The intestinal barrier and its regulation by neuroimmune factors
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Bjarnason, 1995, Intestinal permeability: an overview, Gastroenterology, 108, 1566, 10.1016/0016-5085(95)90708-4
Travis, 1992, Intestinal permeability: functional assessment and significance, Clin Sci (Lond), 82, 471, 10.1042/cs0820471
Turner, 2009, Intestinal mucosal barrier function in health and disease, Nat Rev Immunol, 9, 799, 10.1038/nri2653
Watson, 2001, Functional modeling of tight junctions in intestinal cell monolayers using polyethylene glycol oligomers, Am J Physiol Cell Physiol, 281, C388, 10.1152/ajpcell.2001.281.2.C388
Krug, 2009, Tricellulin forms a barrier to macromolecules in tricellular tight junctions without affecting ion permeability, Mol Biol Cell, 20, 3713, 10.1091/mbc.e09-01-0080
Sanderson, 1993, Uptake and transport of macromolecules by the intestine: possible role in clinical disorders (an update), Gastroenterology, 104, 622, 10.1016/0016-5085(93)90436-G
Didierlaurent, 2002, How the gut senses its content, Cell Microbiol, 4, 61, 10.1046/j.1462-5822.2002.00177.x
Ponda, 2005, Mucosal epithelium in health and disease, Curr Mol Med, 5, 549, 10.2174/1566524054863933
Heyman, 1989, Endocytosis and processing of protein by isolated villus and crypt cells of the mouse small intestine, J Pediatr Gastroenterol Nutr, 9, 238, 10.1097/00005176-198908000-00018
Swaan, 1998, Recent advances in intestinal macromolecular drug delivery via receptor-mediated transport pathways, Pharm Res, 15, 826, 10.1023/A:1011908128045
Neutra, 1987, Transport of membrane-bound macromolecules by M cells in follicle-associated epithelium of rabbit Peyer’s patch, Cell Tissue Res, 247, 537, 10.1007/BF00215747
Frey, 1996, Role of the glycocalyx in regulating access of microparticles to apical plasma membranes of intestinal epithelial cells: implications for microbial attachment and oral vaccine targeting, J Exp Med, 184, 1045, 10.1084/jem.184.3.1045
Marsh, 2001, Endocytosis
Liu, 2001, Clathrin-Mediated Endocytosis. Endocytosis, 1
Heuser, 1980, Three-dimensional visualization of coated vesicle formation in fibroblasts, J Cell Biol, 84, 560, 10.1083/jcb.84.3.560
Goldstein, 1982, Receptor-mediated endocytosis and the cellular uptake of low density lipoprotein, Ciba Found Symp, 92, 77
Hewlett, 1994, The coated pit and macropinocytic pathways serve distinct endosome populations, J Cell Biol, 124, 689, 10.1083/jcb.124.5.689
Viswanathan, 2004, Microbes and their products - physiological effects upon mammalian mucosa, Adv Drug Deliv Rev, 56, 727, 10.1016/j.addr.2003.09.005
Lu, 2001, Pathologic and physiologic interactions of bacteria with the gastrointestinal epithelium, Am J Clin Nutr, 73, 1124S, 10.1093/ajcn/73.6.1124S
Owen, 1986, M cell transport of Vibrio cholerae from the intestinal lumen into Peyer’s patches: a mechanism for antigen sampling and for microbial transepithelial migration, J Infect Dis, 153, 1108, 10.1093/infdis/153.6.1108
Hamasaki, 2004, Association of early endosomal autoantigen 1 with macropinocytosis in EGF-stimulated A431 cells, Anat Rec A Discov Mol Cell Evol Biol, 277, 298, 10.1002/ar.a.20027
Lanzetti, 2004, Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases, Nature, 429, 309, 10.1038/nature02542
Amyere, 2000, Constitutive macropinocytosis in oncogene-transformed fibroblasts depends on sequential permanent activation of phosphoinositide 3-kinase and phospholipase C, Mol Biol Cell, 11, 3453, 10.1091/mbc.11.10.3453
