Neurogastroenterology and Motility
SCOPUS (1989-2025)SCIE-ISI
1365-2982
1350-1925
Anh Quốc
Cơ quản chủ quản: Wiley-Blackwell Publishing Ltd , WILEY
Lĩnh vực:
Endocrine and Autonomic SystemsPhysiologyGastroenterology
Phân tích ảnh hưởng
Các bài báo tiêu biểu
Increased mast cells in the irritable bowel syndrome
Tập 12 Số 5 - Trang 449-457 - 2000
Mast cells (MC) release potent mediators which alter enteric nerve and smooth
muscle function and may play a role in the pathogenesis of the irritable bowel
syndrome (IBS). The aim of this study was to determine if MC were increased in
the colon of IBS patients compared to controls. Biopsy specimens were obtained
from the caecum, ascending colon, descending colon and rectum of 28 patients: 14
IBS ...
Brain–gut connections in functional GI disorders: anatomic and physiologic relationships
Tập 18 Số 2 - Trang 91-103 - 2006
Abstract Understanding the neural regulation of gut function and sensation
makes it easier to understand the interrelatedness of emotionality,
symptom‐attentive behavior or hypervigilance, gut function and pain. The gut and
the brain are highly integrated and communicate in a bidirectional fashion
largely through the ANS and HPA axis. Within the CNS, the locus of gut control
is chiefly within the...
Enteroendocrine cells: a review of their role in brain–gut communication
Tập 28 Số 5 - Trang 620-630 - 2016
AbstractBackgroundSpecialized endoderm‐derived epithelial cells, that is,
enteroendocrine cells (EECs), are widely distributed throughout the
gastrointestinal (GI) tract. Enteroendocrine cells form the largest endocrine
organ in the body and play a key role in the control of GI secretion and
motility, the regulation of food intake, postprandial glucose levels and
metabolism. EECs sense luminal con...
The placebo effect in irritable bowel syndrome trials: a meta‐analysis1
Tập 17 Số 3 - Trang 332-340 - 2005
Abstract Background: Despite the apparent high placebo response rate in
randomized placebo‐controlled trials (RCT) of patients with irritable bowel
syndrome (IBS), little is known about the variability and predictors of this
response.Objectives: To describe the magnitude of response in placebo arms of
IBS clinical trials and to identify which factors predict the variability of the
placebo respo...
Dysregulation of the hypothalamic‐pituitary‐adrenal (HPA) axis in irritable bowel syndrome
Tập 21 Số 2 - Trang 149-159 - 2009
Abstract Enhanced stress responsiveness has been implicated as a potential
mechanism contributing to the pathophysiology of irritable bowel syndrome (IBS),
and should be reflected in altered function of the
hypothalamic‐pituitary‐adrenal (HPA) axis and the sympathetic nervous system.
Both of these systems can modulate mucosal immune function. The aims of this
study were: (i) to characterize the b...
High‐resolution manometry predicts the success of oesophageal bolus transport and identifies clinically important abnormalities not detected by conventional manometry
Tập 16 Số 5 - Trang 533-542 - 2004
AbstractBackground and aims: High‐resolution manometry (HRM) is a recent
development in oesophageal measurement; its value in the clinical setting
remains a matter of controversy. (i) We compared the accuracy with which bolus
transport could be predicted from conventional manometry and HRM. (ii) The
clinical value of HRM was assessed in a series of patients with
endoscopy‐negative dysphagia in wh...
Enterochromaffin cell hyperplasia and decreased serotonin transporter in a mouse model of postinfectious bowel dysfunction
Tập 17 Số 6 - Trang 863-870 - 2005
Abstract Patients with postinfective irritable bowel syndrome and Trichinella
spiralis‐infected mice share many features including visceral hypersensitivity
and disordered motility. We assessed enterochromaffin (EC) numbers and serotonin
transporter (SERT) using National Institute of Health (NIH) female mice studied
for up to 56 days post‐T. spiralis infection. The effects of steroid treatment
an...
Ligand‐gated ion channels in the enteric nervous system
Tập 14 Số 6 - Trang 611-623 - 2002
Abstract There are many cell surface receptors expressed by neurones in the
enteric nervous system (ENS). These receptors respond to synaptically released
neurotransmitters, circulating hormones and locally released substances. Cell
surface receptors are also targets for many therapeutically used drugs. This
review will focus on ligand‐gated ion channels, i.e. receptors in which the
ligand binding...
Overlap between functional GI disorders and other functional syndromes: what are the underlying mechanisms?
Tập 24 Số 10 - Trang 895-913 - 2012
Abstract Background Irritable bowel syndrome and other gastrointestinal (GI)
and non‐GI disorders such as functional dyspepsia, fibromyalgia,
temporomandibular joint disorder, interstitial cystitis/painful bladder
syndrome, and chronic fatigue syndrome are known as functional pain syndromes.
They commonly coexist within the same individual. The pathophysiologic
mechanisms of these disorders are ...