Neurogastroenterology and Motility
SCOPUS (1989-2023)SCIE-ISI
1365-2982
1350-1925
Anh Quốc
Cơ quản chủ quản: Wiley-Blackwell Publishing Ltd , WILEY
Lĩnh vực:
Endocrine and Autonomic SystemsPhysiologyGastroenterology
Các bài báo tiêu biểu
Increased mast cells in the irritable bowel syndromeMast cells (MC) release potent mediators which alter enteric nerve and smooth muscle function and may play a role in the pathogenesis of the irritable bowel syndrome (IBS). The aim of this study was to determine if MC were increased in the colon of IBS patients compared to controls. Biopsy specimens were obtained from the caecum, ascending colon, descending colon and rectum of 28 patients:... ... hiện toàn bộ
Tập 12 Số 5 - Trang 449-457 - 2000
Brain–gut connections in functional GI disorders: anatomic and physiologic relationshipsAbstract Understanding the neural regulation of gut function and sensation makes it easier to understand the interrelatedness of emotionality, symptom‐attentive behavior or hypervigilance, gut function and pain. The gut and the brain are highly integrated and communicate in a bidirectional fashion largely through the ANS and HPA axis. Within the CNS, the locus of gu...
Tập 18 Số 2 - Trang 91-103 - 2006
Enteroendocrine cells: a review of their role in brain–gut communicationAbstract Background Specialized endoderm‐derived epithelial cells, that is, enteroendocrine cells (EEC s), are widely distributed throughout the gastrointestinal (GI ) tract. Enteroendocrine cells form the larges...
Tập 28 Số 5 - Trang 620-630 - 2016
The placebo effect in irritable bowel syndrome trials: a meta‐analysis1Abstract Background: Despite the apparent high placebo response rate in randomized placebo‐controlled trials (RCT) of patients with irritable bowel syndrome (IBS), little is known about the variability and predictors of this response.Objectives: To describe the magnitude of response in placebo arms of ...
Tập 17 Số 3 - Trang 332-340 - 2005
Dysregulation of the hypothalamic‐pituitary‐adrenal (HPA) axis in irritable bowel syndromeAbstract Enhanced stress responsiveness has been implicated as a potential mechanism contributing to the pathophysiology of irritable bowel syndrome (IBS), and should be reflected in altered function of the hypothalamic‐pituitary‐adrenal (HPA) axis and the sympathetic nervous system. Both of these systems can modulate mucosal immune function. The aims of this study ...
Tập 21 Số 2 - Trang 149-159 - 2009
High‐resolution manometry predicts the success of oesophageal bolus transport and identifies clinically important abnormalities not detected by conventional manometryAbstract Background and aims: High‐resolution manometry (HRM) is a recent development in oesophageal measurement; its value in the clinical setting remains a matter of controversy. (i) We compared the accuracy with which bolus transport could be predicted from conventional manometry and HRM. (ii) The clinical value of HRM was assessed in a se...
Tập 16 Số 5 - Trang 533-542 - 2004
Enterochromaffin cell hyperplasia and decreased serotonin transporter in a mouse model of postinfectious bowel dysfunctionAbstract Patients with postinfective irritable bowel syndrome and Trichinella spiralis ‐infected mice share many features including visceral hypersensitivity and disordered motility. We assessed enterochromaffin (EC) numbers and serotonin transporter (SERT) using National Institute of Health (NIH) female mice studied for up to 56 days post‐...
Tập 17 Số 6 - Trang 863-870 - 2005
Ligand‐gated ion channels in the enteric nervous systemAbstract There are many cell surface receptors expressed by neurones in the enteric nervous system (ENS). These receptors respond to synaptically released neurotransmitters, circulating hormones and locally released substances. Cell surface receptors are also targets for many therapeutically used drugs. This review will focus on ligand‐gated ion channel...
Tập 14 Số 6 - Trang 611-623 - 2002
Overlap between functional GI disorders and other functional syndromes: what are the underlying mechanisms?Abstract Background Irritable bowel syndrome and other gastrointestinal (GI) and non‐GI disorders such as functional dyspepsia, fibromyalgia, temporomandibular joint disorder, interstitial cystitis/painful bladder syndrome, and chronic fatigue syndrome are known as functional pain syndromes. They commonly coexist within the same individual. T...
Tập 24 Số 10 - Trang 895-913 - 2012