WAT for storage; the reverse is true during fasting. However, the mechanism for
the tissue-sp...
Cancer drug pan-resistance: pumps, cancer stem cells, quiescence, epithelial to mesenchymal transition, blocked cell death pathways, persisters or what?
Tập 2 Số 5 - Trang 120066 - 2012
Although chemotherapy of tumours has scored successes, drug resistance remains
the major cause of death of cancer patients. Initial treatment often leaves
residual disease, from which the tumour regrows. Eventually, most tumours become
resistant to all available chemotherapy. I call this pan-resistance to
distinguish it from multi-drug resistance, usually describing resistance caused
by upregulati...
Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse
Tập 5 Số 12 - Trang 150209 - 2015
To address the long-known relationship between supernumerary centrosomes and
cancer, we have generated a transgenic mouse that permits inducible expression
of the master regulator of centriole duplication, Polo-like-kinase-4 (Plk4).
Over-expression of Plk4 from this transgene advances the onset of tumour
formation that occurs in the absence of the tumour suppressor p53. Plk4
over-expression also l...
RETRACTED: Long non-coding RNA LINC00152 promotes gallbladder cancer metastasis and epithelial–mesenchymal transition by regulating HIF-1α via miR-138
Tập 7 Số 1 - 2017
Long non-coding RNA LINC00152 had been reported as an oncogene in gastric and
hepatocellular cancer. In this study, we show that LINC00152 is overexpressed in
gallbladder cancer (GBC) tissue samples and cell lines. The high LINC00152
levels correlated negatively with the overall survival time in GBC patients.
Functionally, LINC00152 dramatically promoted cell migration, invasion and
epithelial–mes...
MicroRNA-independent roles of the RNase III enzymes Drosha and Dicer
Tập 3 Số 10 - Trang 130144 - 2013
The ribonuclease III enzymes Drosha and Dicer are renowned for their central
roles in the biogenesis of microRNAs (miRNAs). For many years, this has
overshadowed the true versatility and importance of these enzymes in the
processing of other RNA substrates. For example, Drosha also recognizes and
cleaves messenger RNAs (mRNAs), and potentially ribosomal RNA. The cleavage of
mRNAs occurs via recogn...