Ragnarsson, 2008, Yersinia pseudotuberculosis induces transcytosis of nanoparticles across human intestinal villus epithelium via invasin-dependent macropinocytosis, Lab Invest, 88, 1215, 10.1038/labinvest.2008.86
Hommelgaard, 2005, Caveolae: stable membrane domains with a potential for internalization, Traffic, 6, 720, 10.1111/j.1600-0854.2005.00314.x
Tuma, 2003, Transcytosis: crossing cellular barriers, Physiol Rev, 83, 871, 10.1152/physrev.00001.2003
Farquhar, 1963, Junctional complexes in various epithelia, J Cell Biol, 17, 375, 10.1083/jcb.17.2.375
Mitic, 2000, Molecular physiology and pathophysiology of tight junctions I. Tight junction structure and function: lessons from mutant animals and proteins, Am J Physiol Gastrointest Liver Physiol, 279, G250, 10.1152/ajpgi.2000.279.2.G250
Nusrat, 2000, Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells, Am J Physiol Gastrointest Liver Physiol, 279, G851, 10.1152/ajpgi.2000.279.5.G851
Furuse, 1993, Occludin: a novel integral membrane protein localizing at tight junctions, J Cell Biol, 2, 1777, 10.1083/jcb.123.6.1777
Morita, 1999, Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands, Proc Natl Acad Sci USA, 96, 511, 10.1073/pnas.96.2.511
Liu, 2000, Human junction adhesion molecule regulates tight junction resealing in epithelia, J Cell Sci, 113, 2363, 10.1242/jcs.113.13.2363
Tepass, 2003, Claudin complexities at the apical junctional complex, Nat Cell Biol, 5, 595, 10.1038/ncb0703-595
Ikenouchi, 2005, Tricellulin constitutes a novel barrier at tricellular contacts of epithelial cells, J Cell Biol, 171, 939, 10.1083/jcb.200510043
Tsukita, 2001, Multifunctional strands in tight junctions, Nat Rev Mol Cell Biol, 2, 285, 10.1038/35067088
Laukoetter, 2007, JAM-A regulates permeability and inflammation in the intestine in vivo, J Exp Med, 204, 3067, 10.1084/jem.20071416
Mitic, 1998, Molecular architecture of tight junctions, Annu Rev Physiol, 60, 121, 10.1146/annurev.physiol.60.1.121
Madara, 1986, Effects of cytochalasin D on occluding junctions of intestinal absorptive cells: further evidence that the cytoskeleton may influence paracellular permeability and junctional charge selectivity, J Cell Biol, 102, 2125, 10.1083/jcb.102.6.2125
Turner, 1997, Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylation, Am J Physiol, 273, C1378, 10.1152/ajpcell.1997.273.4.C1378
Matsuda, 2004, A peculiar internalization of claudins, tight junction-specific adhesion molecules, during the intercellular movement of epithelial cells, J Cell Sci, 117, 1247, 10.1242/jcs.00972
Utech, 2005, Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: myosin II-dependent vacuolarization of the apical plasma membrane, Mol Biol Cell, 16, 5040, 10.1091/mbc.e05-03-0193
Mankertz, 2000, Expression from the human occludin promoter is affected by tumor necrosis factor alpha and interferon gamma, J Cell Sci, 113, 2085, 10.1242/jcs.113.11.2085
Bojarski, 2001, Permeability of human HT-29/B6 colonic epithelium as a function of apoptosis, J Physiol, 535, 541, 10.1111/j.1469-7793.2001.00541.x
Bruewer, 2003, Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms, J Immunol, 171, 6164, 10.4049/jimmunol.171.11.6164
Schulzke, 2006, Disrupted barrier function through epithelial cell apoptosis, Ann N Y Acad Sci, 1072, 288, 10.1196/annals.1326.027
Shen, 2005, Actin depolymerization disrupts tight junctions via caveolae-mediated endocytosis, Mol Biol Cell, 16, 3919, 10.1091/mbc.e04-12-1089
