A COMPARATIVE STUDY OF MODIFIED BIELSCHOWSKY, BODIAN AND THIOFLAVIN S STAINS ON ALZHEIMER'S NEUROFIBRILLARY TANGLES
Tóm tắt
Serial sections of the brains of two cases with Alzheimer's disease were stained with the standard Bodian, modified Bielschowsky (reformed Gros‐Schultze's modification) and thioflavin S methods. The numbers of demonstrated Alzheimer's neurofibrillary tangles (NFTs) were different between the two silver stains: from 15 to 75% more NFTs were shown and more distinctly with the modified Bielschowsky stain than with the Bodian stain. Many of the NFTs in both cases were of eosinophilic and less argentophilic type. Although the NFTs were not counted, the thioflavin S stain seemed to have no apparent advantage over the modified Bielschowsky stain in the demonstration of NFTs.
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Tài liệu tham khảo
Carson F., 1980, Theory and Practice of Histotechnology, 252
Casanova M.F., 1984, Senile plaques in Alzheimer's disease: new approaches for their detection, (abstract), Annals of Neurology, 16, 119
Cross R.B., 1982, Demonstration of neurofibrillary tangles in paraffin sections: a quick and simple method using a modification of Palmgren's method, Medical Laboratory Sciences, 39, 67
Hooper M.W., 1976, The limbic system in Alzheimer's disease: a neuropathologic investigation, American Journal Pathology, 85, 1
Luna L.G., 1968, Manual of histological staining methods of the Armed Forces Institute of Pathology, 195
Okamoto K., 1982, The fine structure of eosinophilic stages of Alzheimer's neurofibrillary tangles, Clinical Neurology (Tokyo), 22, 840
Romeis B., 1928, Taschenbuch der mikroskopischen Technik, 448
Schwartz P., 1970, Amyloidosis. Cause and Manifestation of Senile Deterioration.