EFFECTS OF METHYLMERCURY ON IN VIVO PROTEIN SYNTHESIS IN ISOLATED CEREBRAL AND CEREBELLAR NEURONS

Neuropathology and Applied Neurobiology - Tập 3 Số 4 - Trang 225-236 - 1977
Tore Syversen1
1University of Bergen, Laboratory of Clinical Biochemistry, Bergen, Norway and The University of Rochester, Department of Radiation Biology and Biophysics, Rochester, NY, USA

Tóm tắt

Effects of methylmercury on in vivo protein synthesis in isolated cerebral and cerebellar neuronsA preparative method is described for the bulk isolation of two neuronal populations from cerebellum, namely the granule cell and Purkinje cell bodies. This isolation method was used for studying in vivo effects of methylmercury on protein synthesis. The experimental rats were given a single i.p. dose of 10 mg/kg methylmercury. Mercury levels are reported in blood, total brain, cerebral neurons and two cerebellar neuron populations. The methylmercury was shown to inhibit incorporation of radioactive leucine into protein. The time course and degree of inhibition were dependent on cell type. The highest inhibition was found in neurons which are morphologically the most mercury sensitive species of the cells tested.

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Thông tin xuất bản

Neuropathology and Applied Neurobiology

Tập 3 Số 4

225-236

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