Neurogastroenterology and Motility

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Oesophageal wall stretch: the stimulus for distension induced oesophageal sensation
Neurogastroenterology and Motility - Tập 16 Số 6 - Trang 721-728 - 2004
Tomoshiro Takeda, Toshinaga Nabae, Ghassan S. Kassab, Jinyuan Liu, Ravinder K. Mittal
Abstract  Recently, we reported a novel ultrasound technique to assess the biomechanical properties of the oesophagus in humans. To investigate whether the oesophageal sensation induced by oesophageal distension correlates with wall tension, wall stress or wall strain, we studied 20 healthy subjects using a manometry catheter equipped with a high‐compliance bag and a high‐frequency intraluminal ul... hiện toàn bộ
Ghrelin regulates gastric phase III‐like contractions in freely moving conscious mice
Neurogastroenterology and Motility - Tập 21 Số 1 - Trang 78-84 - 2009
Jun Zheng, Hajime Ariga, Hiroshi Taniguchi, Kirk Ludwig, Toru Takahashi
Abstract  In humans and dogs, motilin regulates phase III contractions of migrating motor complex (MMC) in the interdigestive state, while ghrelin regulates MMC in rats. It still remains unclear whether ghrelin regulates phase III contractions of the mouse stomach. A miniature strain gauge transducer was sutured on the antrum to detect circular muscle contractions and gastric contractions of the i... hiện toàn bộ
Reversal of visceral hypersensitivity in rat by Menthacarin®, a proprietary combination of essential oils from peppermint and caraway, coincides with mycobiome modulation
Neurogastroenterology and Motility - Tập 30 Số 6 - 2018
Sara Botschuijver, Olaf Welting, Evgeni Levin, Daniele Maria-Ferreira, E Koch, R.C. Montijn, Jurgen Seppen, Theodorus B. M. Hakvoort, Frank Schuren, Wouter J. de Jonge, René M. van den Wijngaard
AbstractBackgroundIrritable bowel syndrome (IBS) is a common gastrointestinal disorder associated with altered gastrointestinal microflora and increased nociception to colonic distension. This visceral hypersensitivity can be reversed in our rat maternal separation model by fungicides. Menthacarin® is a proprietary combination of essential oils from Mentha x piperita L. and Carum carvi. Because th... hiện toàn bộ
Action potential generation, Kit receptor immunohistochemistry and morphology of steel‐Dickie (Sl/Sld) mutant mouse small intestine
Neurogastroenterology and Motility - Tập 10 Số 1 - Trang 11-26 - 1998
H B Mikkelsen, J Malysz, J D Huizinga, L Thuneberg
In contrast to wild‐type mice, homozygotes with mutations of the W locus do not express the functional Kit receptor and are severely deficient in the Auerbach's plexus (AP)‐associated subtype of interstitial cells of Cajal (ICC‐AP). With a morphologically intact neural and muscular structure, the absence in these mutants of both small‐intestinal slow waves and ICC‐AP constitutes strong evidence fo... hiện toàn bộ
From the bench to the ‘crib’‐side: implications of scientific advances to paediatric neurogastroenterology and motility
Neurogastroenterology and Motility - Tập 18 Số 4 - Trang 251-262 - 2006
Denesh K. Chitkara, Carlo Di Lorenzo
Manometry studies in children: minimum standards for procedures
Neurogastroenterology and Motility - Tập 14 Số 4 - Trang 411-420 - 2002
Carlo Di Lorenzo, Craig Hillemeier, Paul E. Hyman, Vera Loening–Baucke, Samuel Nurko, Ann Rosenberg, J. A. J. M. Taminiau
Brain activity during distention of the descending colon in humans
Neurogastroenterology and Motility - Tập 16 Số 3 - Trang 299-309 - 2004
Toyohiro Hamaguchi, Michiko Kano, H. Rikimaru, Motoyori Kanazawa, M. Itoh, Kazuhiko Yanai, Shin Fukudo
Abstract  Brain‐gut interaction is considered to be a major factor in the pathophysiology of irritable bowel syndrome. However, only limited information has been provided on the influence of gastrointestinal tract stimulation on the brain. Our aim in this study was to determine the specific regions of the brain that are responsible for visceral perception and emotion provoked by distention of the ... hiện toàn bộ
Protease‐activated receptor‐4 (PAR4): a role as inhibitor of visceral pain and hypersensitivity
Neurogastroenterology and Motility - Tập 21 Số 11 - Trang 1189 - 2009
Céline Augé, Daniela Balz-Hara, Martin Steinhoff, Nathalie Vergnolle, Nicolas Cénac
Abstract  Protease‐activated receptor‐4 (PAR4) belongs to the family of receptors activated by the proteolytic cleavage of their extracellular N‐terminal domain and the subsequent binding of the newly released N‐terminus. While largely expressed in the colon, the role of PAR4 in gut functions has not been defined. We have investigated the effects of PAR4 agonist on colonic sensations and sensory n... hiện toàn bộ
New insights into human enteric neuropathies
Neurogastroenterology and Motility - Tập 16 Số s1 - Trang 143-147 - 2004
Roberto De Giorgio, Stefania Guerrini, Giovanni Barbara, Cesare Cremon, Vincenzo Stanghellini, Roberto Corinaldesi
AbstractThe functioning of enteric neuronal circuitries has been elucidated in the recent past. Evidence is now gathering to explain how dysfunction of the enteric nervous system (ENS) may lead to human gastrointestinal motor disorders. These conditions include achalasia, congenital hypertrophic pyloric stenosis, chronic intestinal pseudo‐obstruction, Hirschsprung's disease, chronic idiopathic con... hiện toàn bộ
Enterochromaffin cell hyperplasia and decreased serotonin transporter in a mouse model of postinfectious bowel dysfunction
Neurogastroenterology and Motility - Tập 17 Số 6 - Trang 863-870 - 2005
Johanna Wheatcroft, D. Wakelin, Adrian L. Smith, Christine R. Mahoney, Gary M. Mawe, Robert E. Spiller
Abstract  Patients with postinfective irritable bowel syndrome and Trichinella spiralis‐infected mice share many features including visceral hypersensitivity and disordered motility. We assessed enterochromaffin (EC) numbers and serotonin transporter (SERT) using National Institute of Health (NIH) female mice studied for up to 56 days post‐T. spiralis infection. The effects of steroid treatment an... hiện toàn bộ
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