Ivanov, 2004, Endocytosis of epithelial apical junctional proteins by a clathrin-mediated pathway into a unique storage compartment, Mol Biol Cell, 15, 176, 10.1091/mbc.e03-05-0319
Fasano, 2008, Physiological, pathological, and therapeutic implications of zonulin-mediated intestinal barrier modulation: living life on the edge of the wall, Am J Pathol, 173, 1243, 10.2353/ajpath.2008.080192
Tripathi, 2009, Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2, Proc Natl Acad Sci USA, 106, 16799, 10.1073/pnas.0906773106
Heyman, 2005, Gut barrier dysfunction in food allergy, Eur J Gastroenterol Hepatol, 17, 1279, 10.1097/00042737-200512000-00003
Heyman, 1988, Antigen absorption by the jejunal epithelium of children with cow’s milk allergy, Pediatr Res, 24, 197, 10.1203/00006450-198808000-00012
Laitinen, 2005, Management of food allergy: vitamins, fatty acids or probiotics?, Eur J Gastroenterol Hepatol, 17, 1305, 10.1097/00042737-200512000-00007
Heyman, 1994, Mononuclear cells from infants allergic to cow’s milk secrete tumor necrosis factor alpha, altering intestinal function, Gastroenterology, 106, 1514, 10.1016/0016-5085(94)90405-7
Berin, 1998, The influence of mast cells on pathways of transepithelial antigen transport in rat intestine, J Immunol, 161, 2561, 10.4049/jimmunol.161.5.2561
Berin, 1997, Rapid transepithelial antigen transport in rat jejunum: impact of sensitization and the hypersensitivity reaction, Gastroenterology, 113, 856, 10.1016/S0016-5085(97)70180-X
Yang, 2000, Enhanced intestinal transepithelial antigen transport in allergic rats is mediated by IgE and CD23 (FcepsilonRII), J Clin Invest, 106, 879, 10.1172/JCI9258
Yu, 2001, Enhanced transepithelial antigen transport in intestine of allergic mice is mediated by IgE/CD23 and regulated by interleukin-4, Gastroenterology, 121, 370, 10.1053/gast.2001.26470
Matysiak-Budnik, 2008, Secretory IgA mediates retrotranscytosis of intact gliadin peptides via the transferrin receptor in celiac disease, J Exp Med, 205, 143, 10.1084/jem.20071204
Meddings, 1997, Review article: intestinal permeability in Crohn’s disease, Aliment Pharmacol Ther, 11, 47, 10.1111/j.1365-2036.1997.tb00808.x
Hollander, 1992, The intestinal permeability barrier. A hypothesis as to its regulation and involvement in Crohn’s disease, Scand J Gastroenterol, 27, 721, 10.3109/00365529209011172
Xavier, 2007, Unravelling the pathogenesis of inflammatory bowel disease, Nature, 448, 427, 10.1038/nature06005
Hollander, 1986, Increased intestinal permeability in patients with Crohn’s disease and their relatives. A possible etiologic factor, Ann Intern Med, 105, 883, 10.7326/0003-4819-105-6-883
Soderholm, 1999, Different intestinal permeability patterns in relatives and spouses of patients with Crohn’s disease: an inherited defect in mucosal defence?, Gut, 44, 96, 10.1136/gut.44.1.96
Marin, 1983, A freeze fracture study of Crohn’s disease of the terminal ileum: changes in epithelial tight junction organization, Am J Gastroenterol, 78, 537
Soderholm, 2002, Augmented increase in tight junction permeability by luminal stimuli in the non-inflamed ileum of Crohn’s disease, Gut, 50, 307, 10.1136/gut.50.3.307
Hollander, 1988, Crohn’s disease - a permeability disorder of the tight junction?, Gut, 29, 1621, 10.1136/gut.29.12.1621
Zeissig, 2004, Downregulation of epithelial apoptosis and barrier repair in active Crohn’s disease by tumour necrosis factor alpha antibody treatment, Gut, 53, 1295, 10.1136/gut.2003.036632
Zeissig, 2007, Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn’s disease, Gut, 56, 61, 10.1136/gut.2006.094375
