Neuropathology and Applied Neurobiology

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EXPERIMENTAL BILATERAL CAROTID ARTERY OCCLUSION: A STUDY OF THE OPTIC NERVE IN THE RAT
Neuropathology and Applied Neurobiology - Tập 10 Số 6 - Trang 423-428 - 1984
Junichi Takamatsu, Atsushi Hirano, Dana Levy, Paul Henkind
Experimental bilateral carotid artery occlusion: a study of the optic nerve in the ratThe presence of marked changes in the neural retina and retinal vessels of Long‐Evans pigmented rat following bilateral carotid ligation has been previously documented by serial ophthalmologic examinations. Light and electron microscopic studies of the optic nerve in this experimental ani...... hiện toàn bộ
Pathological features of preclinical or early clinical stages of corticobasal degeneration: a comparison with advanced cases
Neuropathology and Applied Neurobiology - Tập 41 Số 7 - Trang 893-905 - 2015
Naoki Nishida, Koji Yoshida, Yukiko Hata, Yuichi Arai, Koshi Kinoshita
AimsThe manner in which pathological lesions of corticobasal degeneration (CBD) progress remains poorly understood. Because the pathology of early disease stages may be fundamental for elucidating a border between clinical and preclinical states of CBD... hiện toàn bộ
The role of cytochrome c oxidase deficient hippocampal neurones in Alzheimer's disease
Neuropathology and Applied Neurobiology - Tập 28 Số 5 - Trang 390-396 - 2002
David A. Cottrell, Gillian M. Borthwick, Margaret A. Johnson, Paul G. Ince, Douglass M. Turnbull
Defects of mitochondrial function have been proposed as a potential mechanism in the development and pathogenesis of Alzheimer's disease (AD) and neuronal apoptosis. Mitochondrial enzyme‐deficient pyramidal neurones are found in greater quantities in the hippocampus of AD patients than in age‐matched controls. The presence of these neurones indicates that high levels of mutant mtDNA (mitoc...... hiện toàn bộ
WHO 2016 Classification of gliomas
Neuropathology and Applied Neurobiology - Tập 44 Số 2 - Trang 139-150 - 2018
Pieter Wesseling, David Capper
AbstractGliomas are the most frequent intrinsic tumours of the central nervous system and encompass two principle subgroups: diffuse gliomas and gliomas showing a more circumscribed growth pattern (‘nondiffuse gliomas’). In the revised fourth edition of the WHO Classification of ... hiện toàn bộ
Cerebral amyloid angiopathy: micro‐haemorrhages demonstrated by magnetic resonance susceptibility‐weighted imaging
Neuropathology and Applied Neurobiology - Tập 35 Số 1 - Trang 116-119 - 2009
Salim Y. Ghostine, Ravi Raghavan, Négar Khanlou, Harry V. Vinters, Karen A. Tong, William Johnson, Udochukwu Oyoyo, D K Kido
THE DEVELOPMENT OF THE HUMAN BLOOD‐BRAIN AND BLOOD‐CSF BARRIERS
Neuropathology and Applied Neurobiology - Tập 12 Số 4 - Trang 337-358 - 1986
Kjeld Møllgård, Norman R. Saunders
The development of the human blood‐brain and blood‐CSF barriersThe commonly held belief that the fetal blood‐brain and blood‐CSF barriers are immature is reviewed. Results obtained from carefully conducted experiments with horseradish peroxidase and optimal freeze‐fracturing suggest that the chick, rat and monkey brain barrier systems to proteins are tight from the earlies...... hiện toàn bộ
DIABETIC NEUROPATHY: ABNORMALITIES OF SCHWANN CELL AND PERINEURIAL BASAL LAMINAE. IMPLICATIONS FOR DIABETIC VASCULOPATHY
Neuropathology and Applied Neurobiology - Tập 15 Số 4 - Trang 339-355 - 1989
R. H. M. King, J. Llewelyn, P. K. Thomas, S. G. Gilbey, P J Watkins
During Wallerian degeneration, the Schwann cell basal laminal ensheathment around myelinated nerve fibres remains after the removal of myelin and axonal debris, forming a corrugated tube within which Schwann cell proliferation takes place. In nerve biopsies from patients with diabetic neuropathy, such residual basal laminal tubes tend to be circular rather than corrugated and appear to be ...... hiện toàn bộ
Focal brain damage enhances experimental allergic encephalomyelitis in brain and spinal cord
Neuropathology and Applied Neurobiology - Tập 21 Số 3 - Trang 189-200 - 1995
M. Phillips, Roy O. Weller, S. Kida, Fausto Iannotti
The immunological basis of multiple sclerosis (MS) is well recognized but the factors inducing MS lesions are unclear. In this study, we test the hypothesis that focal brain injury, inflicted during the pre‐clinical stages of experimental allergic encephalomyelitis (EAE), will enhance the severity of immunological damage in the cerebral hemispheres and spinal cord. Acute EAE was induced in...... hiện toàn bộ
Cytokine‐induced enhancement of autoimmune inflammation in the brain and spinal cord: implications for multiple sclerosis
Neuropathology and Applied Neurobiology - Tập 30 Số 4 - Trang 374-384 - 2004
Dong Sun, Tracey A. Newman, V. Hugh Perry, Roy O. Weller
Multiple sclerosis and experimental autoimmune encephalomyelitis (EAE) are autoimmune inflammatory diseases in which cytokines are intimately involved. Here we test the hypothesis that injection of pro‐inflammatory cytokines, tumour necrosis factor‐α (TNFα) and interferon gamma (IFNγ) into the brain of animals in the prodromal phase of EAE significantly enhances inflammation in the central...... hiện toàn bộ
Review: Molecular pathogenesis of blood–brain barrier breakdown in acute brain injury
Neuropathology and Applied Neurobiology - Tập 37 Số 1 - Trang 3-23 - 2011
Sukriti Nag, Anish Kapadia, Duncan J. Stewart
S. Nag, A. Kapadia and D. J. Stewart (2011) Neuropathology and Applied Neurobiology37, 3–23
Molecular pathogenesis of blood–brain barrier breakdown in acute brain injuryHistorically, the blood–brain barrier (BBB) was considered to be at the level of cerebral endothelium. Currently, the interaction of ...... hiện toàn bộ
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