Neuropathology and Applied Neurobiology
SCOPUS (1975-2025)SCIE-ISI
0305-1846
1365-2990
Anh Quốc
Cơ quản chủ quản: WILEY , Wiley-Blackwell Publishing Ltd
Lĩnh vực:
HistologyNeurology (clinical)Physiology (medical)Pathology and Forensic MedicineNeurology
Các bài báo tiêu biểu
Review: Activation patterns of microglia and their identification in the human brain
Tập 39 Số 1 - Trang 3-18 - 2013
Microglia in the central nervous system are usually maintained in a quiescent
state. When activated, they can perform many diverse functions which may be
either beneficial or harmful depending on the situation. Although microglial
activation may be accompanied by changes in morphology, morphological changes
cannot accurately predict the function being undertaken by a microglial cell.
Studies of pe...
Tập 44 Số 2 - Trang 139-150 - 2018
AbstractGliomas are the most frequent intrinsic tumours of the central nervous
system and encompass two principle subgroups: diffuse gliomas and gliomas
showing a more circumscribed growth pattern (‘nondiffuse gliomas’). In the
revised fourth edition of the WHO Classification of CNS tumours published in
2016, classification of especially diffuse gliomas has fundamentally changed:
for the first tim...
A COMPARATIVE STUDY OF MODIFIED BIELSCHOWSKY, BODIAN AND THIOFLAVIN S STAINS ON ALZHEIMER'S NEUROFIBRILLARY TANGLES
Tập 12 Số 1 - Trang 3-9 - 1986
Serial sections of the brains of two cases with Alzheimer's disease were stained
with the standard Bodian, modified Bielschowsky (reformed Gros‐Schultze's
modification) and thioflavin S methods. The numbers of demonstrated Alzheimer's
neurofibrillary tangles (NFTs) were different between the two silver stains:
from 15 to 75% more NFTs were shown and more distinctly with the modified
Bielschowsky s...
Aberrant microRNA expression in the brains of neurodegenerative diseases: miR‐29a decreased in Alzheimer disease brains targets neurone navigator 3
Tập 36 Số 4 - Trang 320-330 - 2010
M. Shioya, S. Obayashi, H. Tabunoki, K. Arima, Y. Saito, T. Ishida and J. Satoh
(2010) Neuropathology and Applied Neurobiology36, 320–330
Aberrant microRNA
expression in the brains of neurodegenerative diseases: miR‐29a decreased in
Alzheimer disease brains targets neurone navigator 3 Aims: MicroRNAs (miRNAs)
are small non‐coding RNAs that regulate translational repression of target
mRNAs. Accumul...
Review: The role of vitamin D in nervous system health and disease
Tập 39 Số 5 - Trang 458-484 - 2013
Vitamin D and its metabolites have pleomorphic roles in both nervous system
health and disease. Animal models have been paramount in contributing to our
knowledge and understanding of the consequences of vitamin D deficiency on brain
development and its implications for adult psychiatric and neurological
diseases. The conflation of in vitro, ex vivo, and animal model data provide
compelling eviden...
Review
Tập 24 Số 2 - Trang 104-117 - 1998
P. G. Ince, J. Lowe and P. J. Shaw (1998) Neuropathology and Applied
Neurobiology24, 104–117Amyotrophic lateral sclerosis: current issues in
classification, pathogenesis and molecular pathologyThe classification of
amyotrophic lateral sclerosis (ALS) is reconsidered in the light of developments
in the molecular pathogenesis and histopathology of the condition. A current
view is encapsulated in the...
Human adult neurogenesis across the ages: An immunohistochemical study
Tập 42 Số 7 - Trang 621-638 - 2016
AbstractAimsNeurogenesis in the postnatal human brain occurs in two neurogenic
niches; the subventricular zone (SVZ) in the wall of the lateral ventricles and
the subgranular zone (SGZ) of the hippocampus. The extent to which this
physiological process continues into adulthood is an area of ongoing research.
This study aimed to characterize markers of cell proliferation and assess the
efficacy of ...
Review: Environmental enrichment and brain repair: harnessing the therapeutic effects of cognitive stimulation and physical activity to enhance experience‐dependent plasticity
Tập 40 Số 1 - Trang 13-25 - 2014
Environmental enrichment (EE) increases levels of novelty and complexity,
inducing enhanced sensory, cognitive and motor stimulation. In wild‐type
rodents, EE has been found to have a range of effects, such as enhancing
experience‐dependent cellular plasticity and cognitive performance, relative to
standard‐housed controls. Whilst environmental enrichment is of course a
relative term, dependent on...
REVIEW: tau protein pathology in Alzheimer’s disease and related disorders
Tập 25 Số 3 - Trang 171-187 - 1999
Abundant neurofibrillary lesions made of hyperphosphorylated
microtubule‐associated protein tau constitute one of the defining
neuropathological features of Alzheimer’s disease. However, tau containing
filamentous inclusions in neurones and/or glial cells also define a number of
other neurodegenerative disorders clinically characterized by dementia and/or
motor syndromes. All these disorders, ther...
Pathological inclusion bodies in tauopathies contain distinct complements of tau with three or four microtubule‐binding repeat domains as demonstrated by new specific monoclonal antibodies
Tập 29 Số 3 - Trang 288-302 - 2003
Pathological inclusions containing fibrillar aggregates of hyperphosphorylated
tau protein are a characteristic feature in the tauopathies, which include
Alzheimer's disease, frontotemporal dementia with parkinsonism linked to
chromosome 17 (FTDP‐17), progressive supranuclear palsy, corticobasal
degeneration and Pick's disease. Tau isoform composition and cellular and
regional distribution as well...