Sartor, 1997, Pathogenesis and immune mechanisms of chronic inflammatory bowel diseases, Am J Gastroenterol, 92, 5S
Hugot, 2003, Crohn’s disease: the cold chain hypothesis, Lancet, 362, 2012, 10.1016/S0140-6736(03)15024-6
Fiocchi, 1998, Inflammatory bowel disease: etiology and pathogenesis, Gastroenterology, 115, 182, 10.1016/S0016-5085(98)70381-6
Soderholm, 1999, Epithelial permeability to proteins in the noninflamed ileum of Crohn’s disease?, Gastroenterology, 117, 65, 10.1016/S0016-5085(99)70551-2
Schurmann, 1999, Transepithelial transport processes at the intestinal mucosa in inflammatory bowel disease, Int J Colorectal Dis, 14, 41, 10.1007/s003840050181
Soderholm, 2004, Increased epithelial uptake of protein antigens in the ileum of Crohn’s disease mediated by tumour necrosis factor alpha, Gut, 53, 1817, 10.1136/gut.2004.041426
Bischoff, 1999, Mast cells are an important cellular source of tumour necrosis factor alpha in human intestinal tissue, Gut, 44, 643, 10.1136/gut.44.5.643
Lilja, 2000, Tumor necrosis factor-alpha in ileal mast cells in patients with Crohn’s disease, Digestion, 61, 68, 10.1159/000007737
Kelsall, 1996, Distinct populations of dendritic cells are present in the subepithelial dome and T cell regions of the murine Peyer’s patch, J Exp Med, 183, 237, 10.1084/jem.183.1.237
Rescigno, 2001, Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria, Nat Immunol, 2, 361, 10.1038/86373
Silva, 2008, Intestinal epithelial barrier dysfunction and dendritic cell redistribution during early stages of inflammation in the rat: role for TLR-2 and -4 blockage, Inflamm Bowel Dis, 14, 632, 10.1002/ibd.20379
Keita, 2008, Increased uptake of non-pathogenic E. coli via the follicle-associated epithelium in longstanding ileal Crohn’s disease, J Pathol, 215, 135, 10.1002/path.2337
Salim, 2009, CD83+ CCR7− dendritic cells accumulate in the subepithelial dome and internalize translocated Escherichia coli HB101 in the Peyer’s patches of ileal Crohn’s disease, Am J Pathol, 174, 82, 10.2353/ajpath.2009.080273
Gitter, 2001, Epithelial barrier defects in ulcerative colitis: characterization and quantification by electrophysiological imaging, Gastroenterology, 121, 1320, 10.1053/gast.2001.29694
Heller, 2005, Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution, Gastroenterology, 129, 550, 10.1016/j.gastro.2005.05.002
Schmitz, 1999, Tumor necrosis factor-alpha (TNFalpha) regulates the epithelial barrier in the human intestinal cell line HT-29/B6, J Cell Sci, 112, 137, 10.1242/jcs.112.1.137
Wallon, 2008, Increased macromolecular permeability in non-inflamed colon of ulcerative colitis involves muscarinic receptor signalling via subepithelial eosinophils, Gastroenterology, 134, A397
Dunlop, 2006, Abnormal intestinal permeability in subgroups of diarrhea-predominant irritable bowel syndromes, Am J Gastroenterol, 101, 1288, 10.1111/j.1572-0241.2006.00672.x
Spiller, 2000, Increased rectal mucosal enteroendocrine cells, T lymphocytes, and increased gut permeability following acute Campylobacter enteritis and in post-dysenteric irritable bowel syndrome, Gut, 47, 804, 10.1136/gut.47.6.804
Marshall, 2004, Intestinal permeability in patients with irritable bowel syndrome after a waterborne outbreak of acute gastroenteritis in Walkerton, Ontario, Aliment Pharmacol Ther, 12, 1317, 10.1111/j.1365-2036.2004.02284.x
Piche, 2009, Impaired intestinal barrier integrity in the colon of patients with irritable bowel syndrome: involvement of soluble mediators, Gut, 58, 196, 10.1136/gut.2007.140806
Gecse, 2008, Increased faecal serine protease activity in diarrhoeic IBS patients: a colonic lumenal factor impairing colonic permeability and sensitivity, Gut, 57, 591, 10.1136/gut.2007.140210
Coutinho, 2002, Neonatal maternal separation alters stress-induced responses to viscerosomatic nociceptive stimuli in rat, Am J Physiol Gastrointest Liver Physiol, 282, G307, 10.1152/ajpgi.00240.2001
Barreau, 2007, New insights in the etiology and pathophysiology of irritable bowel syndrome: contribution of neonatal stress models, Pediatr Res, 62, 240, 10.1203/PDR.0b013e3180db2949
Santos, 1998, Release of mast cell mediators into the jejunum by cold pain stress in humans, Gastroenterology, 114, 640, 10.1016/S0016-5085(98)70577-3
Alonso, 2008, Maladaptive intestinal epithelial responses to life stress may predispose healthy women to gut mucosal inflammation, Gastroenterology, 135, 163, 10.1053/j.gastro.2008.03.036
Barbara, 2004, Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome, Gastroenterology, 126, 693, 10.1053/j.gastro.2003.11.055
Guilarte, 2007, Diarrhoea-predominant IBS patients show mast cell activation and hyperplasia in the jejunum, Gut, 56, 203, 10.1136/gut.2006.100594
Farthing, 2000, Enterotoxins and the enteric nervous system - a fatal attraction, Int J Med Microbiol, 5, 491, 10.1016/S1438-4221(00)80073-9
Berthoud, 2004, Neuroanatomy of extrinsic afferents supplying the gastrointestinal tract, Neurogastroenterol Motil, 16, 28, 10.1111/j.1743-3150.2004.00471.x
Neunlist, 2003, Human ENS regulates the intestinal epithelial barrier permeability and a tight junction-associated protein ZO-1 via VIPergic pathways, Am J Physiol Gastrointest Liver Physiol, 285, G1028, 10.1152/ajpgi.00066.2003
Aube, 2006, Changes in enteric neurone phenotype and intestinal functions in a transgenic mouse model of enteric glia disruption, Gut, 55, 630, 10.1136/gut.2005.067595
Savidge, 2007, Enteric glia regulate intestinal barrier function and inflammation via release of S-nitrosoglutathione, Gastroenterology, 132, 1344, 10.1053/j.gastro.2007.01.051
Ottaway, 1987, Vasoactive intestinal peptide-containing nerves in Peyer’s patches, Brain Behav Immun, 1, 148, 10.1016/0889-1591(87)90017-1
Stead, 1987, Neuropeptide regulation of mucosal immunity, Immunol Rev, 100, 333, 10.1111/j.1600-065X.1987.tb00538.x
Bienenstock, 1987, The role of mast cells in inflammatory processes: evidence for nerve/mast cell interactions, Int Arch Allergy Appl Immunol, 82, 238, 10.1159/000234197
Stead, 1992, Innervation of mucosal immune cells in the gastrointestinal tract, Reg Immunol, 4, 91
Santos, 2001, Role of mast cells in chronic stress induced colonic epithelial barrier dysfunction in the rat, Gut, 48, 630, 10.1136/gut.48.5.630
Wallon, 2008, Corticotropin-releasing hormone (CRH) regulates macromolecular permeability via mast cells in normal human colonic biopsies in vitro, Gut, 57, 50, 10.1136/gut.2006.117549
Stead, 1988, Inflammatory Bowel Disease: Current Status and Future Approach, 43
Van der Kleij, 2003, Functional expression of neurokinin 1 receptors on mast cells induced by IL-4 and stem cell factor, J Immunol, 171, 2074, 10.4049/jimmunol.171.4.2074
Soderholm, 2001, Stress and gastrointestinal tract. II. Stress and intestinal barrier function, Am J Physiol Gastrointest Liver Physiol, 280, G7, 10.1152/ajpgi.2001.280.1.G7
Barclay, 1987, Effect of psychological stress on salt and water transport in the human jejunum, Gastroenterology, 93, 91, 10.1016/0016-5085(87)90319-2
Barclay, 1988, Effect of cold-induced pain on salt and water transport in the human jejunum, Gastroenterology, 94, 994, 10.1016/0016-5085(88)90558-6
Saunders, 1997, Cholinergic nerves mediate stress-induced intestinal transport abnormalities in Wistar-Kyoto rats, Am J Physiol, 273, G486
Pothoulakis, 1998, Neuroimmune mechanisms of intestinal responses to stress. Role of corticotropin-releasing factor and neurotensin, Ann N Y Acad Sci, 840, 635, 10.1111/j.1749-6632.1998.tb09602.x
Keita AV Söderholm JD Ericson AC Stress-induced barrier disruption of rat follicle-associated epithelium involves corticotropin-releasing hormone, acetylcholine, substance P, and mast cells Neurogastroenterol Motil 10.1111/j.1365-2982.2010.01471.x
Kiliaan, 1998, Stress stimulates transepithelial macromolecular uptake in rat jejunum, Am J Physiol, 1, G1037
Santos, 1999, Corticotropin-releasing hormone mimics stress-induced colonic epithelial pathophysiology in the rat, Am J Physiol, 277, G391
Cameron, 2007, Muscarinic acetylcholine receptor activation increases transcellular transport of macromolecules across mouse and human intestinal epithelium in vitro, Neurogastroenterol Motil, 19, 47, 10.1111/j.1365-2982.2006.00845.x
Demaude, 2009, Acute stress increases colonic paracellular permeability in mice through a mast cell-independent mechanism: involvement of pancreatic trypsin, Life Sci, 84, 847, 10.1016/j.lfs.2009.03.016
Gareau, 2007, Neonatal maternal separation of rat pups results in abnormal cholinergic regulation of epithelial permeability, Am J Physiol Gastrointest Liver Physiol, 293, G198, 10.1152/ajpgi.00392.2006
Santos, 2008, Stress neuropeptides evoke epithelial responses via mast cell activation in the rat colon, Psychoneuroendocrinology, 33, 1248, 10.1016/j.psyneuen.2008.07.002
Barreau, 2007, Pathways involved in gut mucosal barrier dysfunction induced in adult rats by maternal deprivation: corticotrophin-releasing factor and nerve growth factor interplay, J Physiol, 580, 347, 10.1113/jphysiol.2006.120907
Smith, 2010, Early weaning stress impairs development of mucosal barrier function in the porcine intestine, Am J Physiol Gastrointest Liver Physiol, 298, G352, 10.1152/ajpgi.00081.2009
Kawahito, 1995, Corticotropin releasing hormone in colonic mucosa in patients with ulcerative colitis, Gut, 37, 544, 10.1136/gut.37.4.544
Levenstein, 2000, Stress and exacerbation in ulcerative colitis: a prospective study of patients enrolled in remission, Am J Gastroenterol, 95, 1213, 10.1111/j.1572-0241.2000.02012.x
Bitton, 2003, Psychosocial determinants of relapse in ulcerative colitis: a longitudinal study, Am J Gastroenterol, 98, 2203, 10.1111/j.1572-0241.2003.07717.x
Castagliuolo, 1996, A neurotensin antagonist, SR 48692, inhibits colonic responses to immobilization stress in rats, Proc Natl Acad Sci USA, 93, 12611, 10.1073/pnas.93.22.12611
Castagliuolo, 1996, Acute stress causes mucin release from rat colon: role of corticotropin releasing factor and mast cells, Am J Physiol, 271, G884
Demaude, 2006, Phenotypic changes in colonocytes following acute stress or activation of mast cells in mice: implications for delayed epithelial barrier dysfunction, Gut, 55, 655, 10.1136/gut.2005.078675
Theoharides, 1999, Stress-induced rat intestinal mast cell intragranular activation and inhibitory effect of sulfated proteoglycans, Dig Dis Sci, 8, 87S
Moeser, 2007, Stress signaling pathways activated by weaning mediate intestinal dysfunction in the pig, Am J Physiol Gastrointest Liver Physiol, 292, G173, 10.1152/ajpgi.00197.2006
Castagliuolo, 1998, Colonic mucin release in response to immobilization stress is mast cell dependent, Am J Physiol, 274, G1094
Soderholm, 2002, Chronic stress induces mast cell-dependent bacterial adherence and initiates mucosal inflammation in rat intestine, Gastroenterology, 123, 1099, 10.1053/gast.2002.36019
Crowe, 1993, Anti-immunoglobulin E-stimulated ion transport in human large and small intestine, Gastroenterology, 105, 764, 10.1016/0016-5085(93)90894-I
Fihn, 2003, Involvement of enteric nerves in permeability changes due to deoxycholic acid in rat jejunum in vivo, Acta Physiol Scand, 178, 241, 10.1046/j.1365-201X.2003.01144.x
Youakim, 1999, Interferon-gamma decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin, Am J Physiol, 276, G1279
Madara, 1989, Interferon-gamma directly affects barrier function of cultured intestinal epithelial monolayers, J Clin Invest, 83, 724, 10.1172/JCI113938
Wang, 2005, Interferon-gamma and tumor necrosis factor-alpha synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression, Am J Pathol, 166, 409, 10.1016/S0002-9440(10)62264-X
Watson, 2004, Green tea polyphenol (−)-epigallocatechin gallate blocks epithelial barrier dysfunction provoked by IFN-gamma but not by IL-4, Am J Physiol Gastrointest Liver Physiol, 287, G954, 10.1152/ajpgi.00302.2003
McKay, 2007, Phosphatidylinositol 3′-kinase is a critical mediator of interferon-gamma-induced increases in enteric epithelial permeability, J Pharmacol Exp Ther, 320, 1013, 10.1124/jpet.106.113639
Clark, 2005, Interferon gamma induces translocation of commensal Escherichia coli across gut epithelial cells via a lipid raft-mediated process, Gastroenterology, 128, 1258, 10.1053/j.gastro.2005.01.046
Yang, 2002, Interferon-gamma expression by intraepithelial lymphocytes results in a loss of epithelial barrier function in a mouse model of total parenteral nutrition, Ann Surg, 236, 226, 10.1097/00000658-200208000-00011
Cenac, 2004, PAR2 activation alters colonic paracellular permeability in mice via IFN-gamma-dependent and -independent pathways, J Physiol, 558, 913, 10.1113/jphysiol.2004.061721
Ferrier, 2003, Stress-induced disruption of colonic epithelial barrier: role of interferon-gamma and myosin light chain kinase in mice, Gastroenterology, 125, 795, 10.1016/S0016-5085(03)01057-6
Gitter, 2000, Leaks in the epithelial barrier caused by spontaneous and TNF-alpha-induced single-cell apoptosis, FASEB J, 14, 1749, 10.1096/fj.99-0898com
Clayburgh, 2005, Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo, J Clin Invest, 115, 2702, 10.1172/JCI24970
Zareie, 2001, Monocyte/macrophage activation by normal bacteria and bacterial products: implications for altered epithelial function in Crohn’s disease, Am J Pathol, 158, 1101, 10.1016/S0002-9440(10)64057-6
Suenaert, 2002, Anti-tumor necrosis factor treatment restores the gut barrier in Crohn’s disease, Am J Gastroenterol, 97, 2000, 10.1111/j.1572-0241.2002.05914.x
Payne, 2004, Mast cell tryptase: a review of its physiology and clinical significance, Anaesthesia, 59, 695, 10.1111/j.1365-2044.2004.03757.x
Cenac, 2002, Induction of intestinal inflammation in mouse by activation of proteinase-activated receptor-2, Am J Pathol, 161, 1903, 10.1016/S0002-9440(10)64466-5
He, 2004, Key role of mast cells and their major secretory products in inflammatory bowel disease, World J Gastroenterol, 10, 309, 10.3748/wjg.v10.i3.309
Bueno, 2008, Protease-activated receptor 2 and gut permeability: a review, Neurogastroenterol Motil, 20, 580, 10.1111/j.1365-2982.2008.01139.x
Coelho, 2002, Proteinases and proteinase-activated receptor 2: a possible role to promote visceral hyperalgesia in rats, Gastroenterology, 122, 1035, 10.1053/gast.2002.32387
Jacob, 2005, c-Cbl mediates ubiquitination, degradation, and down-regulation of human protease-activated receptor 2, J Biol Chem, 280, 16076, 10.1074/jbc.M500109200
Roka, 2007, Colonic luminal proteases activate colonocyte proteinase-activated receptor-2 and regulate paracellular permeability in mice, Neurogastroenterol Motil, 19, 57, 10.1111/j.1365-2982.2006.00851.x
Roka, 2007, Dexamethasone prevents visceral hyperalgesia but not colonic permeability increase induced by luminal protease-activated receptor-2 agonist in rats, Gut, 56, 1072, 10.1136/gut.2006.115352
Al Sadi, 2007, IL-1beta causes an increase in intestinal epithelial tight junction permeability, J Immunol, 178, 4641, 10.4049/jimmunol.178.7.4641
Al Sadi, 2008, Mechanism of IL-1beta-induced increase in intestinal epithelial tight junction permeability, J Immunol, 180, 5653, 10.4049/jimmunol.180.8.5653
Berin, 1999, Role for IL-4 in macromolecular transport across human intestinal epithelium, Am J Physiol, 276, C1046, 10.1152/ajpcell.1999.276.5.C1046
Di L, 2002, Factors regulating the effect of IL-4 on intestinal epithelial barrier function, Int Arch Allergy Immunol, 129, 219, 10.1159/000066778
Wisner, 2008, Opposing regulation of the tight junction protein claudin-2 by interferon-gamma and interleukin-4, J Surg Res, 144, 1, 10.1016/j.jss.2007.03.059
Ceponis, 2000, Interleukins 4 and 13 increase intestinal epithelial permeability by a phosphatidylinositol 3-kinase pathway. Lack of evidence for STAT 6 involvement, J Biol Chem, 275, 29132, 10.1074/jbc.M003516200
Prasad, 2005, Inflammatory processes have differential effects on claudins 2, 3 and 4 in colonic epithelial cells, Lab Invest, 85, 1139, 10.1038/labinvest.3700316
Nylander, 2001, COX inhibition excites enteric nerves that affect motility, alkaline secretion, and permeability in rat duodenum, Am J Physiol Gastrointest Liver Physiol, 281, G1169, 10.1152/ajpgi.2001.281.5.G1169
Bischoff, 2007, Role of mast cells in allergic and non-allergic immune responses: comparison of human and murine data, Nat Rev Immunol, 7, 93, 10.1038/nri2018
Bischoff, 2009, Physiological and pathophysiological functions of intestinal mast cells, Semin Immunopathol, 31, 185, 10.1007/s00281-009-0165-4
Ponferrada, 2007, The role of PPARgamma on restoration of colonic homeostasis after experimental stress-induced inflammation and dysfunction, Gastroenterology, 132, 1791, 10.1053/j.gastro.2007.02.032
Gookin, 2003, PG-mediated closure of paracellular pathway and not restitution is the primary determinant of barrier recovery in acutely injured porcine ileum, Am J Physiol Gastrointest Liver Physiol, 285, G967, 10.1152/ajpgi.00532.2002
Eutamene, 1998, Involvement of interleukin-1, prostaglandins and mast cells in rectal distension-induced colonic water secretion in rats, J Physiol, 506, 245, 10.1111/j.1469-7793.1998.245bx.x
Zamuner, 2003, Cyclooxygenase 2 mediates post-inflammatory colonic secretory and barrier dysfunction, Gut, 52, 1714, 10.1136/gut.52.12.1714
Zamuner, 2005, Predisposition to colorectal cancer in rats with resolved colitis: role of cyclooxygenase-2-derived prostaglandin d2, Am J Pathol, 167, 1293, 10.1016/S0002-9440(10)61216-3